JP4375609B2 - Topical skin preparation - Google Patents
Topical skin preparation Download PDFInfo
- Publication number
- JP4375609B2 JP4375609B2 JP2003332802A JP2003332802A JP4375609B2 JP 4375609 B2 JP4375609 B2 JP 4375609B2 JP 2003332802 A JP2003332802 A JP 2003332802A JP 2003332802 A JP2003332802 A JP 2003332802A JP 4375609 B2 JP4375609 B2 JP 4375609B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- ether
- zeolite
- external preparation
- poe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 53
- 230000000699 topical effect Effects 0.000 title 1
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- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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- 229910001432 tin ion Inorganic materials 0.000 description 1
- FAKFSJNVVCGEEI-UHFFFAOYSA-J tin(4+);disulfate Chemical compound [Sn+4].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O FAKFSJNVVCGEEI-UHFFFAOYSA-J 0.000 description 1
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- 239000004408 titanium dioxide Substances 0.000 description 1
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- JIVZKJJQOZQXQB-UHFFFAOYSA-N tolazoline Chemical compound C=1C=CC=CC=1CC1=NCCN1 JIVZKJJQOZQXQB-UHFFFAOYSA-N 0.000 description 1
- 229960002312 tolazoline Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
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- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- JLGLQAWTXXGVEM-UHFFFAOYSA-N triethylene glycol monomethyl ether Chemical compound COCCOCCOCCO JLGLQAWTXXGVEM-UHFFFAOYSA-N 0.000 description 1
- KOECRLKKXSXCPB-UHFFFAOYSA-K triiodobismuthane Chemical compound I[Bi](I)I KOECRLKKXSXCPB-UHFFFAOYSA-K 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- SVETUDAIEHYIKZ-IUPFWZBJSA-N tris[(z)-octadec-9-enyl] phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCCOP(=O)(OCCCCCCCC\C=C/CCCCCCCC)OCCCCCCCC\C=C/CCCCCCCC SVETUDAIEHYIKZ-IUPFWZBJSA-N 0.000 description 1
- 229960005066 trisodium edetate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 description 1
- 235000013799 ultramarine blue Nutrition 0.000 description 1
- LNRUEZIDUKQGRH-YZUCMPLFSA-N umbelliferose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 LNRUEZIDUKQGRH-YZUCMPLFSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
- 239000009538 yokuinin Substances 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 229940105125 zinc myristate Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- RXBXBWBHKPGHIB-UHFFFAOYSA-L zinc;diperchlorate Chemical compound [Zn+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O RXBXBWBHKPGHIB-UHFFFAOYSA-L 0.000 description 1
- MLVWCBYTEFCFSG-UHFFFAOYSA-L zinc;dithiocyanate Chemical compound [Zn+2].[S-]C#N.[S-]C#N MLVWCBYTEFCFSG-UHFFFAOYSA-L 0.000 description 1
- GBFLQPIIIRJQLU-UHFFFAOYSA-L zinc;tetradecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O GBFLQPIIIRJQLU-UHFFFAOYSA-L 0.000 description 1
- OJYLAHXKWMRDGS-UHFFFAOYSA-N zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は皮膚外用剤に関する。さらに詳しくは、抗菌性ゼオライトを配合した皮膚外用剤において耐汚染着性に優れた皮膚外用剤に関する。 The present invention relates to an external preparation for skin. More specifically, the present invention relates to a skin external preparation excellent in antifouling property in a skin external preparation containing antibacterial zeolite.
抗菌性ゼオライトは、防腐剤や消臭剤として化粧料や医薬部外品等の皮膚外用剤に配合されている。 Antibacterial zeolite is blended in skin external preparations such as cosmetics and quasi-drugs as antiseptics and deodorants.
例えば、抗菌性ゼオライトを配合した抗菌性スプレー用組成物(特許文献1参照)や防臭化粧料(特許文献2参照)が開発されている。また、耐変色性を改良した防臭化粧料として、抗菌性ゼオライトにシリコーンを配合した技術が開示されている(特許文献3参照)。 For example, antibacterial spray compositions containing antibacterial zeolite (see Patent Document 1) and deodorant cosmetics (see Patent Document 2) have been developed. Moreover, the technique which mix | blended silicone with the antibacterial zeolite is disclosed as a deodorant cosmetics which improved discoloration resistance (refer patent document 3).
しかしながら、耐汚染着性を改良した皮膚外用剤や化粧料の報告はなされていない。 However, there have been no reports on external preparations for skin or cosmetics with improved anti-staining properties.
一方、ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルは、化粧料に配合する界面活性剤として公知である(特許文献4参照)。 On the other hand, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether is known as a surfactant to be blended in cosmetics (see Patent Document 4).
抗菌性ゼオライトは単体では安定した皮膚外用剤成分ではある。
しかしながら、皮膚外用剤に抗菌性ゼオライトを配合すると変色が起こり、衣類に付着した場合衣類が汚染着する場合がある。
Antibacterial zeolite alone is a stable skin external preparation component.
However, when antibacterial zeolite is blended with the external preparation for skin, discoloration occurs, and the clothes may contaminate when attached to the clothes.
変色の原因は不明ではあるが、皮膚外用剤中には多くの原料が存在するため、配合原料若しくは配合原料の不純物等と反応して微妙に変色するものと考えられる。 The cause of discoloration is unknown, but since many raw materials exist in the external preparation for skin, it is considered that the discoloration is subtly caused by reaction with the blended raw materials or impurities of the blended raw materials.
例えば、特にアルミニウムハイドロキシクロライドを配合した制汗化粧料において、防腐剤若しくは消臭剤として抗菌性ゼオライトを配合すると、化粧料の外観上好ましくない変色が起こることが本発明者により確認されている。 For example, it has been confirmed by the present inventor that when antibacterial zeolite is blended as an antiseptic or deodorant, particularly in antiperspirant cosmetics blended with aluminum hydroxide, undesirable discoloration occurs in the cosmetic appearance.
また、制汗化粧料が衣類に付着し、汗と日光等においても好ましくない変色が起こり、それが衣類に付着すると汚染着することが本発明者により確認されている。 Further, it has been confirmed by the present inventor that antiperspirant cosmetics adhere to clothing, and undesired discoloration occurs even in sweat and sunlight, and when it adheres to clothing, it stains.
本発明者は上述の課題に鑑みて鋭意研究した結果、驚くべきことに、抗菌性ゼオライトとポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルとを併用すると、耐汚染着効果があることを見出し、本発明を完成するに至った。 As a result of diligent research in view of the above-mentioned problems, the present inventor has surprisingly found that antibacterial zeolite and polyoxyethylene polyoxypropylene 2-decyltetradecyl ether are used in combination with antifouling effect. The present invention has been completed.
本発明の目的は、抗菌性ゼオライトを配合した皮膚外用剤において、衣類への耐汚染着効果に極めて優れた皮膚外用剤を提供するものである。 An object of the present invention is to provide a skin external preparation that is extremely excellent in anti-staining effect on clothes in a skin external preparation containing antibacterial zeolite.
すなわち、本発明は、抗菌性ゼオライトとポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルとを含有する皮膚外用剤において、
前記抗菌性ゼオライトが銀イオン、亜鉛イオン、アンモニウムイオン担持ゼオライトであり、
前記抗菌性ゼオライトの含有量が皮膚外用剤全量に対して0.05〜90質量%であり、
前記ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルの含有量が皮膚外用剤全量に対して0.01〜5質量%であることを特徴とする、衣類に対する耐汚染着効果に優れる皮膚外用剤を提供するものである。
That is, the present invention is a skin external preparation containing antibacterial zeolite and polyoxyethylene polyoxypropylene 2-decyltetradecyl ether,
The antibacterial zeolite is silver ion, zinc ion, ammonium ion supported zeolite,
The content of the antibacterial zeolite is 0.05 to 90% by mass with respect to the total amount of the external preparation for skin,
A skin external preparation having an excellent antifouling effect on clothes , characterized in that the content of the polyoxyethylene polyoxypropylene 2-decyltetradecyl ether is 0.01 to 5% by mass with respect to the total amount of the skin external preparation. Is to provide.
また、本発明は、ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルのポリオキシエチレン単位が、20〜28E.O.で、ポリオキシプロピレン単位が、10〜16P.O.であることを特徴とする上記の皮膚外用剤を提供するものである。
さらに、本発明は、抗菌性ゼオライトとポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルとを含有する皮膚外用剤において、
前記抗菌性ゼオライトが銀イオン、亜鉛イオン、アンモニウムイオン担持ゼオライトであり、
前記抗菌性ゼオライトの含有量が皮膚外用剤全量に対して0.05〜90質量%であり、
前記ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルの含有量が皮膚外用剤全量に対して0.01〜5質量%であることによって、前記皮膚外用剤の衣類に対する耐汚染着効果を高める方法を提供するものである。
In the present invention, the polyoxyethylene unit of the polyoxyethylene polyoxypropylene 2-decyltetradecyl ether is 20 to 28 EO, and the polyoxypropylene unit is 10 to 16 P.O. O. The above-mentioned external preparation for skin is provided.
Furthermore, the present invention provides an external preparation for skin containing antibacterial zeolite and polyoxyethylene polyoxypropylene 2-decyltetradecyl ether.
The antibacterial zeolite is silver ion, zinc ion, ammonium ion supported zeolite,
The content of the antibacterial zeolite is 0.05 to 90% by mass with respect to the total amount of the external preparation for skin,
A method for enhancing the antifouling effect on the clothing of the skin external preparation, wherein the content of the polyoxyethylene polyoxypropylene 2-decyltetradecyl ether is 0.01 to 5% by mass relative to the total amount of the external preparation for skin. Is to provide.
本発明によれば、抗菌性ゼオライトを配合した皮膚外用剤において、皮膚外用剤の衣類への付着による汚染着を防止したり、汚染着の度合いを緩和したりする効果を発揮する皮膚外用剤を提供できる。 According to the present invention, in a skin external preparation containing antibacterial zeolite, a skin external preparation that exhibits the effect of preventing contamination due to adhesion of the skin external preparation to clothing or reducing the degree of contamination. Can be provided.
以下、本発明について詳述する。 Hereinafter, the present invention will be described in detail.
本発明に用いる抗菌性ゼオライトは、ゼオライトのイオン交換可能な部分に抗菌性金属イオンを保持しているゼオライトである。
すなわち、ゼオライトのイオン交換可能なイオンの一部又は全部が抗菌性金属で置換されたゼオライトである。本発明においては、銀イオンと亜鉛イオンの抗菌性金属イオンと共にアンモニウムイオンで置換されたゼオライトを用いる。
The antibacterial zeolite used in the present invention is a zeolite holding an antibacterial metal ion in the ion-exchangeable part of the zeolite.
