CN107582637B - One kind two is to lipid-lowering capsule - Google Patents
One kind two is to lipid-lowering capsule Download PDFInfo
- Publication number
- CN107582637B CN107582637B CN201710897886.8A CN201710897886A CN107582637B CN 107582637 B CN107582637 B CN 107582637B CN 201710897886 A CN201710897886 A CN 201710897886A CN 107582637 B CN107582637 B CN 107582637B
- Authority
- CN
- China
- Prior art keywords
- extract
- glossy privet
- eclipta
- capsule
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The present invention relates to a kind of Chinese medicinal capsules of reducing blood lipid, are more particularly to one kind two to lipid-lowering capsule.Provided by the invention two active constituent to lipid-lowering capsule comprising following parts by weight: glossy privet fruit total triterpenic acid 20-40, eclipta total saposins 50-70, eclipta general flavone 10-20；The capsule further includes pharmaceutically acceptable auxiliary material.Provided by the invention two to lipid-lowering capsule, is made of the fruit of glossy privet and Yeradetajo extract that are obtained using modern Hydrolysis kinetics technology, and chemical constituent is clear, stable and controllable for quality, and lipid-lowering effect is good.
Description
Technical field
The present invention relates to a kind of Chinese medicinal capsules of reducing blood lipid, are more particularly to one kind two to lipid-lowering capsule.
Background technique
Erzhi pills original name " glossy privet is red ", is made of the fruit of glossy privet, 2 taste medicine of eclipta.The fruit of glossy privet winter solstice adopts, the eclipta Summer Solstice
Day adopts, therefore named to say erzhi pills, is the classics recipe of tcm clinical practice prolonged application.Its flavour of a drug defective ejaculation and medicinal peace are mended without stagnant,
Grow and it is oiliness, be the recipe of enriching yin and nourishing kidney, have liver and kidney benefiting, tonifying yin blood, strengthen the bone, black beard and hair the effect of.
" doctor is just " (at book in 1569, the publishing in 1587) of three ability of Deity is recorded: " erzhi pills, clear upper benefit lower first
Side, inexpensive and function is very big, informal dress has special effect repeatly, and the winter solstice takes purpleflower holly fruit (i.e. the fruit of glossy privet) to be regardless of how many, dries in the shade, and is mixed with mulse
Thoroughly, box diel, sack wipe skin, dry, and for end, new watt of bottle is harvested and stored.The tens of jin of Eclipta prostrata are taken to the summer solstice, smash nature juice
Cook paste and prodrug end are ball, and if Phoenix Tree Seed is big, every to take hundred balls, wine is sent down when facing sleeping.Its function is very big, just clothes just can make the old without
Tired from night, the ten days does not double physical strength, but the beard and hair that can bleach be it is black, manage waist and knee, strengthen the bone, strong asthenic yin, wine and women-sensual pursuits convulsive seizure due to phlegm-fire it
People's clothes, especially more special effect."
2010 editions " Chinese Pharmacopoeia " are recorded erzhi pills, existing research shows that erzhi pills mainly have enhancing immune, reducing blood lipid,
The effects of antithrombotic, anti-oxidant and protect liver.And the early-stage study of present inventor shows: erzhi pills have very well hyperlipidemia
Therapeutic effect, serum triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) can be significantly reduced, hence it is evident that increase it is highly dense
It spends lipoprotein cholesterol (HDL-C), is better than Effects of Xuezhikang on antiatherosclerosis index, additionally have and adjust lipid metaboli pass
Key enzyme improves the multiple actions such as hemorheology, and without obvious toxic-side effects.
Cardiovascular disease is the disease of current threat human health most serious, and it is close that China dies of cardiovascular disease person every year
3000000 people.Hyperlipidemia is the Major Risk Factors for inducing cardiovascular disease, has report to show, at present my adult dyslipidemia
Illness rate 18.6%, part developed regions illness rate are more up to 30% or more.Hyperlipidemia is prevented and treated for preventing coronary disease
The cardiovascular diseases such as disease, headstroke are of great significance.Currently, the drug for the treatment of hyperlipidemia mainly has chemical drugs and Chinese medicine,
Since Western medicine product has curative effect fast, mechanism of action is clear, is widely applied clinically, especially Statins, fibrates
Chemical drugs, brand effectiveness is high, and intervention market is early, and 60% or more is reached in market sales volume.But Western medicine action target spot and drug effect phase
To single, there is many toxic side effects, it is unfavorable for taking for a long time.Chinese medicine because its multiple target point work and it is highly-safe, increasingly by
To favor, but there is also chemical compositions at present it is complicated, action target spot is unclear, unstable quality the problems such as, curative effect also being not so good as
It is significant to learn medicine.Therefore the modern Chinese herbal medicine that exploitation drug effect is significant, effective component is clear, action target spot understands, stable and controllable for quality is
As development trend.
