CN105477213A - Traditional Chinese medicine composition for reducing blood fat and preparing method thereof - Google Patents
Traditional Chinese medicine composition for reducing blood fat and preparing method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K9/20—Pills, tablets, discs, rods
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A61K9/4866—Organic macromolecular compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a traditional Chinese medicine composition for reducing blood fat and a preparing method thereof. The traditional Chinese medicine composition is prepared from hawthorn fruit, radix astragali, rhizoma atractylodis macrocephalae, polygonum cuspidatum, semen cassia, radix bupleuri, polygala tenuifolia and rhizoma alismatis. Animal pharmacodynamics results show that the traditional Chinese medicine composition for reducing blood fat has a remarkable effect on reducing serum total cholesterol (TC) and triglyceride (TG). Therefore, the traditional Chinese medicine composition can reduce blood fat and is suitable for people suffering from hyperlipidemia for long-term taking so that blood fat can be controlled.
Description
Invention field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine composition for the treatment of blood fat reducing, the invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
At present, along with growth in the living standard, the diet of people is also more and more abundanter, and the patient of hyperlipidemia is also very general, be common in middle-aged and elderly people, but along with the change of dietary structure and the rising of drinking amount, its prevalence of adolescence also increasing year by year. hyperlipidemia is a kind of common and multiple metabolic disease, comprise hypercholesterolemia, hypertriglyceridemia and plyability hyperlipemia, this is one of principal element causing atherosclerosis and coronary heart disease.The clinical manifestation of hyperlipidemia is the xanthoma of lipid caused by intradermal deposition and the arteriosclerosis of lipid caused by Ink vessel transfusing deposition mainly.
The Drug therapy of hyperlipidemia, chemical medicine aspect mainly comprises cholesterol absorption inhibitor class, acyl-coenzyme a cholesterol acyltransferase inhibitor, Statins, shellfish special class, nicotinic acid class etc.But although chemical medicine treatment curative effect is very fast, toxic and side effects is comparatively large, cure the symptoms, not the disease, and price is relatively high.
It is low except toxic and side effects that treatment by Chinese herbs hyperlipemia compares chemical medicine, has unique advantage, and can improve the adaptability of patient.Modern study mainly contains two kinds of modes: single medicinal material and prescription.Have scholar with reference to medical monograph over the years and magazine, statistics has the Chinese medicine of effect for reducing fat more than 135 kinds.The effective ingredient about more than 40 of its blood fat reducing is planted, mainly contain: saponins, Anthraquinones, flavonoid, alkaloids, volatile oil and fatty oils, polysaccharide, in addition, the compounds such as minority steroid, terpenoid are still had to show certain effect for reducing fat in research in recent years.Single medicinal material treatment hyperlipidemia, do not have the overall medication advantage of compound recipe, although the Reducing Blood Lipid by Chinese medicine medicine kind of current Clinical practice is many, action effect is not obvious, can not play good therapeutical effect.Therefore research screening is evident in efficacy, and the low Chinese medicine compound of side effect is particularly important.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition of blood fat reducing;
Another object of the present invention is to provide a kind of preparation method of Chinese medicine composition of blood fat reducing.
The object of the invention is by following technical scheme realize:
Chinese medicinal composition for reducing blood fat of the present invention is prepared from by the raw material comprising following weight portion:
Fructus Crataegi 8-18 part, Radix Astragali 4-16 part, Rhizoma Atractylodis Macrocephalae 4-15 part, Rhizoma Polygoni Cuspidati 5-12 part, Semen Cassiae 5-10 part, Radix Bupleuri 5-10 part, Radix Polygalae 2-8 part, Rhizoma Alismatis 2-6 part.
Preferably, be prepared from by the raw material of following weight portion: Fructus Crataegi 10-15 part, Radix Astragali 8-10 part, Rhizoma Atractylodis Macrocephalae 10-12 part, Rhizoma Polygoni Cuspidati 7-9 part, Semen Cassiae 7-9 part, Radix Bupleuri 6-8 part, Radix Polygalae 5-7 part, Rhizoma Alismatis 3-5 part.
