CN101254155B

CN101254155B - Skin preparations for external use

Info

Publication number: CN101254155B
Application number: CN2008100853282A
Authority: CN
Inventors: 中根俊彦; 石野弘和; 伊佐尚; 小口希; 富永直树; 神谷有喜子
Original assignee: Shiseido Co Ltd
Current assignee: Shiseido Co Ltd
Priority date: 2002-10-25
Filing date: 2003-10-21
Publication date: 2010-12-08
Anticipated expiration: 2023-10-21
Also published as: CN1708283A; CN1708283B; JP2004143104A; CN101254155A

Abstract

A skin preparation for external use which contains antibacterial zeolite and an ethyelenediaminehydroxyethyltriacetic acid trisalt. A skin preparation for external use which contains antibacterial zeolite and alum and/or baked alum. A skin preparation for external use which contains antibacterial zeolite and polyoxyethylene polyoxypropylene 2-decyltetradecyl ether. It is intended to provide a skin preparation for external use containing antibacterial zeolite which has an effect of preventing the skin preparation for external use from color change or relieving the extent of the color change.

Description

Skin preparations for extenal use

The application is that the PCT application number is the dividing an application for the application for a patent for invention of " skin preparations for extenal use " that PCT/JP2003/013406 (its application number that enters country's stage is 200380102015.9), the applying date be on October 21st, 2003, denomination of invention.

Technical field

The present invention relates to skin preparations for extenal use.Skin preparations for extenal use of the present invention mainly is purpose with the deodorant, preferably as utilizations such as deodorant skin preparations for extenal use, deodorant cosmetics, antiperspirant cosmetics, deodorization cosmetics.

(1) in more detail, relate to the good skin preparations for extenal use of discoloration-resistant in the skin preparations for extenal use that is combined with antibacterial zeolite.

(2) in addition, in more detail, relating to a kind of skin preparations for extenal use, is the deodorant cosmetics that are combined with antibacterial zeolite, and preparation stabilities such as the dispersibility of its powder composition and discoloration-resistant are good, and uses sense of touch very good.

(3) in addition, in more detail, relate to the good skin preparations for extenal use of stain resistance in the skin preparations for extenal use that is combined with antibacterial zeolite.

Background technology

[invention of claim 1]

Antibacterial zeolite is engaged in the skin preparations for extenal use such as cosmetics or health product as antiseptic or deodorizer.

The antibiotic property spraying compositions (with reference to patent documentation 1-1) and the deodorant cosmetics (with reference to patent documentation 1-2) that are combined with antibacterial zeolite have for example been developed.In addition, as the deodorant cosmetics of having improved discoloration-resistant, the technology (with reference to patent documentation 1-3) that cooperates siloxanes in antibacterial zeolite is disclosed.

Patent documentation 1-1 spy opens clear 63-250325 communique

Patent documentation 1-2 spy opens flat 8-26956 communique

Patent documentation 1-3 spy opens flat 8-92051 communique

Simple antibacterial zeolite is stable skin preparations for extenal use composition.But,, cause variable color sometimes if in skin preparations for extenal use, cooperate antibacterial zeolite.

The reason of variable color is also indeterminate, thinks with the reactions such as impurity that cooperate raw material or cooperation raw material variable color to take place knifeedge owing to have plurality of raw materials in the skin preparations for extenal use.

For example, the inventor confirms, particularly in being combined with the antiperspirant cosmetics of polymeric aluminum chloride, if cooperate antibacterial zeolite as antiseptic or deodorizer, in appearance bad variable color can take place at cosmetics.In addition, the inventor confirms, particularly cooperates the occasion of antibacterial zeolite in being combined with the skin preparations for extenal use of various surfactants, also bad variable color can take place.

The inventor has carried out concentrated research in view of above-mentioned problem, and the antibacterial zeolite that the result is surprised to find in the ethylenediamine ethoxy triacetic acid three salt pair skin preparations for extenal use has the effect of the variable color of preventing, thereby has finished the present invention.

The object of the present invention is to provide a kind ofly in being combined with the skin preparations for extenal use of antibacterial zeolite, prevent the variable color of skin preparations for extenal use, perhaps relax the very good skin preparations for extenal use of effect of variable color degree.

[invention of claim 2～6]

The powder of antibacterial zeolite is engaged in the skin preparations for extenal use such as cosmetics or health product as antiseptic or deodorizer.

For example, antibiotic property spraying compositions (with reference to patent documentation 2-1) and the deodorant cosmetics (with reference to patent documentation 2-2) that are combined with antibacterial zeolite have been developed.In addition, as the deodorant cosmetics of having improved discoloration-resistant, the technology (with reference to patent documentation 2-3) that cooperates siloxanes in antibacterial zeolite is disclosed.

On the other hand, as the antiperspirant cosmetics that contain Alumen, developed disposable sheet cosmetics (with reference to patent documentation 2-4).

Patent documentation 2-1 spy opens clear 63-250325 communique

Patent documentation 2-2 spy opens flat 8-26956 communique

Patent documentation 2-3 spy opens flat 8-92051 communique

Patent documentation 2-4 spy opens the 2001-114660 communique

The deodorant cosmetics are to be used to prevent or to suppress to distribute or secrete offending body odor, perhaps make to distribute or cosmetics that secretory component disappears.As the form of this goods, generally as utilizations such as astringent, emulsifiable paste, powder, rod or aerosols.

Body odor is because antiperspirant decomposes stink to take place.Body odor for preventing to produce along with antiperspirant has following method.

(1) utilizes the method for astriction deodorant

Generation by potent astriction inhibition antiperspirant prevents body odor indirectly.For example often use astringents such as zinc phenolsulfonate, citric acid or various aluminium compounds.In addition, ethanol also has astriction.Wherein, particularly often use aluminium compound (polymeric aluminum chloride), the occasion of aerosol-type has been developed the complex with the good propylene glycol of Freon gas intermiscibility.

(2) utilize the method for bactericidal action deodorant

It is because the decomposition of antibacterial causes that antiperspirant decomposes the generation foul smell.Therefore, utilize antibacterial to prevent the breeding of antibacterial, directly anti-antisudorific decomposes, fouls.For example, often use TMTD (tetramethylthiuram disulfide), benzalkonium chloride, CF3 etc.In addition, zinc oxide, quintessence oil, spice, chlorophyll compound etc. also have antibacterial action, the performance odor-resistant result.

(3) utilize the method for masking action deodorant

Common body odor can be sheltered with perfume or floral water etc., eliminates its stink.In addition, the method that cooperates above-mentioned antibacterial promotion odor-resistant result in perfume or floral water is also arranged.

The disclosed deodorant cosmetics of patent documentation 2-1～2-3 are deodorant methods of utilizing the bactericidal action of antibacterial zeolite.But, if utilize the deodorant cosmetics of antibacterial zeolite to use, then exist variable color takes place with the antiperspirant that contains halogen headed by the polymeric aluminum chloride, be difficult to keep the problem of preparation stability.And its usability also exists the rough problem of the sense of touch of skin.Therefore, wish that a kind of preparation stability of exploitation is good, and usability is also good, has the deodorant cosmetics of good odor-resistant result.

The object of the present invention is to provide a kind of preparation stability and usability good, and the good skin preparations for extenal use of odor-resistant result.

The inventor etc. are based on above-mentioned viewpoint, for solving above-mentioned problem, concentrated research has been carried out in the variable color of in the past deodorant cosmetics and the stopping cause of the usability on skin, found that if cooperate the halogen compounds of using as antiperspirant such as polymeric aluminum chloride, inhomogeneity appears in then preparation generation variable color, and preparation, thereby coagulation takes place, cause rough sense, hinder usability.If also find to cooperate Alumen or burnt alum to replace cooperating with the halogen compounds headed by the polymeric aluminum chloride, then preparation stability improves, and no longer includes rough sense during use, and can access good odor-resistant result, thereby finished the present invention.

The deodorant cosmetics that are combined with antibacterial zeolite in the past, during as antiperspirant, preparation stabilities such as dispersibility and variable color can not be satisfactory at the chemical compound that cooperates great amount of hydroxy group aluminum chloride etc. to contain halogen.Think that this is to cause variable color because antiperspirants such as antibiotic property metal in the antibacterial zeolite and polymeric aluminum chloride interact.In the present invention, the most important is when having found that the Alumen that will play a role as antiperspirant or burnt alum cooperate simultaneously with antibacterial zeolite, preparation stability is good, and the use sense of touch on the skin is also good, and this is must not expected effect according to prior art.In addition, compare with the use level of antibacterial zeolite, Alumen and/or burnt alum, so long as product to dispersibility and the discolouration not in-problem use level of influence not in fact, can cooperate polymeric aluminum chloride etc. to contain the antiperspirant of halogen in the present invention.At this moment, the use level that contains the antiperspirant of halogen is preferably below the 5 quality % with respect to the skin preparations for extenal use total amount.

In addition, in the present invention,, think to exert an influence along with dispersibility improves the stability of formulation effect about using the good this point of sense of touch, but its mechanism of action and indeterminate.

[invention of claim 7～8]

For example, antibiotic property spraying compositions (with reference to patent documentation 3-1) and the deodorant cosmetics (with reference to patent documentation 3-2) that are combined with antibacterial zeolite have been developed.In addition, as the deodorant cosmetics of having improved discoloration-resistant, the technology (with reference to patent documentation 3-3) that cooperates siloxanes in antibacterial zeolite is disclosed.

But report has not been improved the skin preparations for extenal use and the cosmetics of stain resistance.

On the other hand, polyoxyethylene polyoxypropylene 2-decyl myristyl ether is known (with reference to patent documentation 3-4) as the surfactant that is engaged in the cosmetics.

Patent documentation 3-1 spy opens clear 63-250325 communique

Patent documentation 3-2 spy opens flat 8-26956 communique

Patent documentation 3-3 spy opens flat 8-92051 communique

No. 3323339 communique of patent documentation 3-4 patent

Antibacterial zeolite itself is stable skin preparations for extenal use composition.

But, if cooperate antibacterial zeolite in skin preparations for extenal use, then variable color can take place, attached to the occasion on the medicated clothing, pollution clothes sometimes.

For example, the inventor confirms, particularly in being combined with the antiperspirant cosmetics of polymeric aluminum chloride, if cooperate antibacterial zeolite as antiseptic or deodorizer, in appearance bad variable color can take place at cosmetics.

In addition, the inventor confirms that the antiperspirant cosmetics down bad variable color can take place attached on the medicated clothing at antiperspirant and daylight etc., if it is attached on the medicated clothing, and will pollution clothes.

The inventor has carried out concentrated research in view of above-mentioned problem, uses antibacterial zeolite and polyoxyethylene polyoxypropylene 2-decyl myristyl ether simultaneously if the result is surprised to find, and then has the anti-pollution effect, thereby has finished the present invention.

The object of the present invention is to provide a kind of in being combined with the skin preparations for extenal use of antibacterial zeolite, extremely good skin preparations for extenal use to the anti-pollution effect of medicated clothing.

Summary of the invention

[invention of claim 1]

That is to say, the invention provides a kind of skin preparations for extenal use, wherein, contain antibacterial zeolite and ethylenediamine ethoxy triacetic acid three salt.

[invention of claim 2～6]

That is to say, the invention provides a kind of skin preparations for extenal use, wherein, contain antibacterial zeolite and Alumen and/or burnt alum.

In addition, the present invention also provides above-mentioned skin preparations for extenal use, and wherein, the content of above-mentioned antibacterial zeolite is 0.1～90 quality % with respect to the skin preparations for extenal use total amount.

And the present invention also provides above-mentioned skin preparations for extenal use, and wherein, the content of above-mentioned Alumen and/or burnt alum is counted more than 0.1 by mass ratio with respect to the content of above-mentioned antibacterial zeolite.

In addition, the present invention also provides above-mentioned skin preparations for extenal use, and wherein, the content of above-mentioned antibacterial zeolite is 0.1～70 quality % with respect to deodorant cosmetics total amount, and the content of above-mentioned Alumen and/or burnt alum is 0.01～80 quality % with respect to the skin preparations for extenal use total amount.

And the present invention also provides above-mentioned skin preparations for extenal use, wherein, the mean diameter of above-mentioned antibacterial zeolite is below the 10 μ m, in particle size distribution, the particle that particle diameter surpasses 15 μ m is below 20%, and the mean diameter of above-mentioned Alumen and/or burnt alum is 0.01～50 μ m.

[invention of claim 7～8]

That is to say, the invention provides a kind of skin preparations for extenal use, wherein, contain antibacterial zeolite and polyoxyethylene polyoxypropylene 2-decyl myristyl ether.

In addition, the present invention also provides above-mentioned skin preparations for extenal use, it is characterized in that, the polyoxyethylene unit of polyoxyethylene polyoxypropylene 2-decyl myristyl ether is 20～28E.O., and the polyoxypropylene unit is 10～16P.O..

The specific embodiment

Below, be described in detail the present invention.

[invention of claim 1]

The antibacterial zeolite that uses among the present invention, be zeolite can ion exchange part maintain the zeolite of antibiotic property metal ion.That is, zeolite can ion exchange the zeolite that obtained by the antibiotic property metal replacement of part or all of ion.In the present invention, also preferred and antibiotic property metal ion one is reinstated the zeolite that the ammonium ion displacement obtains.

