CN101264169B - Alcohol-clearing liver nourishing capsule and manufacturing technique - Google Patents
Alcohol-clearing liver nourishing capsule and manufacturing technique Download PDFInfo
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- CN101264169B CN101264169B CN2007100851901A CN200710085190A CN101264169B CN 101264169 B CN101264169 B CN 101264169B CN 2007100851901 A CN2007100851901 A CN 2007100851901A CN 200710085190 A CN200710085190 A CN 200710085190A CN 101264169 B CN101264169 B CN 101264169B
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Abstract
The invention relates to a medicine for preventing and curing alcoholic liver diseases and hyperlipidemia and the production technology, belonging to the technical field of Chinese traditional medicine, which comprises lobular ligustrum leaves, crab apple leaves, medlar leaves, Artemisia capillaris, kudzu root, kudzu flower, schisandra, cassia seed and radix glycyrrhizae. The materials are extracted using alcohol extraction technology and then made into grain, capsule or tablets. Compared with the prior art, the medicine has the advantages of good efficacy, side effects eliminating, wide medicine sources and convenient taking. The medicine cures 39 cases of alcohol liver with clinical comparison experiments with the total effective rate being 91.67%, apparently higher than the comparison group (P<0.01); the therapeutic effects to TC, TG and ALT are also higher than the comparison group (P<0.05). In drinking amount tests of normal population, the Qingchun Jiangan Capsule can improve the drinking amount by 20% to 30%. The research data from experimental research, clinical comparison experiment and drinking amount tests of normal population show that Qingchun Jiangan Capsule has obvious therapeutic effects in preventing and curing alcoholic liver diseases and hyperlipidemia.
Description
The invention belongs to the Chinese medicine technical field, relate to the medicine and the manufacturing process of a kind of prevention and treatment alcoholic liver disease, hyperlipemia.
At present, the more and more higher alcoholic liver disease of prevalence rate, hyperlipemia still there is not specific short.Clinical used for many years silymarin and fenofibrate also curative effect is very little.Therefore, the development Chinese herbal and crude drugs preparations that price is low, side effect is little prevents and treats very necessity of alcoholic liver disease, hyperlipemia.
Task of the present invention provides a kind of prevention and treats alcoholic liver disease, hyperlipemia curative effect height, and side effect is little, and cost is low, the Chinese medicine preparation of taking convenience, thus overcome the deficiency that has medicine now.
Task of the present invention realizes with following scheme.
Medicine of the present invention is made up of the raw material of following weight ratio: Ligustrum quihoui leaf 0.1-2.0, Folium Crataegi 1.0-3.0, Folium Lycii 0.1-2.0, Herba Artemisiae Scopariae 0.1-2.0, Radix Puerariae 1.0-3.0, Flos puerariae lobatae 0.1-1.5, Fructus Schisandrae Chinensis 0.1-2.0, Semen Cassiae 0.1-2.0, Radix Glycyrrhizae 0.1-1.5.
Another prescription of medicine of the present invention is made up of the raw material of following weight ratio: Ligustrum quihoui leaf 1.0, Folium Crataegi 2.0, Folium Lycii 1.0, Herba Artemisiae Scopariae 1.0, Radix Puerariae 2.0, Flos puerariae lobatae 0.5, Fructus Schisandrae Chinensis 1.0, Semen Cassiae 1.0, Radix Glycyrrhizae 0.5.
The preparation technology of medicine of the present invention is: with the Ligustrum quihoui leaf, Folium Crataegi, Folium Lycii, Herba Artemisiae Scopariae, Radix Puerariae, Flos puerariae lobatae, Fructus Schisandrae Chinensis, Semen Cassiae, nine kinds of medical materials of Radix Glycyrrhizae, doubly measure reflux, extract, three times with 50-70% ethanol 3-5, merge extractive liquid,, it is the extractum of 1.10-1.15 50 ℃ the time that ethanol liquid is concentrated into relative density, add ethanol, make and contain alcohol amount and reach 60%, cold preservation, filter, reclaim ethanol and be condensed into thick paste, relative density is 1.30-1.35 in the time of 50 ℃, with the thick paste drying, it is standby to be ground into fine powder, makes granule after 2 hours, encapsulated, or make tablet with tablet machine.
Medicine of the present invention is through controlled clinical trial treatment alcoholic liver 36 examples, and total effective rate is 91.67%, apparently higher than matched group (P＜0.01), TC, TG, ALT curative effect also is higher than matched group (P＜0.05).The test of normal population drinking amount, the refreshing and mellow liver nourishing capsule can improve drinking amount 20-30%.Comprehensive refreshing and mellow liver nourishing capsule shows that at drink research data aspect three of the experimental tests of experimentation, controlled clinical trial and normal population the refreshing and mellow liver nourishing capsule has tangible curative effect aspect the blood fat reducing of relieving the effect of alcohol.