That is, a zeolite in which some or all of the ion-exchangeable ions of the zeolite are replaced with an antibacterial metal. In the present invention, zeolite substituted with ammonium ions together with antibacterial metal ions such as silver ions and zinc ions is used.
ゼオライトは天然ゼオライト及び合成ゼオライトのいずれでもよい。ゼオライトは、一般に三次元骨格構造を有するアルミノシリケートであり、一般式としては、XM2/nO・Al2O3・YSiO2・ZH2Oで表示される。この一般式において、Mはイオン交換可能なイオンを表し、通常は1または2価の金属イオンである。nは(金属)イオンの原子価である。X及びYはそれぞれ金属酸化物、シリカ係数、Zは結晶水の数を表示している。 The zeolite may be either natural zeolite or synthetic zeolite. Zeolites is generally an aluminosilicate having a three-dimensional skeleton structure, the formula is displayed in XM 2 / n O · Al 2 O 3 · YSiO 2 · ZH 2 O. In this general formula, M represents an ion-exchangeable ion, and is usually a monovalent or divalent metal ion. n is the valence of the (metal) ion. X and Y are the metal oxide and silica coefficient, respectively, and Z is the number of crystal water.
ゼオライトの具体例としては、例えば、A−型ゼオライト、X−型ゼオライト、Y−型ゼオライト、T−型ゼオライト、高シリカゼオライト、ソーダライト、モルデナイト、アナルサイム、クリノプチロライト、チャバサイト、エリオナイト等を挙げることができる。これらのゼオライトのイオン交換容量は、A−型ゼオライト7meq/g、X−型ゼオライト6.4meq/g、Y−型ゼオライト5meq/g、T−型ゼオライト3.4meq/g、ソーダライト11.5meq/g、モルデナイト2.6meq/g、アナルサイム5meq/g、クリノプチロライト2.6meq/g、チャバサイト5meq/g、エリオナイト3.8meq/gである。いずれも抗菌性金属イオンやアンモニウムイオンでイオン交換するに十分の容量を有している。 Specific examples of the zeolite include, for example, A-type zeolite, X-type zeolite, Y-type zeolite, T-type zeolite, high silica zeolite, sodalite, mordenite, analcym, clinoptilolite, chabasite, erionite. Etc. The ion exchange capacities of these zeolites are as follows: A-type zeolite 7 meq / g, X-type zeolite 6.4 meq / g, Y-type zeolite 5 meq / g, T-type zeolite 3.4 meq / g, Sodalite 11.5 meq / G, mordenite 2.6 meq / g, analsim 5 meq / g, clinoptilolite 2.6 meq / g, chabasite 5 meq / g, erionite 3.8 meq / g. Both have sufficient capacity for ion exchange with antibacterial metal ions and ammonium ions.
ゼオライト中のイオン交換可能なイオンは、例えば、ナトリウムイオン、カルシウムイオン、カリウムイオン、マグネシウムイオン、鉄イオン等である。
また、これらのイオンに置換される抗菌性金属イオンは、例えば、銀、銅、亜鉛、水銀、錫、鉛、ビスマス、カドミウム、クロム、又はタリウムのイオンであり、本発明においては、銀イオンと亜鉛イオンの抗菌性金属イオンで交換される。
Examples of ion-exchangeable ions in the zeolite include sodium ions, calcium ions, potassium ions, magnesium ions, and iron ions.
In addition, the antibacterial metal ions substituted for these ions are, for example, silver, copper, zinc, mercury, tin, lead, bismuth, cadmium, chromium, or thallium ions. Exchanged with antibacterial metal ions of zinc ions.
抗菌性金属イオンは、抗菌性の観点からは、ゼオライト中に0.1〜15質量%含有されていることが好ましい。 The antibacterial metal ion is preferably contained in the zeolite in an amount of 0.1 to 15% by mass from the viewpoint of antibacterial properties.
例えば、銀イオン0.1〜15%及び亜鉛イオンを0.1〜8質量%含有する抗菌性ゼオライトが好ましい。一方、アンモニウムイオンは、ゼオライト中に20質量%まで含有させることができるが、ゼオライトの変色を有効に防止するという観点から、ゼオライト中の0.5〜5%がより好ましく、0.5〜2質量%がさらに好ましい。なお、質量%とは110℃乾燥基準のゼオライト中の質量百分率である。 For example, an antibacterial zeolite containing 0.1 to 15% silver ions and 0.1 to 8% by mass of zinc ions is preferable. On the other hand, ammonium ions can be contained in the zeolite up to 20% by mass, but from the viewpoint of effectively preventing discoloration of the zeolite, 0.5 to 5% in the zeolite is more preferable, and 0.5 to 2 is preferable. More preferred is mass%. In addition, the mass% is a mass percentage in the zeolite on the basis of 110 ° C. drying.
本発明において、抗菌性ゼオライトは市販品を使用できるが、抗菌性ゼオライトの製造方法としては、例えば下記の如く調製される。
すなわち、予め調製した銀イオン、銅イオン、亜鉛イオン等の抗菌性金属イオンを含有する混合水溶液にゼオライトを接触させて、ゼオライト中のイオン交換可能なイオンと上記イオンとを置換させる。
In the present invention, commercially available antibacterial zeolite can be used, but as a method for producing the antibacterial zeolite, for example, it is prepared as follows.
That is, the zeolite is brought into contact with a mixed aqueous solution containing antibacterial metal ions such as silver ions, copper ions, and zinc ions prepared in advance to replace the ions capable of ion exchange in the zeolite with the ions.
接触は、10〜70℃、好ましくは40〜60℃で3〜24時間、好ましくは10〜24時間バッチ式又は連続式(例えば、カラム法)によって行うことができる。 The contact can be carried out at 10 to 70 ° C., preferably 40 to 60 ° C. for 3 to 24 hours, preferably 10 to 24 hours by a batch method or a continuous method (for example, a column method).
なお、上記混合水溶液のpHは3〜10好ましくは5〜7に調整することが適当である。該調整により、銀の酸化物等のゼオライト表面又は細孔内への析出を防止できるので好ましい。また、混合水溶液中の各イオンは、通常いずれも塩として供給される。例えば、銀イオンは、硝酸銀、硫酸銀、過塩素酸銀、酢酸銀、ジアンミン銀硝酸塩、ジアンミン銀硫酸塩等であり、銅イオンは、硝酸銅(II)、過塩素酸銅、酢酸銅、テトラシアノ銅酸カリウム、硫酸銅等であり、亜鉛イオンは硝酸亜鉛(II)、硫酸亜鉛、過塩素酸亜鉛、チオシアン酸亜鉛、酢酸亜鉛等であり、水銀イオンは、過塩素酸水銀、硝酸水銀、酢酸水銀であり、錫イオンは、硫酸錫等、鉛イオンは硫酸鉛、硝酸鉛等であり、ビスマスイオンは、塩化ビスマス、ヨウ化ビスマス等であり、カドミウムイオンは、過塩素酸カドミウム、硫酸カドミウム、硝酸カドミウム、酢酸カドミウムであり、クロムイオンは、過塩素酸クロム、硫酸クロム、硫酸アンモニウムクロム、硝酸クロム等であり、タリウムイオンは、過塩素酸タリウム、硫酸タリウム、硝酸タリウム、酢酸タリウム等を用いることができる。 In addition, it is appropriate to adjust the pH of the mixed aqueous solution to 3 to 10, preferably 5 to 7. This adjustment is preferable because precipitation of silver oxide or the like on the zeolite surface or pores can be prevented. Each ion in the mixed aqueous solution is usually supplied as a salt. For example, silver ions are silver nitrate, silver sulfate, silver perchlorate, silver acetate, diammine silver nitrate, diammine silver sulfate, etc., and copper ions are copper (II) nitrate, copper perchlorate, copper acetate, tetracyano. Examples include potassium copperate and copper sulfate. Zinc ions include zinc nitrate (II), zinc sulfate, zinc perchlorate, zinc thiocyanate, and zinc acetate. Mercury ions include mercury perchlorate, mercury nitrate, and acetic acid. Mercury, tin ions such as tin sulfate, lead ions such as lead sulfate and lead nitrate, bismuth ions such as bismuth chloride and bismuth iodide, cadmium ions include cadmium perchlorate, cadmium sulfate, Cadmium nitrate and cadmium acetate. Chromium ions are chromium perchlorate, chromium sulfate, ammonium sulfate, chromium nitrate, etc., and thallium ions are thallium perchlorate. It can be used thallium sulfate, thallium nitrate, thallium acetate, and the like.
ゼオライト中の抗菌性金属イオンの含有量は、前記混合水溶液中の各イオン(塩)濃度を調整することによって、適宜制御することができる。 The content of antibacterial metal ions in the zeolite can be appropriately controlled by adjusting the concentration of each ion (salt) in the mixed aqueous solution.
例えば、抗菌性ゼオライトが銀イオンを含有する場合、前記混合水溶液中の銀イオン濃度を0.002M/l〜0.15M/lとすることによって、適宜銀イオン含有量0.1〜5%の抗菌性ゼオライトを得ることができる。
また、抗菌性ゼオライトがさらに銅イオン、亜鉛イオンを含有する場合、前記混合水溶液中の銅イオン濃度は0.1M/l〜0.85M/l、亜鉛イオン濃度は0.15M/l〜1.2M/lとすることによって、適宜銅イオン含有量0.1〜8%、亜鉛イオン含有量0.1〜8%の抗菌性ゼオライトを得ることができる。
For example, when the antibacterial zeolite contains silver ions, the silver ion concentration in the mixed aqueous solution is 0.002 M / l to 0.15 M / l, so that the silver ion content is appropriately 0.1 to 5%. An antibacterial zeolite can be obtained.
When the antibacterial zeolite further contains copper ions and zinc ions, the copper ion concentration in the mixed aqueous solution is 0.1 M / l to 0.85 M / l, and the zinc ion concentration is 0.15 M / l to 1. By setting it to 2 M / l, an antibacterial zeolite having a copper ion content of 0.1 to 8% and a zinc ion content of 0.1 to 8% can be obtained as appropriate.
抗菌性ゼオライトは、上記の混合水溶液以外に、各イオンを単独で含有する水溶液を用い、各水溶液とゼオライトとを逐次接触させることによって、イオン交換することもできる。各水溶液中の各イオンの濃度は、前記混合水溶液中の各イオン濃度に準じて定めることができる。 In addition to the above mixed aqueous solution, the antibacterial zeolite can be ion-exchanged by using an aqueous solution containing each ion alone and sequentially contacting each aqueous solution with the zeolite. The concentration of each ion in each aqueous solution can be determined according to the concentration of each ion in the mixed aqueous solution.