Zeolite can be a natural zeolite, also can be synthetic zeolite.Zeolite generally is the aluminosilicate with three-dimensional framework structure, general formula XM _2/nOAl ₂O ₃YSiO ₂ZH ₂O represents.In this general formula, M represent can ion exchange ion, be generally 1 or the metal ion of divalent.N is (metal) ionic atomicity.X and Y represent metal-oxide, silicon dioxide coefficient respectively, and Z represents the number of water of crystallization.

As the instantiation of zeolite, can exemplify A-type zeolite, X-type zeolite, Y-type zeolite, T-type zeolite, high silica zeolites, sodalite, modenite, analcime, clinoptilolite, chabasie, erionite etc.The ion exchange capacity of these zeolites is A-type zeolite 7meq/g, X-type zeolite 6.4meq/g, Y-type zeolite 5meq/g, T-type zeolite 3.4meq/g, sodalite 11.5meq/g, modenite 2.6meq/g, analcime 5meq/g, clinoptilolite 2.6meq/g, chabasie 5meq/g, erionite 3.8meq/g.All have with antibiotic property metal ion or ammonium ion and carry out the required enough capacity of ion exchange.

In the zeolite can ion exchange ion be for example sodium ion, calcium ion, potassium ion, magnesium ion, iron ion etc.In addition, replace these ionic antibiotic property metal ions and be for example silver, copper, zinc, hydrargyrum, stannum, lead, bismuth, cadmium, chromium or thallic ion, the ion of preferred silver, copper or zinc, more preferably silver ion.

Consider that from the viewpoint of antibiotic property the antibiotic property metal ion preferably contains 0.1～15 quality % in zeolite.For example, the antibacterial zeolite that preferably contains silver ion 0.1～15% and copper ion or zinc ion 0.1～8 quality %.On the other hand, in zeolite, can contain ammonium ion and reach 20 quality %, but consider, more preferably 0.5～5% in the zeolite, further preferred 0.5～2 quality % from the viewpoint that effectively prevents the zeolite variable color.In addition, quality % is meant the quality percentage in the zeolite of 110 ℃ of dry standards.

In the present invention, antibacterial zeolite can use commercially available product, as the manufacture method of antibacterial zeolite, for example can as described belowly make.That is, zeolite is contacted with the mixed aqueous solution that contains antibiotic property metal ions such as silver ion, copper ion, zinc ion of preparation in advance, make ion and the above-mentioned ion exchange that to carry out ion exchange in the zeolite.Contact can be at 10～70 ℃, under preferred 40～60 ℃, adopt batch (-type) or continous way (for example, the post method) to carry out preferred 10～24 hours 3～24 hours.In addition, the pH of above-mentioned mixed aqueous solution preferably is adjusted to 3～10, and preferred 5～7.Regulate by this, can prevent that the oxide etc. of silver from separating out in zeolite surface or pore, therefore preferred.In addition, each ion in the mixed aqueous solution is all supplied with as salt usually.For example, silver ion can use silver nitrate, silver sulfate, silver perchlorate, silver acetate, diamino YINXIAO hydrochlorate, diamino silver sulfate etc., copper ion can use copper nitrate (II), cupric perchlorate, copper acetate, four cyano copper acid potassium, copper sulfate etc., zinc ion can use zinc nitrate (II), zinc sulfate, zinc perchlorate, Zinc sulfocyanate., zinc acetate etc., mercury ion can use mercuric perchlorate, Mercury pernitrate., mercuric acetate, tin ion can use STANNOUS SULPHATE CRYSTALLINE etc., lead ion can use lead sulfate, plumbi nitras etc., bismuth ion can use bismuth chloride, bismuth iodide etc., cadmium ion can use cadmium perchlorate, cadmium sulfate, cadmium nitrate, cadmium acetate, chromium ion can use perchloric acid chromium, chromic sulfate, chromium ammonium suplhate, chromic nitrate etc., thallium ion can use the perchloric acid thallium, thallium sulfate, thallium nitrate, thallium acetate etc.

The content of the antibiotic property metal ion in the zeolite can suitably be controlled by each ion (salt) concentration of adjusting in the above-mentioned mixed aqueous solution.For example, antibacterial zeolite contains the occasion of silver ion, is 0.002M/l～0.15M/l by making the concentration of silver ions in the above-mentioned mixed aqueous solution, can suitably obtain silver ion content and be 0.1～5% antibacterial zeolite.In addition, antibacterial zeolite further contains the occasion of copper ion, zinc ion, by making the copper ion concentration in the above-mentioned mixed aqueous solution is 0.1M/l～0.85M/l, zinc ion concentration is 0.15M/l～1.2M/l, can suitably obtain content of copper ion 0.1～8%, the antibacterial zeolite of zinc ion content 0.1～8%.Antibacterial zeolite also can contain each ionic aqueous solution separately by using except that above-mentioned mixed aqueous solution, each aqueous solution is contacted with zeolite, carries out ion exchange.Each ion concentration in each aqueous solution can be determined according to each ion concentration in the above-mentioned mixed aqueous solution.

Zeolite after ion exchange finishes divides the washing after drying at gram.Drying is preferably descended or reduces pressure (to carry out under 70～90 ℃ under 1～30Torr) condition at 105 ℃～115 ℃.

In addition, stannum, bismuth etc. does not have the ion exchange of the ion or the organic ion of suitable water soluble salt, can use alcohol or acetone and other organic solvent solution to react, and makes it can not separate out the basic salt of slightly solubility.

There is no particular limitation for the use level of antibacterial zeolite in skin preparations for extenal use.Can suitably determine according to the goods form that cooperates purpose and skin preparations for extenal use.

For example, the occasion as antiseptic cooperates cooperates about 0.05～10 quality % with respect to the skin preparations for extenal use total amount usually.In addition, the occasion as antibacterial cooperates usually with respect to the skin preparations for extenal use total amount, cooperates 0.1～90 quality % according to the goods form.For example in the skin preparations for extenal use of lotion or cream type, be 0.1～20 quality % preferably with respect to the skin preparations for extenal use total amount, in the skin preparations for extenal use of powder-type, be 0.5～80 quality % preferably with respect to the skin preparations for extenal use total amount, in the skin preparations for extenal use of excellent type, being 0.5～60 quality % with respect to the skin preparations for extenal use total amount preferably, in the skin preparations for extenal use of aerosol type, is 0.5～50 quality % with respect to skin preparations for extenal use preferably.

Ethylenediamine ethoxy triacetic acid three salt that use among the present invention are as the known skin preparations for extenal use gradation composition of chelating agen.As salt, can exemplify alkali metal salts such as sodium, potassium, particular certain cancers.Can utilize Network レワ Star ト OH-300 commercially available products such as (Teikoku Chemical Industries Co., Ltd).The dried powder of ethylenediamine ethoxy triacetic acid three salt is coupled in the skin preparations for extenal use of the present invention as three water salt usually.

In the present invention, ethylenediamine ethoxy triacetic acid three salt prevent that as the variable color that is combined with the skin preparations for extenal use of antibacterial zeolite agent from playing a role specifically.In addition, have with as similar chemical constitution such as the ethylenediamine ethoxy triacetic acid trisodium of ethylenediamine ethoxy triacetic acid three salt, do not have the variable color of skin preparations for extenal use to prevent effect as the well-known EDTA-3Na of chelating agen etc.

The use level of ethylenediamine ethoxy triacetic acid three salt can suitably be determined according to the use level and the goods form of antibacterial zeolite.Usually, converting by no hydrate, is about 0.01～5 quality % with respect to the skin preparations for extenal use total amount.

When skin preparations for extenal use of the present invention being used for purposes such as deodorization cosmetics or antiperspirant cosmetics, the preferred aluminium compound that cooperates as antiperspirant.

In the skin preparations for extenal use of the present invention, except that above-mentioned essential constituent, can also suitably cooperate other compositions that use in the common skin preparations for extenal use as required, in for example following composition that exemplifies more than a kind or 2 kinds, can be according to required dosage form according to the conventional method manufacturing.

[invention of claim 2～6]

The antibacterial zeolite that uses among the present invention, can use zeolite can ion exchange part maintain the zeolite powder of antibiotic property metal ion.That is, zeolite can ion exchange the powder of the zeolite that obtained by the antibiotic property metal replacement of part or all of ion.In the present invention, also preferred and antibiotic property metal ion one is reinstated the zeolite that the ammonium ion displacement obtains.

Consider that from the viewpoint of antibiotic property the antibiotic property metal ion preferably contains 0.1～15 quality % in zeolite.For example, the antibacterial zeolite that preferably contains silver ion 0.1～15% and copper ion or zinc ion 0.1～8 quality %.On the other hand, in zeolite, can contain ammonium ion and reach 20 quality %, but consider, more preferably 0.5～5 quality % in the zeolite, further preferred 0.5～2 quality % from the viewpoint that effectively prevents the zeolite variable color.In addition, quality % is meant the quality percentage in the zeolite of 110 ℃ of dry standards.

Zeolite after ion exchange finishes is at the thorough washing after drying.Drying is preferably descended or reduces pressure (to carry out under 70～90 ℃ under 1～30Torr) condition at 105 ℃～115 ℃.

There is no particular limitation for the use level of antibacterial zeolite.Can suitably determine according to the goods form of deodorant cosmetics.Usually, according to the goods form, cooperate 0.1～90 quality %, preferred 1～70 quality %, more preferably 5～70 quality % with respect to deodorant cosmetics total amount.

Alumen that uses among the present invention and/or burnt alum can use the powder of commercially available product.Commercially available product is preferably utilized for example タイエ-ス S150, タイエ-ス S100, タイエ-ス K150, タイエ-ス K20 (Taimei Kagaku Kogyo Kabushiki Kaisha) etc.

There is no particular limitation for the use level of Alumen and/or burnt alum.Can suitably determine according to the goods form of skin preparations for extenal use.Usually, according to the goods form, cooperate 0.1～90 quality %, preferred 1～80 quality %, more preferably 5～70 quality % with respect to the skin preparations for extenal use total amount.

In addition, the content of Alumen and/or burnt alum is preferably counted more than 0.1 by mass ratio with respect to the content of antibacterial zeolite.When the goods form was the aerosol spray type, preferred antibacterial zeolite was 0.1～80 quality %, and Alumen and/or burnt alum be 0.1～80 quality %, more preferably was respectively 0.5～70 quality %.The occasion of rod type, preferred antibacterial zeolite is 0.1～70 quality %, and Alumen and/or burnt alum be 0.1～70 quality %, more preferably is respectively 0.5～60 quality %.The goods form is the occasion of powder-type, and preferred antibacterial zeolite is 0.1～99.9 quality %, and Alumen and/or burnt alum be 0.1～99.9 quality %, more preferably is respectively 50～95 quality %.The goods form is the occasion of lotion type, and preferred antibacterial zeolite is 0.1～30 quality %, and Alumen and/or burnt alum be 0.1～30 quality %, more preferably is respectively 0.5～20 quality %.

The mean diameter of above-mentioned antibacterial zeolite is preferably below the 10 μ m.0.1～5 μ m more preferably.In addition, mean diameter is the occasion of this scope, and in its particle size distribution, the particle that preferable particle size surpasses 1 μ m is below 20%.

On the other hand, the mean diameter of preferred above-mentioned Alumen or burnt alum is the micropartical powder of 0.01～50 μ m.

In skin preparations for extenal use of the present invention, except that above-mentioned essential constituent, can suitably cooperate other compositions that use in the common skin preparations for extenal use as required, in the composition that for example exemplifies below more than a kind or 2 kinds, according to required dosage form according to the conventional method manufacturing.As preferred goods, preferably as deodorant cosmetics, the antiperspirant cosmetics of deodorant with skin preparations for extenal use.

There is no particular limitation for the goods form of skin preparations for extenal use of the present invention.For example, can exemplify aerosol type, ロ-Le オ Application type, powder-type and compressing powder (powder for molding) type, excellent type etc.The occasion of aerosol type in automiser sprays such as aerosol container or allotter, is filled according to conventional method with propellant such as liquid gas and alcohol and to be made.The occasion of ロ-Le オ Application type is filled manufacturing with alcohol according to conventional method in ロ-Le オ Application container.The occasion of powder-type and compressing powder type is mixed together with powder composition, oil content, and the occasion of powder-type is directly according to the conventional method manufacturing, the occasion of compressing powder type, with various make-up machine molding according to the conventional method manufacturing.The occasion of rod type is mixed together with oil content (solid oil content, liquid oil content), is filled into molding manufacturing in the container according to conventional method.

[invention of claim 7～8]

The antibacterial zeolite that uses among the present invention, be zeolite can ion exchange part maintain the zeolite of antibiotic property metal ion.

That is, zeolite can ion exchange the zeolite that obtained by the antibiotic property metal replacement of part or all of ion.In the present invention, also preferred and antibiotic property metal ion one is reinstated the zeolite that the ammonium ion displacement obtains.

In the zeolite can ion exchange ion be for example sodium ion, calcium ion, potassium ion, magnesium ion, iron ion etc.

In addition, replace these ionic antibiotic property metal ions and be for example silver, copper, zinc, hydrargyrum, stannum, lead, bismuth, cadmium, chromium or thallic ion, the ion of preferred silver, copper or zinc, more preferably silver ion.

Consider that from the viewpoint of antibiotic property the antibiotic property metal ion preferably contains 0.1～15 quality % in zeolite.