Medicine of the present invention is compared good effect with existing medicine, is had no side effect, the medicine source is wide, taking convenience.Be prevention and treatment alcoholic liver disease, the comparatively ideal medicine of hyperlipemia.
Embodiment one
Prescription: Ligustrum quihoui leaf 1.0, Folium Crataegi 2.0, Folium Lycii 1.0, Herba Artemisiae Scopariae 1.0, Radix Puerariae 2.0, Flos puerariae lobatae 0.5, Fructus Schisandrae Chinensis 1.0, Semen Cassiae 1.0, Radix Glycyrrhizae 0.5.
Method for making: with Ligustrum quihoui leaf, Folium Crataegi, Folium Lycii, Herba Artemisiae Scopariae, Radix Puerariae, Flos puerariae lobatae, Fructus Schisandrae Chinensis, Semen Cassiae, nine kinds of medical materials of Radix Glycyrrhizae, doubly measure reflux, extract, three times with 50-70% ethanol 3-5, merge extractive liquid,, it is the extractum of 1.10-1.15 50 ℃ the time that ethanol liquid is concentrated into relative density, add ethanol, make and contain alcohol amount and reach 60%, cold preservation, filtration, reclaim ethanol and be condensed into thick paste, relative density is 1.30-1.35 in the time of 50 ℃, with the thick paste drying, be ground into fine powder, add excipient and make granule.
Embodiment two
Prescription: Ligustrum quihoui leaf 1.5, Folium Crataegi 1.5, Folium Lycii 1.0, Herba Artemisiae Scopariae 1.0, Radix Puerariae 1.5, Flos puerariae lobatae 0.5, Fructus Schisandrae Chinensis 1.5, Semen Cassiae 1.0, Radix Glycyrrhizae 0.5.
Method for making: earlier Flos puerariae lobatae is ground into 200 order fine powders.With Ligustrum quihoui leaf, Folium Crataegi, Folium Lycii, Herba Artemisiae Scopariae, Radix Puerariae, Fructus Schisandrae Chinensis, Semen Cassiae, eight kinds of medical materials of Radix Glycyrrhizae, doubly measure reflux, extract, three times with 50-70% ethanol 3-5, merge extractive liquid, is condensed into extractum with ethanol liquid, adds ethanol, make and contain alcohol amount and reach 60%, cold preservation, filtration are reclaimed ethanol and also are condensed into thick paste, with the thick paste drying, be ground into fine powder, make granule after 2 hours, encapsulated.
Case one
Chen, man, 47 years old.Cause is often drunk, surplus prescription on individual diagnosis half a year of upper abdomen distending pain.History of drinking history is arranged 21 years, every day drinking amount 0,3kg.Have a medical check-up: body temperature is normal, and the bodily form is fat slightly, 82 kilograms of body weight.The hepatic region tenderness is not obvious.Liver function: ALT 112u, AST 109u, TBIL 18umol/, triglyceride 6.41umol/l.B ultrasonic shows fatty liver.Be diagnosed as alcoholic fatty liver, hyperlipemia.Give 4 of refreshing and mellow liver nourishing capsules, every day 3 times, oral meal serve on for 4 weeks.Check every index of liver function and triglyceride are normal.It is normal that the B ultrasonic ultrasonogram recovers.
Case two
Lee, man, 52 years old.Because of often drinking, look into and the fatty liver prescription on individual diagnosis.History of drinking history is arranged 25 years, every day drinking amount 0.25kg.Have a medical check-up: body temperature is normal, and the bodily form is fat slightly, body weight 79kg.The hepatic region tenderness is not obvious.Liver function: ALT 127u, AST 151u, TBIL 12umol/l, triglyceride 7.40umol/l.B ultrasonic shows fatty liver.Be diagnosed as alcoholic fatty liver, hyperlipemia.Give 4 of refreshing and mellow liver nourishing capsules, every day 3 times, oral meal serve on for 4 weeks.It is normal that check liver function and triglyceride recover.The B ultrasonic ultrasonogram is normal.
Case three
Chu, man, 34 years old.Because of often drinking, look into and the fatty liver prescription on individual diagnosis.History of drinking history is arranged 9 years, every day drinking amount 0.45kg.Have a medical check-up: the bodily form is fat slightly, body weight 65kg.The hepatic region tenderness is not obvious.Liver function: ALT 92u, AST 84u, TBIL 13umol/l, triglyceride 4.91umol/l.B ultrasonic shows fatty liver.Be diagnosed as alcoholic fatty liver.Give 4 of refreshing and mellow liver nourishing capsules, every day 3 times, oral meal serve on for 4 weeks.It is normal that check liver function and triglyceride recover.The B ultrasonic ultrasonogram is normal again.
