CN101262780B - 一种延长动物生命的方法 - Google Patents
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- CN101262780B CN101262780B CN2006800334222A CN200680033422A CN101262780B CN 101262780 B CN101262780 B CN 101262780B CN 2006800334222 A CN2006800334222 A CN 2006800334222A CN 200680033422 A CN200680033422 A CN 200680033422A CN 101262780 B CN101262780 B CN 101262780B
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Abstract
本发明涉及延长老龄动物生命的方法,所述方法包括给动物饲喂含一种或多种总剂量足以延长动物的寿命的抗氧化剂的组合物。
Description
相关申请的交叉引用
本申请要求2005年7月14日提交的第60/699,145号美国临时专利申请的优先权,其在此引作参考。
发明领域
总的来说,本发明涉及用于延长动物生命的方法,具体的说是使用抗氧化剂延长动物的生命。
发明背景
随着年龄增长,自由基诱导的氧化应激作用是导致组织长期退化的一个主要因素。活细胞的正常活动不断产生自由基。自由基能与许多生物分子发生不可逆的反应,因而导致生物体的逐渐退化,最终导致衰老和死亡。通常情况下,自由基被生物体内产生的抗氧化酶以及源自营养的抗氧化剂所中和。目前已开展许多关于抗氧化剂是否能减少氧化应激或影响动物生命的研究。当前,由于营养或医疗护理的改善,动物生命得以延长,生活质量得以提高,但仍需要一种新的或可供选择的方法或组合物用于延长动物的生命,尤其是年老的动物。
发明概述
本发明提供一种延长动物生命的方法。所述方法包括当动物年老时给予其一种含抗氧化剂的组合物。该组合物包含一种或多种抗氧化剂,以及其他附加成份。组合物中一种或多种抗氧化剂的总量足以延长动物生命。
在一实施方案中,含抗氧化剂的组合物作为食物组合物饲喂给动物。
本发明所提供的产品包含:(a)一种包装,包含含有一种或多种抗氧化剂的组合物,当将组合物给予年老动物时,抗氧化剂的总量足以延长其寿命;(b)将本组合物饲喂年老动物使其生命延长的信息或用法说明的传达工具,所提及的传达工具附于或包含于所述包装内。
本发明还提供一个药盒,包含:(a)第一包装,包含一种或多种足够剂量的含抗氧化剂组合物,饲喂老龄动物可延长生命;(b)第二包装,含食物基料;(c)一份传达如何将含有抗氧化剂的组合物添加到食物中并将所得富含抗氧化剂组合物饲喂老龄动物以以延长动物生命的信息或使用说明的传达工具。
上述产品或药盒所提供的传达工具本身也是本发明的一个实施方案。
对于本领域技术人员而言,很容易理解本发明的其他或进一步的目的、特征及优点。
发明详述
本详述的目的不仅在于使本领域的技术人员熟悉本发明的原理以及实际应用,使其能够根据他们特殊的应用需求修改和应用本发明。本发明的详细描述以及特定实例的目的仅在于例证说明,因此本发明并非仅限于此处所描述的内容,其可作多种修改。
本发明提供一种延长动物生命的方法。具体的讲是一种给老龄动物饲喂含抗氧化剂的组合物以延长其生命的方法。
本发明中的词汇“老龄”指相对年老的年龄,至少为动物物种寿命三分之一的年龄。例如家养犬或猫平均寿命约15年,“老龄”动物年龄至少要超过5年。
本发明中“寿命增强”和“延长生命”可交换使用,指的是当动物由于自然原因死亡或当动物的身体发生严重的不可逆转的恶化时,由兽医决定施行安乐死(仅限非人类)的情况时使其生命延长。因此,一方面,本发明方法的执行可使由自然原因引起的动物死亡得到延迟;另一方面,出于人道原因要终结动物生命时,本发明的实施可使这个期限延期。
本发明中所涉及的动物包括人类及非人类,许多实施方案中为脊椎动物,例如鱼、鸟、爬虫类或哺乳类。本方法尤其适用于平均生命大于1年的动物,如大于3年或5年的,例如实施方案中所涉及的动物指非鼠科动物。哺乳动物中所涉及的动物可以为食肉目,不仅限于犬科和猫科动物。
一个特殊的实施方案中涉及的动物为伴侣动物。此处“伴侣动物”指的是作为宠物为人类饲养的任意动物个体,或其他多种已广泛被家养的动物,如狗(家犬)和猫,无论是单只动物还是几只一起群养。因此本发明中的“伴侣动物”除了宠物犬猫以外还包括役用犬、农场里用作鼠类控制的役用猫等。
一些实施方案中,本发明提供了延长犬科动物寿命的方法。方法为当动物年老时饲喂一种含抗氧化剂的组合物。在某个实施方案中,当饲喂了该组合物后狗的生命延长到至少约7年。另外一个实施方案中,本发明提供了延长猫科动物(如猫)生命的方法。方法为当动物年老时饲喂一种含抗氧化剂的组合物。在特殊实施方案中,当饲喂了该组合物后,猫的寿命延长到至少约7年。不管是狗还是猫,接受含抗氧化剂组合物的动物任选存活至少约8年,甚至至少约9到10年。许多实施方案中,受试的狗或猫均为老龄,此类术语一般在狗或猫的营养学上有所应用。
除了上述例子外,本发明还适用于其它动物,包括非人类的哺乳动物如非人灵长类(猴子、猩猩等)、伴侣动物或役用动物(如马等)、农场(如山羊、绵羊、猪、牛等)以及野生和观赏动物(如狼、熊、鹿等)。该方法一般还适用于非哺乳类动物,如伴侣、农场、观赏以及野生鸟类,(包括鸣禽、鹦鹉、鸭子、鹅、鸡、火鸡、鸵鸟等)。“动物”指的是人类或非人动物,包括鸟类、牛、犬、马、猫、鼠、羊、猪等动物,更适合于犬或猫。
本发明所提及的方法包括给动物饲喂一种含抗氧化剂组合物。组合物中一种或多种抗氧化剂的总量足够用于老龄动物的生命延长。
本发明组合物应以一定的频率饲喂给动物持续一段时间以有效延长动物生命。此处“足以延长动物生命的抗氧化剂总量”的说法,通过上下文的意思应理解成以一定的频率持续一段时间的反复饲喂动物该产品。通常也是最方便的方式是每天至少饲喂一次,饲喂频率可以适度减少,如每周两次或每周一次也是有效的。若想达到最佳效果,则应持续饲喂较长时间,至少6个月或1年,乃至2年,3年。在一实施方案中,动物在其余生中一直使用本发明组合物。
在一个实施方案中,起始时间可以从动物生命的任意时刻开始(即饲喂的起始时间无上下限),只要是在动物开始衰老时饲喂即可。然而在特殊的实施方案中,当动物已经衰老时才开始饲喂本发明组合物也是可行的。例如对于犬和猫等伴侣动物,可以在其5岁、6岁、7岁、8岁、9岁或者乃至10岁时开始饲喂本发明组合物。
在一些实施方案中,在整个饲喂期间仅饲喂某一种含抗氧化剂组合物。而在其他实施方案中采取在不同时期饲喂不同含抗氧化剂组合物的方法。例如,在不同的时期最好能选择不同的抗氧化剂,并调整剂量。
在一些实施方案中,本发明的含抗氧化剂组合物制成经口服饲喂的形式。具体而言,这种组合物可以是食物组合物、添加剂、奖赏或消遣食品,应注意的是,部分而非全部饮食补充、奖赏和消遣食品本身也是食物组合物。食物组合物应通过饲喂方式给予。若是伴侣动物,本发明中的食物组合物通常是适合于此类动物营养的。此处所提及的食物组合物更适合于称为“宠物食物”。宠物食物更加适合于犬或猫的特殊营养需求,其中包括它们的某些亚群,例如大品种狗、成年狗或猫、中年狗或猫、老年狗或猫。
在一个实施方案中,含抗氧化剂组合物为动物提供了基本上全营养食物。“全营养食物”指的是为动物提供的饮食中所包含的营养足以维持动物的健康状态。
在另一个实施方案中,含抗氧化剂的食物组合物是添加剂,即与其它饮食相搭配以总体上改善营养均衡或食物特性的食物组合物。这类添加剂包括作为其食物的添加剂未经稀释而饲喂的组合物、分开给予动物的与动物日粮的其它部分自由选择的组合物,以及用动物常规食物稀释和混合以产生基本上营养全面的饮食的组合物。这种添加剂也可以是非食物组合物,例如以类似药物剂形,包括粉末、液体、糖浆、药丸等。
在另一种实施方案中,含抗氧化剂组合物是一种奖赏方式,例如在非进餐时间可作为一种奖赏或诱惑饲喂动物。对于狗而言,奖赏食品至少应包括一些有营养价值的食物,如狗饼干。作为奖赏的食物也可以基本上无营养(抗氧化剂被视为有营养时除外)。因此直接饲喂含抗氧化剂组合物或涂抹在食物表面均可作为对动物的一种奖赏。
在其他实施方案中,含抗氧化剂组合物可作为动物的一种口用玩具。玩具包括咀嚼消遣,如狗用的人造骨头。组合物通常在玩具食物的表面形成一层外衣或者作为其表面的组分之一,或兼而有之。许多玩具类食物在市场上均有出售,包括部分消耗性玩具(如含塑料制品的)以及完全消耗性玩具(如牛皮或人造骨)。玩具对于人类或非人类都是有用的,尤其是对于伴侣动物、家畜、观赏动物,特别是狗、猫、鸟等。
在一些实施方案中,抗氧化剂组合物可以满足动物对食物摄取的特殊需求。老年狗和猫对食物摄取的典型需求见表1。
表1成年动物食物中的典型营养需求(%饮食干重)
食物组分 | 老年狗 | 老年猫 |
粗蛋白 | 15-23 | 30-45 |
粗脂肪 | 7-15 | 10-25 |
粗纤维 | >2 | <10 |
钙 | 0.5-1.0 | 0.6-1.0 |
磷 | 0.25-0.75 | 0.5-0.7 |
钠 | 0.15-0.35 | 0.2-0.5 |
镁 | 0.05-0.1 |
如前所述的有效组合物包含一种或多种抗氧化剂(即,可以直接或间接淬灭自由基的物质)。许多具有淬灭和吸收自由基功能的物质常被用作本发明中的成份(如水果、蔬菜、维生素以及其他化合物),天然的氧自由基吸收量高的物质包括菠菜渣、番茄渣、柑橘果肉、葡萄渣、胡萝卜、绿花椰菜、绿茶、玉米麸、米糠等。具有自由基淬灭或吸收能力的食物或副产品包括菠菜、番茄、柑橘、葡萄、胡萝卜、绿花椰菜、绿茶、玉米麸、米糠等。具有自由基淬灭或吸收能力的化合物包括辅酶Q10(泛醌)、β-胡萝卜素、还原虾红素(3,3’-二羟基-4,4’-二酮-β-胡萝卜素)、谷光甘肽、L-肉毒碱、α-硫辛酸、叶黄素、番茄红素、N-乙酰半胱氨酸、多酚、S-腺苷蛋氨酸、硒、大豆异黄酮、牛磺酸、生育三烯酚类、维生素C以及维生素E。
在一些实施方案中,本发明所使用的组合物包含维生素E。此处“维生素E”指的是适合于动物消化的任意形式的维生素E,包括但不仅限于各种生育酚或生育三烯酸化合物以及对映异构体或消旋体,还包括任何一种具有维生素E活性的混合物,如α-生育酚(5,7,8-三甲基母育酚)、β-生育酚(5,8-二甲基母育酚)、γ-生育酚(7,8-二甲基母育酚)、δ-生育酚(8-甲基母育酚)、α-生育酚(5,7,8-三甲基母育酚)、β-生育酚(5,8-二甲基母育酚)、γ-生育酚(7,8-二甲基母育酚)、δ-生育酚(8-甲基母育酚)。维生素E可与上述任何一种组合物共同饲喂;或以衍生物的形式,例如酯类包括生育酚乙酸酯、丁二酸酯、棕榈酸酯等等,动物摄入后表现出维生素E生物活性。通常,本发明中维生素E包含α-生育酚或其酯。此处维生素E量表示为(外消旋-)α-生育酚醋酸酯当量。需要说明的是,一种组合物可包含100ppm到2,000ppm的维生素E,例如从150ppm到1500ppm,或从500ppm到1,000ppm的维生素E。
在一些实施方案中,本发明所使用的组合物包含维生素C。此处“维生素C”指的是适合于动物消化的任意形式的维生素C,包括但不仅限于各种抗坏血酸、左旋抗坏血酸以及各种衍生物,例如磷酸钙、胆固醇以及抗坏血酸-2-一磷酸盐。抗坏血酸盐包括钠盐、钙盐、锌盐二价铁盐。酯类包括硬脂酸盐、棕榈酸盐及其衍生物。维生素C以任意形态如液态、半固态、固态或热稳定型被动物摄取消化后均具有活性。此处维生素C的量表示为抗坏血酸当量。需要说明的是,一种组合物可包含25ppm到10,000ppm的维生素C,例如从50ppm到5,000ppm,或从75ppm到1,000ppm。
在一些实施方案中,本发明所使用的组合物包含α-硫辛酸。需要说明的是,一种组合物可包含约25ppm到约600ppm的α-硫辛酸,例如从约50ppm到约200ppm,或从约100ppm到约200ppm。α-硫辛酸可作为酸或脂酸盐衍生物形式给予(美国专利号5,621,117)。
在一些实施方案中,本发明所使用的组合物包含左旋肉毒碱。一般而言,给猫饲喂的组合物中左旋肉毒碱的含量比狗的略高。需要说明的是,给猫饲喂的组合物中的含量大约为100ppm到5,000ppm,例如从200ppm到600ppm,或400ppm到600ppm左旋肉毒碱。需要说明的是,给狗饲喂的组合物中的含量大约为50ppm到5,000ppm,例如从100ppm到400ppm,或200ppm到400ppm左旋肉毒碱。左旋肉毒碱可以左旋肉毒碱或衍生物形式给予,例如盐(氢氯化物)、酯(延胡索酸酯或丁二酸酯),或者乙酰化肉毒碱。
含抗氧化剂组合物可任选含有一种或多种β-胡萝卜素,含量约1ppm至15ppm;硒,含量约0.1ppm至5ppm;叶黄素,含量约5ppm至15ppm;辅酶Q10,含量约25ppm至100ppm;腺苷甲硫氨酸,含量约50ppm至100ppm;牛磺酸,含量约500ppm至1500ppm;大豆异黄酮,含量约25ppm至200ppm;N-乙酰半胱氨酸,含量约50ppm至1600ppm;谷胱甘肽,含量约50ppm至250ppm;银杏提取物,含量约50ppm至120ppm。
在一些实施方案中,含抗氧化剂组合物含有不止一种上述的抗氧化剂,例如含维生素E、维生素C、左旋肉毒碱、α-硫辛酸。在某一个例子中,含有大约50ppm至10,000ppm的维生素C、100ppm至2,000ppm的维生素E、25ppm至600ppm的α-硫辛酸、100ppm至5,000ppm的左旋肉毒碱。另外一个例子中,含有大约50ppm至100ppm的维生素C、500ppm至1,000ppm的维生素E、100ppm至200ppm的α-硫辛酸、200ppm至400ppm的左旋肉毒碱。
在另外一个实施方案中,含抗氧化剂组合物含有维生素E、维生素C、左旋肉毒碱、α-硫辛酸、β-胡萝卜素以及牛磺酸。例如某种组合物中含有大约50ppm至10,000ppm的维生素C、100ppm至2,000ppm的维生素E、25ppm至600ppm的α-硫辛酸、100ppm至5,000ppm的左旋肉毒碱、25ppm的β-胡萝卜素,500ppm至8900ppm的牛磺酸。另外一种组合物中含有大约50ppm至100ppm的维生素C、500ppm至1,000ppm的维生素E、100ppm至200ppm的α-硫辛酸、200ppm至400ppm、5ppm至15ppm的β-胡萝卜素、1,000ppm至8900ppm的牛磺酸。
在一些实施方案中,使用氧自由基吸收能力高的成份来替换氧自由基吸收能力低的成份(如玉米),从而改变食物组合物。例如食物中添加菠菜渣、番茄渣、柑橘浆、葡萄渣、胡萝卜颗粒、椰菜、绿茶、银杏、玉米麸等,用以替换1%至5%的氧自由基吸收能力低的成分。
通常按照常规的宠物食物制造工艺将食物制成干的、罐装、湿的或半潮湿状态。
加工过程中可加入一种或多种抗氧化剂,在混匀其它组分过程中或之后均可,按常规方式操作即可。可通过常规方法将一种或多种抗氧化剂混入组合物中。
制备示例性罐装或湿状食物时,地下动物以及禽源蛋白质组织可和其他组分混合,如鱼油、谷粒、其它营养平衡组分、特殊用途的添加剂(如维生素、矿物质、无机盐、纤维素、甜菜酱、疏松剂等等);加工过程中应加入足够量的水。这些组分可在适于边加热边混合的容器内混合加热。可以采用任何合适的方式加热混合物,如直接蒸汽注射或用配有热交换器的容器加热。加入最后一种组分后将混合物加热至50至212华氏温度,例如从70至140华氏温度。这个温度范围之外的温度也可接受,但从商业角度而言若不使用加工助剂是不切实际的。加热至适当温度后,原料将变成浓稠的液体状,再装进罐中,盖上盖子密封,装进常规的灭菌设备中。通常加热至230华氏温度后维持一段时间后达到灭菌效果,维持的时间根据温度和组组合物的不同而定。
食物组合物也可根据常规工艺制作成干燥状态。干的组分通常包括动物蛋白、植物蛋白、谷物等可以研磨并混合在一起。再将潮湿的或液态的组分包括脂肪、油、动物蛋白、水等加入干物质内混匀。再将混合物加工成粗磨或类似的干燥碎片。在高压高温状态下干或湿的组分经过挤压后成形,经过小口出来后由旋转式刀片切割成小块。湿的组分经过干燥后任选可加上一种或多种包衣,如香料、脂肪、油、粉末等等,也可以通过烘焙混合物的方式制作,而不是挤压,此处混合物应在干燥加热前放入模型内。
奖赏性的食物也可参照上述干性食物组合物的工艺进行加工。另外也可以在外部涂抹或向内注射抗氧化剂。
需要说明的是,此处的玩具在外部已涂抹了含抗氧化剂组合物。
本发明的另一个实施方案中,详细描述了含抗氧化剂组合物的一种包装。任何能保持组合物自然状态的包装形式均可,包括罐子、外包装袋、盒内包装袋的选择等等均无限制。此外在该实施方案中还进一步包括关于将含抗氧化剂组合物饲喂年老动物以延长其生命这一信息的信息或指导说明的传达工具。该传达工具附于本包装中。任何合适的传达工具的合适形式均可使用,例如文件形式,包括标签、小册子、广告、包装插页、计算机可读数字或光学介质如磁碟或CD、音频介绍如音带或CD、或可视播放如可视带或DVD等。以及可以在别处查阅补充信息的传达工具,如互联网。
然而,另外一个实施方案中,药盒包含含有含抗氧化剂组合物的第一包装,以及含食物基料的第二包装。该药盒包括传达如何将含抗氧化剂组合物加入(任选边加边混合)食物基料的信息或指导说明的传达工具。其中会详细说明加入适于特定情况下的给定量的食物基料的含抗氧化剂组合物的量。此外,该传达工具还提供了如何将所得富含抗氧化剂的食物组合物饲喂老龄动物以延长动物生命的信息或指导说明。上述传达工具可以单独,或者与食物包装一起,以合适的形式提供,例如,上述包括一页或多页网页在内的形式。
此处的传达工具,包含例如文件如标签、小册子、广告、包装插页、磁带或CD、音频介绍如音带或CD、或可视播放如可视带或DVD等,和/或一页或多页网页等,也是本发明的一个部分。
本发明不只限于特定的方法学、操作程序、各种试剂等,此处所使用术语的目的在于详细解释实施的具体方案,而不是限制本发明的范围。此处附加的权利要求书中,“一”或“该”均包括复数再内,除非上下文有特殊规定。同样的“包含”或“含有”指的是包含在内的而不是排他的意思。
除另有说明以外,所有的专业和科学术语以及字母缩写均是本发明所属领域内的常规涵义。虽然可以试用任何组合物、方法、制品或其它类似于或等价于本文所述的工具或材料,但优选本发明所描述的组合物、方法、制品或工具或材料。
所有的专利、专利申请、出版物以及引用的参考文献也合法地通过引用并入本文。关于参考文献讨论的目的仅在于本专利所述内容的总结。不承认任何这类专利、专利申请、出版物和参考文献、或者其中任何一部分是本发明的相关现有技术,并特别保留质疑类似专利、专利申请、出版物和其他参考文献的正确性和相关性的权利。
实施例
尽管可以理解,除非另有说明这些实施例的引入仅仅是用来说明,不能用来限制本发明的范围,但是本发明仍可通过以下优选实施方案的实施例进一步说明。
实施例1
12只老龄毕格犬(平均10.03年)作为一组,从饲喂与表1中所述大致类似的对照食物(对照食物也含大约100ppm的维生素E)开始。第二组为12只平均年龄10.16的毕格犬,从饲喂食物A开始,食物A和对照食物相似,但含有大约950ppm的维生素E、300ppm的左旋肉毒碱、100ppm的α-硫辛酸以及约80ppm的维生素C。此外,对照食物中的约5%的玉米在食物A中被替换为1%左右的番茄渣、1%左右的菠菜、1%左右的胡萝卜、1%左右的柑橘浆和1%左右的葡萄渣。所有的毕格犬饲喂对照食物或食物A持续至其余生。饲喂对照食物犬的平均死亡年龄为13.52,而饲喂食物A犬的平均死亡年龄为14.21。5只对照组的犬在13岁之前死亡,而饲喂食物A的犬均未在13岁时死亡。对照组的毕格犬的平均残存期为3.49年,而实验组的毕格犬为4.06年。
表2对照食物和食物A的区别
组分 | 对照食物 | 食物A |
维生素E | 约100ppm | 约950ppm |
维生素C | 未检出 | 约80ppm |
α-硫辛酸 | 未添加 | 约100ppm |
左旋肉毒碱 | 未添加 | 300ppm |
菠菜 | 未添加 | 1% |
番茄渣 | 未添加 | 1% |
胡萝卜 | 未添加 | 1% |
葡萄渣 | 未添加 | 1% |
柑橘浆 | 未添加 | 1% |
本发明说明书已经对本发明的典型优选实施方案进行了描述,其中使用了一些具体术语,其目的不是为了限制,而只是作为一般性的描述。本发明涉及的范围体现在下文的权利要求中。很明显,根据本发明的详细描述,可以对本发明内容进行修改和变更,因此,除详细的描述外,本发明内容还包括附加的权利要求。
Claims (23)
1.一种延长动物寿命的方法,所述方法包括当动物年老时给予动物含总剂量足以延长动物寿命的一种或多种抗氧化剂的组合物,其中所述方法不用于预防或治疗疾病,其中该动物在其余生中一直被给予该组合物,其中所述“年老”是指至少为动物物种正常寿命三分之一的年龄。
2.权利要求1的方法,其中的动物为伴侣动物。
3.权利要求1的方法,其中的动物为犬或猫科动物。
4.权利要求3的方法,其中当所述动物至少7岁时,给予这种组合物。
5.权利要求3的方法,其中自从所述动物至少7岁时,对该动物给予这种组合物,持续至少2年。
6.权利要求3的方法,其中自从所述动物至少7岁时,对该动物给予这种组合物,持续所述动物的余生。
7.权利要求1的方法,其中所述组合物为食物、添加剂、奖赏性食物或玩具。
8.权利要求1的方法,其中每种抗氧化剂独立选自维生素E、维生素C、左旋肉毒碱以及α-硫辛酸。
9.权利要求1的方法,其中每种抗氧化剂独立选自番茄渣、葡萄渣、菠菜渣、柑橘浆、胡萝卜粒。
10.权利要求1的方法,其中所述组合物为食物组合物,通过饲喂给予动物。
11.权利要求10的方法,其中所述食物组合物从营养学角度而言适合饲喂伴侣动物。
12.权利要求10的方法,其中所述组合物含50ppm至10,000ppm的维生素C。
13.权利要求10的方法,其中所述组合物含50ppm至100ppm的维生素C。
14.权利要求10的方法,其中所述组合物含100ppm至2,000ppm的维生素E。
15.权利要求10的方法,其中所述组合物含500ppm至1,000ppm的维生素E。
16.权利要求10的方法,其中所述组合物含25ppm至600ppm的α-硫辛酸。
17.权利要求10的方法,其中所述组合物含100ppm至200ppm的α-硫辛酸。
18.权利要求10的方法,其中所述组合物含100ppm至5,000ppm的左旋肉毒碱。
19.权利要求10的方法,其中所述组合物含200ppm至400ppm的左旋肉毒碱。
20.权利要求10的方法,其中所述组合物含:50ppm至10,000ppm的维生素C、100ppm至2,000ppm的维生素E、25ppm至600ppm的α-硫辛酸以及100ppm至5,000ppm的左旋肉毒碱。
21.权利要求10的方法,其中所述组合物含:50ppm至100ppm的维生素C、500ppm至1,000ppm的维生素E、100ppm至200ppm的α-硫辛酸以及200ppm至400ppm的左旋肉毒碱。
22.抗氧化剂在制备制品中的用途,该制品用于延长动物寿命,该制品含有:
含组合物的包装,组合物中包含当给予年老动物时总剂量足以延长该动物寿命的一种或多种抗氧化剂;以及
传达将所述组合物给予年老动物以延长动物寿命的信息或用法说明的传达工具,所述传达工具附于或装在所述包装内,
其中该动物在其余生中一直被给予该组合物,其中所述“年老”是指至少为动物物种正常寿命三分之一的年龄。
23.抗氧化剂在制备药盒中的用途,该药盒用于延长动物寿命,该药盒含有:
含组合物的第一包装,组合物中包含当给予年老动物时总剂量足以延长该动物寿命的一种或多种抗氧化剂;
含食物基料的第二包装;以及
传达以下信息或用法说明的工具:(i)将含有抗氧化剂的组合物添加到食物基料中,(ii)将所得富含抗氧化剂的组合物给予年老动物,以延长该动物寿命,
其中该动物在其余生中一直被给予该组合物,其中所述“年老”是指至少为动物物种正常寿命三分之一的年龄。
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EP1906912B1 (en) | 2012-08-15 |
RU2402919C2 (ru) | 2010-11-10 |
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US20090155393A1 (en) | 2009-06-18 |
JP5284087B2 (ja) | 2013-09-11 |
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RU2008105553A (ru) | 2009-08-20 |
AU2006267068B2 (en) | 2011-01-06 |
US8722112B2 (en) | 2014-05-13 |
EP1906912A1 (en) | 2008-04-09 |
BRPI0613000A2 (pt) | 2012-12-04 |
CA2615060A1 (en) | 2007-01-18 |
AU2006267068A1 (en) | 2007-01-18 |
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