For example, the antibacterial zeolite that preferably contains silver ion 0.1～15% and copper ion or zinc ion 0.1～8 quality %.On the other hand, in zeolite, can contain ammonium ion and reach 20 quality %, but consider, more preferably 0.5～5% in the zeolite, further preferred 0.5～2 quality % from the viewpoint that effectively prevents the zeolite variable color.In addition, quality % is meant the quality percentage in the zeolite of 110 ℃ of dry standards.

In the present invention, antibacterial zeolite can use commercially available product, as the manufacture method of antibacterial zeolite, for example can as described belowly make.

That is, zeolite is contacted with the mixed aqueous solution that contains antibiotic property metal ions such as silver ion, copper ion, zinc ion of preparation in advance, make ion and the above-mentioned ion exchange that to carry out ion exchange in the zeolite.

Contact can be at 10～70 ℃, under preferred 40～60 ℃, adopt batch (-type) or continous way (for example, the post method) to carry out preferred 10～24 hours 3～24 hours.

In addition, the pH of above-mentioned mixed aqueous solution preferably is adjusted to 3～10, and preferred 5～7.Regulate by this, can prevent that the oxide etc. of silver from separating out in zeolite surface or pore, therefore preferred.In addition, each ion in the mixed aqueous solution is all supplied with as salt usually.For example, silver ion can use silver nitrate, silver sulfate, silver perchlorate, silver acetate, diamino YINXIAO hydrochlorate, diamino silver sulfate etc., copper ion can use copper nitrate (II), cupric perchlorate, copper acetate, four cyano copper acid potassium, copper sulfate etc., zinc ion can use zinc nitrate (II), zinc sulfate, zinc perchlorate, Zinc sulfocyanate., zinc acetate etc., mercury ion can use mercuric perchlorate, Mercury pernitrate., mercuric acetate, tin ion can use STANNOUS SULPHATE CRYSTALLINE etc., lead ion can use lead sulfate, plumbi nitras etc., bismuth ion can use bismuth chloride, bismuth iodide etc., cadmium ion can use cadmium perchlorate, cadmium sulfate, cadmium nitrate, cadmium acetate, chromium ion can use perchloric acid chromium, chromic sulfate, chromium ammonium suplhate, chromic nitrate etc., thallium ion can use the perchloric acid thallium, thallium sulfate, thallium nitrate, thallium acetate etc.

The content of the antibiotic property metal ion in the zeolite can suitably be controlled by each ion (salt) concentration of adjusting in the above-mentioned mixed aqueous solution.

For example, antibacterial zeolite contains the occasion of silver ion, is 0.002M/l～0.15M/l by making the concentration of silver ions in the above-mentioned mixed aqueous solution, can suitably obtain silver ion content and be 0.1～5% antibacterial zeolite.

In addition, antibacterial zeolite further contains the occasion of copper ion, zinc ion, by making the copper ion concentration in the above-mentioned mixed aqueous solution is 0.1M/l～0.85M/l, zinc ion concentration is 0.15M/l～1.2M/l, can suitably obtain content of copper ion 0.1～8%, the antibacterial zeolite of zinc ion content 0.1～8%.

Antibacterial zeolite also can contain each ionic aqueous solution separately by using except that above-mentioned mixed aqueous solution, each aqueous solution is contacted with zeolite, carries out ion exchange.Each ion concentration in each aqueous solution can be determined according to each ion concentration in the above-mentioned mixed aqueous solution.

For example, the occasion as antiseptic cooperates cooperates about 0.05～10 quality % with respect to the skin preparations for extenal use total amount usually.

In addition, the occasion as antibacterial cooperates usually with respect to the skin preparations for extenal use total amount, cooperates 0.1～90 quality % according to the goods form.

For example in the skin preparations for extenal use of lotion or cream type, be 0.1～20 quality % preferably with respect to the skin preparations for extenal use total amount, in the skin preparations for extenal use of powder-type, be 0.5～80 quality % preferably with respect to the skin preparations for extenal use total amount, in the skin preparations for extenal use of excellent type, being 0.5～60 quality % with respect to the skin preparations for extenal use total amount preferably, in the skin preparations for extenal use of aerosol type, is 0.5～50 quality % with respect to skin preparations for extenal use preferably.

The polyoxyethylene polyoxypropylene 2-decyl myristyl ether that uses among the present invention is known composition as the surfactant that is coupled in the skin preparations for extenal use.Usually the solubilizing agent as spice is coupled in the lotion.

In the present invention, preferred polyoxyethylene polyoxypropylene 2-decyl myristyl ether (20～28E.O.) (10～16P.O.), play a role specifically as the antistain agent of the skin preparations for extenal use that is combined with antibacterial zeolite.

In addition, as other activating agents that the solubilizing agent of spice is used, for example polyoxyethylene (E.O.60) hardened castor oil does not have the contamination preventing effect of skin preparations for extenal use.

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether (20～28E.O.) (can suitably determine according to the use level of antibacterial zeolite and goods form by 10～16P.O.) use level.Usually, be about 0.01～5 quality % with respect to the skin preparations for extenal use total amount.

In the skin preparations for extenal use of the present invention, except that above-mentioned essential constituent, can also suitably cooperate other compositions that use in the common skin preparations for extenal use as required, in for example following composition that exemplifies more than a kind or 2 kinds, according to required dosage form according to the conventional method manufacturing.

[composition that can cooperate among the present invention]

As the powder composition, can exemplify inorganic powder (for example Talcum, Kaolin, Muscovitum, sericite (sericite), white mica, phlogopite, synthetic mica, rubellan, biotite, Vermiculitum, magnesium carbonate, calcium carbonate, aluminium silicate, barium silicate, calcium silicates, magnesium silicate, strontium silicate, wolframic acid slaine, magnesium, silicon dioxide, barium sulfate, calcium sulfuricum ustum (bassanite), calcium phosphate, fluor-apatite, hydroxyapatite, ceramic powders, metallic soap (for example Grillocin P 176, calcium palmitate, aluminium stearate), boron nitride etc.); Organic dust (for example polyamide powder (nylon powder), polyethylene powders, polymethyl methacrylate powder, benzoguanamine resin powder, poly-tetrafluoroethylene powder, cellulose powder etc.); Inorganic Chinese white (for example titanium dioxide, zinc oxide etc.); Inorganic red series pigments (for example ferrum oxide (colcother), iron titanate etc.); Inorganic brown series pigments (for example gamma-iron oxide etc.); Inorganic yellow series pigments (for example iron oxide yellow, loess etc.); Inorganic black series pigments (for example iron oxide black, low price titanium oxide etc.); Inorganic violet pigment (for example manganese violet, cobalt violet etc.); Inorganic green series pigments (for example chromium oxide, chromic oxide gel, cobalt titanate etc.); Inorganic blue series pigments (for example ultramarine, dark purple etc.); Pearl pigment (for example titanium dioxide-coated Muscovitum, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated Talcum, painted titanium dioxide-coated Muscovitum, bismuth oxychloride, guanin etc.); Metallic powdery pigment (for example aluminium powder, copper powder etc.); Organic pigments such as zirconium, barium or aluminum color lake (for example red No. 201, red No. 202, red No. 204, red No. 205, red No. 220, red No. 226, red No. 228, red No. 405, orange No. 203, orange No. 204, yellow No. 205, organic pigments such as yellow No. 401 and blue No. 404, red No. 3, red No. 104, red No. 106, red No. 227, red No. 230, red No. 401, red No. 505, orange No. 205, yellow No. 4, yellow No. 5, yellow No. 202, yellow No. 203, green No. 3 and blue No. 1 etc.); Natural pigment (for example chlorophyll, beta-carotene etc.) etc.

As liquid fat, for example can enumerate American Avocado Tree oil, Camellia oil, turtle oil, macadimia nut oil, Semen Maydis oil, ermine oil, olive oil, Oleum Brassicae campestris, egg oil, Oleum sesami, basswood oil, Semen Tritici aestivi germ oil, Flos Camelliae Japonicae caul-fat, Oleum Ricini, Semen Lini oil, safflower oil, Oleum Gossypii semen, perilla oil, soybean oil, Oleum Arachidis hypogaeae semen, Oleum Camelliae, Semen Torreyae oil, Testa oryzae oil, Oleum Verniciae fordii, Japanese Paulownia oil, Jojoba oil, germ oil, triglycerin etc.

As solid grease, for example can enumerate cocoa butter, Oleum Cocois, sclerosis Oleum Cocois, Petiolus Trachycarpi oil, palm-kernel oil, haze tallow kernel oil, fixed oil, haze tallow, hardened castor oil etc.

As wax, for example can enumerate Cera Flava, candelilla wax, cotton wax, Brazil wax, Fructus Lauri nobilis wax, Chinese wax, spermaceti, brown matchmaker's wax, bran wax, lanoline, kapok wax, acetic acid lanoline, aqueous lanoline, sugarcane wax, lanolin fatty acid isopropyl ester, month own ester of silicic acid, reduction lanoline, jojoba wax, hard lanoline, shellac wax, POE lanoline alcohol ether, POE lanolin alcohol acetate, POE cholesterol ethers, lanolin fatty acid Polyethylene Glycol, POE hydrogenated lanolin alcohol ether, ceresin, microwax etc.

As hydrocarbon ils, can list for example liquid paraffin, ceresine, squalane, isooctadecane, paraffin, Squalene, vaseline etc.

As higher fatty acids, for example can enumerate lauric acid, myristic acid, Palmic acid, stearic acid, mountain Yu acid, oleic acid, 9-undecylenic acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexenoic acid (DHA) etc.

As higher alcohol, for example can enumerate straight chain alcohol (for example lauryl alcohol, spermol, stearyl alcohol, tadenan, myristyl alcohol, oleyl alcohol, cetostearyl alcohol etc.); Branched-chain alcoho (for example single batiolum (batilol), 2-decyl tetradecanol, lanolin alcohol, cholesterol, plant sterol, hexyl dodecanol, isooctadecanol, octyldodecanol etc.) etc.

As ester oil, can list isopropyl myristate; sad hexadecane ester; myristic acid octyl group dodecane ester; isopropyl palmitate; butyl stearate; lauric acid hexyl ester; myristic acid tetradecane ester; decyl oleate; the sad hexyl of dimethyl ester in the last of the ten Heavenly stems; cetyl lactate; lactic acid tetradecane ester; the acetic acid lanoline; stearic iso-16 alkyl esters; isostearic acid 2-Methylpentadecane ester; 12-hydroxy stearic acid cholesteryl ester; two-2 ethyl hexanoic acid glycol ester; the dipentaerythritol fatty acid ester; single isostearic acid N-alkyl diol ester; two capric acid DOPCP; malic acid two isooctadecane esters; two-2-heptyl hendecanoic acid glyceride; three-2 ethyl hexanoic acid trihydroxymethylpropanyl ester; three isostearic acid trihydroxymethylpropanyl esters; four-2 ethyl hexanoic acid pentaerythritol ester; three-2 ethyl hexanoic acid glyceride; tricaprylin; three different tripalmitins; three isostearic acid trihydroxymethylpropanyl esters; the cetyl 2-ethylhexanoate; 2-ethylhexyl cetylate; tripalmitin; three-2-heptyl hendecanoic acid glyceride; the Castor Oil Fatty Acid methyl ester; Cetiol; acetoglyceride; Palmic acid 2-heptyl hendecane ester; diisobutyl adipate; N-lauroyl-L-glutamic acid-2-octyl group dodecane ester; adipic acid two-2-heptyl hendecane ester; the ethyl laurate; Diisooctyl Sebacate; myristic acid 2-hexyl ester in the last of the ten Heavenly stems; Palmic acid 2-hexyl ester in the last of the ten Heavenly stems; adipic acid 2-hexyl ester in the last of the ten Heavenly stems; Dermol DIPS; succinic acid 2-Octyl Nitrite; triethyl citrate etc.

As silicone oil, for example can list chain polysiloxanes (for example dimethyl polysiloxane, methyl phenyl silicone, diphenyl polysiloxanes etc.); Cyclic polysiloxanes (for example octamethylcy-clotetrasiloxane, decamethylcyclopentaandoxane, ten diformazan basic rings, six siloxanes etc.), the silicone resin that forms tridimensional network, silicone rubber, various modified polyorganosiloxane (polysiloxanes of amino modified polysiloxane, polyether-modified polysiloxanes, alkyl-modified polysiloxanes, fluorine modification etc.) etc.

As anion surfactant, for example can list fatty acid soaps (for example sodium laurate, sodium palmitate etc.); High alkyl sulfate salt (for example sodium lauryl sulfate, lauryl potassium sulfate etc.); Alkyl ether sulphate salts (for example POE-triethanolamine lauryl sulfate, POE-sodium lauryl sulfate etc.); N-acyl group sarcosine (for example sodium N-lauroyl sarcosinate etc.); High fatty acid amide sulfonate (for example N-myristoyl-N methyl taurine sodium, coco-nut oil fatty acid N-methyltaurine sodium, lauroyl N-methyltaurine sodium etc.); Phosphate ester salt (POE-vaccenic acid base ether phosphoric acid sodium, POE-octadecyl ether phosphoric acid etc.); Sulfosuccinate (for example two-2-ethylhexyl sodium sulfosuccinate, single lauroyl single ethanol amide polyoxyethylene sodium sulfosuccinate, lauryl polypropylene glycol sodium sulfosuccinate etc.); Alkylbenzenesulfonate (for example linear dodecylbenzene sodium sulfonate, linear DBSA triethanolamine, linear DBSA etc.); High-grade aliphatic ester sulfuric acid (coco-nut oil fatty acid glyceride sodium sulfate etc. for example hardens); N-acyl glutamate (for example N-lauroyl glutamate one sodium, N-stearyl disodium glutamate, N-myristoyl-L-monosodium glutamate etc.); Sulfated oil (for example hyoscyami wet goods); The POE-alkyl ether carboxylic acid; POE-alkyl allyl ether carboxylate; Alpha-alkene sulfonate; The higher fatty acids sulfonated ester; The secondary alcohol sulfuric acid; Higher fatty acids alkanolamide sulfuric acid; Lauroyl single ethanol amide sodium succinate; N-palmityl aspartic acid two (triethanolamine); Casein sidium etc.

