CN101257797B - 嘌呤类化合物的选择性n-9糖基化的方法 - Google Patents

嘌呤类化合物的选择性n-9糖基化的方法 Download PDF

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Publication number
CN101257797B
CN101257797B CN2006800297083A CN200680029708A CN101257797B CN 101257797 B CN101257797 B CN 101257797B CN 2006800297083 A CN2006800297083 A CN 2006800297083A CN 200680029708 A CN200680029708 A CN 200680029708A CN 101257797 B CN101257797 B CN 101257797B
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China
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alkyl
amino
hydrogen
formula
purine
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Chinese (zh)
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CN101257797A (zh
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M·J·罗宾斯
钟明宏
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Brigham Young University
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Brigham Young University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2006800297083A 2005-06-14 2006-06-14 嘌呤类化合物的选择性n-9糖基化的方法 Active CN101257797B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69030705P 2005-06-14 2005-06-14
US60/690,307 2005-06-14
PCT/US2006/023193 WO2006138396A2 (en) 2005-06-14 2006-06-14 Methods for selective n-9 glycosylation of purines

Publications (2)

Publication Number Publication Date
CN101257797A CN101257797A (zh) 2008-09-03
CN101257797B true CN101257797B (zh) 2013-06-12

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CN2006800297083A Active CN101257797B (zh) 2005-06-14 2006-06-14 嘌呤类化合物的选择性n-9糖基化的方法

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US (1) US7855285B2 (enExample)
EP (1) EP1895841A4 (enExample)
JP (1) JP4966969B2 (enExample)
CN (1) CN101257797B (enExample)
AU (1) AU2006259431B2 (enExample)
CA (1) CA2653247C (enExample)
IL (1) IL188123A (enExample)
WO (1) WO2006138396A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232387B2 (en) * 2009-08-18 2012-07-31 Scinopharm Taiwan, Ltd. Process for the preparation of cladribine
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
US20150376219A1 (en) * 2014-06-30 2015-12-31 Minghong Zhong Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods
CN109928930A (zh) * 2019-03-13 2019-06-25 宁夏倬昱新材料科技有限公司 一种2-丙基咪唑制备工艺
CN116462719B (zh) * 2023-04-28 2025-08-29 上海兆维科技发展有限公司 α构型的脱氧核苷的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030023078A1 (en) * 2000-02-18 2003-01-30 Montgomery John A. Method for synthesizing 2-chloro-9-(2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amine
WO2004018490A1 (en) * 2002-08-21 2004-03-04 Ash Stevens, Inc. Process for the preparation of 9-beta-anomeric nucleoside analogs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2709634A1 (de) 1977-03-05 1978-09-07 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
IL64501A (en) 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4579849A (en) 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
US4760137A (en) 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US4801710A (en) 1984-10-26 1989-01-31 Merck & Co., Inc. Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives
US5459255A (en) 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
JP3906488B2 (ja) 1995-02-21 2007-04-18 味の素株式会社 プリン誘導体の製造方法
US5989569A (en) * 1997-06-06 1999-11-23 The Procter & Gamble Company Delivery system for a tooth whitener using a permanently deformable strip of material
CZ9901996A3 (cs) 1999-06-04 2001-01-17 Ústav organické chemie a biochemie AV ČR Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030023078A1 (en) * 2000-02-18 2003-01-30 Montgomery John A. Method for synthesizing 2-chloro-9-(2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amine
WO2004018490A1 (en) * 2002-08-21 2004-03-04 Ash Stevens, Inc. Process for the preparation of 9-beta-anomeric nucleoside analogs

Also Published As

Publication number Publication date
EP1895841A4 (en) 2010-08-18
JP2008546703A (ja) 2008-12-25
WO2006138396A2 (en) 2006-12-28
AU2006259431A1 (en) 2006-12-28
AU2006259431B2 (en) 2011-09-29
CA2653247C (en) 2012-12-18
JP4966969B2 (ja) 2012-07-04
IL188123A0 (en) 2008-03-20
CN101257797A (zh) 2008-09-03
US20080207891A1 (en) 2008-08-28
IL188123A (en) 2013-02-28
EP1895841A2 (en) 2008-03-12
WO2006138396A3 (en) 2007-04-19
CA2653247A1 (en) 2006-12-28
US7855285B2 (en) 2010-12-21

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