イオン交換が終了したゼオライトは、十分に洗浄した後乾燥する。乾燥は105℃〜115℃又は減圧(1〜30Torr)下において70〜90℃で行うことが好ましい。 The zeolite after ion exchange is thoroughly washed and dried. Drying is preferably performed at 105 to 115 ° C. or 70 to 90 ° C. under reduced pressure (1 to 30 Torr).
なお、錫、ビスマス等適当な水溶性塩類のないイオンや有機イオンのイオン交換は、アルコールやアセトン等の有機溶媒溶液を用いて難溶性の塩基性塩が析出しないように反応させることができる。 It should be noted that ion exchange of ions and organic ions without suitable water-soluble salts such as tin and bismuth can be carried out using an organic solvent solution such as alcohol or acetone so that hardly soluble basic salts do not precipitate.
抗菌性ゼオライトの皮膚外用剤中の配合量は特に限定されない。配合目的並びに皮膚外用剤の製品形態によって、適宜決定される。 The blending amount of the antibacterial zeolite in the external preparation for skin is not particularly limited. It is determined appropriately depending on the purpose of blending and the product form of the external preparation for skin.
例えば、防腐剤として配合される場合は、通常、皮膚外用剤全量に対して0.05〜10質量%程度が配合される。 For example, when mix | blending as a preservative, about 0.05-10 mass% is normally mix | blended with respect to the skin external preparation whole quantity.
また、殺菌剤として配合される場合は、通常、皮膚外用剤全量に対して0.1〜90質量%が製品形態に応じて配合される。
例えば、ローションやクリームタイプの皮膚外用剤においては、皮膚外用剤全量に対して0.1〜20質量%が好ましく、粉末タイプの皮膚外用剤においては、皮膚外用剤全量に対して0.5〜80質量%が好ましく、スチックタイプの皮膚外用剤においては、皮膚外用剤全量に対して0.5〜60質量%が好ましく、スプレータイプの皮膚外用剤に対しては0.5〜50質量%が好ましい。
Moreover, when mix | blending as a disinfectant, 0.1-90 mass% is normally mix | blended according to a product form with respect to the skin external preparation whole quantity.
For example, in a lotion or cream type skin external preparation, 0.1 to 20% by mass is preferable with respect to the total amount of the skin external preparation, and in a powder type skin external preparation, 0.5 to 0.5% with respect to the total amount of the skin external preparation. 80% by mass is preferable, and in a stick type skin external preparation, 0.5 to 60% by mass is preferable with respect to the total amount of the skin external preparation, and 0.5 to 50% by mass is applicable to a spray type external skin preparation. preferable.
本発明に用いるポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルは、皮膚外用剤に配合する界面活性剤として公知成分である。通常は香料の可溶化剤としてローションに配合される。 The polyoxyethylene polyoxypropylene 2-decyltetradecyl ether used in the present invention is a known component as a surfactant to be blended in a skin external preparation. Usually, it is blended in a lotion as a solubilizer for a fragrance.
本発明においては、ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテル(20〜28E.O.)(10〜16P.O.)が好ましく、特異的に抗菌性ゼオライトを配合した皮膚外用剤の汚染着防止剤として作用する。
なお、香料の可溶化剤として用いられている他の活性剤、例えばポリオキシエチレン(E.O.60)硬化ひまし油には、皮膚外用剤の汚染着防止効果はない。
In the present invention, polyoxyethylene polyoxypropylene 2-decyl tetradecyl ether (20 to 28 E.O.) (10 to 16 P.O.) is preferable, and contamination of a skin external preparation specifically blended with antibacterial zeolite Acts as an anti-sticking agent.
It should be noted that other active agents used as perfumes solubilizers, such as polyoxyethylene (EO60) hydrogenated castor oil, have no anti-staining effect of the external preparation for skin.
ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテル(20〜28E.O.)(10〜16P.O.)の配合量は、抗菌性ゼオライトの配合量及び製品形態に応じて適宜決定される。通常、皮膚外用剤全量に対して0.01〜5質量%程度である。 The amount of polyoxyethylene polyoxypropylene 2-decyltetradecyl ether (20 to 28 E.O.) (10 to 16 P.O.) is appropriately determined according to the amount of antibacterial zeolite and the product form. Usually, it is about 0.01-5 mass% with respect to the skin external preparation whole quantity.
本発明の皮膚外用剤を、消臭化粧料若しくは制汗化粧料などの用途に用いる場合においては、制汗剤であるアルミニウム化合物を配合することが好ましい。 When the external preparation for skin of the present invention is used for applications such as deodorant cosmetics or antiperspirant cosmetics, it is preferable to blend an aluminum compound that is an antiperspirant.
本発明の皮膚外用剤には上記した必須構成成分の他に通常皮膚外用剤に用いられる他の成分、例えば、下記に例示する成分の一種又は二種以上を必要に応じて適宜配合し、目的とする剤形に応じて常法により製造することが出来る。 In addition to the above-mentioned essential components, the skin external preparation of the present invention is appropriately blended with other components that are usually used in skin external preparations, for example, one or more of the components exemplified below as required. Depending on the dosage form, it can be produced by a conventional method.
粉末成分としては、例えば、無機粉末(例えば、タルク、カオリン、雲母、絹雲母(セリサイト)、白雲母、金雲母、合成雲母、紅雲母、黒雲母、パーミキュライト、炭酸マグネシウム、炭酸カルシウム、ケイ酸アルミニウム、ケイ酸バリウム、ケイ酸カルシウム、ケイ酸マグネシウム、ケイ酸ストロンチウム、タングステン酸金属塩、マグネシウム、シリカ、硫酸バリウム、焼成硫酸カルシウム(焼セッコウ)、リン酸カルシウム、弗素アパタイト、ヒドロキシアパタイト、セラミックパウダー、金属石鹸(例えば、ミリスチン酸亜鉛、パルミチン酸カルシウム、ステアリン酸アルミニウム)、窒化ホウ素等);有機粉末(例えば、ポリアミド樹脂粉末(ナイロン粉末)、ポリエチレン粉末、ポリメタクリル酸メチル粉末、ベンゾグアナミン樹脂粉末、ポリ四弗化エチレン粉末、セルロース粉末等);無機白色顔料(例えば、二酸化チタン、酸化亜鉛等);無機赤色系顔料(例えば、酸化鉄(ベンガラ)、チタン酸鉄等);無機褐色系顔料(例えば、γ−酸化鉄等);無機黄色系顔料(例えば、黄酸化鉄、黄土等);無機黒色系顔料(例えば、黒酸化鉄、低次酸化チタン等);無機紫色系顔料(例えば、マンガンバイオレット、コバルトバイオレット等);無機緑色系顔料(例えば、酸化クロム、水酸化クロム、チタン酸コバルト等);無機青色系顔料(例えば、群青、紺青等);パール顔料(例えば、酸化チタンコーテッドマイカ、酸化チタンコーテッドオキシ塩化ビスマス、酸化チタンコーテッドタルク、着色酸化チタンコーテッドマイカ、オキシ塩化ビスマス、魚鱗箔等);金属粉末顔料(例えば、アルミニウムパウダー、カッパーパウダー等);ジルコニウム、バリウム又はアルミニウムレーキ等の有機顔料(例えば、赤色201号、赤色202号、赤色204号、赤色205号、赤色220号、赤色226号、赤色228号、赤色405号、橙色203号、橙色204号、黄色205号、黄色401号、及び青色404号などの有機顔料、赤色3号、赤色104号、赤色106号、赤色227号、赤色230号、赤色401号、赤色505号、橙色205号、黄色4号、黄色5号、黄色202号、黄色203号、緑色3号及び青色1号等);天然色素(例えば、クロロフィル、β−カロチン等)等が挙げられる。 Examples of the powder component include inorganic powders (for example, talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, saucite, biotite, permiculite, magnesium carbonate, calcium carbonate, silicic acid. Aluminum, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, barium sulfate, calcined calcium sulfate (baked gypsum), calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, metal Soap (for example, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc .; Organic powder (for example, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, benzoguanamine resin powder Polytetrafluoroethylene powder, cellulose powder, etc.); inorganic white pigments (eg, titanium dioxide, zinc oxide, etc.); inorganic red pigments (eg, iron oxide (Bengara), iron titanate, etc.); inorganic brown pigments (eg, For example, γ-iron oxide, etc.); inorganic yellow pigments (for example, yellow iron oxide, ocher, etc.); inorganic black pigments (for example, black iron oxide, low-order titanium oxide, etc.); inorganic purple pigments (for example, manganese) Violet, cobalt violet, etc.); inorganic green pigments (eg, chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (eg, ultramarine blue, bitumen, etc.); pearl pigments (eg, titanium oxide coated mica, Titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigment For example, aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium or aluminum lake (for example, red 201, red 202, red 204, red 205, red 220, red 226, red 228) Organic pigments such as red 405, orange 203, orange 204, yellow 205, yellow 401, and blue 404, red 3, red 104, red 106, red 227, red 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3 and Blue No. 1); natural pigments (eg, chlorophyll, β-carotene, etc.) Etc.
液体油脂としては、例えば、アボガド油、ツバキ油、タートル油、マカデミアナッツ油、トウモロコシ油、ミンク油、オリーブ油、ナタネ油、卵黄油、ゴマ油、パーシック油、小麦胚芽油、サザンカ油、ヒマシ油、アマニ油、サフラワー油、綿実油、エノ油、大豆油、落花生油、茶実油、カヤ油、コメヌカ油、シナギリ油、日本キリ油、ホホバ油、胚芽油、トリグリセリン等が挙げられる。 Examples of liquid oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern castor oil, castor oil, linseed oil , Safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin and the like.
固体油脂としては、例えば、カカオ脂、ヤシ油、硬化ヤシ油、パーム油、パーム核油、モクロウ核油、硬化油、モクロウ、硬化ヒマシ油等が挙げられる。 Examples of the solid fat include cacao butter, coconut oil, hardened coconut oil, palm oil, palm kernel oil, owl kernel oil, hardened oil, owl, and hardened castor oil.
ロウとしては、例えば、ミツロウ、カンデリラロウ、綿ロウ、カルナウバロウ、ベイベリーロウ、イボタロウ、鯨ロウ、モンタンロウ、ヌカロウ、ラノリン、カポックロウ、酢酸ラノリン、液状ラノリン、サトウキビロウ、ラノリン脂肪酸イソプロピル、ラウリン酸ヘキシル、還元ラノリン、ホホバロウ、硬質ラノリン、セラックロウ、POEラノリンアルコールエーテル、POEラノリンアルコールアセテート、POEコレステロールエーテル、ラノリン脂肪酸ポリエチレングリコール、POE水素添加ラノリンアルコールエーテル、セレシン、マイクロクリスタリンワックス等が挙げられる。 Examples of the wax include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, Examples include jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, ceresin, and microcrystalline wax.