As cationic surfactant, for example can list alkyl trimethyl ammonium salt (for example chlorination stearyl trimethyl ammonium, Trimethyllaurylammonium chloride etc.); Alkyl pyridine Salt (cetylpyridinium chloride for example

Deng); The chloro distearyl dimethyl ammonium dialkyl dimethyl ammonium salt; Chlorination gathers (N, N '-dimethyl-3,5-methylenepiperidines ); Alkyl quaternary ammonium salts; Alkyl dimethyl benzyl ammonium salt, alkyl isoquinolin Salt; Dialkyl group モリホニウ system salt, POE-alkylamine; Alkylamine salt; The polyamine derivative of fatty acid; The amylalcohol derivative of fatty acid; Benzalkonium chloride; Benzethonium chloride etc.

As amphoteric surfactant, for example can list imidazoline type amphoteric surfactant (2-undecyl-N for example, N, N-(hydroxyethyl carboxymethyl)-2-imidazoline sodium, 2-cocoa acyl group-2-imidazoline Hydroxide-1-carboxyl ethyoxyl disodium salt etc.); Betaine type amphoteric surfactant (2-heptadecyl-N-carboxymethyl-N-hydroxyethyl imidazoline for example

Betanin, lauryl dimethylamino acetic acid betanin, alkyl betaine, amido betaines, sulfobetaines etc.) etc.

As the lipophile non-ionic surface active agent, for example can list fatty acid esters of sorbitan class (for example Arlacel-80, anhydro sorbitol list isostearate, Arlacel-20, Arlacel-40, Arlacel-60, Arlacel-83, sorbitan trioleate, five-2 ethyl hexanoic acid, two dehydrating glycerin sorbitol esters, four-2 ethyl hexanoic acid, two dehydrating glycerin sorbitol esters etc.); Glycerol polyglyceryl fatty acid ester class (for example single cottonseed oil fatty acid glyceride, single glycerol sinapate, sesquialter olein, glyceryl monostearate, α, α '-oleic acid pyroglutamic acid glyceride, glycerol monostearate malate etc.); Methyl glycol fatty acid ester class (for example propylene glycolmonostearate etc.); The hardened castor oil derivant; Glycerol alkyl ether etc.

As hydrophilic non-ionic surfactant, for example can list POE-fatty acid esters of sorbitan class (for example POE-Arlacel-80, POE-Arlacel-60, POE-Arlacel-80, POE-anhydro sorbitol four oleates etc.); POE Span class (for example POE-sorbitan monolaurate, POE-sorbitol monooleate, POE-sorbitol five oleates, POE-sorbitol monostearate etc.); POE-glycerine fatty acid esters (for example POE-monoleates such as POE-glyceryl monostearate, POE-glycerol list isostearate, POE-glycerol three isostearates etc.); POE-fatty acid ester (for example POE-distearate, the single dioleate of POE-, diglycol stearate etc.); POE-alkyl ether (for example POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-docosyl ether, POE-2-octyl group lauryl ether, POE-cholesterol ethers etc.); Pluronic type class (for example pluronic etc.); POEPOP-alkyl ether (for example POEPOP-cetyl ether, POEPOP-2-decyl myristyl ether, POEPOP-monobutyl ether, POEPOP-hydrogenated lanolin, POEPOP-glycerin ether etc.); Four POE, four POP-ethylenediamine condensation substance classes (for example テトロニ Star Network etc.); POE-Oleum Ricini hardened castor oil derivant (for example POE-Oleum Ricini, POE-hardened castor oil, POE-hardened castor oil list isostearate, POE-hardened castor oil three isostearates, POE-hardened castor oil list pyroglutamic acid list isostearic acid diester, POE-hardened castor oil maleate etc.); POE-Cera Flava lanolin derivative (for example POE-sorbitol Cera Flava etc.); Alkanolamide (for example cocoanut fatty acid diethanolamide, lauric monoethanolamide, fatty acid isopropanol amide etc.); The POE-methyl glycol fatty acid ester; The POE-alkylamine; The POE-fatty acid amide; Sucrose fatty acid ester; Alkyl ethoxy dimethyl oxidation amine; Three oil base phosphoric acid etc.

As wetting agent, for example can exemplify out Polyethylene Glycol, propylene glycol, glycerol, 1,3 butylene glycol, xylitol, sorbitol, maltose alcohol, chondroitin sulfate, hyaluronic acid, mucoitinsulfuric acid, the acid of カロニ Application, アテロ ossein, cholesterol-12-hydroxy stearic acid ester, sodium lactate, bile salt, d1-pyrrolidone carboxylic acid salt, short chain solubility ossein, two glycerol (EO) PO addition product, イザヨイバラ extract, yarrow (セイヨウノコギリソウ) extract, the smoked grass (extract of メリロ-ト) etc.

As natural water soluble polymer, for example can list plant family macromolecule (for example arabic gum, tragakanta, galactan, guar gum, carob, carrageenan, carrageenin, pectin, agar, Network イ Application スシ-De (マ Le メロ), alginate jelly (brown alga extract), starch (rice, corn, Rhizoma Solani tuber osi, Semen Tritici aestivi), glycyrrhizic acid); Microbiology class macromolecule (for example xanthan gum, glucosan, succinoglucan, pullulan etc.); Other (for example from the collagen of fish, gelatin, wheat protein, fibroin etc.) etc. from fish.

As semisynthetic water soluble polymer, for example can list starch based macromolecule (for example carboxymethyl starch, methyl hydroxypropyl starch etc.); Cellulose family macromolecule (methylcellulose, ethyl cellulose, methylhydroxypropylcellulose, hydroxyethyl-cellulose, cellulose sodium sulfate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder etc.); Alginic acid family macromolecule (for example sodium alginate, propylene glycol alginate etc.) etc.

As synthetic water soluble polymer, for example can list vinyl-based macromolecule (for example polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, CVP Carbopol ETD2050 etc.); Polyoxyethylene family macromolecule (for example poloxalkol of Polyethylene Glycol 20,000,40,000,60,000 etc.); Acrylic polymer (for example sodium polyacrylate, polyethyl acrylate, polyacrylamide etc.); Polyethylene imine, cationic polymer etc.

As thickening agent, for example can list arabic gum, carrageenin, carrageenan, the tragakanta, carob, Network イ Application スシ-De (マ Le メロ), casein, dextrin, gelatin, pectic acid sodium, sodium alginate, methylcellulose, ethyl cellulose, CMC, hydroxyethyl-cellulose, hydroxypropyl cellulose, PVA, PVM, PVP, sodium polyacrylate, CVP Carbopol ETD2050, locust bean gum, guar gum, tamarind gum, the dialkyl dimethyl ammonium sulfate cellulose, xanthan gum, Magnesiumaluminumsilicate, bentonite, Strese Hofmann's hectorite., silicic acid AlMg (propolis), ラ Port Na イト, silicic acid anhydride etc.

As UV absorbent, for example can enumerate following chemical compound.

(1) benzoic acids UV absorbent

For example para-amino benzoic acid (hereinafter to be referred as PABA), PABA monoglyceride, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester etc.

(2) anthranilic acid UV absorbent

High menthyl ester of N-acetyl group ortho-aminobenzoic acid etc. for example.

(3) salicylic acid UV absorbent

For example amyl salicylate, salicylic acid menthyl ester, the high menthyl ester of salicylic acid, ethylhexyl salicylate, phenyl salicytate, salicylic acid benzene methyl, to isopropyl alcohol phenyl salicylic acid esters etc.

(4) cinnamic acid UV absorbent

Cinnamic acid monooctyl ester for example; Ethyl 4-isopropylcinnamate.; methyl-2; 5-diisopropyl cinnamate; ethyl-2; 4-diisopropyl cinnamate; methyl-2,4-diisopropyl cinnamate; propyl group-p-methoxycinnamic acid ester; isopropyl-to methoxyl group cinnamon acid ester; isopentyl-p-methoxycinnamic acid ester; octyl group-p-methoxycinnamic acid ester (2-ethylhexyl-p-methoxycinnamic acid ester); 2-ethoxyethyl group-p-methoxycinnamic acid ester; cyclohexyl-p-methoxycinnamic acid ester; ethyl-alpha-cyano-beta-phenyl cinnamate; 2-ethylhexyl-alpha-cyano-beta-phenyl cinnamate; 2-ethyl hexanoyl base-di-p-methoxy cinnamic acid monoglyceride etc.

(5) triazines UV absorbent

Two resorcyl triazines for example.

More particularly, two { (4-(2-ethyl hexyl oxy)-2-hydroxyl) phenyl }-6-(4-methoxyphenyl) 1,3,5-triazines, 2,4 for example, 6-three { 4-(2-ethyl hexyl oxy carbonyl) anilino-} 1,3,5-triazines etc.

(6) other UV absorbent

3-(4 '-methylbenzene methylene)-d for example, 1-Camphora, 3-benzylidene-d, 1-Camphora; 2-phenyl-5-methylbenzoxazole; 2,2 '-hydroxy-5-methyl base phenyl benzotriazole; 2-(2 '-hydroxyl-5 '-uncle's octyl phenyl) benzotriazole; 2-(2 '-hydroxyl-5 '-aminomethyl phenyl benzotriazole; ジベ Application ザラジ Application, veratroyl methylmethane, 4-methoxyl group-4 '-tert-butyl group dibenzoyl methane; 5-(3,3-dimethyl-2-norbornane subunit (norbornylidene))-3-pentane-2-ketone etc.Pyridyl derivatives such as dimorpholine radical pyridazine ketone.

As the metal ion sealer, for example can list 1-hydroxyl ethane-1,1-di 2 ethylhexyl phosphonic acid, 1-hydroxyl ethane-1,1-di 2 ethylhexyl phosphonic acid tetrasodium salt, disodiumedetate, sodium versenate, tetrasodium ethylenediamine tetraacetate, sodium citrate, sodium polyphosphate, Polymeric sodium metaphosphate., gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, ethylenediaminetetraacetic acid etc.

As lower alcohol, for example can list ethanol, propanol, isopropyl alcohol, isobutanol, the tert-butyl alcohol etc.

As polyhydric alcohol, for example can list dihydroxylic alcohols (for example ethylene glycol, propylene glycol, 1, ammediol, 1,2-butanediol, 1,3 butylene glycol, 1,4-butanediol, 2,3-butanediol, 1,5-pentanediol, 2-butylene-1,4-glycol, hexanediol, ethohexadiol etc.); Trihydroxylic alcohol (for example glycerol, trimethylolpropane etc.); Tetrahydroxylic alcohol (for example 1,2, tetramethylolmethanes such as 6-hexane triol etc.); Pentabasis alcohol (for example xylitol etc.); Hexahydroxylic alcohols (for example sorbitol, mannitol etc.); Polyhydric alcohol polymer (for example diethylene glycol, dipropylene glycol, 2,2'-ethylenedioxybis(ethanol)., polypropylene glycol, tetraethylene glycol (TEG), two glycerol, Polyethylene Glycol, triglycerin, four glycerol, polyglycereol etc.); Dihydroxylic alcohols alkyl ether (for example ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol one phenyl ether, ethylene glycol one hexyl ether, ethylene glycol one 2-methyl hexyl ether, ethylene glycol isoamyl ether, ethylene glycol phenyl methyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol bisthioglycolate ethylether, ethylene glycol bisthioglycolate butyl ether etc.); Dihydroxylic alcohols alkyl ether (for example diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol-butyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, 2,2'-ethylenedioxybis(ethanol). monomethyl ether, 2,2'-ethylenedioxybis(ethanol). monoethyl ether, Glycol Monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethylether, dipropylene glycol butyl ether etc.); Diatomic alcohol ether acid ester (for example ethylene glycol monomethyl ether acetas, ethylene glycol monoethyl ether acetas, ethylene glycol monobutyl ether acetic acid ester, ethylene glycol one phenyl ether acetas, ethylene glycol bisthioglycolate adipate ester, 3,6-Dioxa-1,2,7,8-octantetracarbonsaeure. ester, diethylene glycol monoethyl ether acetas, diethylene glycol-butyl ether acetas, Glycol Monomethyl ether acetas, propylene glycol monoethyl ether acetas, propylene glycol one propyl ether acetas, propylene glycol one phenyl ether acetas etc.); Glycerol one alkyl ether (for example .alpha.-hexadecylglyceryl ether, selachyl alcohol, batilol etc.); Sugar alcohol (for example Sorbitol, maltose alcohol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, amylolysis sugar, maltose, xylose, amylolysis sugar are gone back carbinol etc.); Glyceride; Tetrahydrofurfuryl alcohol; The POE-tetrahydrofurfuryl alcohol; The POP-butyl ether; The POPPOE-butyl ether; Three polyoxypropylene glycerin ethers; The POP-glycerin ether; POP-glycerin ether phosphoric acid; POPPOE-tetramethylolmethane ether, polyglycereol etc.

As monosaccharide, for example can list triose (for example D-glyceraldehyde, dihydroxy acetone etc.); Tetrose (for example D-erythrose, D-Erythrulose, D-threose, erithritol etc.); Pentose (for example L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose etc.); Hexose (for example D-glucose, D-talose, D-psicose, D-galactose, D-fructose, L-galactose, L-mannose, D-Tagatose etc.); Seven carbon sugar (for example aldoheptose, ヘプロ-ス etc.); Eight carbon sugar (for example octulose etc.); Deoxysaccharide (for example 2-deoxy-D-ribose, 6-deoxidation-L-galactose, 6-deoxy-L-mannose etc.); Amino sugar (for example D-glycosamine, D-galactosamine, sialic acid, amino sugar aldehydic acid, 3-O-.alpha.-carboxyethyl-D-glucosamine. etc.); Alduronic acid (for example D-glucuronic acid, D-mannuronic acid, L-glucuronic acid, D-galacturonic acid, L-iduronic acid etc.) etc.

As oligosaccharide, for example can list sucrose, umbelliferose, lactose, planteose, isolychnose class, α, α-trehalose, Raffinose, LychnisFlos-Cuculi saccharide, ウ Application PVC リシ Application, stachyose pistil flower saccharide etc.

As polysaccharide, for example can list cellulose, Network イ Application スシ-De, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, arabic gum, Heparan sulfate, hyaluronic acid, Tragacanth, keratan sulfate, chrondroitin, xanthan gum, mucoitinsulfuric acid, guar gum, glucosan, keratosulfate, locust bean gum, succinoglucan, the acid of カロニ Application etc.

As aminoacid, for example can list neutral amino acid (for example threonine, cysteine etc.); Basic amino acid (for example oxylysine etc.) etc.In addition, as amino acid derivativges, for example can list acyl group sodium sarcosinate (sodium N-lauroyl sarcosinate), acyl glutamate, acyl group Beta-alanine sodium, glutathion, 2-pyrrolidone-5-carboxylic acid etc.

As organic amine, for example can list-ethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1 ammediol, 2-amino-2-methyl-1-propanol etc.

As macromolecule Emulsion, for example can list acrylic resin Emulsion, polyethyl acrylate Emulsion, acrylic resin liquid, polyalkyl acrylate Emulsion, polyvinyl acetate resins Emulsion, Heveatex etc.

As the pH regulator agent, for example can list buffer agents such as lactic acid-sodium lactate, citric acid-sodium citrate, succinic acid-sodium succinate etc.

As vitamins, for example can list vitamin A, B1, B2, B6, C, E and derivant thereof, pantothenic acid and derivant, biotin etc.

As antioxidant, for example can list tocopherol, dibenzylatiooluene, butylated hydroxyanisole (BHA), gallate ester etc.

As the antioxidation auxiliary agent, for example can list phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, ethylenediaminetetraacetic acid etc.

As other composition that can cooperate, for example can list antiseptic (for example methyl parahydroxybenzoate, ethylparaben, butyl p-hydroxybenzoate, phenyl phenol etc.); Antiinflammatory (for example glycyrrhizin derivative, Enoxolone derivative, salicyclic acid derivatives, sabinol, zinc oxide, allantoin etc.); Whitening agent (for example Herba Saxifragae extract, arbutin, tranexamic acid, L-ascorbic acid, L-magnesium L-ascorbyl-2-phosphate salt, L-ascorbic acid glucoside, 4-methoxyl group potassium salicylate etc.); Various extracts (for example Cortex Phellodendri, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae, when medicine, birch, Salvia japonica Thunb., Folium Eriobotryae, Radix Ginseng, Aloe, Radix Malvae sylvestris, orris, Fructus Vitis viniferae, Semen Coicis, Fructus Luffae, Bulbus Lilii, Stigma Croci, Rhizoma Chuanxiong, Rhizoma Zingiberis Recens, Herba Hyperici Erecti, radix ononidis, Bulbus Allii, Fructus Capsici, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Sargassum etc.), activating agent (for example Lac regis apis, sensitization element, cholesterol derivative etc.); Blood flow ameliorant (for example benzyl nicotinate, nicotinic acid Beta-Butoxy ethyl ester, capsaicin, (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone, Mylabris tincture, ichthyol, tannin, α-Borneolum Syntheticum, nicotinic acid tocopherol, inositol six nicotinates, cyclandelate, cinnarizine, benzazoline, acetylcholine, verapamil, cephalanthin, gamma oryzanol etc.); Lipotropism bleeding (for example sulfur, thianthol etc.); Antiinflammatory (for example thiolaurine, hypotaurine etc.); Antibacterial (for example benzoic acid and its esters, isopropyl methyl phenol, 9-undecylenic acid and its esters, 9-undecylenic acid single ethanol amide, cetyltrimethylammonium chloride, cetylpyridinium chloride

, benzalkonium chloride, benzethonium chloride, chlorination alkyl diamino ethyl glycine, chlorination chlohexidine, o-phenyl phenol, chlorhexidine gluconate, cresol, toluene-sodium-sulfonchloramide, chlorxylone, chlorocresol, Chlorphenesin, methaform, 5-chloro-2-methyl-4-isothiazoline-3-ketone, salicylic acid and its esters, 1,3-dihydroxymethyl-5,5-dimethyl hydantoin, bromination alkyl isoquinolin

, Bradosol Bromide, sorbic acid and its esters, thymol, arasan, dehydroacetic acid and its esters, triclosan, trichlorocarbanilide, p-Hydroxybenzoate, parachlorophenol, CF3,1,2,3,-thrihydroxy-benzene, phenol, hexachlorophene, 2-methyl-4-isothiazoline-3-ketone, NN "-methylene two (N '-(3-methylol-2,5-dioxo-4-imidazolidinyl urea, sodium N-lauroyl sarcosinate, resorcinol etc.) etc.

Embodiment

Be described more specifically the present invention below in conjunction with embodiment.The present invention is not subjected to the qualification of these embodiment.Unless otherwise specified, use level is quality %.

[invention of claim 1]

According to the prescription shown in " table 1-1 " and " table 1-2 ", the antiperspirant lotion of preparation powder lotion type, the degree of visual valuation variable color.As a comparative example, prescription, the cooperation chelating agen EDTA-3Na2H to not cooperating ethylenediamine ethoxy triacetic acid trisodium ₂O replaces the prescription of ethylenediamine ethoxy triacetic acid trisodium to discuss.About the degree of variable color, be evaluated as zero in the time of in the scope that allows as skin preparations for extenal use, be evaluated as in the time of not in this scope *.

Table 1-1

Antibacterial zeolite A: the zeolite (the about 1.5 μ m of mean diameter) that supports silver ion, zinc ion

Table 1-2

Antibacterial zeolite B: the zeolite (シ Na ネ Application ゼオミ Star Network Co., Ltd. system, ゼオミ Star Network AJ10N, the about 1.5 μ m of mean diameter) that supports silver ion, zinc ion, ammonium ion

By The above results as can be known, at comparative example that does not cooperate ethylenediamine ethoxy triacetic acid trisodium and cooperation chelating agen EDTA-3Na2H ₂O replaces in the comparative example of ethylenediamine ethoxy triacetic acid trisodium, and the antibiotic property silver zeolite variable color of sedimentary white powder is a gray purple, and the variable color degree is big.

Relative therewith, in the embodiment that is combined with ethylenediamine ethoxy triacetic acid trisodium, sedimentary antibiotic property silver zeolite becomes redness a little, in degree that can be cognitive, the variable color degree is very little, is in the scope as the skin preparations for extenal use permission, has brought into play the good color changeable effect that prevents as can be known.

Below provide other embodiment of the present invention.

[embodiment 1-7] compressing powder

Polymeric aluminum chloride 5 quality %

Zinc oxide (flowers of zinc) 5

Talcum 76.99

Liquid paraffin 3

Antibacterial zeolite B 10

Ethylenediamine ethoxy triacetic acid trisodium 0.01

[embodiment 1-8] Le-ス powder

Polymeric aluminum chloride 5 quality %

Zinc oxide (flowers of zinc) 5

Talcum 79.99

Antibacterial zeolite B 10

Ethylenediamine ethoxy triacetic acid trisodium 0.01

The spraying of [embodiment 1-9] astringent type

(former formula of liquid)

Distilled water 10 quality %

Polymeric aluminum chloride 10

Dehydrated alcohol 73.9

Isopropyl myristate 2

1,3 butylene glycol 3

Antibacterial zeolite B 1

Ethylenediamine ethoxy triacetic acid trisodium 0.1

(filling formulation)

Stock solution 50

LPG 50

[embodiment 1-10] powder spray

Polymeric aluminum chloride 20 quality %

Silicic acid anhydride 15

Talcum 20.21

Zinc oxide (flowers of zinc) 5

Isopropyl myristate 21.79

Dimethyl polysiloxane 10

Fatty acid esters of sorbitan 3

Antibacterial zeolite B 5

Ethylenediamine ethoxy triacetic acid trisodium 0.1

(filling formulation)

Stock solution 10

LPG 90

[embodiment 1-11] powder spray

Polymeric aluminum chloride 20 quality %

Silicic acid anhydride 15

Talcum 20.21

Zinc oxide (flowers of zinc) 5

Isopropyl myristate 21.79

Polyoxyethylene polyoxypropylene atactic polymer methyl ether 10

Fatty acid esters of sorbitan 3

Antibacterial zeolite B 5

Ethylenediamine ethoxy triacetic acid trisodium 0.1

(filling formulation)

Stock solution 10

LPG 90

[embodiment 1-12] rod

Polymeric aluminum chloride 20 quality %

Talcum 7.9

Zinc oxide (flowers of zinc) 5

Hard paraffin 2

Stearyl alcohol 8

Liquid paraffin 15

Cyclic dimethyl polysiloxane 36

Fatty acid esters of sorbitan 1

Antibacterial zeolite B 5

Ethylenediamine ethoxy triacetic acid trisodium 0.1

[embodiment 1-13] cream

Distilled water 45 quality %

Squalane 20

Cyclic dimethyl polysiloxane 15

Two glyceryl isostearates 3

Succinic acid diethoxy ethyl ester 5

Organically modified montmorillonite clay 1.5

1,3 butylene glycol 5.49

Antibacterial zeolite A 5

Ethylenediamine ethoxy triacetic acid trisodium 0.01

[embodiment 1-14] emulsion

Distilled water 20 quality %

Polymeric aluminum chloride 20

P-methoxycinnamic acid monooctyl ester 5

Oxybenzone 3

The 4-tert-butyl group-4 '-methoxy benzoylmethane 1

Hydrophobization is handled zinc oxide 5

Polyoxyethylene polyoxypropylene atactic polymer methyl ether 10

Silicone oil 15

Silicones 1

Two glyceryl isostearates 1

Organically modified montmorillonite clay 0.5

1,3 butylene glycol 5.49

Antibacterial zeolite B 13

Ethylenediamine ethoxy triacetic acid trisodium 0.01

[embodiment 1-15] ointment

Distilled water 53.74 quality %

Polymeric aluminum chloride 20

Glycerol 10

1,3 butylene glycol 3

Potassium hydroxide 0.25

Stearic acid 2

Glycerol monostearate 2

Spermol 1

Liquid paraffin 5

Vaseline 2

Antibacterial zeolite B 1

Ethylenediamine ethoxy triacetic acid trisodium 0.01

[embodiment 1-16] gel

Distilled water 63.27 quality %

Polymeric aluminum chloride 20

Dipropylene glycol 5

PEG1500 5.5

CVP Carbopol ETD2050 0.4

Methylcellulose 0.2

POE (15) oleyl alcohol ether 0.5

Potassium hydroxide 0.1

EDTA 0.02

Antibacterial zeolite B 5

Ethylenediamine ethoxy triacetic acid trisodium 0.01

[embodiment 1-17] sheet that wets

Distilled water 62.81 quality %

Dehydrated alcohol 35

Polyoxyethylene hardened castor oil 0.1

Citric acid (food) 0.02

Sodium citrate 0.06

Antibacterial zeolite B 2

Ethylenediamine ethoxy triacetic acid trisodium 0.01

[invention of claim 2～6]

" embodiment 2-1～2-3, comparative example 2-1～2-4 "

[deodorant powder spray]

According to embodiment 2-1～2-3 shown in the table 2-1 and the composition of comparative example 2-1～2-4, make the deodorant powder spray according to following method for making, adopt following method to estimate stability of formulation (discoloration-resistant), usability, odor-resistant result.Evaluation result is concluded and is shown in table 2-1.

Method for making

The powder composition is fully mixed preparation powder part with Henschel mixer (Henschel mixer).In addition, oiliness composition and surfactant etc. are used the blender mixed dissolution, as the oil phase part.Powder filler part 5.3g and oil phase part 2.9g in the aluminum aerosol container of the long-pending 80mL of container contents after pincers are tight, fill propellant (LPG0.18MPa/20 ℃), obtain the powder spray agent.

(1) usability

Use the deodorant powder spray of at room temperature placing 6 months, carry out following test.40 experimenters sprayed embodiment and comparative example 3 seconds from the distance of the arbitrary axillary fossa 10cm in the distance left and right sides, with hands the sample of coating were smeared out, and used sense of touch to carry out sensory evaluation to it separately.In addition, think rough owing to coagulation between the powder causes.

＜evaluation criterion 〉

The result of sensory evaluation represents to be judged as the number of " not having rough use sense of touch " with experimenter's number.

More than the A:32 name

The B:20 name is above below 31

Below the C:19 name

(2) odor-resistant result (bromhidrosis)

In the summer of perspiring easily, adopt 40 male respondents that oneself feel to have bromhidrosis, carry out the method for sensory evaluation by judgement person.Random assortment respectively adopts the dual blind method of testing to carry out about being assigned as of test specimen, and is undertaken by personnel beyond respondent and the judgement person promptly that sample distributes and password is preserved.With 70% ethanol wiping respondent's axillary fossa,, used sample 3 seconds by the distance of 10cm up to there not being bromhidrosis.Forbid that each respondent has a bath, uses shower, washing oxter, judgement person is according to the foul smell degree of following standard evaluation respondent's left and right sides axillary fossa after 24 hours.

Evaluation adopts 6 point-scores to judge according to following standard, represents judged result with 40 male respondents' meansigma methods.The high more expression stink of numerical value is strong more.

Estimate:

0 minute: be destitute of smell

1 minute: very weak stink

2 minutes: weak stink

3 minutes: moderate stink

4 minutes: strong slightly stink

5 minutes: intensive stink

Judged result:

A:0 is lower than 2 fens more than dividing

B:2 is lower than 3 fens more than dividing

More than C:3 divides

(3) discoloration-resistant

The deodorant powder spray of filling in the aerosol container was sprayed 3 seconds at blank sheet of paper from the distance of about 10cm, with it as sample, sun exposure is 3 hours without, and does not carry out sun-exposed sample relatively, and whether the color by each sample of the person's of specializing in visual valuation variation has taken place.In addition, evaluation criterion adopts following standard to estimate.Change in color is few more, and is preferred more as goods, we can say to have preparation stability.

＜evaluation criterion 〉

A: feel that color does not change fully

B: feel that color changes slightly

C: feel that color obviously changes

Table 2-1

?

Embodiment 2-1

Embodiment 2-2

Embodiment 2-3

Comparative example 2-1

Comparative example 2-2

Comparative example 2-3

Comparative example 2-4

a?

10.0?

3?

6?

10.0?

-?

b?

4.0?

4?

3?

-?

4?

c?

-?

28.0?

-?

28.0?

-?

d?

10.0?

e?

6.0?

f?

25.0?

32.0?

30.0?

1.0?

29.0?

7.0?

35.0?

g?

0.7?

h?

0.3?

i?

0.9?

j?

18.0?

k?

9.08?

l?

13.0?

m?

1.0?

n?

2.0?

o?

0.02?

Add up to

100.0?

Usability

35 A?

37 A?

39 A?

4 C?

20 B?

19 C?

29 B?

Odor-resistant result

A?

B?

C?

Color stability

A?

C?

B?

A?

The powder composition

A: the zeolite of load Ag-bearing zinc ammonium

(シ Na ネ Application ゼオミ Star Network Co., Ltd. system, ゼオミ Star Network AJ10N, the about 1.5 μ m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 0.5%)

B: Alumen (mean diameter 1 μ m)

C: polymeric aluminum chloride

D: zinc oxide

E: spherical calcium alginate

F: starch

G: calcium stearate

H: metasilicic acid magnesium aluminate

I: spherical polyethylene powders (mean diameter 12 μ m)

Oiliness composition and surfactant

J: sad cetyl ester

K: dimethyl polysiloxane (6mPas, 25 ℃)

L: methyl phenyl silicone (13mPas, 25 ℃)

M: sesquialter isostearic acid Isosorbide Dinitrate

N:PPG-13 decyl テトラデセス-24

O: natural type vitamin E

Can be learnt that by the foregoing description and comparative example deodorant powder spray of the present invention is compared with comparative example, usability, deodorant and discoloration-resistant are good.

In addition, coagulation does not take place in the powder of the deodorant powder spray of embodiment, and dispersibility is also good.

Below, provide other embodiment of skin preparations for extenal use of the present invention.

[embodiment 2-4]

[compressing powder type deodorant cosmetics]

(powder part)

Support the zeolite (about 3 μ of mean diameter 4.0 quality %m, the particle that particle diameter surpasses 15 μ m is below 0.5%) of silver ion, ammonium ion

Alumen (mean diameter 0.05 μ m) 1.5

Polymeric aluminum chloride 0.5

Zinc oxide 3.0

Talcum 87.0

(oil content)

Methyl phenyl silicone (13mPaS, 25 ℃) 3.0

Liquid paraffin 1.0

(additive)

Spice is an amount of

(method for making) is partially mixed with powder with Henschel mixer, behind interpolation oil content and the additive, pulverizes with 5HP flour mill (thin river ミ Network ロ Application society system) in this mixture, with its compression forming in middle ware, obtains compressing powder type deodorant cosmetics.

The compressing powder type deodorant cosmetics that obtain in use can not lump, and usability (not having rough sense) is good, and odor-resistant result, discoloration-resistant are also abundant.

[embodiment 2-5]

[deodorization powder]

Burnt alum (mean diameter 4 μ m) 13.0 quality %

Support the zeolite (the about 2 μ m of mean diameter, the particle that 7.0 particle diameters surpass 15 μ m is below 1%) of silver ion, ammonium ion

Spherical nylon powder 5.0

Dimethyl polysiloxane (molecular weight 450,000) 1.0

Synthetic isoparaffin 1.0

Spice is an amount of

Talcum 73.0

(method for making) mixes mentioned component successively with Henschel mixer, obtains the deodorization powder.The deodorization powder usability (not having rough sense), odor-resistant result, the discoloration-resistant that obtain are good.

[embodiment 2-6]

[powder spray agent]

(powder part)

Alumen (mean diameter 5 μ m) 4.0 quality %

Polymeric aluminum chloride 2.0

Support the zeolite (the about 1.5 μ m in average particle 1.0 footpaths, the particle that particle diameter surpasses 15 μ m is below 0.5%) of silver ion, copper ion, ammonium ion

Talcum 0.5

(oil content)

Decamethylcyclopentasiloxane 1.5

Spice 0.2

(propellant)

Isopentane 10.0

Liquefied petroleum gas 80.8

(method for making) is partially mixed with powder with kneader, with blender oil content is mixed, and is filled into successively respectively in the aerosol can, sprays propellant again in jar, obtains the powder spray agent.

The favorable dispersibility of the powder spray agent that obtains in propellant (propellant), the nozzle during injection can not stop up, and odor-resistant result, discoloration-resistant are good.

[embodiment 2-7]

[powder spray agent]

(powder part)

Alumen (mean diameter 20 μ m) 3.0 quality %

Support the zeolite (the about 5 μ m in average particle 2.0 footpaths, the particle that particle diameter surpasses 15 μ m is below 1%) of silver ion, zinc ion, ammonium ion

Zinc oxide 0.2

Silica 1 .5

(oil content)

Polyoxyethylene nonylplenyl ether 0.5

Dimethyl polysiloxane (20mPaS, 25 ℃) 0.1

Isopropyl myristate 0.5

(additive)

Polyoxyethylene sorbitan monooleate dehydration 0.1

Spice 0.1

(propellant)

Liquefied petroleum gas 92.0

(method for making) is partially mixed with powder with kneader, with blender oil content is mixed the back and adds additive, is filled into successively respectively in the aerosol can, fills propellant again in jar, obtains the powder spray agent.

The favorable dispersibility of powder spray agent in propellant that obtains, the nozzle during injection can not stop up, and odor-resistant result, discoloration-resistant are good.

[embodiment 2-8]

[die mould deodorization powder]

(powder part)

Burnt alum (mean diameter 0.5 μ m) 10.0 quality %

Support the zeolite (mean diameter 10.0 about 1.5 μ m, the particle that particle diameter surpasses 15 μ m is below 0.1%) of copper ion, zinc ion, ammonium ion

Talcum 60.0

(oil content)

Methyl phenyl silicone (13mPaS, 25 ℃) 10.0

Liquid paraffin 10.0

(method for making) is partially mixed with powder with Henschel mixer, behind the interpolation oil content, pulverizes with 5HP flour mill (thin river ミ Network ロ Application society system) in this mixture, with its compression forming in middle ware, obtains die mould deodorization powder.

Die mould deodorization powder usability (not having rough sense) that obtains and odor-resistant result, discoloration-resistant are abundant.

[embodiment 2-9]

[deodorant spray]

(powder part)

Alumen (mean diameter 10 μ m) 1.0 quality %

Support the zeolite (the about 5 μ m of mean diameter, the particle that 3.0 particle diameters surpass 15 μ m is below 5%) of zinc ion, ammonium ion

Zinc oxide 2.0

(oil content)

Decamethylcyclopentasiloxane 5.0

(additive)

Isopropyl myristate 0.5

Four-2 ethyl hexanoic acid, two dehydrating glycerin sorbitol esters 0.5

(propellant)

Normal butane 75.0

Iso-butane 13.0

(method for making) is partially mixed with powder with kneader, after with blender oil content and additive being mixed, is filled into successively in the aerosol can, recharges propellant, obtains the deodorant spray.

For the deodorant spray that obtains, the dispersibility of powder in propellant is good, and usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-10]

[infant powder]

(powder part)

Burnt alum (mean diameter 50 μ m) 15.0 quality %

Talcum 65.3

Calcium carbonate 17.0

Support the zeolite (the about 8 μ m of mean diameter, the particle that 2.0 particle diameters surpass 15 μ m is below 1%) of silver ion, ammonium ion

(oil content)

Methyl phenyl silicone (13mPaS, 25 ℃) 0.4

Dimethyl polysiloxane ethylene glycol copolymer 0.1

(additive)

Antiseptic 0.2

(method for making) fully mixes mentioned component with blender, obtains infant powder.

The infant powder usability that obtains (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-11]

[deodorant stick]

メチ Le トリメチコ Application 60.0 quality %

Squalane 10.0

Chloroflo 10.0

Alumen (mean diameter 0.05 μ m) 5.0

Support the zeolite (the about 10 μ m of mean diameter, the particle that 15.0 particle diameters surpass 15 μ m is below 20%) of zinc ion, ammonium ion

(method for making) will mix the material that mentioned component obtains and be filled in the container, obtain deodorant stick.

When the deodorant stick that obtains was coated in the oxter, usability (not having rough sense), odor-resistant result, discoloration-resistant were good.

[embodiment 2-12]

[ロ-Le オ Application deodorant]

Dodecamethylcyclohexasiloxane 67.0 quality %

Ethanol 20.0

Sorbitol 4.0

Burnt alum (mean diameter 1 μ m) 1.0

Aluminum chloride 1.0

Magnesium oxide 2.0

Support the zeolite (the about 2 μ m in average particle 5.0 footpaths, the particle that particle diameter surpasses 15 μ m is below 3%) of silver ion, copper ion, ammonium ion

(method for making) mixes mentioned component, in the ロ that packs into-Le オ Application container, obtains ロ-Le オ Application deodorant cosmetics.

The ロ that obtains-Le オ Application deodorant cosmetics do not have the cohesion of powder, and usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-13]

[powder spray agent]

(powder part)

Alumen (mean diameter 0.01 μ m) 2.0 quality %

Polymeric aluminum chloride 0.5

Support the zeolite (the about 1.5 μ m in average particle 1.0 footpaths, the particle that particle diameter surpasses 15 μ m is below 0.5%) of zinc ion, copper ion, ammonium ion

Talcum 0.5

(oil content)

Decamethylcyclopentasiloxane 1.5

Spice 0.2

(propellant)

Isopentane 10.0

Liquefied petroleum gas 83.3

(method for making) is partially mixed with powder with kneader, after with blender oil content being mixed, is filled into respectively in the aerosol can successively, recharges propellant, obtains the powder spray agent.

The favorable dispersibility of deodorant spray in propellant that obtains, the nozzle during injection can not stop up, and the smearing property on the skin is good, and antiperspirant, odor-resistant result, discoloration-resistant are good.

[embodiment 2-14]

[powder spray agent]

(powder part)

Burnt alum (mean diameter 5 μ m) 0.5 quality %

Support the zeolite (mean diameter 1.5 about 1.0 μ m, the particle that particle diameter surpasses 15 μ m is below 0.05%) of silver ion, copper ion, ammonium ion

Zinc oxide 0.2

Silica 1 .5

(oil content)

Polyoxyethylene nonylplenyl ether 0.5

Dimethyl polysiloxane (1.5mPaS, 25 ℃) 0.1

Isopropyl myristate 0.5

(additive)

Polyoxyethylene sorbitan monooleate dehydration 0.1

Spice 0.1

(propellant)

Compressed petroleum gas 95.0

Even the powder spray agent long preservation that obtains uses sense of touch also good, powder does not partly have coagulation, can give full play to odor-resistant result, discoloration-resistant yet.

[embodiment 2-15]

[die mould deodorization powder]

(powder part)

Alumen (mean diameter 15 μ m) 30.0 quality %

Support the zeolite (the about 1.5 μ m in average particle 20.0 footpaths, the particle that particle diameter surpasses 15 μ m is below 1%) of silver ion, zinc ion, ammonium ion

Talcum 30.0

(oil content)

Methyl phenyl silicone (13mPaS, 25 ℃) 10.0

Liquid paraffin 10.0

The die mould deodorization powder that obtains in use can not lump, and the use sense of touch on the skin is good, and odor-resistant result, discoloration-resistant are also abundant.