More preferably, be prepared from by the raw material of following weight portion: Fructus Crataegi 12 parts, the Radix Astragali 9 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Rhizoma Polygoni Cuspidati 8 parts, Semen Cassiae 8 parts, Radix Bupleuri 7 parts, Radix Polygalae 6 parts, Rhizoma Alismatis 4 parts.
Crude drug source and the property of medicine of the present invention's Chinese medicine used are as follows:
Fructus Crataegi: this product is rosaceous plant Fructus Pyri Pashiae Crataeguspin, natiidaBge.var.majorN.E.Br. or Fructus Crataegi Crat promoting digestion and invigorating the stomach, and circulation of qi promoting dissipating blood stasis, changes turbid blood fat reducing.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipemia.
The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali Astragalusmembranaceus (Fisch) Bge.var.mongholicus (Bge) Hsiao or Radix Astragali Astragalusmembranaceus (Fisch) Bge..Tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, hemiplegia, and arthralgia pain is numb, and carbuncle difficulty is burst, and bursts for a long time and does not hold back.
The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atract μ lodesmacrocephalaKoidz..Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Semen Cassiae: this product is the dry mature seed of leguminous plant Semen Cassiae CassiaobtusifoliaL or little Semen Cassiae CassiatoraL.Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.Radix Polygalae: Fructus Alpiniae Oxyphyllae of calming the nerves, restoring normal coordination between the heart and kidney, eliminates the phlegm, detumescence.The insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Rhizoma Alismatis: this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alismaorientalis (Sam.) Juzep..Promoting diuresis to eliminate damp pathogen, expels the heat-evil, and changes turbid blood fat reducing.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.
Another aspect of the present invention there is provided the preparation method of Chinese medicine composition effective ingredient of the present invention, can be will to filter the Aqueous extracts obtaining described raw material after above-mentioned raw material of Chinese medicine together decocting, condensed water extract, add ethanol, precipitation, supernatant reclaims ethanol, continues concentrated obtained clear paste; Or above-mentioned raw material of Chinese medicine one is reinstated the alcohol extract that ethanol extraction obtains described raw material, continue to be condensed into clear paste;
Scheme one: all medical material decocts with water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, collecting decoction, filters, concentrated, the percent by volume adding concentrated solution weight 0.5 times be 30% ~ 70% ethanol stir, leave standstill 24 hours, supernatant reclaims ethanol and concentrated obtained 70 DEG C of relative densities are 1.10 ~ 1.25 clear paste, to obtain final product.
Scheme two: all medical material adds ethanol extraction 2-3 time that percent by volume is 30 ~ 70%, and each ethanol consumption is 4-10 times of medical material total amount, and extraction time is 1-3 hour, merge extractive liquid, filter, reclaiming ethanol and being condensed into 70 DEG C of relative densities is the clear paste of 1.10 ~ 1.25, to obtain final product.
Chinese medicinal composition for reducing blood fat of the present invention, can with pharmaceutically acceptable carrier combination, make various common dosage forms, as tablet, granule, capsule, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get one of scheme one to scheme two gained effective ingredient, be dried to dried cream powder, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: granule
Get one of scheme one to scheme two gained effective ingredient, be dried to dried cream powder, add granule and commonly use adjuvant, production method is prepared into granule of the present invention routinely.
Above-mentioned granule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent or whole.
Method 3: capsule
Get one of scheme one to scheme two gained effectiveness composition, be dried to dried cream powder, add capsule and commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 4: syrup
Get one of scheme one to scheme two gained effective ingredient, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Method 5: mixture
Get one of scheme one to scheme two gained effective ingredient, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.
