AU2006259431B2 - Methods for selective N-9 glycosylation of purines - Google Patents

Methods for selective N-9 glycosylation of purines Download PDF

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Publication number
AU2006259431B2
AU2006259431B2 AU2006259431A AU2006259431A AU2006259431B2 AU 2006259431 B2 AU2006259431 B2 AU 2006259431B2 AU 2006259431 A AU2006259431 A AU 2006259431A AU 2006259431 A AU2006259431 A AU 2006259431A AU 2006259431 B2 AU2006259431 B2 AU 2006259431B2
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AU
Australia
Prior art keywords
hydrogen
alkylamino
purine
contacting
formula
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AU2006259431A
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AU2006259431A1 (en
Inventor
Morris J. Robins
Minghong Zhong
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Brigham Young University
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Brigham Young University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2006259431A 2005-06-14 2006-06-14 Methods for selective N-9 glycosylation of purines Active AU2006259431B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69030705P 2005-06-14 2005-06-14
US60/690,307 2005-06-14
PCT/US2006/023193 WO2006138396A2 (en) 2005-06-14 2006-06-14 Methods for selective n-9 glycosylation of purines

Publications (2)

Publication Number Publication Date
AU2006259431A1 AU2006259431A1 (en) 2006-12-28
AU2006259431B2 true AU2006259431B2 (en) 2011-09-29

Family

ID=37571119

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006259431A Active AU2006259431B2 (en) 2005-06-14 2006-06-14 Methods for selective N-9 glycosylation of purines

Country Status (8)

Country Link
US (1) US7855285B2 (enExample)
EP (1) EP1895841A4 (enExample)
JP (1) JP4966969B2 (enExample)
CN (1) CN101257797B (enExample)
AU (1) AU2006259431B2 (enExample)
CA (1) CA2653247C (enExample)
IL (1) IL188123A (enExample)
WO (1) WO2006138396A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232387B2 (en) * 2009-08-18 2012-07-31 Scinopharm Taiwan, Ltd. Process for the preparation of cladribine
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
US20150376219A1 (en) * 2014-06-30 2015-12-31 Minghong Zhong Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods
CN109928930A (zh) * 2019-03-13 2019-06-25 宁夏倬昱新材料科技有限公司 一种2-丙基咪唑制备工艺
CN116462719B (zh) * 2023-04-28 2025-08-29 上海兆维科技发展有限公司 α构型的脱氧核苷的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007518A1 (en) * 1997-06-06 2000-02-17 The Procter & Gamble Company A delivery system for an oral care substance using a permanently deformable strip of material
US20030023078A1 (en) * 2000-02-18 2003-01-30 Montgomery John A. Method for synthesizing 2-chloro-9-(2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amine
WO2004018490A1 (en) * 2002-08-21 2004-03-04 Ash Stevens, Inc. Process for the preparation of 9-beta-anomeric nucleoside analogs

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2709634A1 (de) 1977-03-05 1978-09-07 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
IL64501A (en) 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4579849A (en) 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
US4760137A (en) 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US4801710A (en) 1984-10-26 1989-01-31 Merck & Co., Inc. Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives
US5459255A (en) 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
JP3906488B2 (ja) 1995-02-21 2007-04-18 味の素株式会社 プリン誘導体の製造方法
CZ9901996A3 (cs) 1999-06-04 2001-01-17 Ústav organické chemie a biochemie AV ČR Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007518A1 (en) * 1997-06-06 2000-02-17 The Procter & Gamble Company A delivery system for an oral care substance using a permanently deformable strip of material
US20030023078A1 (en) * 2000-02-18 2003-01-30 Montgomery John A. Method for synthesizing 2-chloro-9-(2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amine
WO2004018490A1 (en) * 2002-08-21 2004-03-04 Ash Stevens, Inc. Process for the preparation of 9-beta-anomeric nucleoside analogs

Also Published As

Publication number Publication date
EP1895841A4 (en) 2010-08-18
JP2008546703A (ja) 2008-12-25
WO2006138396A2 (en) 2006-12-28
AU2006259431A1 (en) 2006-12-28
CA2653247C (en) 2012-12-18
JP4966969B2 (ja) 2012-07-04
IL188123A0 (en) 2008-03-20
CN101257797A (zh) 2008-09-03
US20080207891A1 (en) 2008-08-28
IL188123A (en) 2013-02-28
EP1895841A2 (en) 2008-03-12
WO2006138396A3 (en) 2007-04-19
CN101257797B (zh) 2013-06-12
CA2653247A1 (en) 2006-12-28
US7855285B2 (en) 2010-12-21

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