Claims (4)
1. the medicine of a prevention and treatment alcoholic liver disease, hyperlipemia, it is characterized in that it is made by the dry product raw material of following weight ratio: Ligustrum quihoui leaf 0.1-2.0, Folium Crataegi 1.0-3.0, Folium Lycii 0.1-2.0, Herba Artemisiae Scopariae 0.1-2.0, Radix Puerariae 1.0-3.0, Flos puerariae lobatae 0.1-1.5, Fructus Schisandrae Chinensis 0.1-2.0, Semen Cassiae 0.1-2.0, Radix Glycyrrhizae 0.1-1.5.
2. medicine according to claim 1 is characterized in that it is made by the raw material of following weight ratio: Ligustrum quihoui leaf 1.0, Folium Crataegi 2.0, Folium Lycii 1.0, Herba Artemisiae Scopariae 1.0, Radix Puerariae 2.0, Flos puerariae lobatae 0.5, Fructus Schisandrae Chinensis 1.0, Semen Cassiae 1.0, Radix Glycyrrhizae 0.5.
3. medicine according to claim 1 and 2, its preparation technology is: with the Ligustrum quihoui leaf, Folium Crataegi, Folium Lycii, Herba Artemisiae Scopariae, Radix Puerariae, Flos puerariae lobatae, Fructus Schisandrae Chinensis, Semen Cassiae, nine kinds of medical materials of Radix Glycyrrhizae, doubly measure reflux, extract, three times with 50-70% ethanol 3-5, merge extractive liquid,, it is the extractum of 1.10-1.15 50 ℃ the time that ethanol liquid is concentrated into relative density, add ethanol, make and contain alcohol amount and reach 60%, cold preservation, filter, reclaim ethanol and be condensed into thick paste, relative density is 1.30-1.35 in the time of 50 ℃, with the thick paste drying, it is standby to be ground into fine powder, make granule after 2 hours, encapsulated, or make tablet with tablet machine.
4. medicine according to claim 1 and 2 is characterized in that pharmaceutical formulation is capsule, granule and tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100851901A CN101264169B (en) | 2007-03-18 | 2007-03-18 | Alcohol-clearing liver nourishing capsule and manufacturing technique |
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| CN2007100851901A CN101264169B (en) | 2007-03-18 | 2007-03-18 | Alcohol-clearing liver nourishing capsule and manufacturing technique |
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| CN101264169A CN101264169A (en) | 2008-09-17 |
| CN101264169B true CN101264169B (en) | 2011-08-24 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389471B (en) * | 2011-11-22 | 2013-07-10 | 唐晶磊 | Alcohol effect relieving electuary |
| CN102613366A (en) * | 2012-04-24 | 2012-08-01 | 哈尔滨工业大学 | Anti-alcoholic tea and preparation method thereof |
| CN102613573A (en) * | 2012-04-28 | 2012-08-01 | 哈尔滨工业大学 | Medicine granules with anti-alcoholic function and sobering-up function and preparation method of medicine granules |
| CN103999966B (en) * | 2014-05-16 | 2016-02-10 | 安徽皖斛堂生物科技有限公司 | A kind of stem of noble dendrobium Dealcoholic liver-protecting tea and preparation method thereof |
| CN105287899A (en) * | 2015-11-20 | 2016-02-03 | 钱峰 | Traditional Chinese medicine alcoholism-relieving tea and production technology thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229674A (en) * | 1999-02-09 | 1999-09-29 | 郑力国 | Tonic Chinese medicine for preventing harm of alcohol to human body, and its process method |
| CN1698747A (en) * | 2005-05-26 | 2005-11-23 | 淄博市第一医院 | Chinese medicinal liquor for treating alcoholic liver disease |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229674A (en) * | 1999-02-09 | 1999-09-29 | 郑力国 | Tonic Chinese medicine for preventing harm of alcohol to human body, and its process method |
| CN1698747A (en) * | 2005-05-26 | 2005-11-23 | 淄博市第一医院 | Chinese medicinal liquor for treating alcoholic liver disease |
Non-Patent Citations (3)
| Title |
|---|
| 孙劲晖等.中医药防治酒精性肝病的临床和实验研究进展.中医药学报.2002,30(2),65-67. * |
| 徐向田等.清醇健肝胶囊防治酒精性肝病临床和实验研究.中国中医药信息杂志.2004,11(2),105-106. * |
| 莫滚.中医治疗脂肪肝近况.广西中医药.2007,30(3),4-6. * |
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Application publication date: 20080917 Assignee: Junan xiangtian rehabilitation Hospital Assignor: Xu Xiangtian Contract record no.: X2020980010045 Denomination of invention: Qingchun Jiangan capsule and its manufacturing technology Granted publication date: 20110824 License type: Common License Record date: 20201229 |
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