Present inventor uses the theory and mode of component compatibility, furthers investigate to " erzhi pills ", utilizes the modern times
Hydrolysis kinetics technology obtains the fruit of glossy privet and each effective component of eclipta, completes the fruit of glossy privet and eclipta reducing blood lipid active princlple group
Determination, and utilize inside and outside screening model, it is determined that the optimization blends and preparation process of active princlple group have been succeeded in developing more
Target spot works, drug effect is obvious, chemical composition is relatively clear, stable and controllable for quality two to lipid-lowering capsule.
Summary of the invention
That the purpose of the present invention is to provide a kind of chemical compositions is clear, lipid-lowering effect is good, stable and controllable for quality two to
Lipid-lowering capsule.
The present invention provides one kind two to lipid-lowering capsule, which includes the active constituent of following weight parts:
Glossy privet fruit total triterpenic acid 20-40, eclipta total saposins 50-70, eclipta general flavone 10-20；
The glossy privet fruit total triterpenic acid extracts from the fruit of glossy privet；
The eclipta total saposins extract from eclipta；
The eclipta general flavone extracts from eclipta.
Preferably, which includes the active constituent of following weight parts:
Glossy privet fruit total triterpenic acid 25-35, eclipta total saposins 55-65, eclipta general flavone 12-18；
It is highly preferred that the capsule includes the active constituent of following weight parts:
Glossy privet fruit total triterpenic acid 30, eclipta total saposins 60, eclipta general flavone 15.
Further, of the present invention two to lipid-lowering capsule further include pharmaceutically acceptable auxiliary material；
Preferably, the auxiliary material is selected from sucrose, dextrin, starch, talcum powder, microcrystalline cellulose, hydroxypropyl cellulose, shell
One of glycan, polyvidone are a variety of；
Preferably, the auxiliary material is selected from the combination of one of microcrystalline cellulose and sodium carboxymethyl starch or both；
It is highly preferred that the auxiliary material is the microcrystalline cellulose and sodium carboxymethyl starch that weight ratio is 1: 1.
Further, of the present invention two into lipid-lowering capsule, the glossy privet fruit total triterpenic acid, the total soap of eclipta
The weight ratio of glycosides, the total amount of eclipta general flavone and auxiliary material is 0.5-3；
Preferably, the glossy privet fruit total triterpenic acid, eclipta total saposins, the total amount of eclipta general flavone and auxiliary material weight
Amount is than being 2.
Of the present invention two can be prepared by the step of following sequences to lipid-lowering capsule:
After glossy privet fruit total triterpenic acid, eclipta total saposins, eclipta general flavone are mixed by formulation dosage, formula is added and uses
The auxiliary material of amount mixes, and fills capsule.
The fruit of glossy privet: the dry mature fruit of oleaceae plant glossy privet.
Eclipta: the dry aerial parts of compositae plant Eclipta prostrata.
The beneficial effects of the present invention are: provided by the invention two to lipid-lowering capsule, by utilizing modern Hydrolysis kinetics technology
The fruit of glossy privet of acquisition and the extract of eclipta are made, and chemical constituent is clear, stable and controllable for quality, and lipid-lowering effect is good.
Specific embodiment
The present invention can further be well understood by the specific embodiment and comparative example of invention now given below.
But they are not limitation of the invention.
The fruit of glossy privet as described below and eclipta medicinal material are purchased from Hangzhou East China prepared slices of Chinese crude drugs Co., Ltd.