[embodiment 2-16]

[deodorant spray]

(propellant)

Normal butane 76.0 quality %

Iso-butane 15.0

(oil content)

Dimethyl polysiloxane (1.5mPaS, 25 ℃) 5.0

(powder part)

Burnt alum (mean diameter 4.5 μ m) 2.5

Support the zeolite (the about 0.5 0.5 μ m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 1%) of zinc ion, ammonium ion

(additive)

Isopropyl myristate 0.5

Four-2 ethyl hexanoic acid, two dehydrating glycerin sorbitol esters 0.5

(method for making) is partially mixed with powder with kneader, after with blender oil content and additive being mixed, is filled in the aerosol can, recharges propellant, obtains the deodorant spray.

For the deodorant spray that obtains, the favorable dispersibility of powder part in propellant has dry and comfortable, comfortable sense of touch, also can give full play to odor-resistant result, discoloration-resistant.

[embodiment 2-17]

[infant powder]

(powder part)

Talcum 55.0 quality %

Alumen (mean diameter 25 μ m) 25.0

Calcium carbonate 17.0

Support the zeolite (the about 2.38 μ m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 20%) of silver ion, cuprammonium ion

(oil content)

Methyl phenyl silicone (13mPaS, 25 ℃) 0.4

Dimethyl polysiloxane ethylene glycol copolymer 0.1

(additive)

Antiseptic 0.2

The not coagulation of infant powder that obtains has slick usability, and odor-resistant result, discoloration-resistant are good.

[embodiment 2-18]

[deodorant stick]

Methyl three メチコ Application 60.0 quality %

Squalane 10.0

Chloroflo 10.0

Support 10.0 (the about 1.5 μ m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 1.5%) that boil of silver ion, copper ion, zinc ion, ammonium ion

Burnt alum (mean diameter 7 μ m) 9.0

Aluminum zirconium hydroxychloride 1.0

When the deodorant stick that obtains is coated in the oxter, smooth, good sense of touch is arranged, odor-resistant result, discoloration-resistant are good.

[embodiment 2-19]

[ロ-Le オ Application deodorant cosmetics]

Dodecamethylcyclohexasiloxane 51.0 quality %

Ethanol 20.0

Sorbitol 4.0

Support the zeolite (the about 10 5.0 μ m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 10%) of copper ion, ammonium ion

Alumen (mean diameter 32 μ m) 15.0

Aluminum zirconium hydroxychloride 5.0

The ロ that obtains-Le オ Application deodorant cosmetic powder does not partly have coagulation, and frank usability is arranged, and makes skin dry and comfortable, and odor-resistant result, discoloration-resistant are good.

[embodiment 2-20]

[washing body fluid]

N-lauryl-L glutamic acid triethanolamine 6.0 quality %

N-lauryl methyl sodium taurocholate 3.0

Lauric acid triethanolamine 9.5

Myristic acid triethanolamine 9.5

The lauryl imidazoles

Betanin 5.0

Lauryl diglycollic amide 5.0

Propylene glycol 7.0

Support the zeolite (the about 5 μ 0.5m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 5%) of silver ion, ammonium ion

Burnt alum (mean diameter 0.01 μ m) 1.0

Aluminum chloride 0.3

Polymeric aluminum chloride 0.2

Methyl phenyl silicone (13mPaS, 25 ℃) 1.0

Distilled water surplus

Spice 0.01

Antiseptic 0.1

Sodium ethylene diamine tetracetate 0.01

(method for making) is heated to 70 ℃ with distilled water, adds other compositions successively, stirring and dissolving.Be cooled to room temperature, be filled in and be equipped with in the resin bottle that stirs ball, obtain washing body fluid.

The body fluid of washing that obtains has washability, foamability, and stability, the usability (not having rough sense) of while system are good, and odor-resistant result, discoloration-resistant are also good.

[embodiment 2-21]

[fuchsin lotion]

Ethanol 12.5 quality %

(oil content)

Methyl three メチコ Application 2.0

(wetting agent)

Glycerol 2.0

1,3 butylene glycol 2.0

(powder agent)

Ferrum oxide (colcother) 0.15

Zinc oxide 0.5

Support the zeolite (the about 1.5 0.5 μ m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 0.2%) of silver ion, ammonium ion

Alumen (mean diameter 36 μ m) 0.5

Kaolin 1.5

(medicament)

Camphora 0.2

Phenol 0.02

Spice 0.01

Anti-stripping agent 0.01

Distilled water surplus

(method for making) joins spice in ethanol, wetting agent, the oil content and dissolves.Camphora, phenol are dissolved in distilled water, to wherein adding powder agent, preventing that stripping agent stirs mutually with above-mentioned ethanol wetting agent, powder agent moistening, dispersion.With filtering about 160 orders, obtain the fuchsin lotion.

Above-mentioned fuchsin lotion has the effect of the heating anesthesia of the skin after the solar radiation of making, and does not have usability, odor-resistant result and the discoloration-resistant of rough sense good simultaneously.

[embodiment 2-22]

[Oleum sesami]

(oil content)

Olive oil 39.69 quality %

Liquid paraffin 25.0

Squalane 20.0

(powder)

Dimethyl polysiloxane (6mPaS, 25 ℃) 3.0

Support the zeolite (the about 5 μ m in average particle 2.0 footpaths, the particle that particle diameter surpasses 15 μ m is below 20%) of silver ion, zinc ion, ammonium ion

Burnt alum (mean diameter 3 μ m) 10.0

(other)

Vitamin E acetate 0.2

Antioxidant 0.1

Spice 0.01

(method for making) added powder medicine, antioxidant, spice in the oil content to and stirred, and the oil that obtains is filled into is equipped with in the resin bottle that stirs ball, obtains Oleum sesami.

Above-mentioned Oleum sesami usability (not having rough sense) is good, and odor-resistant result, discoloration-resistant are good.

[embodiment 2-23]

[cleansing milk]

(fatty acid)

Stearic acid 10.0 quality %

Palmic acid 10.0

Myristic acid 10.0

Lauric acid 4.0

(oil content)

Methyl phenyl silicone (13mPaS, 25 ℃) 2.0

(alkali)

Potassium hydroxide 6.0

(wetting agent)

PEG1500 10.0

Glycerol 15.0

(surfactant)

Glyceryl monostearate 2.0

POE (20) Arlacel-60 2.0

(powder)

Support the zeolite (the about 10 2.0 μ m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 20%) of silver ion, ammonium ion

Alumen (mean diameter 9 μ m) 2.0

Antiseptic 0.1

Sodium ethylene diamine tetracetate 0.05

Spice 0.01

Distilled water surplus

(method for making) remains in 70 ℃ with fatty acid, oil content, wetting agent, antiseptic heating for dissolving.The distilled water that is dissolved with alkali is in advance added in the oil phase of stirring.After the interpolation, temporarily remain in 70 ℃, neutralization reaction is finished.Then, add fused surfactant, chelating agen, spice and powder, mix, the degassing, filtration postcooling obtain cleansing milk.

Washability, the foaming characteristic of above-mentioned cleansing milk are good, and have the good usability that does not have rough sense, and odor-resistant result, discoloration-resistant are also good.

[embodiment 2-24]

[facial film (exfoliated)]

(fruit glaze agent)

Polyvinyl acetate base ester emulsion 15.0 quality %

Polyvinyl alcohol 10.0

(wetting agent)

Sorbitol 5.0

PEG400 5.0

(oil content)

Jojoba oil 2.0

Methyl phenyl silicone (13mPaS, 25 ℃) 1.0

Squalane 1.0

(surfactant)

POE Arlacel-60 1.0

(powder)

Oxidation 4.0

Support the zeolite (the about 1.5 μ m of mean diameter, the particle that 3.0 particle diameters surpass 15 μ m is below 2%) of silver ion, ammonium ion

Burnt alum (mean diameter 45 μ m) 4.0

Talcum 4.0

(alcohol)

Ethanol 8.0

Spice 0.01

Antiseptic 0.1

Distilled water surplus

(method for making) adds powder in the distilled water, after fully disperseing, adds wetting agent, be heated to 70～80 ℃ after, add fruit glaze agent, dissolve.In ethanol, add spice, antiseptic, surfactant, oil content.It is joined above-mentioned aqueous phase mixes.The degassing, filtration, cooling obtain facial film.

Above-mentioned facial film usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-25]

[compressing powder]

(powder)

Alumen (mean diameter 0.4 μ m) 50.0 quality %

Polymeric aluminum chloride 1.0

Support the zeolite (mean diameter 5.0 about 6 μ m, the particle that particle diameter surpasses 15 μ m is below 15%) of silver ion, zinc ion, ammonium ion

Talcum 37.0

(oil content)

Liquid paraffin 2.0

Methyl phenyl silicone (13mPaS, 25 ℃) 1.0

Spice is an amount of

After (method for making) fully mixed the powder composition, even spraying was dissolved in the spice in the oil content, mixes.After this powder pulverizing, compression forming obtains compressing powder.

Above-mentioned compressing powder usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-26]

[soap]

Glycerol monolaurate sodium sulfovinate surplus

Sodium lauryl sulfate 10.0 quality %

Coco-nut oil fatty acid sodium 30.0

Hexadecanol 3.5

Methyl phenyl silicone (13mPaS, 25 ℃) 0.5

Support the zeolite (the about 1.5 1.0 μ m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 1%) of silver ion, ammonium ion

Burnt alum (mean diameter 5 μ m) 4.0

Spice 0.01

Dyestuff 0.01

Antioxidant 0.1

Sodium ethylene diamine tetracetate 0.01

(method for making) joins mentioned component in the mixer, after mixing is stirred, undertaken mixing and compression by cylinder, squeezer, and molding, extruding are carried out mold pressing for bar-shaped to it, obtain soap.

Above-mentioned soap usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-27]

[エモリエ Application ト lotion]

(oil content)

Hexadecanol 1.0 quality %

Cera Flava 0.5

Vaseline 2.0

Squalane 6.0

Dimethyl polysiloxane (1.5mPaS, 25 ℃) 2.0

(alcohol)

Ethanol 5.0

(wetting agent)

Glycerol 4.0

1,3 butylene glycol 4.0

(surfactant)

POE (10) monoleate 1.0

Glyceryl monostearate 1.0

(mucoid)

Network イ Application スシ-De extracting solution (5% aqueous solution) 20.0

(powder)

Support the zeolite (flat 2.0 equal particle diameter 3.5 μ m, the particle that particle diameter surpasses 15 μ m is below 5%) of silver ion, copper ion, zinc ion, ammonium ion

Alumen (mean diameter 12 μ m) 1.0

Phenyl phenol 0.05

Coloring agent 0.01

Spice 0.01

Distilled water surplus

(method for making) adds wetting agent, coloring agent in the distilled water, is heated to 70 ℃ and adjusts.In oil content, add surfactant, antiseptic, be heated to 70 ℃ and adjust.It is joined previous aqueous phase, carry out pre-emulsifying.Stir to wherein adding Network イ Application スシ-De extracting solution, powder and ethanol, make emulsified particle evenly with homogenizer after, the degassing, filter, cooling, obtain エモリエ Application ト lotion.

Above-mentioned エモリエ Application ト lotion usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-28]

[oil-base gel (oil-in-water type)]

(oil content)

Liquid paraffin 10.0 quality %

Glycerol three-2-ethylhexanoate 48.0

Decamethylcyclopentasiloxane 2.0

(wetting agent)

Sorbitol 10.0

PEG400 5.0

(surfactant)

Lauroyl N-methyltaurine sodium 5.0

POE octyl group dodecyl alcohol ether 10.0

(powder)

Support the zeolite (mean diameter 2.0 about 2.0 μ m, the particle that particle diameter surpasses 15 μ m is below 3%) of silver ion, zinc ion, ammonium ion

Burnt alum (mean diameter 18 μ m) 2.0

Spice 0.01

Distilled water surplus

(method for making) joins wetting agent, acyl group N-methyltaurine in the distilled water, is heated to 70 ℃ and adjusts.In oil content, add POE octyl group lauryl ether, spice, be heated to 70 ℃ and adjust.Itself and powder are slowly joined previous aqueous phase.After making emulsified particle evenly with homogenizer, the degassing, filter, cooling, obtain oil-base gel.

Above-mentioned oil-base gel usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-29]

[cream]

(oil content)

Hexadecanol 5.0 quality %

Stearic acid 3.0

Methyl phenyl silicone (13mPaS, 25 ℃) 1.0

Vaseline 4.0

Squalane 9.0

Glycerol three 2-ethylhexanoate 7.0

(wetting agent)

Dipropylene glycol 5.0

Glycerol 5.0

(surfactant)

Propylene glycol monostearate 3.0

POE (20) hexadecane alcohol ether 3.0

(alkali)

Triethanolamine 1.0

(powder)

Support the zeolite (the about 1.5 1.0 μ m of mean diameter, the particle that particle diameter surpasses 15 μ m is below 1.5%) of silver ion, ammonium ion

Alumen (mean diameter 0.9 μ m) 0.1

Antiseptic 0.1

Antioxidant 0.05

Spice 0.01

Distilled water surplus

(method for making) joins wetting agent, alkali in the distilled water, adjusts at 70 ℃.After the oil content heating for dissolving, add surfactant, antiseptic, antioxidant, spice, adjust at 70 ℃.It is joined previous aqueous phase, carry out pre-emulsifying.Add powder, make emulsified particle evenly with homogenizer after, the degassing, filter, cooling.

Above-mentioned cream usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-30]

[wet sheet]

Ion exchange water 65.38 quality %

Ethanol 30.00

The zeolite of load Ag-bearing zinc ammonium (mean diameter 3 μ m, the particle that particle diameter 1.0 surpasses 15 μ m is below 1%)

Alumen (mean diameter 0.09 μ m) 3.0

Polyoxyethylene polyoxypropylene decyl myristyl ether 0.4

Citric acid 0.04

Sodium citrate 0.04

Adenine 0.05

Ethylenediamine ethoxy triacetic acid trisodium 0.05

Camphora 0.01

Menthol 0.03

(method for making) adds insoluble composition after water soluble ingredient is fully dissolved in ion exchange water, make it abundant dispersion, makes it immersion non-woven fabrics simultaneously, is filled into then in the aluminum tiny pocket packing, thereby obtains.

Above-mentioned wet sheet usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-31]

[powder in the powder puff]

Talcum 69.66 quality %

Poly-methyl シ Le silsequioxane globular powder 10.0

Spherical calcium alginate powder 3.0

The zeolite of load Ag-bearing zinc ammonium (mean diameter 10 μ m, the particle that grain 2.0 footpaths surpass 15 μ m is below 18%)

Burnt alum (mean diameter 6 μ m) 5.0

Ethylparaben 0.1

Salicylic acid 0.2

Zinc oxide fine particles (mean diameter 60nm) 5.0

Zinc oxide coated ball shaped polyethylene powder 5.0

Ferrum oxide (Huang) 0.015

Ferrum oxide (red) 0.025

After (method for making) fully mixes mentioned component with Henschel mixer, will pulverize the material that obtains with flour mill and be filled in the fabric bag of nonwoven, and put it in the powder puff, thereby obtain.

Powder usability in the above-mentioned powder puff (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-32]

[deodorant stick (wax system)]

Decamethylcyclopentasiloxane 0.1 quality %

Dimethyl polysiloxane (1.5mPaS, 25 ℃) 10.0

Stearyl alcohol 8.0

Polyoxypropylene (40) butyl ether 7.0

Sesquialter isostearic acid Isosorbide Dinitrate 2.5

Hardened castor oil 1.5

Alumen (mean diameter 0.15 μ m) 20.0

The zeolite (mean diameter 3.0 μ m, the particle that 18.0 particle diameters surpass 15 μ m is below 10%) of load Ag-bearing zinc ammonium

Talcum 10.7

Zinc oxide fine particles (mean diameter 60nm) 1.0

HP-0.1

Zinc oxide coats spherical nylon 12 1.0

Calcium disodium edathamil 0.1

(method for making) after fully mixing, adds the powder composition with oiliness composition heating and melting, and heating mixes with the high-speed mixer homodisperse simultaneously, flows into mould, and cooling obtains rod.

Above-mentioned deodorant stick usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-33]

[deodorant stick (not having oil system)]

Talcum 49.0 quality %

Sericite 20.0

(two メチコ Application/vinyls, two メチコ Application) cross linked polymer 5.0 globular powders

Burnt alum (mean diameter 4 μ m) 10.0

Poly-methyl シ Le silsequioxane globular powder 5.0

The zeolite (mean diameter 0.9 μ m, the particle that 10.0 particle diameters surpass 15 μ m is below 0.3%) of load Ag-bearing zinc ammonium

Magnesiumaluminumsilicate 1.0

(method for making) fully mixes 20 parts ion exchange water with respect to 1 part of the weight of Magnesiumaluminumsilicate, becomes gel, then, fully mixes, disperses other compositions, makes slurry, flows into mould then, puts it in the drying machine, makes water evaporates, and cooling obtains rod.

[embodiment 2-34]

[aqueous gel]

POE (14) POP (7) dimethyl ether 7.0 quality %

PEG1500 8.0

Support the zeolite (mean diameter 5 μ m, the particle that particle diameter 1.0 surpasses 15 μ m is below 20%) of silver-bearing copper ammonium

Alumen (mean diameter 10 μ m) 3.0

Carboxy vinyl polymer 0.4

Methylcellulose 0.2

POE (15) oleyl alcohol ether 1.0

Potassium hydroxide 0.1

Epsilon-polylysine 0.2

Tetrasodium ethylenediamine tetraacetate 0.05

Spice 0.1

Distilled water 78.95

After (method for making) was dissolved in water soluble polymer in the distilled water equably, dissolving epsilon-polylysine, tetrasodium ethylenediamine tetraacetate added surfactant in POE (14) POP (7) dimethyl ether, and heating for dissolving is to wherein adding spice.Slowly add the water of previous preparation, add potassium hydroxide aqueous solution at last, fully to stir in order neutralizing, thereby to obtain.

Above-mentioned aqueous gel usability (not having rough sense), odor-resistant result, discoloration-resistant are good.

[embodiment 2-35]

[the medicinal body fluid of washing]

Lauryl sulfate ester triethanolamine salt (40% aqueous solution) 40.0 quality %

Lauryl polyoxyethylene (3 moles) sodium sulfate salt (30% water-soluble 20.0 liquid)

Lauryl diglycollic amide 5.0

The zeolite (mean diameter 3.5 μ m, the particle that 2.0 particle diameters surpass 15 μ m is below 1%) of load Ag-bearing zinc ammonium

Alumen (mean diameter 42 μ m) 2.0

Glycerol monopalmitate 1.0

Lanolin derivative 2.0

Propylene glycol 5.0

Distilled water surplus

Spice is an amount of

Dyestuff is an amount of

Ethylenediamine ethoxy triacetic acid trisodium (two water salt) is an amount of

After (method for making) fully mixes water soluble ingredient, add the powder composition, fully mix and disperse, be filled in the container simultaneously, thereby obtain.Use after fully vibrating during use.

The above-mentioned body fluid usability (not having rough sense), odor-resistant result, discoloration-resistant washed is good.

[invention of claim 7～8]

According to the prescription shown in " table 3-1 " and " table 3-2 ", preparation powder lotion type antiperspirant lotion, a certain amount of (the 4 μ g/cm of coating on medicated clothing ²).Be exposed to sunlight (10 minutes), after washing with lotion and washing machine with common medicated clothing, the visual assessment pollution level.As a comparative example, (20～28E.O.) (10～16P.O.) prescription, cooperate the prescription of polyoxyethylene (E.O.60) hardened castor oil to study to mismatching polyoxyethylene polyoxypropylene 2-decyl myristyl ether.The degree of polluting is evaluated as zero when the scope that allows as skin preparations for extenal use, be evaluated as in the time of not in this scope *.

Table 3-1

Table 3-2

By The above results as can be known, do not cooperate polyoxyethylene polyoxypropylene 2-decyl myristyl ether (20～28E.O.) (10～16P.O.) comparative example and cooperate polyoxyethylene (E.O.60) hardened castor oil to replace polyoxyethylene polyoxypropylene 2-decyl myristyl ether (20～28E.O.) (in 10～16P.O.) the comparative example, pollute big.

Relative therewith, (20～28E.O.) (among 10～16P.O.) the embodiment, polluting very for a short time, is in the scope that allows as skin preparations for extenal use, has brought into play good anti-pollution effect as can be known being combined with polyoxyethylene polyoxypropylene 2-decyl myristyl ether.

Below provide other embodiment of the present invention.

[embodiment 3-7] compressing powder

Polymeric aluminum chloride 5 quality %

Zinc oxide 5

The Talcum surplus

Liquid paraffin 3

Antibacterial zeolite B 10

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 0.01

(20E.O.)(16P.O.)

[embodiment 3-8] Le-ス powder

Polymeric aluminum chloride 5 quality %

Zinc oxide (flowers of zinc) 5

The Talcum surplus

Antibacterial zeolite B 10

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 0.05 (22E.O.) (15P.O.)

The spraying of [embodiment 3-9] astringent type

(former formula of liquid)

Distilled water 10 quality %

Polymeric aluminum chloride 10

The dehydrated alcohol surplus

Isopropyl myristate 2

1,3 butylene glycol 3

Antibacterial zeolite B 1

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 1 (26E.O.) (13P.O.)

(filling formulation)

Stock solution 50

LPG 50

[embodiment 3-10] powder spray

Polymeric aluminum chloride 20 quality %

Silicic acid anhydride 15

Talcum 20

Zinc oxide (flowers of zinc) 5

The isopropyl myristate surplus

Dimethyl polysiloxane 10

Fatty acid esters of sorbitan 3

Antibacterial zeolite B 5

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 0.1 (24E.O.) (12P.O.)

(filling formulation)

Stock solution 10

LPG 90

[embodiment 3-11] powder spray

Alumen 20 quality %

Silicic acid anhydride 15

Talcum 20

Zinc oxide (flowers of zinc) 5

The isopropyl myristate surplus

Polyoxyethylene polyoxypropylene atactic polymer methyl ether 10

Fatty acid esters of sorbitan 3

Antibacterial zeolite B 5

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 0.1 (27E.O.) (11P.O.)

(filling formulation)

Stock solution 10

LPG 90

[embodiment 3-12] rod

Polymeric aluminum chloride 20 quality %

Talcum 8

Zinc oxide (flowers of zinc) 5

Hard paraffin 2

Stearyl alcohol 8

Liquid paraffin 15

The cyclic dimethyl polysiloxane surplus

Fatty acid esters of sorbitan 1

Antibacterial zeolite B 5

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 4 (22E.O.) (15P.O.)

[embodiment 3-13] cream

Distilled water surplus

Squalane 20 quality %

Cyclic dimethyl polysiloxane 15

Two glyceryl isostearates 3

Succinic acid diethoxy ethyl ester 5

Organically modified montmorillonite clay 1.5

1,3 butylene glycol 5

Antibacterial zeolite A 5

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 2 (24E.O.) (13P.O.)

[embodiment 3-14] emulsion

Distilled water surplus

Polymeric aluminum chloride 20 quality %

P-methoxycinnamic acid monooctyl ester 5

The 4-tert-butyl group-4 '-methoxy benzoylmethane 1

Hydrophobization is handled zinc oxide 5

Polyoxyethylene polyoxypropylene atactic polymer methyl ether 10

Silicone oil 15

Silicones 1

Two glyceryl isostearates 1

Organically modified montmorillonite clay 0.5

1,3 butylene glycol 5.5

Antibacterial zeolite B 13

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 1 (25E.O.) (11P.O.)

[embodiment 3-15] ointment

Distilled water surplus

Polymeric aluminum chloride 20 quality %

Glycerol 10

1,3 butylene glycol 3

Potassium hydroxide 0.25

Stearic acid 2

Glycerol monostearate 2

Spermol 1

Liquid paraffin 5

Vaseline 2

Antibacterial zeolite B 1

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 2.5 (20E.O.) (16P.O.)

[embodiment 3-16] gel

Distilled water surplus

Polymeric aluminum chloride 20 quality %

Dipropylene glycol 5

PEG1500 5.5

CVP Carbopol ETD2050 0.4

Methylcellulose 0.2

POE (15) oleyl alcohol ether 0.5

Potassium hydroxide 0.1

EDTA 0.02

Antibacterial zeolite B 5

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 0.3 (26E.O.) (12P.O.)

[embodiment 3-17] sheet that wets

Distilled water surplus

Dehydrated alcohol 35 quality %

Polyoxyethylene hardened castor oil 0.1

Structure rafter acid (food) 0.02

Sodium citrate 0.06

Antibacterial zeolite B 2

Polyoxyethylene polyoxypropylene 2-decyl myristyl ether 0.01 (26E.O.) (12P.O.)

The industry practicality

(1) according to the present invention, can be provided in the skin preparations for extenal use that is combined with antibacterial zeolite, performance prevents the skin preparations for extenal use variable color or relaxes the skin preparations for extenal use of the effect of variable color degree.

(2) according to the present invention, provide the preparation stabilities such as the dispersiveness of powder composition and discoloration-resistant good and use the good skin preparations for extenal use of sense of touch. Skin preparations for extenal use of the present invention is because the favorable dispersibility of the powder such as antibacterial zeolite, alum, burning alum, so aggegation can not take place powder, and usability (not having rough sense) is good. And discoloration-resistant is good.

(3) according to the present invention, can be provided in the skin preparations for extenal use that is combined with antibacterial zeolite, performance prevents that skin preparations for extenal use from adhering to and the pollution that causes or the skin preparations for extenal use that relaxes the effect of pollution degree at clothing.

The present invention is in being combined with the skin preparations for extenal use of antibacterial zeolite, and performance prevents from adhering to and the pollution that causes or the effect that relaxes the pollution degree at clothing.

Claims

1. the antipollution application of polyoxyethylene polyoxypropylene 2-decyl myristyl ether in the skin preparations for extenal use that contains the antibacterial zeolite that supports silver ion, zinc ion and ammonium ion.

2. skin preparations for extenal use, wherein, contain the antibacterial zeolite and the polyoxyethylene polyoxypropylene 2-decyl myristyl ether that support silver ion, zinc ion and ammonium ion, wherein above-mentioned polyoxyethylene polyoxypropylene 2-decyl myristyl ether is characterised in that the polyoxyethylene unit is 20～28E.O., and the polyoxypropylene unit is 10～16P.O..