炭化水素油としては、例えば、流動パラフィン、オゾケライト、スクワラン、プリスタン、パラフィン、スクワレン、ワセリン等が挙げられる。 Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalane, pristane, paraffin, squalene, petrolatum and the like.
高級脂肪酸としては、例えば、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘニン酸、オレイン酸、ウンデシレン酸、イソステアリン酸、リノール酸、リノレイン酸、エイコサペンタエン酸(EPA)、ドコサヘキサエン酸(DHA)等が挙げられる。 Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the like. Is mentioned.
高級アルコールとしては、例えば、直鎖アルコール(例えば、ラウリルアルコール、セチルアルコール、ステアリルアルコール、ベヘニルアルコール、ミリスチルアルコール、オレイルアルコール、セトステアリルアルコール等);分枝鎖アルコール(例えば、モノステアリルグリセリンエーテル(バチルアルコール)、2-デシルテトラデシノール、ラノリンアルコール、コレステロール、フィトステロール、ヘキシルドデカノール、イソステアリルアルコール、オクチルドデカノール等)等が挙げられる。 Examples of higher alcohols include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol); branched chain alcohols (eg, monostearyl glycerin ether (batyl alcohol) ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyl decanol, isostearyl alcohol, octyldodecanol and the like.
エステル油としては、例えば、ミリスチン酸イソプロピル、オクタン酸セチル、ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、オレイン酸デシル、ジメチルオクタン酸ヘキシルデシル、乳酸セチル、乳酸ミリスチル、酢酸ラノリン、ステアリン酸イソセチル、イソステアリン酸イソセチル、12-ヒドロキシステアリン酸コレステリル、ジ-2-エチルヘキサン酸エチレングリコール、ジペンタエリスリトール脂肪酸エステル、モノイソステアリン酸N-アルキルグリコール、ジカプリン酸ネオペンチルグリコール、リンゴ酸ジイソステアリル、ジ-2-ヘプチルウンデカン酸グリセリン、トリ-2-エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ-2-エチルヘキサン酸ペンタエリスリトール、トリ-2-エチルヘキサン酸グリセリン、トリオクタン酸グリセリン、トリイソパルミチン酸グリセリン、トリイソステアリン酸トリメチロールプロパン、セチル2-エチルヘキサノエート、2-エチルヘキシルパルミテート、トリミリスチン酸グリセリン、トリ-2-ヘプチルウンデカン酸グリセライド、ヒマシ油脂肪酸メチルエステル、オレイン酸オレイル、アセトグリセライド、パルミチン酸2-ヘプチルウンデシル、アジピン酸ジイソブチル、N-ラウロイル-L-グルタミン酸-2-オクチルドデシルエステル、アジピン酸ジ-2-ヘプチルウンデシル、エチルラウレート、セバシン酸ジ−2-エチルヘキシル、ミリスチン酸2-ヘキシルデシル、パルミチン酸2-ヘキシルデシル、アジピン酸2-ヘキシルデシル、セバシン酸ジイソプロピル、コハク酸2-エチルヘキシル、クエン酸トリエチル等が挙げられる。 Examples of ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, lactic acid Myristyl, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, Diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trime triisostearate Roll propane, tetra-2-ethylhexanoic acid pentaerythritol, tri-2-ethylhexanoic acid glycerin, trioctanoic acid glycerin, triisopalmitic acid glycerin, triisostearic acid trimethylolpropane, cetyl 2-ethylhexanoate, 2-ethylhexyl Palmitate, glyceryl trimyristate, glyceride tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyl adipate Decyl, diisopropyl sebacate, 2-ethylhexyl succinate, and triethyl citrate.
シリコーン油としては、例えば、鎖状ポリシロキサン(例えば、ジメチルポリシロキサン、メチルフェニルポリシロキサン、ジフェニルポリシロキサン等);環状ポリシロキサン(例えば、オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサシロキサン等)、3次元網目構造を形成しているシリコーン樹脂、シリコーンゴム、各種変性ポリシロキサン(アミノ変性ポリシロキサン、ポリエーテル変性ポリシロキサン、アルキル変性ポリシロキサン、フッ素変性ポリシロキサン等)等が挙げられる。 Examples of the silicone oil include linear polysiloxanes (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexyl). And silicone resins that form a three-dimensional network structure, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.) It is done.
アニオン界面活性剤としては、例えば、脂肪酸セッケン(例えば、ラウリン酸ナトリウム、パルミチン酸ナトリウム等);高級アルキル硫酸エステル塩(例えば、ラウリル硫酸ナトリウム、ラウリル硫酸カリウム等);アルキルエーテル硫酸エステル塩(例えば、POE-ラウリル硫酸トリエタノールアミン、POE-ラウリル硫酸ナトリウム等);N-アシルサルコシン酸(例えば、ラウロイルサルコシンナトリウム等);高級脂肪酸アミドスルホン酸塩(例えば、N-ミリストイル-N-メチルタウリンナトリウム、ヤシ油脂肪酸メチルタウリンナトリウム、ラウリルメチルタウリンナトリウム等);リン酸エステル塩(POE-オレイルエーテルリン酸ナトリウム、POE-ステアリルエーテルリン酸等);スルホコハク酸塩(例えば、ジ-2-エチルヘキシルスルホコハク酸ナトリウム、モノラウロイルモノエタノールアミドポリオキシエチレンスルホコハク酸ナトリウム、ラウリルポリプロピレングリコールスルホコハク酸ナトリウム等);アルキルベンゼンスルホン酸塩(例えば、リニアドデシルベンゼンスルホン酸ナトリウム、リニアドデシルベンゼンスルホン酸トリエタノールアミン、リニアドデシルベンゼンスルホン酸等);高級脂肪酸エステル硫酸エステル塩(例えば、硬化ヤシ油脂肪酸グリセリン硫酸ナトリウム等);N-アシルグルタミン酸塩(例えば、N-ラウロイルグルタミン酸モノナトリウム、N-ステアロイルグルタミン酸ジナトリウム、N-ミリストイル-L-グルタミン酸モノナトリウム等);硫酸化油(例えば、ロート油等);POE-アルキルエーテルカルボン酸;POE-アルキルアリルエーテルカルボン酸塩;α-オレフィンスルホン酸塩;高級脂肪酸エステルスルホン酸塩;二級アルコール硫酸エステル塩;高級脂肪酸アルキロールアミド硫酸エステル塩;ラウロイルモノエタノールアミドコハク酸ナトリウム;N-パルミトイルアスパラギン酸ジトリエタノールアミン;カゼインナトリウム等が挙げられる。 Anionic surfactants include, for example, fatty acid soaps (eg, sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (eg, POE-lauryl sulfate triethanolamine, POE-sodium lauryl sulfate, etc.); N-acyl sarcosine acids (eg, sodium lauroyl sarcosine, etc.); higher fatty acid amide sulfonates (eg, sodium N-myristoyl-N-methyl taurate, palm Oil fatty acid methyl taurine sodium, lauryl methyl taurine sodium, etc .; phosphate ester salts (POE-oleyl ether sodium phosphate, POE-stearyl ether phosphate, etc.); sulfosuccinates (eg, di-2-ethylhexyl sulfosuccinate) Sodium salt, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); alkylbenzene sulfonates (eg, sodium linear dodecyl benzene sulfonate, triethanolamine linear dodecyl benzene sulfonate, linear dodecyl benzene) Sulfonic acid, etc.); higher fatty acid ester sulfate (eg, hydrogenated coconut oil fatty acid sodium glycerol sulfate, etc.); N-acyl glutamate (eg, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, N-myristoyl- L-glutamate monosodium etc.); sulfated oil (eg funnel oil etc.); POE-alkyl ether carboxylic acid; POE-alkyl allyl ether cal Α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkylolamide sulfates; lauroyl monoethanolamide sodium succinate; N-palmitoyl aspartate ditriethanolamine ; Sodium caseinate and the like.
カチオン界面活性剤としては、例えば、アルキルトリメチルアンモニウム塩(例えば、塩化ステアリルトリメチルアンモニウム、塩化ラウリルトリメチルアンモニウム等);アルキルピリジニウム塩(例えば、塩化セチルピリジニウム等);塩化ジステアリルジメチルアンモニウムジアルキルジメチルアンモニウム塩;塩化ポリ(N,N'-ジメチル-3,5-メチレンピペリジニウム);アルキル四級アンモニウム塩;アルキルジメチルベンジルアンモニウム塩;アルキルイソキノリニウム塩;ジアルキルモリホニウム塩;POE-アルキルアミン;アルキルアミン塩;ポリアミン脂肪酸誘導体;アミルアルコール脂肪酸誘導体;塩化ベンザルコニウム;塩化ベンゼトニウム等が挙げられる。 Examples of the cationic surfactant include alkyltrimethylammonium salts (eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (eg, cetylpyridinium chloride, etc.); distearyldimethylammonium dialkyldimethylammonium chloride; Poly (N, N'-dimethyl-3,5-methylenepiperidinium chloride); alkyl quaternary ammonium salt; alkyldimethylbenzylammonium salt; alkylisoquinolinium salt; dialkyl morpholinium salt; POE-alkylamine; Examples include alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride and the like.
両性界面活性剤としては、例えば、イミダゾリン系両性界面活性剤(例えば、2-ウンデシル-N,N,N-(ヒドロキシエチルカルボキシメチル)-2-イミダゾリンナトリウム、2-ココイル-2-イミダゾリニウムヒドロキサイド-1-カルボキシエチロキシ2ナトリウム塩等);ベタイン系界面活性剤(例えば、2-ヘプタデシル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリニウムベタイン、ラウリルジメチルアミノ酢酸ベタイン、アルキルベタイン、アミドベタイン、スルホベタイン等)等が挙げられる。 Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide). Side-1-carboxyethyloxy disodium salt, etc.); betaine surfactants (for example, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amide betaine) , Sulfobetaine, etc.).
親油性非イオン界面活性剤としては、例えば、ソルビタン脂肪酸エステル類(例えば、ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンセスキオレエート、ソルビタントリオレエート、ペンタ-2-エチルヘキシル酸ジグリセロールソルビタン、テトラ-2-エチルヘキシル酸ジグリセロールソルビタン等);グリセリンポリグリセリン脂肪酸類(例えば、モノ綿実油脂肪酸グリセリン、モノエルカ酸グリセリン、セスキオレイン酸グリセリン、モノステアリン酸グリセリン、α,α'-オレイン酸ピログルタミン酸グリセリン、モノステアリン酸グリセリンリンゴ酸等);プロピレングリコール脂肪酸エステル類(例えば、モノステアリン酸プロピレングリコール等);硬化ヒマシ油誘導体;グリセリンアルキルエーテル等が挙げられる。 Examples of the lipophilic nonionic surfactant include sorbitan fatty acid esters (for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, Sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate); glycerin polyglycerin fatty acids (eg mono cottonseed oil fatty acid glycerin, monoerucic acid glycerin, sesquioleate glycerin, monostearin) Glycerin acid, α, α'-oleic acid pyroglutamate glycerin, monostearic acid glycerin malic acid, etc.); propylene glycol fatty acid esters (eg monostearies) Propylene glycolate, etc.); hardened castor oil derivative; glycerin alkyl ether, etc.
親水性非イオン界面活性剤としては、例えば、POE-ソルビタン脂肪酸エステル類(例えば、POE-ソルビタンモノオレエート、POE-ソルビタンモノステアレート、POE-ソルビタンモノオレート、POE-ソルビタンテトラオレエート等);POEソルビット脂肪酸エステル類(例えば、POE-ソルビットモノラウレート、POE-ソルビットモノオレエート、POE-ソルビットペンタオレエート、POE-ソルビットモノステアレート等);POE-グリセリン脂肪酸エステル類(例えば、POE-グリセリンモノステアレート、POE-グリセリンモノイソステアレート、POE-グリセリントリイソステアレート等のPOE-モノオレエート等);POE-脂肪酸エステル類(例えば、POE-ジステアレート、POE-モノジオレエート、ジステアリン酸エチレングリコール等);POE-アルキルエーテル類(例えば、POE-ラウリルエーテル、POE-オレイルエーテル、POE-ステアリルエーテル、POE-ベヘニルエーテル、POE-2-オクチルドデシルエーテル、POE-コレスタノールエーテル等);プルロニック型類(例えば、プルロニック等);POE・POP-アルキルエーテル類(例えば、POE・POP-セチルエーテル、POE・POP-2-デシルテトラデシルエーテル、POE・POP-モノブチルエーテル、POE・POP-水添ラノリン、POE・POP-グリセリンエーテル等);テトラPOE・テトラPOP-エチレンジアミン縮合物類(例えば、テトロニック等);POE-ヒマシ油硬化ヒマシ油誘導体(例えば、POE-ヒマシ油、POE-硬化ヒマシ油、POE-硬化ヒマシ油モノイソステアレート、POE-硬化ヒマシ油トリイソステアレート、POE-硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、POE-硬化ヒマシ油マレイン酸等);POE-ミツロウ・ラノリン誘導体(例えば、POE-ソルビットミツロウ等);アルカノールアミド(例えば、ヤシ油脂肪酸ジエタノールアミド、ラウリン酸モノエタノールアミド、脂肪酸イソプロパノールアミド等);POE-プロピレングリコール脂肪酸エステル;POE-アルキルアミン;POE-脂肪酸アミド;ショ糖脂肪酸エステル;アルキルエトキシジメチルアミンオキシド;トリオレイルリン酸等が挙げられる。 Examples of hydrophilic nonionic surfactants include POE-sorbitan fatty acid esters (for example, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE sorbite fatty acid esters (eg, POE-sorbite monolaurate, POE-sorbite monooleate, POE-sorbite pentaoleate, POE-sorbite monostearate, etc.); POE-glycerin fatty acid esters (eg, POE-glycerin) Monostearate, POE-glycerol monoisostearate, POE-monooleate such as POE-glycerol triisostearate, etc.); POE-fatty acid esters (for example, POE-distearate, POE-monodiolate, ethylene glycol distearate, etc.); POE-alkyl ethers (eg POE- Uril ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); Pluronic type (for example, Pluronic, etc.); POE / POP-alkyl ether (For example, POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, etc.); Tetra POE / tetra POP-ethylenediamine condensates (eg Tetronic, etc.); POE-castor oil hardened castor oil derivatives (eg POE-castor oil, POE-hardened castor oil, POE-hardened castor oil monoisostearate, POE-hardened castor Oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearic acid diester, POE-hardened castor oil maleic acid, etc.); PO E-beeswax lanolin derivatives (eg POE-sorbite beeswax); alkanolamides (eg coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid ester; POE-alkylamine POE-fatty acid amide; sucrose fatty acid ester; alkyl ethoxydimethylamine oxide; trioleyl phosphate and the like.
保湿剤としては、例えば、ポリエチレングリコール、プロピレングリコール、グリセリン、1,3-ブチレングリコール、キシリトール、ソルビトール、マルチトール、コンドロイチン硫酸、ヒアルロン酸、ムコイチン硫酸、カロニン酸、アテロコラーゲン、コレステリル-12-ヒドロキシステアレート、乳酸ナトリウム、胆汁酸塩、dl-ピロリドンカルボン酸塩、短鎖可溶性コラーゲン、ジグリセリン(EO)PO付加物、イザヨイバラ抽出物、セイヨウノコギリソウ抽出物、メリロート抽出物等が挙げられる。 Examples of the humectant include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate Sodium lactate, bile salt, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adduct, Izayoi rose extract, yarrow extract, merirot extract and the like.
天然の水溶性高分子としては、例えば、植物系高分子{例えば、アラビアガム、トラガカントガム、ガラクタン、グアガム、キャロブガム、カラヤガム、カラギーナン、ペクチン、カンテン、クインスシード(マルメロ)、アルゲコロイド(カッソウエキス)、デンプン(コメ、トウモロコシ、バレイショ、コムギ)、グリチルリチン酸};微生物系高分子(例えば、キサンタンガム、デキストラン、サクシノグルカン、ブルラン等);その他(例えば、魚由来コラーゲン、魚由来ゼラチン、コムギタンパク、シルクタンパク等)等が挙げられる。 Examples of natural water-soluble polymers include plant-based polymers (for example, gum arabic, gum tragacanth, galactan, guar gum, carob gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), alge colloid (guckweed extract), starch (Rice, corn, potato, wheat), glycyrrhizic acid}; microbial polymers (eg, xanthan gum, dextran, succinoglucan, bull run); others (eg, fish-derived collagen, fish-derived gelatin, wheat protein, silk protein) Etc.).
半合成の水溶性高分子としては、例えば、デンプン系高分子(例えば、カルボキシメチルデンプン、メチルヒドロキシプロピルデンプン等);セルロース系高分子(メチルセルロース、エチルセルロース、メチルヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、セルロース硫酸ナトリウム、ヒドロキシプロピルセルロース、カルボキシメチルセルロース、カルボキシメチルセルロースナトリウム、結晶セルロース、セルロース末等);アルギン酸系高分子(例えば、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等)等が挙げられる。 Semi-synthetic water-soluble polymers include, for example, starch polymers (eg, carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose polymers (methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate) Hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder and the like); alginic acid polymers (for example, sodium alginate, propylene glycol alginate, etc.) and the like.
合成の水溶性高分子としては、例えば、ビニル系高分子(例えば、ポリビニルアルコール、ポリビニルメチルエーテル、ポリビニルピロリドン、カルボキシビニルポリマー等);ポリオキシエチレン系高分子(例えば、ポリエチレングリコール20,000、40,000、60,000のポリオキシエチレンポリオキシプロピレン共重合体等);アクリル系高分子(例えば、ポリアクリル酸ナトリウム、ポリエチルアクリレート、ポリアクリルアミド等);ポリエチレンイミン;カチオンポリマー等が挙げられる。 Synthetic water-soluble polymers include, for example, vinyl polymers (eg, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer); polyoxyethylene polymers (eg, polyethylene glycol 20,000, 40,000, 60,000). Polyoxyethylene polyoxypropylene copolymer, etc.); acrylic polymers (for example, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethyleneimine; cationic polymers, and the like.
増粘剤としては、例えば、アラビアガム、カラギーナン、カラヤガム、トラガカントガム、キャロブガム、クインスシード(マルメロ)、カゼイン、デキストリン、ゼラチン、ペクチン酸ナトリウム、アラギン酸ナトリウム、メチルセルロース、エチルセルロース、CMC、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、PVA、PVM、PVP、ポリアクリル酸ナトリウム、カルボキシビニルポリマー、ローカストビーンガム、グアーガム、タマリントガム、ジアルキルジメチルアンモニウム硫酸セルロース、キサンタンガム、ケイ酸アルミニウムマグネシウム、ベントナイト、ヘクトライト、ケイ酸AlMg(ビーガム)、ラポナイト、無水ケイ酸等が挙げられる。 Examples of the thickener include gum arabic, carrageenan, caraya gum, gum tragacanth, carob gum, quince seed (malmello), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, CMC, hydroxyethylcellulose, hydroxypropyl Cellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, cellulose dialkyldimethylammonium sulfate, xanthan gum, magnesium aluminum silicate, bentonite, hectorite, AlMg silicate (Beegum), Examples thereof include laponite and silicic anhydride.
紫外線吸収剤としては下記化合物が挙げられる。
(1)安息香酸系紫外線吸収剤
例えば、パラアミノ安息香酸(以下、PABAと略す)、PABAモノグリセリンエステル、N,N-ジプロポキシPABAエチルエステル、N,N-ジエトキシPABAエチルエステル、N,N-ジメチルPABAエチルエステル、N,N-ジメチルPABAブチルエステル、N,N-ジメチルPABAエチルエステルなど。
(2)アントラニル酸系紫外線吸収剤
例えば、ホモメンチル-N- アセチルアントラニレートなど。
(3)サリチル酸系紫外線吸収剤
例えば、アミルサリシレート、メンチルサリシレート、ホモメンチルサリシレート、オクチルサリシレート、フェニルサリシレート、ベンジルサリシレート、p-イソプロパノールフェニルサリシレートなど。
(4)ケイ皮酸系紫外線吸収剤
例えば、オクチルシンナメート、エチル-4-イソプロピルシンナメート、メチル-2,5-ジイソプロピルシンナメート、エチル-2,4-ジイソプロピルシンナメート、メチル-2,4-ジイソプロピルシンナメート、プロピル-p-メトキシシンナメート、イソプロピル-p-メトキシシンナメート、イソアミル-p-メトキシシンナメート、オクチル-p-メトキシシンナメート(2-エチルヘキシル-p-メトキシシンナメート) 、2-エトキシエチル-p-メトキシシンナメート、シクロヘキシル-p-メトキシシンナメート、エチル-α-シアノ-β-フェニルシンナメート、2-エチルヘキシル-α-シアノ-β-フェニルシンナメート、グリセリルモノ-2-エチルヘキサノイル-ジパラメトキシシンナメートなど。
(5)トリアジン系紫外線吸収剤
例えば、ビスレゾルシニルトリアジン。
さらに具体的には、ビス{〔4−(2−エチルヘキシロキシ)−2−ヒドロキシ〕フェニル}−6−(4−メトキシフェニル)1,3,5−トリアジン、2,4,6−トリス{4−(2−エチルヘキシロキシカルボニル)アニリノ}1,3,5−トリアジンなど。
(6)その他の紫外線吸収剤
例えば、3-(4'-メチルベンジリデン)-d,l-カンファー、3-ベンジリデン-d,l-カンファー、2-フェニル-5-メチルベンゾキサゾール、2,2'-ヒドロキシ-5-メチルフェニルベンゾトリアゾール、2-(2'-ヒドロキシ-5'-t-オクチルフェニル) ベンゾトリアゾール、2-(2'-ヒドロキシ-5'-メチルフェニルベンゾトリアゾール、ジベンザラジン、ジアニソイルメタン、4-メトキシ-4'-t-ブチルジベンゾイルメタン、5-(3,3-ジメチル-2-ノルボルニリデン)-3-ペンタン-2-オンなど。ジモルホリノピリダジノンなどのピリダジン誘導体。
Examples of the ultraviolet absorber include the following compounds.