The preparation of 1 glossy privet fruit total triterpenic acid of embodiment
Glossy privet fruit total triterpenic acid of the present invention is prepared by the following method:
Fruit of glossy privet powder is taken, 70% ethyl alcohol of 15 times of amounts will be added in fruit of glossy privet powder, circumfluence distillation 2 times, mention every time
Take 2h；
Extracting solution is concentrated into 0.2g crude drug/mL, adjusting pH is 8.0, is adsorbed on AB-8 macroreticular resin, loading flow velocity is
4 column volume/h, wash 5 column volumes, and 90% column volume of ethanol elution 4 collects the eluent of 90% ethanol elution, decompression
It is concentrated to give glossy privet fruit extract；
Through detecting, triterpenic acid containing glossy privet fruit total 50% in the glossy privet fruit extract.
The preparation of 2 eclipta total saposins of embodiment
Eclipta powder is taken, 70% ethyl alcohol of eclipta powder is impregnated into 0.5h, then with 20 times of 70% ethyl alcohol measured heat
Refluxing extraction 1h, then 70% alcohol heat reflux measured with 16 times extract 0.5h；
Extracting solution is concentrated into 0.25g crude drug/mL, is adsorbed on AB-8 macroreticular resin, loading flow velocity be 3 column volumes/
H, washes 4 column volumes, and 70% column volume of ethanol elution 4 collects the eluent of 70% ethanol elution, black drought is concentrated under reduced pressure to obtain
Lotus extract 1；
Through detecting, total saposins containing eclipta 55% in the Yeradetajo extract 1.
The preparation of 3 eclipta general flavone of embodiment
Eclipta powder is taken, 70% ethyl alcohol of eclipta powder is impregnated into 0.5h, then with 20 times of 70% ethyl alcohol measured heat
Refluxing extraction 1h, then 70% alcohol heat reflux measured with 16 times extract 0.5h；
Extracting solution is concentrated into 0.25g crude drug/mL, is adsorbed on AB-8 macroreticular resin, loading flow velocity be 3 column volumes/
H, washes 4 column volumes, and 40% column volume of ethanol elution 3 collects the eluent of 40% ethanol elution, black drought is concentrated under reduced pressure to obtain
Lotus extract 2；
Through detecting, general flavone containing eclipta 45% in the Yeradetajo extract 2.
Embodiment 4
One kind two to lipid-lowering capsule, capsule includes following components in parts by weight:
Said components are mixed, No. 1 capsule, every capsule weight 0.2g are filled.
Embodiment 5
One kind two to lipid-lowering capsule, capsule includes following components in parts by weight:
Said components are mixed, No. 1 capsule, every capsule weight 0.2g are filled.
Embodiment 6
One kind two to lipid-lowering capsule, capsule includes following components in parts by weight:
Said components are mixed, No. 1 capsule, every capsule weight 0.2g are filled.
Comparative example 1
One kind two to lipid-lowering capsule, capsule includes following components in parts by weight:
Said components are mixed, No. 1 capsule, every capsule weight 0.2g are filled.
Comparative example 2
One kind two to lipid-lowering capsule, capsule includes following components in parts by weight:
Said components are mixed, No. 1 capsule, every capsule weight 0.2g are filled.
Comparative example 3
One kind two to lipid-lowering capsule, capsule includes following components in parts by weight:
Said components are mixed, No. 1 capsule, every capsule weight 0.2g are filled.
Comparative example 4
Prepare traditional erzhi pills: the fruit of glossy privet, eclipta (each 500g) crush, finely ground, cross 20 meshes, add water to cook 3 times, the
1 time plus 10 times of amount water, the 2nd time plus 8 times of amount water, the 3rd time plus 8 times of amount water, each 2h merge decoction liquor, filtering, and filtrate is concentrated into
The thick paste that relative density is 1.30 to obtain the final product.
1 blood fat reducing function of experimental example compares
Establish olive Antihyperlipidemia capsule:
High lipid food, ad lib and drinking-water are fed to 200g or so male Wistar rat.Separately set feeding chow diet
Rat make negative control.Eye socket takes hematometry lipids contents after two weeks, with judgment models success.