Chinese medicine thinks that hypercalcinuria is deficiency in origin and excess in superficiality, belong to " blood stasis ", " expectorant is turbid " category, clinically dialectically be attributed to that caused by liver and kidney deficiency, insufficiency of the spleen expectorant are turbid, qi depression to blood stasis, during treatment, mostly adopt liver and kidney tonifying, invigorating the spleen and benefiting QI, nourishing YIN and benefiting blood, blood circulation promoting and blood stasis dispelling, clearing away heat and loosing the bowels, the medicine that eliminates indigestion and phlegm.We reuse Fructus Crataegi, the Radix Astragali, Crataegolic acid, sweet, tepor.Return spleen, stomach, Liver Channel, promoting digestion and invigorating the stomach, circulation of qi promoting, promoting blood circulation to remove blood stasis, change turbid blood fat reducing.For meat stagnation, gastral cavilty distension, blood stasis amenorrhea, the diseases such as hyperlipemia; The Radix Astragali is sweet, tepor.Return lung, spleen channel, tonify Qi of the kidney, expel pathogenetic factors and reinforce antipathogenetic qi.Modern pharmacology effect shows to have blood fat reducing, study of anti-atherogenic effect, is monarch drug altogether, shape spleen invigoratingization is turbid, effect of blood circulation promoting and blood stasis dispelling with Fructus Crataegi.The Rhizoma Atractylodis Macrocephalae is bitter, sweet, temperature.Returning spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, is traditional Chinese medical science spleen reinforcing key medicine; The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian, dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, relieving cough and resolving phlegm; Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, expels the heat-evil, and changes turbid blood fat reducing, with ministerial drug in the Rhizoma Atractylodis Macrocephalae side of being all.Semen Cassiae clearing away heat to improve acuity of vision, loosening bowel to relieve constipation; Radix Bupleuri reconciling superficies and interior, soothing the liver, yang invigorating; Radix Polygalae is calmed the nerves Fructus Alpiniae Oxyphyllae, eliminating phlegm for diminishing swelling; Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, expels the heat-evil, and changes turbid blood fat reducing, adjuvant in the side of being all.
Advantage: Chinese medicine composition of the present invention has significant effect for reducing blood fat, and prescription crude drug source is extensive, cheap; Safety is simultaneously higher, is applicable to people with hyperlipidemia life-time service.
Detailed description of the invention
Below in conjunction with specific embodiment, set forth the present invention further.Should be understood that these embodiments are only not used in for illustration of the present invention to limit the scope of the invention.
Embodiment 1: the preparation of Tablets
Get Fructus Crataegi 8 parts, the Radix Astragali 16 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Rhizoma Polygoni Cuspidati 5 parts, Semen Cassiae 5 parts, Radix Bupleuri 5 parts, Radix Polygalae 2 parts, Rhizoma Alismatis 2 parts.By above-mentioned whole medical material 70% alcohol reflux three times, each ethanol consumption is equivalent to 10 times, 8 times, 4 times of medical material gross weight respectively, each extraction time is respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filters, be condensed into 70 DEG C of relative densities be 1.10 ~ 1.25 clear paste filtrate concentrate, be dried to dried cream powder, get dried cream powder 1 part, make particle drying with starch portion, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 2: the preparation of granule of the present invention
Get Fructus Crataegi 8 parts, the Radix Astragali 10 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Rhizoma Polygoni Cuspidati 5 parts, Semen Cassiae 10 parts, Radix Bupleuri 7 parts, Radix Polygalae 2 parts, Rhizoma Alismatis 2 parts.By above-mentioned whole medical material extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, and each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, concentrated, the ethanol adding concentrated solution weight 0.5 times 30% stirs, and leaves standstill 24 hours, supernatant reclaims ethanol and concentrated obtained 70 DEG C of relative densities are 1.10 ~ 1.25 clear paste, be dried to dried cream powder, add adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule.
Embodiment 3: the preparation of capsule of the present invention
Get Fructus Crataegi 18 parts, the Radix Astragali 16 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Polygoni Cuspidati 12 parts, Semen Cassiae 10 parts, Radix Bupleuri 10 parts, Radix Polygalae 8 parts, Rhizoma Alismatis 6 parts.By above-mentioned whole medical material, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, concentrated, the ethanol adding concentrated solution weight 0.5 times 50% stirs, leave standstill 24 hours, supernatant reclaims ethanol and is condensed into the clear paste that relative density is 1.10 ~ 1.25 (70 DEG C), is dried to dried cream powder, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, obtained capsule.
Embodiment 4: the preparation of mixture of the present invention
Get Fructus Crataegi 14 parts, the Radix Astragali 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Polygoni Cuspidati 10 parts, Semen Cassiae 9 parts, Radix Bupleuri 8 parts, Radix Polygalae 7 parts, Rhizoma Alismatis 6 parts.By above-mentioned whole medical material, extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, concentrated, the ethanol adding concentrated solution weight 0.5 times 70% stirs, leave standstill 24 hours, supernatant reclaims ethanol and is also condensed into the clear paste that relative density is 1.10 ~ 1.25 (70 DEG C), adds mixture adjuvant sucrose, ethyl ester, water, potassium sorbate stir, obtained mixture.
Embodiment 5: the preparation of syrup of the present invention
Get Fructus Crataegi 12 parts, the Radix Astragali 9 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Rhizoma Polygoni Cuspidati 8 parts, Semen Cassiae 8 parts, Radix Bupleuri 7 parts, Radix Polygalae 6 parts, Rhizoma Alismatis 4 parts.By above-mentioned whole medical material, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filter, concentrated, the ethanol adding concentrated solution weight 0.5 times 70% stirs, leave standstill 24 hours, supernatant reclaims ethanol and is also condensed into the clear paste that relative density is 1.10 ~ 1.25 (70 DEG C), adds syrup adjuvant sucrose, Mel, potassium sorbate, water stirs, obtained syrup in extractum.
Effect experiment:
One, Chinese medicine composition is on the impact of blood fat disease level
1, experiment material
(1) animal
SD rat, male and female half and half, body weight 180 ~ 210g, buys from Guangxi Medical University's Experimental Animal Center (production licence number: SCXK osmanthus 2009-0002).
(2) medicine and instrument
Embodiment of the present invention 1-5 group, 0.9% normal saline (Pharmaceutical Group Co., Ltd of Nanning Baihui), XUEZHIKANG JIAONANG (Beijing WBL Peking University Biotech Co., Ltd), automatic clinical chemistry analyzer (manufacturer: step auspicious medical international corporation, model: BS-190).
2, experimental technique
(1) configuration of Xuezhikang suspension: get Xuezhikang, is ground to tiny powder, uses 0.9% physiological saline solution, is configured to the Xuezhikang suspension of 0.06g/ml;
The collocation method of each Chinese medicine composition solution: get tablet and granule and capsule (getting content) respectively a certain amount of, is configured to the solution containing crude drug 0.05g/ml with physiological saline solution; Get mixture respectively and syrup sample is a certain amount of, add normal saline dilution and become solution containing crude drug 0.05g/ml.
(2) high lipid food configuration and modelling: high lipid food formula is made up of 86% normal feedstuff+2% cholesterol+2% sucrose+10% Adeps Sus domestica.Except Normal group gives normal diet, all the other respectively organize every rat 20g high lipid food, within continuous 4 weeks, cause high blood lipid model.
(3) grouping experiment: be divided at random by 80 rats: blank group, model control group, Xuezhikang matched group, embodiment 1-5 group, often organizes 10 animals, totally 8 groups.Except blank group, all the other 7 treated animals continue high lipid food of feeding.Each group of rat equal-volume (20ml/kg) gastric infusion, every day gavage 1 time, the normal saline of model group and blank group gavage isopyknic 0.9%, the dosage of Xuezhikang group is 1.2g/kg, embodiment 1-5 group dosage is 1g/kg, and comparative example group gives Xuezhikang, and dosage is 1.2g/kg, dosage period 14d, at the end of experiment, Rat Fast can't help water 12h.Pluck eyeball and get blood, centrifugalize serum, survey the content of serum lipids.
3, experimental result
Table 1TC, TG, LDL, HDL statistical result
Note: compare with blank group, * P < 0.05, * * P < 0.01; Compare with model control group, #P < 0.05, ##P < 0.01; Compare with Xuezhikang group,
■p < 0.05,
■ ■p < 0.01.
Result: compared with blank group.TC, TG, LDL level of hyperlipemia model group has pole to raise (P < 0.01) significantly and HDL level has extremely significantly reduction (P < 0.01), and rat hyperlipidemia model modeling success is described.
Compared with model group, Xuezhikang has the effect (P < 0.01) extremely significantly reducing TC, TG, LDL, has no impact to HDL level; Chinese medicine composition embodiment 1-5 group of the present invention, compared with model group, has the effect (P < 0.01) extremely significantly reducing TC, TG, LDL (P < 0.01) and raise HDL-C level.
Compared with Xuezhikang group, Chinese medicine composition embodiment 1-5 group of the present invention has pole significant difference (P < 0.01) affecting in TC, TG and HDL level.
Experimental result shows, this Chinese medicine composition has the significance effect of Experiment on therapy animal hyperlipidemia, and in raising HDC level in compared with Xuezhikang, there is optimal efficiency with in overall efficacy strength.
4, discuss
Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein, LDL (LDL) is higher all can cause hyperlipemia, and high density lipoprotein (HDL) is the base substance of blood lipid metabolism, is a kind of anti-
atherosclerosis's
plasma lipoproteincan by the cholesterol " sucking-off " in atherosclerotic blood vessel wall, and be transported to liver and carry out metabolite clearance.
Animal data shows, compared with model group, Chinese medicine composition embodiment 1-5 group of the present invention, compared with model group, has the effect (P < 0.01) extremely significantly reducing TC, TG, LDL (P < 0.01) and raising HDL levels.Compared with Xuezhikang group, Chinese medicine composition embodiment 1-5 group of the present invention has the effect (P < 0.01) extremely significantly reducing TC, TG (P < 0.01) and raising HDL levels.Therefore, above experimental result points out this Chinese medicine composition to have the effect for the treatment of hyperlipidemia.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1. the Chinese medicine composition and preparation method thereof of a blood fat reducing, it is characterized in that, described compositions is made up of the raw material comprising following weight portion: Fructus Crataegi 8-18 part, Radix Astragali 4-16 part, Rhizoma Atractylodis Macrocephalae 4-15 part, Rhizoma Polygoni Cuspidati 5-12 part, Semen Cassiae 5-10 part, Radix Bupleuri 5-10 part, Radix Polygalae 2-8 part, Rhizoma Alismatis 2-6 part.
2., according to Chinese medicine composition according to claim 1, it is characterized in that it is prepared from by the raw material of following weight portion: Fructus Crataegi 10-15, Radix Astragali 8-10 part, Rhizoma Atractylodis Macrocephalae 10-12 part, Rhizoma Polygoni Cuspidati 7-9 part, Semen Cassiae 7-9 part, Radix Bupleuri 6-8 part, Radix Polygalae 5-7 part, Rhizoma Alismatis 3-5 part.
3., according to Chinese medicine composition according to claim 1, it is characterized in that it is prepared from by the raw material of following weight portion: Fructus Crataegi 12 parts, the Radix Astragali 9 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Rhizoma Polygoni Cuspidati 8 parts, Semen Cassiae 8 parts, Radix Bupleuri 7 parts, Radix Polygalae 6 parts, Rhizoma Alismatis 4 parts.
4. the preparation method of the Chinese medicine composition described in claim 1-3, is characterized in that its active component adopts water extraction or 30-70% ethanol extraction to be prepared from.
5. the preparation method of Chinese medicine composition according to claim 4, it is characterized in that its active component is prepared from by the following method: all medical material decocts with water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, collecting decoction, filter, concentrated, the percent by volume adding concentrated solution weight 0.5 times be 30% ~ 70% ethanol stir, leave standstill 24 hours, supernatant reclaims ethanol and concentrated obtained 70 DEG C of relative densities are 1.10 ~ 1.25 clear paste, to obtain final product.
6. the preparation method of Chinese medicine composition according to claim 4, it is characterized in that its active component is prepared from by the following method: all medical material adds ethanol extraction 2-3 time that percent by volume is 30 ~ 70%, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-3 hour, merge extractive liquid, filter, reclaiming ethanol and being condensed into 70 DEG C of relative densities is the clear paste of 1.10 ~ 1.25, to obtain final product.
7., according to the Chinese medicine composition described in claim 1-3, it is the pharmaceutics of Chinese drugs common formulations such as tablet, granule, capsule, syrup, mixture, pill, drop pill, medicinal tea or powder.
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| CN115282201A (en) * | 2022-08-29 | 2022-11-04 | 湖南中医药大学 | Traditional Chinese medicine compatibility formula composition for preventing and treating diabetes combined with fatty liver and preparation method and application thereof |
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