(1) Benzoic acid ultraviolet absorbers For example, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester and the like.
(2) Anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate.
(3) Salicylic acid ultraviolet absorbers such as amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, and the like.
(4) Cinnamic acid UV absorbers For example, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4- Diisopropyl cinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxy Ethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl -Diparamethoxycinnamate.
(5) Triazine-based ultraviolet absorber, for example, bisresorcinyl triazine.
More specifically, bis {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) 1,3,5-triazine, 2,4,6-tris { 4- (2-ethylhexyloxycarbonyl) anilino} 1,3,5-triazine and the like.
(6) Other UV absorbers For example, 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor, 2-phenyl-5-methylbenzoxazole, 2,2 '-Hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole, dibenzalazine, dianisoyl Methane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, etc. Pyridazine derivatives such as dimorpholinopyridazinone.
金属イオン封鎖剤としては、例えば、1-ヒドロキシエタン-1,1-ジフォスホン酸、1-ヒドロキシエタン-1,1-ジフォスホン酸四ナトリウム塩、エデト酸二ナトリウム、エデト酸三ナトリウム、エデト酸四ナトリウム、クエン酸ナトリウム、ポリリン酸ナトリウム、メタリン酸ナトリウム、グルコン酸、リン酸、クエン酸、アスコルビン酸、コハク酸、エデト酸等が挙げられる。 Examples of the sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate. Sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid and the like.
低級アルコールとしては、例えば、エタノール、プロパノール、イソプロパノール、イソブチルアルコール、t-ブチルアルコール等が挙げられる。 Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
多価アルコールとしては、例えば、2価のアルコール(例えば、エチレングリコール、プロピレングリコール、トリメチレングリコール、1,2-ブチレングリコール、1,3-ブチレングリコール、テトラメチレングリコール、2,3-ブチレングリコール、ペンタメチレングリコール、2-ブテン-1,4-ジオール、ヘキシレングリコール、オクチレングリコール等);3価のアルコール(例えば、グリセリン、トリメチロールプロパン等);4価アルコール(例えば、1,2,6-ヘキサントリオール等のペンタエリスリトール等);5価アルコール(例えば、キシリトール等);6価アルコール(例えば、ソルビトール、マンニトール等);多価アルコール重合体(例えば、ジエチレングリコール、ジプロピレングリコール、トリエチレングリコール、ポリプロピレングリコール、テトラエチレングリコール、ジグリセリン、ポリエチレングリコール、トリグリセリン、テトラグリセリン、ポリグリセリン等);2価のアルコールアルキルエーテル類(例えば、エチレングリコールモノメチルエーテル、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、エチレングリコールモノフェニルエーテル、エチレングリコールモノヘキシルエーテル、エチレングリコールモノ2-メチルヘキシルエーテル、エチレングリコールイソアミルエーテル、エチレングリコールベンジルエーテル、エチレングリコールイソプロピルエーテル、エチレングリコールジメチルエーテル、エチレングリコールジエチルエーテル、エチレングリコールジブチルエーテル等);2価アルコールアルキルエーテル類(例えば、ジエチレングリコールモノメチルエーテル、ジエチレングリコールモノエチルエーテル、ジエチレングリコールモノブチルエーテル、ジエチレングリコールジメチルエーテル、ジエチレングリコールジエチルエーテル、ジエチレングリコールブチルエーテル、ジエチレングリコールメチルエチルエーテル、トリエチレングリコールモノメチルエーテル、トリエチレングリコールモノエチルエーテル、プロピレングリコールモノメチルエーテル、プロピレングリコールモノエチルエーテル、プロピレングリコールモノブチルエーテル、プロピレングリコールイソプロピルエーテル、ジプロピレングリコールメチルエーテル、ジプロピレングリコールエチルエーテル、ジプロピレングリコールブチルエーテル等);2価アルコールエーテルエステル(例えば、エチレングリコールモノメチルエーテルアセテート、エチレングリコールモノエチルエーテルアセテート、エチレングリコールモノブチルエーテルアセテート、エチレングリコールモノフェニルエーテルアセテート、エチレングリコールジアジベート、エチレングリコールジサクシネート、ジエチレングリコールモノエチルエーテルアセテート、ジエチレングリコールモノブチルエーテルアセテート、プロピレングリコールモノメチルエーテルアセテート、プロピレングリコールモノエチルエーテルアセテート、プロピレングリコールモノプロピルエーテルアセテート、プロピレングリコールモノフェニルエーテルアセテート等);グリセリンモノアルキルエーテル(例えば、キミルアルコール、セラキルアルコール、バチルアルコール等);糖アルコール(例えば、ソルビトール、マルチトール、マルトトリオース、マンニトール、ショ糖、エリトリトール、グルコース、フルクトース、デンプン分解糖、マルトース、キシリトース、デンプン分解糖還元アルコール等);グリソリッド;テトラハイドロフルフリルアルコール;POE-テトラハイドロフルフリルアルコール;POP-ブチルエーテル;POP・POE-ブチルエーテル;トリポリオキシプロピレングリセリンエーテル;POP-グリセリンエーテル;POP-グリセリンエーテルリン酸;POP・POE-ペンタンエリスリトールエーテル、ポリグリセリン等が挙げられる。 Examples of the polyhydric alcohol include divalent alcohols (for example, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, Pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc.); trivalent alcohol (eg, glycerin, trimethylolpropane, etc.); tetravalent alcohol (eg, 1,2,6) Pentaerythritol such as hexanetriol); pentahydric alcohol (eg, xylitol, etc.); hexavalent alcohol (eg, sorbitol, mannitol, etc.); polyhydric alcohol polymer (eg, diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene Glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin, etc.); divalent alcohol alkyl ethers (for example, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene) Glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, etc.) ; Dihydric alcohol alkyl ester Tellurium (for example, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether , Propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, etc.); divalent alcohol Ether esters (eg, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diazinate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol) Monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc .; glycerin monoalkyl ethers (for example, Kimyl alcohol, Serakir al Sugar alcohol (eg, sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, amylolytic sugar, maltose, xylitolose, amylolytic sugar reducing alcohol, etc.); Solid; tetrahydrofurfuryl alcohol; POE-tetrahydrofurfuryl alcohol; POP-butyl ether; POP / POE-butyl ether; tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphate; POP / POE-pentaneerythritol Examples include ether and polyglycerin.
単糖としては、例えば、三炭糖(例えば、D-グリセリルアルデヒド、ジヒドロキシアセトン等);四炭糖(例えば、D-エリトロース、D-エリトルロース、D-トレオース、エリスリトール等);五炭糖(例えば、L-アラビノース、D-キシロース、L-リキソース、D-アラビノース、D-リボース、D-リブロース、D-キシルロース、L-キシルロース等);六炭糖(例えば、D-グルコース、D-タロース、D-ブシコース、D-ガラクトース、D-フルクトース、L-ガラクトース、L-マンノース、D-タガトース等);七炭糖(例えば、アルドヘプトース、ヘプロース等);八炭糖(例えば、オクツロース等);デオキシ糖(例えば、2-デオキシ-D-リボース、6-デオキシ-L-ガラクトース、6-デオキシ-L-マンノース等);アミノ糖(例えば、D-グルコサミン、D-ガラクトサミン、シアル酸、アミノウロン酸、ムラミン酸等);ウロン酸(例えば、D-グルクロン酸、D-マンヌロン酸、L-グルロン酸、D-ガラクツロン酸、L-イズロン酸等)等が挙げられる。 Monosaccharides include, for example, tricarbon sugars (eg, D-glyceryl aldehyde, dihydroxyacetone, etc.); tetracarbon sugars (eg, D-erythrose, D-erythrulose, D-treose, erythritol, etc.); pentose sugars (eg, , L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc .; hexose (eg, D-glucose, D-talose, D) -Bucicose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, etc.); pentose sugar (eg, aldheptose, heproose, etc.); octose sugar (eg, octulose, etc.); For example, 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-L-mannose, etc .; amino sugar (eg, D-glucosamine, D-galactosamine, shea Acid, Aminouron acid, muramic acid); uronic acid (e.g., D- glucuronic acid, D- mannuronic acid, L- guluronic acid, D- galacturonic acid, L- iduronic acid) and the like.
オリゴ糖としては、例えば、ショ糖、ウンベリフェロース、ラクトース、プランテオース、イソリクノース類、α,α−トレハロース、ラフィノース、リクノース類、ウンビリシン、スタキオースベルバスコース類等が挙げられる。 Examples of the oligosaccharide include sucrose, umbelliferose, lactose, planteose, isolicnose, α, α-trehalose, raffinose, lycnose, umbilicin, stachyose verbus course and the like.
多糖としては、例えば、セルロース、クインスシード、コンドロイチン硫酸、デンプン、ガラクタン、デルマタン硫酸、グリコーゲン、アラビアガム、ヘパラン硫酸、ヒアルロン酸、トラガントガム、ケラタン硫酸、コンドロイチン、キサンタンガム、ムコイチン硫酸、グアガム、デキストラン、ケラト硫酸、ローカストビンガム、サクシノグルカン、カロニン酸等が挙げられる。 Examples of the polysaccharide include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran, kerato sulfate. , Locust bingham, succinoglucan, caronic acid and the like.
アミノ酸としては、例えば、中性アミノ酸(例えば、スレオニン、システイン等);塩基性アミノ酸(例えば、ヒドロキシリジン等)等が挙げられる。また、アミノ酸誘導体として、例えば、アシルサルコシンナトリウム(ラウロイルサルコシンナトリウム)、アシルグルタミン酸塩、アシルβ-アラニンナトリウム、グルタチオン、ピロリドンカルボン酸等が挙げられる。 Examples of amino acids include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like. Examples of amino acid derivatives include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl β-alanine sodium, glutathione, and pyrrolidone carboxylic acid.
有機アミンとしては、例えば、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、モルホリン、トリイソプロパノールアミン、2-アミノ-2-メチル−1,3-プロパンジオール、2-アミノ-2-メチル-1-プロパノール等が挙げられる。 Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol. Is mentioned.
高分子エマルジョンとしては、例えば、アクリル樹脂エマルジョン、ポリアクリル酸エチルエマルジョン、アクリルレジン液、ポリアクリルアルキルエステルエマルジョン、ポリ酢酸ビニル樹脂エマルジョン、天然ゴムラテックス等が挙げられる。 Examples of the polymer emulsion include an acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and a natural rubber latex.
pH調製剤としては、例えば、乳酸−乳酸ナトリウム、クエン酸−クエン酸ナトリウム、コハク酸−コハク酸ナトリウム等の緩衝剤等が挙げられる。 Examples of the pH adjuster include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
ビタミンとしては、例えば、ビタミンA、B1、B2、B6、C、Eおよびその誘導体、パントテン酸およびその誘導体、ビオチン等が挙げられる。 Examples of vitamins include vitamins A, B1, B2, B6, C, E and derivatives thereof, pantothenic acid and derivatives thereof, biotin and the like.
酸化防止剤としては、例えば、トコフェロール類、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、没食子酸エステル類等が挙げられる。 Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.
酸化防止助剤としては、例えば、リン酸、クエン酸、アスコルビン酸、マレイン酸、マロン酸、コハク酸、フマル酸、ケファリン、ヘキサメタフォスフェイト、フィチン酸、エチレンジアミン四酢酸等が挙げられる。 Examples of the antioxidant assistant include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.
その他の配合可能成分としては、例えば、防腐剤(メチルパラベン、エチルパラベン、ブチルパラベン、フェノキシエタノール等);消炎剤(例えば、グリチルリチン酸誘導体、グリチルレチン酸誘導体、サリチル酸誘導体、ヒノキチオール、酸化亜鉛、アラントイン等);美白剤(例えば、ユキノシタ抽出物、アルブチン、トラネキサム酸、L−アスコルビン酸、L−アスコルビン酸リン酸エステルマグネシウム塩、L−アスコルビン酸グルコシド、4−メトキシサリチル酸カリウム等);各種抽出物(例えば、オウバク、オウレン、シコン、シャクヤク、センブリ、バーチ、セージ、ビワ、ニンジン、アロエ、ゼニアオイ、アイリス、ブドウ、ヨクイニン、ヘチマ、ユリ、サフラン、センキュウ、ショウキュウ、オトギリソウ、オノニス、ニンニク、トウガラシ、チンピ、トウキ、海藻等)、賦活剤(例えば、ローヤルゼリー、感光素、コレステロール誘導体等);血行促進剤(例えば、ニコチン酸ベンジルエステル、ニコチン酸β−ブトキシエチルエステル、カプサイシン、ジンゲロン、カンタリスチンキ、イクタモール、タンニン酸、α−ボルネオール、ニコチン酸トコフェロール、イノシトールヘキサニコチネート、シクランデレート、シンナリジン、トラゾリン、アセチルコリン、ベラパミル、セファランチン、γ−オリザノール等);抗脂漏剤(例えば、硫黄、チアントール等);抗炎症剤(例えば、チオタウリン、ヒポタウリン等);殺菌剤(例えば、安息香酸及びその塩類、イソプロピルメチルフェノール、ウンデシレン酸及びその塩類、ウンデシレン酸モノエタノールアミド、塩化セチルトリメチルアンモニウム、塩化セチルピリジニウム、塩化ベンザルコニウム、塩化ベンザトニウム、塩化アルキルジアミノエチルグリシン、塩化クロルヘキシジン、オルトフェニルフェノール、グルコン酸クロルヘキシジン、クレゾール、クロラミンT、クロルキシレノール、クロルクレゾール、クロルフェネシン、クロロブタノール、5−クロロ−2−メチル−4−イソチアゾリン−3−オン、サリチル酸及びその塩類、1,3−ジメチロール−5,5−ジメチルヒダントイン、臭化アルキルイソキノリニウム、臭化ドミフェン、ソルビン酸及びその塩類、チモール、チラム、デヒドロ酢酸及びその塩類、トリクロサン、トリクロロカルバニリド、パラオキシ安息香酸エステル、パラクロルフェノール、ハロカルバン、ピロガロール、フェノール、ヘキサクロロフェン、2−メチルー4−イソチアゾリンー3−オン、・・"−メチレンビス(・'−(3−ヒドロキシメチルー2.5−ジオキソ−4−イミダゾリジニルウレア、ラウロイルサルコシンナトリウム、レゾルシン等)等が挙げられる。 Examples of other components that can be blended include preservatives (methyl paraben, ethyl paraben, butyl paraben, phenoxyethanol, etc.); anti-inflammatory agents (eg, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); Whitening agents (for example, Yukinosita extract, arbutin, tranexamic acid, L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid glucoside, potassium 4-methoxysalicylate, etc.); various extracts (for example, buckwheat , Oren, shikon, peony, assembly, birch, sage, loquat, carrot, aloe, mallow, iris, grape, yokuinin, loofah, lily, saffron, senkyu, ginger, hypericum, onionis Garlic, capsicum, chimpi, toki, seaweed, etc.), activator (eg, royal jelly, photosensitizer, cholesterol derivative, etc.); blood circulation promoter (eg, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, gingerone, Cantharis tincture, icutamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandrate, cinnarizine, tolazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, etc .; antiseborrheic agents (eg, sulfur Anti-inflammatory agents (eg, thiotaurine, hypotaurine, etc.); bactericides (eg, benzoic acid and its salts, isopropylmethylphenol, undecylenic acid and its salts, undecylenic acid monoeta Uramide, cetyltrimethylammonium chloride, cetylpyridinium chloride, benzalkonium chloride, benzathonium chloride, alkyldiaminoethylglycine chloride, chlorhexidine chloride, orthophenylphenol, chlorhexidine gluconate, cresol, chloramine T, chlorxylenol, chlorcresol, chlorphenesin Chlorobutanol, 5-chloro-2-methyl-4-isothiazolin-3-one, salicylic acid and its salts, 1,3-dimethylol-5,5-dimethylhydantoin, alkylisoquinolinium bromide, domifene bromide, Sorbic acid and its salts, thymol, thiram, dehydroacetic acid and its salts, triclosan, trichlorocarbanilide, p-hydroxybenzoic acid ester, parachlorophenol, halocarba , Pyrogallol, phenol, hexachlorophene, 2-methyl-4-isothiazolin-3-one, .. "-methylenebis (.'- (3-hydroxymethyl-2.5-dioxo-4-imidazolidinyl urea, lauroyl sarcosine sodium , Resorcinol and the like).
次に実施例をあげて本発明をさらに具体的に説明する。本発明はこれによって限定されるものではない。配合量は特に断りのない限り質量%である。 Next, the present invention will be described more specifically with reference to examples. The present invention is not limited thereby. The blending amount is mass% unless otherwise specified.
「表1」に示す処方で、粉末ローションタイプの制汗ローションを調製し、衣類へ一定量(4μg/cm2)塗布した。日光を暴露(10分)し、通常の衣類用洗剤と洗濯機による洗濯の後、汚染着の度合いを目視により評価した。比較例として、ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテル(20〜28E.O.)(10〜16P.O.)を配合しない処方、ポリオキシエチレン(E.O.60)硬化ひまし油を配合した処方について検討した。汚染着の度合いは、皮膚外用剤として許容範囲にある場合を○、そうでない場合を×として評価した。 A powder lotion type antiperspirant lotion was prepared according to the formulation shown in “Table 1”, and a certain amount (4 μg / cm 2 ) was applied to clothing. After exposure to sunlight (10 minutes), washing with a normal laundry detergent and washing machine, the degree of contamination was visually evaluated. As a comparative example, a formulation that does not contain polyoxyethylene polyoxypropylene 2-decyltetradecyl ether (20-28E.O.) (10-16P.O.), A formulation that contains polyoxyethylene (EO60) hydrogenated castor oil investigated. The degree of contamination was evaluated as ○ when the skin external preparation was within the allowable range, and × when it was not.
上記の結果から、ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテル(20〜28E.O.)(10〜16P.O.)を配合していない比較例及びポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテル(20〜28E.O.)(10〜16P.O.)の代わりにポリオキシエチレン(E.O.60)硬化ひまし油を配合した比較例においては、汚染着が大きいことが分かる。
これに対して、ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテル(20〜28E.O.)(10〜16P.O.)を配合した実施例においては、汚染着が極めて小さく、皮膚外用剤としての許容範囲内であり、優れた耐汚染着効果を発揮していることが分かる。
From the above results, the comparative example and polyoxyethylene polyoxypropylene 2-decyl not containing polyoxyethylene polyoxypropylene 2-decyl tetradecyl ether (20 to 28 E.O.) (10 to 16 P.O.) In the comparative example in which polyoxyethylene (EO60) hydrogenated castor oil is blended in place of tetradecyl ether (20 to 28E.O.) (10 to 16P.O.), it can be seen that contamination is large.
On the other hand, in the Example which mix | blended polyoxyethylene polyoxypropylene 2-decyl tetradecyl ether (20-28E.O.) (10-16P.O.), Contamination | pollution | contamination was very small and the skin external preparation It can be seen that it exhibits an excellent antifouling effect.
以下に本発明のその他の実施例を挙げる。 Other examples of the present invention will be given below.
「実施例4」 プレストパウダー
アルミニウムハイドロキシクロライド 5質量%
酸化亜鉛(亜鉛華) 5
タルク 残余
流動パラフィン 3
抗菌性ゼオライトB 10
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル(20E.O.)
(16P.O.) 0.01
" Example 4 " Press powder aluminum hydroxide 5 mass%
Zinc oxide (zinc flower) 5
Talc Residual liquid paraffin 3
Antibacterial zeolite B 10
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (20E.O.)
(16P.O.) 0.01
「実施例5」 ルースパウダー
アルミニウムハイドロキシクロライド 5質量%
酸化亜鉛(亜鉛華) 5
タルク 残余
抗菌性ゼオライトB 10
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル
(22E.O.)(15P.O.) 0.05
" Example 5 " Loose powder aluminum hydroxide 5 mass%
Zinc oxide (zinc flower) 5
Talc Residual antibacterial zeolite B 10
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (22E.O.) (15P.O.) 0.05
「実施例6」 化粧水型スプレー
(原液処方)
精製水 10質量%
アルミニウムハイドロキシクロライド 10
無水エチルアルコール 残余
ミリスチン酸イソプロピル 2
1,3ブチレングリコール 3
抗菌性ゼオライトB 1
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル
(26E.O.)(13P.O.) 1
(充填処方)
原液 50
LPG 50
" Example 6 " Toner lotion spray (stock solution formulation)
Purified water 10% by mass
Aluminum hydroxide 10
Anhydrous ethyl alcohol Residual isopropyl myristate 2
1,3 Butylene glycol 3
Antibacterial zeolite B 1
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (26E.O.) (13P.O.) 1
(Filling prescription)
Stock solution 50
LPG 50
「実施例7」 パウダースプレー
アルミニウムハイドロキシクロライド 20質量%
無水ケイ酸 15
タルク 20
酸化亜鉛(亜鉛華) 5
ミリスチン酸イソプロピル 残余
ジメチルポリシロキサン 10
ソルビタン脂肪酸エステル 3
抗菌性ゼオライトB 5
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル
(24E.O.)(12P.O.) 0.1
(充填処方)
原液 10
LPG 90
" Example 7 " 20% by mass of powder spray aluminum hydroxide
Silicic anhydride 15
Talc 20
Zinc oxide (zinc flower) 5
Isopropyl myristate Residual dimethylpolysiloxane 10
Sorbitan fatty acid ester 3
Antibacterial zeolite B 5
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (24E.O.) (12P.O.) 0.1
(Filling prescription)
Stock solution 10
LPG 90
「実施例8」 パウダースプレー
ミョウバン 20質量%
無水ケイ酸 15
タルク 20
酸化亜鉛(亜鉛華) 5
ミリスチン酸イソプロピル 残余
ポリオキシエチレン・ポリオキシプロピレン
ランダム重合体メチルエーテル 10
ソルビタン脂肪酸エステル 3
抗菌性ゼオライトB 5
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル
(27E.O.)(11P.O.) 0.1
(充填処方)
原液 10
LPG 90
" Example 8 " 20% by mass of powder spray alum
Silicic anhydride 15
Talc 20
Zinc oxide (zinc flower) 5
Isopropyl myristate Residual polyoxyethylene / polyoxypropylene Random polymer methyl ether 10
Sorbitan fatty acid ester 3
Antibacterial zeolite B 5
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (27E.O.) (11P.O.) 0.1
(Filling prescription)
Stock solution 10
LPG 90
「実施例9」 スティック
アルミニウムハイドロキシクロライド 20質量%
タルク 8
酸化亜鉛(亜鉛華) 5
固形パラフィンワックス 2
ステアリルアルコール 8
流動パラフィン 15
環状ジメチルポリシロキサン 残余
ソルビタン脂肪酸エステル 1
抗菌性ゼオライトB 5
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル
(22E.O.)(15P.O.) 4
" Example 9 " Stick aluminum hydroxide 20 mass%
Talc 8
Zinc oxide (zinc flower) 5
Solid paraffin wax 2
Stearyl alcohol 8
Liquid paraffin 15
Cyclic dimethylpolysiloxane Residual sorbitan fatty acid ester 1
Antibacterial zeolite B 5
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (22E.O.) (15P.O.) 4
「実施例10」 乳液
精製水 残余
アルミニウムハイドロキシクロライド 20質量%
パラメトキシケイ皮酸オクチル 5
4−tertブチル−4’−メトキシベンゾイルメタン 1
疎水化処理酸化亜鉛 5
ポリオキシエチレン・ポリオキシプロピレン
ランダム重合体メチルエーテル 10
シリコーンオイル 15
シリコーンレジン 1
ジイソステアリン酸グリセリン 1
有機変性モンモリロナイト 0.5
1,3ブチレングリコール 5.5
抗菌性ゼオライトB 13
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル
(25E.O.)(11P.O.) 1
" Example 10 " Emulsion purified water Residual aluminum hydroxide 20% by mass
Octyl paramethoxycinnamate 5
4-tertbutyl-4′-methoxybenzoylmethane 1
Hydrophobized zinc oxide 5
Polyoxyethylene / polyoxypropylene Random polymer methyl ether 10
Silicone oil 15
Silicone resin 1
Glycerin diisostearate 1
Organically modified montmorillonite 0.5
1,3 butylene glycol 5.5
Antibacterial zeolite B 13
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (25E.O.) (11P.O.) 1
「実施例11」 軟膏
精製水 残余
アルミニウムハイドロキシクロライド 20質量%
グリセリン 10
1,3ブチレングリコール 3
苛性カリ 0.25
ステアリン酸 2
ステアリン酸モノグリセリド 2
セタノール 1
流動パラフィン 5
ワセリン 2
抗菌性ゼオライトB 1
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル
(20E.O.)(16P.O.) 2.5
" Example 11 " Ointment purified water Residual aluminum hydroxide 20% by mass
Glycerin 10
1,3 Butylene glycol 3
Caustic potash 0.25
Stearic acid 2
Stearic acid monoglyceride 2
Cetanol 1
Liquid paraffin 5
Vaseline 2
Antibacterial zeolite B 1
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (20E.O.) (16P.O.) 2.5
「実施例12」 ジェル
精製水 残余
アルミニウムハイドロキシクロライド 20質量%
ジプロピレングリコール 5
PEG1500 5.5
カルボキシビニルポリマー 0.4
メチルセルロース 0.2
POE(15)オレイルアルコールエーテル 0.5
水酸化カリウム 0.1
EDTA 0.02
抗菌性ゼオライトB 5
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル
(26E.O.)(12P.O.) 0.3
" Example 12 " Gel purified water Residual aluminum hydroxide 20% by mass
Dipropylene glycol 5
PEG1500 5.5
Carboxyvinyl polymer 0.4
Methylcellulose 0.2
POE (15) oleyl alcohol ether 0.5
Potassium hydroxide 0.1
EDTA 0.02
Antibacterial zeolite B 5
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (26E.O.) (12P.O.) 0.3
「実施例13」 ウェットシート
精製水 残余
無水エチルアルコール 35質量%
ポリオキシエチレン硬化ヒマシ油 0.1
クエン酸(食品) 0.02
クエン酸ナトリウム 0.06
抗菌性ゼオライトB 2
ポリオキシエチレンポリオキシプロピレン
2-デシルテトラデシルエーテル
(26E.O.)(12P.O.) 0.01
" Example 13 " Wet sheet purified water Residual anhydrous ethyl alcohol 35% by mass
Polyoxyethylene hydrogenated castor oil 0.1
Citric acid (food) 0.02
Sodium citrate 0.06
Antibacterial zeolite B 2
Polyoxyethylene polyoxypropylene
2-decyltetradecyl ether (26E.O.) (12P.O.) 0.01
本発明は、抗菌性ゼオライトを配合した皮膚外用剤において、衣類への付着による汚染着を防止したり、汚染着の度合いを緩和したりする効果を発揮する。
INDUSTRIAL APPLICABILITY The present invention exerts an effect of preventing contamination due to adhesion to clothing or reducing the degree of contamination in a skin external preparation containing antibacterial zeolite.
Claims (3)
前記抗菌性ゼオライトが銀イオン、亜鉛イオン、アンモニウムイオン担持ゼオライトであり、
前記抗菌性ゼオライトの含有量が皮膚外用剤全量に対して0.05〜90質量%であり、
前記ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルの含有量が皮膚外用剤全量に対して0.01〜5質量%であることを特徴とする、衣類に対する耐汚染着効果に優れる皮膚外用剤。 In an external preparation for skin containing antibacterial zeolite and polyoxyethylene polyoxypropylene 2-decyltetradecyl ether,
The antibacterial zeolite is silver ion, zinc ion, ammonium ion supported zeolite,
The content of the antibacterial zeolite is 0.05 to 90% by mass with respect to the total amount of the external preparation for skin,
A skin external preparation having an excellent antifouling effect on clothes , characterized in that the content of the polyoxyethylene polyoxypropylene 2-decyltetradecyl ether is 0.01 to 5% by mass with respect to the total amount of the skin external preparation. .
前記抗菌性ゼオライトが銀イオン、亜鉛イオン、アンモニウムイオン担持ゼオライトであり、
前記抗菌性ゼオライトの含有量が皮膚外用剤全量に対して0.05〜90質量%であり、
前記ポリオキシエチレンポリオキシプロピレン2-デシルテトラデシルエーテルの含有量が皮膚外用剤全量に対して0.01〜5質量%であることによって、請求項1又は2記載の皮膚外用剤の衣類に対する耐汚染着効果を高める方法。 In an external preparation for skin containing antibacterial zeolite and polyoxyethylene polyoxypropylene 2-decyltetradecyl ether,
The antibacterial zeolite is silver ion, zinc ion, ammonium ion supported zeolite,
The content of the antibacterial zeolite is 0.05 to 90% by mass with respect to the total amount of the external preparation for skin,
The content of the polyoxyethylene polyoxypropylene 2-decyltetradecyl ether is 0.01 to 5% by mass with respect to the total amount of the skin external preparation, whereby the resistance to clothing of the skin external preparation according to claim 1 or 2 is improved. A method to increase the contamination effect.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003332802A JP4375609B2 (en) | 2003-09-25 | 2003-09-25 | Topical skin preparation |
US10/531,737 US20060099161A1 (en) | 2002-10-25 | 2003-10-21 | Skin preparations for external use |
CN200380102015.9A CN1708283B (en) | 2002-10-25 | 2003-10-21 | Skin preparations for external use |
CN2008100853282A CN101254155B (en) | 2002-10-25 | 2003-10-21 | Skin preparations for external use |
EP03756710A EP1557159A4 (en) | 2002-10-25 | 2003-10-21 | Skin preparations for external use |
TW092129104A TW200418511A (en) | 2002-10-25 | 2003-10-21 | Skin preparations for external use |
KR1020107024507A KR20100122963A (en) | 2002-10-25 | 2003-10-21 | Skin preparations for external use |
EP10014088A EP2324887A1 (en) | 2002-10-25 | 2003-10-21 | Deodorizing skin treatment composition |
PCT/JP2003/013406 WO2004037220A1 (en) | 2002-10-25 | 2003-10-21 | Skin preparations for external use |
KR1020057004912A KR101066435B1 (en) | 2002-10-25 | 2003-10-21 | Skin preparations for external use |
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EP1909916B1 (en) * | 2005-07-30 | 2009-05-27 | Unilever PLC | Anhydrous spray compositions containing a particulate antiperspirant active and a moisturising agent |
JP4890889B2 (en) * | 2006-03-07 | 2012-03-07 | 日揮触媒化成株式会社 | Antibacterial cosmetics |
JP5302523B2 (en) * | 2007-08-20 | 2013-10-02 | 株式会社 資生堂 | Topical skin preparation |
JP2009234995A (en) * | 2008-03-27 | 2009-10-15 | Shiseido Co Ltd | External preparation for skin |
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