Administration:
Dyslipidemia rat is grouped at random, every group 5, respectively with embodiment 4, embodiment 5, embodiment 6, comparison
Example 1 provide two to lipid-lowering capsule, comparative example 4 provide traditional erzhi pills (dosage is 150mg/kg) and Effects of Xuezhikang (use
Dose 600mg/kg) mouse is fed, once a day, posterior orbit takes blood within 4 weeks；
Full automatic biochemical apparatus measures 4 contents of blood lipid: including cholesterol (TC), triglycerides (TG), low-density lipoprotein
Cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C)；
Reducing blood lipid the results are shown in Table 1 after being administered 4 weeks；
Table 1
The detection of 2 hydroscopicity of experimental example
Embodiment 4, embodiment 5, embodiment 6, comparative example 2, comparative example 3 provide two to lipid-lowering capsule, mixed respectively
Even component takes in right amount, is placed in added with P2O5Drier in dry 48h, while bottom being filled to the glass of NaCl supersaturated solution
Glass drier is put into 25 DEG C of insulating box for 24 hours, internal relative humidity 75%.It is added in the weighing bottle for having dried constant weight
The component that appropriate each group mixes, precise weighing are placed in above-mentioned glass desicator, and timing sampling weighs, and are counted according to the following equation
Hydroscopicity is calculated, each group different time hydroscopicity measurement result is shown in Table 2:
Hydroscopicity=[constituent mass before (constituent mass before constituent mass-moisture absorption after moisture absorption)/moisture absorption] × 100%
Table 2
| Group | 6h | 12h | 24h | 48h | 60h |
| Embodiment 4 | 2.56 | 4.53 | 6.49 | 8.03 | 9.65 |
| Embodiment 5 | 2.61 | 4.82 | 6.75 | 8.16 | 9.84 |
| Embodiment 6 | 1.65 | 3.17 | 5.23 | 6.07 | 6.82 |
| Comparative example 2 | 2.94 | 5.16 | 7.17 | 8.86 | 10.45 |
| Comparative example 3 | 2.87 | 5.08 | 7.14 | 8.79 | 10.38 |
Claims (1)
1. one kind two to lipid-lowering capsule, capsule is made of the active constituent of following parts by weight: glossy privet fruit extract 40, ink drought
Lotus extract 1 91, Yeradetajo extract 2 23, starch 100；
Wherein, glossy privet fruit extract the preparation method comprises the following steps: take fruit of glossy privet powder, the 70% of 15 times of amounts will be added in fruit of glossy privet powder
Ethyl alcohol circumfluence distillation 2 times, extracts 2h every time；Extracting solution is concentrated into 0.2g crude drug/mL, adjusting pH is 8.0, is adsorbed onto AB-
On 8 macroreticular resins, loading flow velocity is 4 column volume/h, washes 5 column volumes, and 90% column volume of ethanol elution 4 is collected
Glossy privet fruit extract is concentrated under reduced pressure to obtain in the eluent of 90% ethanol elution；Through detecting, glossy privet fruit total is contained in the glossy privet fruit extract
Triterpenic acid 50%；
Wherein, Yeradetajo extract 1 the preparation method comprises the following steps: take eclipta powder, 70% ethyl alcohol of eclipta powder is impregnated
0.5h, 70% alcohol heat reflux then measured with 20 times extract 1h, then 70% alcohol heat reflux measured with 16 times extracts 0.5h；It will
Extracting solution is concentrated into 0.25g crude drug/mL, is adsorbed on AB-8 macroreticular resin, and loading flow velocity is 3 column volume/h, washes 4 columns
Volume, 70% column volume of ethanol elution 4 collect the eluent of 70% ethanol elution, Yeradetajo extract 1 are concentrated under reduced pressure to obtain；
Through detecting, total saposins containing eclipta 55% in the Yeradetajo extract 1；
Wherein, Yeradetajo extract 2 the preparation method comprises the following steps: take eclipta powder, 70% ethyl alcohol of eclipta powder is impregnated
0.5h, 70% alcohol heat reflux then measured with 20 times extract 1h, then 70% alcohol heat reflux measured with 16 times extracts 0.5h；It will
Extracting solution is concentrated into 0.25g crude drug/mL, is adsorbed on AB-8 macroreticular resin, and loading flow velocity is 3 column volume/h, washes 4 columns
Volume, 40% column volume of ethanol elution 3 collect the eluent of 40% ethanol elution, Yeradetajo extract 2 are concentrated under reduced pressure to obtain；
Through detecting, general flavone containing eclipta 45% in the Yeradetajo extract 2；
