CN101244218B - 一种治疗急性肝炎的中草药口服颗粒 - Google Patents
一种治疗急性肝炎的中草药口服颗粒 Download PDFInfo
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Abstract
本发明公开了一种治疗急性肝炎的中草药口服颗粒，特征是其原料组分按重量比为：金钱草20～35、田基黄15～30、竹叶15～30、白茅根15～35、牛筋草25～50、芭蕉芯10～15、六角英25～40。其制作方法是：按重量组分比将金钱草、田基黄、竹叶、白茅根、牛筋草、芭蕉芯、六角英分别粉碎过筛，混合，加蒸馏水煮沸并文火煎煮，过滤再于滤渣中加沸蒸馏水，煮沸并文火煎煮过滤，合并滤液，将滤液浓缩，加淀粉制成团并过筛成条块，烘干并再次过筛成颗粒。本发明材料来源丰富，成本低，安全可靠疗效好，制作工艺简单，无药物残留与毒副作用等问题，是一种构成简单、原材料易得、成本低廉且疗程短的治疗急性肝炎的新型药品。
Description
技术领域
本发明涉及一种中成药复配，具体涉及一种治疗急性肝炎的中草药口服颗粒。
背景技术
肝炎是一种常见的疾患，广泛流行于世界各国，主要侵犯儿童及青壮年，少数患者可转化为肝硬化或肝癌，临床表现为乏力、食欲减退、恶心、呕吐、厌油、腹泻及腹胀，部分病例有发热、黄疸，约有半数患者起病隐匿，只能在检查中发现。目前治疗肝炎的制剂有不少，但它们普遍存在着效果单一，有些制剂的中草药种类过多，制作过程非常烦琐，而且资源严重不足，构成药剂的成本过高；有些成分有药物残留，存在药品的安全问题。
发明内容
本发明的目的提供一种原料资源丰富，成本低，疗效好的治疗急性肝炎的中草药口服颗粒。
本发明所采用的技术方案是：一种治疗急性肝炎的中草药口服颗粒，其特征在于其原料组分按重量比为：
金钱草20～35 田基黄15～30 竹叶15～30 白茅根15～35
牛筋草25～50 芭蕉芯10～15 六角英25～40
方中金钱草味甘、咸，微寒，归肝、胆、肾、膀胱经，功能清利湿热，通淋，消肿。田基黄味甘、微苦，微寒，归肝、脾经，功能清热解毒，利湿退黄，消肿散瘀。竹叶味甘、淡、寒，入心、肺、胆、胃经，功能清心利尿，清热除烦。白茅根味甘，性寒，凉血，止血，清热利尿。牛筋草味甘、淡、平，功能清热解毒，祛风利湿，散瘀止血。六角英味微苦、辛、淡，性凉，无毒，内服解毒、清热、积散结，外用退肿拔毒。入肝经。
本发明所提供的治疗急性肝炎的中草药口服颗粒的制作方法是：按重量组分比将金钱草、田基黄、竹叶、白茅根、牛筋草、芭蕉芯、六角英分别粉碎过筛，混合，按重量体积比加5～8倍蒸馏水，煮沸并文火煎60～150分钟，过滤再于滤渣中按重量体积比加2～5倍沸蒸馏水，煮沸并文火煎30～60分钟后过滤，合并滤液，将滤液浓缩，加淀粉制成团并过筛成条块，50～80℃烘干并再次过筛成颗粒。
本发明所提供的一种治疗急性肝炎的中草药口服颗粒制剂材料来源丰富，成本低，安全可靠疗效好，制作工艺简单，无药物残留与毒副作用等问题，是一种构成简单、原材料易得、成本低廉且疗程短的治疗急性肝炎的新型药品。
具体实施方式
下面用非限定性实施例对本发明作进一步说明。
实例1：取金钱草25克、田基黄15克、竹叶15克、白茅根25克、牛筋草30克、芭蕉芯10克和六角英30克等7种中草药，分别粉碎过筛，混合，加6倍蒸馏水(w/v)，煮沸并文火煎90分钟，过滤再加2倍沸蒸馏水，煮沸并文火煎约40分钟后过滤，合并滤液，旋转蒸发仪浓缩滤液至120毫升，加淀粉制成团并过筛成条块，50℃烘干并再次过筛，制成颗粒制剂。
制剂疗效检测：将昆明种小鼠分为空白对照组、模型对照组、药物组3组，注射2％CCL4油溶液与硫代硫酰胺(TAA)制备小鼠急性化学性肝损伤模型，按1克生药/30克鼠重的浓度灌胃昆明种肝炎小鼠一周，结果：与对照组相比，该药物能明显降低CCL4致小鼠急性肝损伤，血清ALT、AST升高，同时通过肝脏组织切片检测发现，该药物减轻CCL4对肝细胞的病理损伤，因此该药物对四氯化碳致小鼠急性肝损伤具有保护作用。
实例2：取金钱草25克、田基黄25克、竹叶20克、白茅根30克、牛筋草40克、芭蕉芯18克和六角英35克等7种中草药，分别粉碎过筛，混合，加7倍蒸馏水(w/v)，煮沸并文火煎120分钟，过滤再加3倍沸蒸馏水，煮沸并文火煎约80分钟后过滤，合并滤液，旋转蒸发仪浓缩滤液至150毫升，加淀粉制成团并过筛成条块，60℃烘干并再次过筛，制成颗粒制剂。
制剂疗效检测：将昆明种小鼠分为空白对照组、模型对照组、药物组3组，给小鼠iv卡介苗(BCG)5×106个菌/鼠，11天后再iv脂多糖(LPS)7.5μg/只，制备免疫性肝炎模型；按2克生药/30克鼠重的浓度灌胃肝炎小鼠12天，提取血清检测谷丙转氨酶(ALT)、谷草转氨酶(AST)、MDA和超氧化物歧化酶(SOD)等指标；结果：该药物能明显降低免疫性肝炎小鼠血清ALT、AST的作用(P＜0.01)；使SOD的活性升高，MDA含量明显降低。因此该药物对小鼠免疫性肝炎具有治疗作用。
Claims (2)
1.一种治疗急性肝炎的中草药口服颗粒，其特征是其由以下重量比的原料组分制成：
金钱草20～35 田基黄15～30 竹叶15～30 白茅根15～35
牛筋草25～50 芭蕉芯10～15 六角英25～40。
2.一种如权利要求1所述的中草药口服颗粒的制作方法，其特征是：按重量组分比将金钱草、田基黄、竹叶、白茅根、牛筋草、芭蕉芯、六角英分别粉碎过筛，混合，按重量体积比加5～8倍蒸馏水，煮沸并文火煎60～150分钟，过滤再于滤渣中按重量体积比加2～5倍沸蒸馏水，煮沸并文火煎30～60分钟后过滤，合并滤液，将滤液浓缩，加淀粉制成团并过筛成条块，50～80℃烘干并再次过筛成颗粒。
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| Title |
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| 朱虎奎，等.中西医结合治疗慢性肝炎早期肝硬化60例.实用医技杂志.1998,5(3),152-153. |
| 朱虎奎等.中西医结合治疗慢性肝炎早期肝硬化60例.实用医技杂志.1998,5(3),152-153. * |
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