Glossy privet fruit extract, Yeradetajo extract 1, Yeradetajo extract 2, starch are mixed, No. 1 capsule, every capsule are filled
Weight 0.2g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710897886.8A CN107582637B (en) | 2017-09-28 | 2017-09-28 | One kind two is to lipid-lowering capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710897886.8A CN107582637B (en) | 2017-09-28 | 2017-09-28 | One kind two is to lipid-lowering capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107582637A CN107582637A (en) | 2018-01-16 |
| CN107582637B true CN107582637B (en) | 2019-02-26 |
Family
ID=61047275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710897886.8A Active CN107582637B (en) | 2017-09-28 | 2017-09-28 | One kind two is to lipid-lowering capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107582637B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247420A (en) * | 2011-07-04 | 2011-11-23 | 浙江大学 | Preparation method and application of eclipta extract |
-
2017
- 2017-09-28 CN CN201710897886.8A patent/CN107582637B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247420A (en) * | 2011-07-04 | 2011-11-23 | 浙江大学 | Preparation method and application of eclipta extract |
Non-Patent Citations (3)
| Title |
|---|
| 丹墨胶囊的薄层色谱鉴别;李瑞明等;《中国医药导报》;20110630;第8卷(第16期);64-66 * |
| 加味二至胶囊对大鼠复合型脂肪肝的调脂保肝作用;刘春美等;《药学与临床研究》;20081031;第16卷(第5期);347-350 * |
| 正交设计法配合多药效指标综合评价筛选二至丸有效部位群组方的最;姚干等;《中成药》;20090930;第31卷(第9期);1444-1447 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107582637A (en) | 2018-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102423352B (en) | Preparation method of Chinese medicinal granules for treating cardio-cerebrovascular diseases | |
| CN108057039A (en) | A kind of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition and preparation method and application | |
| CN107853517B (en) | Traditional Chinese medicine beverage capable of refreshing and resisting fatigue and preparation method thereof | |
| CN104138526B (en) | A kind of root of three-nerved spicebush iron sheet ginseng granules agent | |
| CN108404062A (en) | Treat the Chinese medicine composition and its preparation method and application of hyperlipidemia | |
| CN102068521B (en) | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method and application thereof | |
| CN103585245B (en) | Preparation method, extract and its application of common pratia herb extract | |
| CN101780242B (en) | Health or medicine composition and preparation method and application thereof | |
| CN102846879B (en) | Composition for depressing blood fat | |
| CN107582637B (en) | One kind two is to lipid-lowering capsule | |
| CN104435072B (en) | A kind of extract and preparation method thereof with auxiliary hyperglycemic, reducing blood lipid | |
| CN101181318A (en) | Shanlu Tea extract for dropping blood pressure and blood fat as well as preparation method thereof | |
| CN105477213A (en) | Traditional Chinese medicine composition for reducing blood fat and preparing method thereof | |
| CN109316565B (en) | Blood fat reducing composition and preparation method and application thereof | |
| CN1115159C (en) | Red sage containing medicine composition and its preparation and use | |
| CN103372040B (en) | Monas cuspurpureus Went Rhizoma Chuanxiong drug regimen of a kind of adjusting blood lipid and preparation method thereof | |
| CN101664423A (en) | Hypoglycemic active part of osmanthus fragrans, preparation method and application thereof | |
| CN111870626B (en) | Pharmaceutical composition with blood fat reducing effect and preparation method and application thereof | |
| CN1876042A (en) | A method for preparing fat-reducing medicine | |
| CN103877513A (en) | Chinese herbal compound composition with blood fat reduction effect, and applications thereof | |
| CN107307401A (en) | A kind of application of composition of integration of drinking and medicinal herbs in lowering blood-fat and reducing weight functional food is prepared | |
| CN103372114B (en) | Red rice and rhizoma alismatis medicinal composition for regulating blood fat and preparation method of composition | |
| CN100348224C (en) | Chinese medicinal capsule used for reducing blood fat, its preparation method and use | |
| CN115104661A (en) | Sleep-aiding polygonatum sibiricum health-care coffee and preparation method thereof | |
| CN104473992A (en) | Platycodon extract and novel application of platycodon extract in preparation of medicines and health products |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |