CN101243995A - Experimental device and method for gas on-site exposure to toxicant - Google Patents
Experimental device and method for gas on-site exposure to toxicant Download PDFInfo
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- CN101243995A CN101243995A CNA200810045039XA CN200810045039A CN101243995A CN 101243995 A CN101243995 A CN 101243995A CN A200810045039X A CNA200810045039X A CN A200810045039XA CN 200810045039 A CN200810045039 A CN 200810045039A CN 101243995 A CN101243995 A CN 101243995A
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Abstract
The invention relates to a biomedical toxicantexposure experimental apparatus and the method of the experimental apparatus, in particular to a gas exposure experimental device and the method. The key technology is to design and make a small sized, movable, and electrically controlled dynamic gas exposure experimental device; the device comprises a miniature fan motor (3), a section of removable and movable toxicant exposure chamber (5), a set of air transmission pipelines and adjusting valves (4) connected with the fan motor and the toxicant exposure chambers, and a set of exhaust tubes (6) and collection bags for waste gas (7) combined with the toxicant exposure chambers; the remote controls for gas flow rate, flow, and exposure time are performed by the miniature adjustable fan motor and the air transmission pipelines; the animal foods and drinking water (15) are provided by the removable toxicant exposure chamber (5) to meet the requirements for long-time and repeated exposure; and the performance evaluations for field gas exposure experiment, toxicological study and the equipment for harmful gas are performed by the different combinations and different exposure modules of the small sized movable exposure device.
Description
Affiliated technical field
The present invention relates to a kind of biomedical exposure experiment Apparatus and method for, further relate to a kind of gas on-site exposure to toxicant experimental provision and method.
Technical background
Gas exposure experiment (gas exposure) is the basic skills of gas toxicity assessment; It is the research multiple gases, comprise aerosol, aerosol, gas-liquid mixture, dusty gas, particularly sucting reaction, dynamic metabolism and Pathophysiology effect thereof and machine-processed important method such as biological medicine aerosol, anesthetic gases, contaminated air, vehicle exhaust, industrial waste gas, military toxic agent and propellant combustion tail gas; Also be research, the basic skills of estimating multiple toxic and harmful safeguard procedures, protective gear and innoxious process for treating, its scientific research and application are wide.According to the different of the gas flow and the mode of adding of contaminating, existing gas exposure experiment is divided into quiet formula (attitude), dynamic formula (attitude) and hybrid, all finish (1.Drew RT.General Principle of Inhalation Toxicology.Springer-Verlag by special use suction contamination equipment or device, Berlin, 1985,1-22; 2. Yin Song, Wang Shujie, Bi Wenfang, etc. industrial chemical toxicity is identified standard and experimental technique. Beijing: and the People's Health Publisher, 1998,10-12).These contamination equipment or device need complicated static state or dynamic air-distributing, plenum system and gas monitor spare; Some suck toxicity contaminated systems also needs (Chinese patent application number: 88101517 such as analog gas preparation and sprayer unit; 02222542; 02240058; 200320117313; 200520026707; 200520035257; 200610033156; 200710027786).These apparatus and method technical sophistications, involve great expense, move difficulty, be not easy to carry out on-the-spot exposure experiment and long-term chronic exposure experiment especially, the complexity that also is difficult to simulated field gas change with the operating personnel repeatedly, the practical situation that repeatedly contacts; Take static contamination method, distribution, supply gas and concentration detects and to require more complicated, be difficult to avoid animal self to get rid of the interference of gas, range of application is limited, experimental precision and usefulness are low, are unsuitable for containing the exposure experiment and the toxicity assessment of mists such as room airs such as oxycarbide, nitrogen oxide, atmosphere, combustion tail gas.
For the poisonous environment of simulated field, (Chinese patent application number: 01262007 such as Han Huifen, Pang Baosen, Zhang Jichun; 200420115516; 200710027786) propose, add the toxicant exposure chamber by poisonous sample gas, the poisonous environment of simulated field, thus carry out sampling analysis test or exposure experiment.This method remedied the inconvenience that the collection in worksite noxious substance brings to the experimenter, dangerous, easily cause deficiencies such as physical impairment danger, but, be difficult to real simulation for the on-the-spot toxic and harmful and the environment of complicated component and toxicity the unknown; Also inconvenience simulation repeatedly, repeatedly, secular contamination contact situation and carry out biochemistry, the experiment of terrified gas exposure.
Summary of the invention
The new equipment and the new method that the purpose of this invention is to provide a kind of easy, science, practical gas on-site exposure to toxicant experiment.Its key problem in technology be design and produce a kind of small-sized, packaged type, the dynamic gas exposure experimental device of electronic control (portabledynamic gas exposure device), this device comprises a miniature air supply motor (3), one section dismantled and assembled and mobile toxicant exposure chamber (5), one cover connects the aspirating pipeline and the control valve (4) of above-mentioned air supply motor and toxicant exposure chamber, exhaustor (6) and gas sampling bag (7) that one cover combines with the toxicant exposure chamber, carry out gas flow rate by miniature adjustable motor and the air duct of supplying gas, the Long-distance Control of flow and contamination time, provide animal foodstuff and drinking-water (15) to satisfy for a long time by dismantled and assembled toxicant exposure chamber (5), contamination needs repeatedly, carries out the gas on-site exposure to toxicant experiment by the various combination and the different contamination patterns of small-sized removable contamination device, the performance evaluation of toxicologic study and harmful gas protective gear.
The advantage of this gas exposure device and method is:
(1) described gas exposure device and method comprise a miniature air supply motor, described miniature air supply motor is made up of mini fan and control circuit thereof, continue or the interrupted contamination gas of carrying to the toxicant exposure chamber by aspirating pipeline, by remote circuit, control fan switch time and air velocity.
(2) described gas exposure device and method have an exposure experiment chamber, and there is an air inlet described toxicant exposure chamber, and this air inlet links by aspirating pipeline and control valve and described miniature air supply motor; There is a gas outlet described toxicant exposure chamber, links by exhaustor and gas sampling bag; Described toxicant exposure chamber can pass through air inlet, the gas outlet forms gas flow, keep gas componant and concentration in the toxicant exposure chamber consistent with requirement of experiment gas or gas on-site, avoid animal to get rid of gas or the interference of other gas, to overcome the defective of static QI invigorating contamination device.
(3) but toxicant exposure chamber's integral disassembly, assembly of described gas exposure device, switching, move and change, foodstuff and drinking-water can be provided, can put into and take out laboratory animals such as rat, mice, do not need to separate animal fixing separately.
(4) toxicant exposure chamber's material of described gas exposure device is clear glass, transparent plastic, can observe the animal situation, but sterilization can be used as disposable use equipment.
(5) gas shield, defecators such as gas-filtering device, filter membrane, mask can be installed in the air inlet of the toxicant exposure chamber of described gas exposure device, gas outlet, carry out gas filtration processing and barrier propterty evaluation.
(6) described gas exposure device comprises that a cover is supplied gas, gas exhaust piping and corresponding joint, the chamber wall thickness ratio of described pipeline and joint was greater than 10: 1, quality is lighter than 0.5 kilogram, gas-flow resistance is less than 1000 kPas, with above-mentioned miniature air supply motor, control valve, toxicant exposure chamber with the gas sampling bag is airtight is connected, can avoid that gas leaks and secondary pollution in the device.
(7) described gas exposure device can be separately or is installed in batch on the moveable platform, connects circuit for remotely controlling, carry out repeatedly, repeatedly, the multiple gas on-site exposure to toxicant experiment of different time, different distance and pattern.
Description of drawings
Below in conjunction with accompanying drawing the preferred embodiment of the present invention is described.
Fig. 1 is the basic structure sketch map of gas exposure device according to the preferred embodiment of the invention.
Fig. 2 is the operation principle sketch map of gas exposure device according to the preferred embodiment of the invention.
Fig. 3 is the connection diagram of a plurality of gas exposure devices according to the preferred embodiment of the invention.
Fig. 4 is multi-mode gas on-site exposure to toxicant experimental technique sketch map according to the preferred embodiment of the invention.
Fig. 5 is gas on-site exposure to toxicant and Protective Research pictorial diagram according to the preferred embodiment of the invention.
Among the figure, 1. gas on-site or experimental gas collecting bag, 2. air inlet pipeline, 3. miniature air supply motor, 4. barometric damper, 5. gas exposure chamber, 6. gas exhaust piping, 7. gas sampling bag, 8. toxicant exposure chamber's air inlet, 9. gas outlet, toxicant exposure chamber, 10. laboratory animal, 11. remote draught fan control circuit, 12. fixed platform, 13. observed and recorded equipment, 14. contamination chamber caps, 15. animal foodstuff and drinking-water bottle, 16. toxicant exposure chamber's interlayer, 17. protection defecators, 18. low dosages are interrupted the contamination pattern, the pattern 19. high dose is contaminated continuously, 20. dosage times changed the contamination pattern.
The specific embodiment
Fig. 1 is the basic structure sketch map of the gas exposure device of the preferred embodiment of the present invention.This device comprises an air inlet pipeline 2; One miniature air supply motor 3; One barometric damper 4; One dismantled and assembled and mobile toxicant exposure chamber 5; Exhaustor 6 and gas sampling bag 7 that one cover combines with gas outlet, toxicant exposure chamber 9.Described aspirating pipeline 2 and exhaustor 6 and above-mentioned miniature air supply motor 3, control valve 4, toxicant exposure chamber 5 and 7 airtight connections of gas sampling bag can be avoided gas leakage and secondary pollution in the device.
Fig. 2 is the operation principle sketch map of gas exposure device according to the preferred embodiment of the invention.Its air flow direction and experiment flow are: on-the-spot air or experimental gas 1 (through collection and composition, measurement of concetration) → air inlet pipeline 2 → miniature air supply motor 3 → barometric damper 4 → intake interface (but pressure measurement speed governing/filtration treatment) → 5 → gas outlet, toxicant exposure chamber 9 (but filtration treatment) → exhaustor 6 and gas sampling bag 7 (detection).By distant control circuit 11, regulate control fan switch time and air velocity, thereby control laboratory animal 10 sucks the time and the dosage of contamination gas, keep toxicant exposure chamber's composition of gases within and concentration consistent with requirement of experiment gas or gas on-site, avoid animal to get rid of gas or the interference of other gas, to overcome the shortcoming of existing static QI invigorating contamination device.
Fig. 3 is the connection diagram of a plurality of gas exposure devices according to the preferred embodiment of the invention.Its method is a plurality of above-mentioned gas contamination devices to be arranged be fixed on the fixed platform 12, utilizes observed and recorded equipment 13 to carry out in good time, dynamic observe, recording laboratory animal contamination reaction and characteristicness.Utilize this method can carry out many, many groups, the experiment of multiple batches of animal contaminated simultaneously, do not need to separate fixing separately animal.
Fig. 4 is multipurpose gas on-site exposure to toxicant experimental technique sketch map according to the preferred embodiment of the invention.Its method is: toxicant exposure chamber's air inlet 8, gas outlet 9 and gas piping 4,6 are broken away from, carry out that the toxicant exposure chamber moves, replacing, sterilization; The chamber cap 14 of will contaminating is opened, and adds animal foodstuff and drinking-water 15 in the toxicant exposure chamber, or takes out laboratory animal 10; According to the experiment needs, place protection defecators 17 such as gas-filtering device, filter membrane, mask in toxicant exposure chamber's air inlet 8, gas outlet 9, protect evaluation experimental; According to experiment needs and requirement, by miniature adjustable motor 3 and the aspirating pipeline 4 of supplying gas, Long-distance Control contamination gas flow rate, flow and contamination time, carry out low dosage and be interrupted contamination pattern 18, the high dose pattern 19 of contaminating continuously, the dosage time change contamination pattern 20 etc. multiple repeatedly, repeatedly, for a long time, remote on-the-spot exposure experiment.
Fig. 5 is gas on-site exposure to toxicant and Protective Research pictorial diagram according to the preferred embodiment of the invention.Wherein Fig. 5 a is the contamination device connection pictorial diagram of the preferred embodiment of the present invention; Fig. 5 b is the gas on-site Protective Research pictorial diagram of the preferred embodiment of the present invention, and the miniature adjustable motor 3 of supplying gas is being worked among the figure, and the air inlet 8 of toxicant exposure chamber 5 has been placed gas protection defecator 17, and different reactions has appearred in the laboratory animal 10 in the toxicant exposure chamber 5.
Claims (5)
1. gas on-site exposure to toxicant experimental provision and method comprise: the dynamic gas exposure experimental device that designs and produces a kind of small-sized, packaged type, electronic control; This device comprises a miniature air supply motor, one section transparent, dismantled and assembled and mobile toxicant exposure chamber, and a cover connects the aspirating pipeline and the control valve of above-mentioned air supply motor and toxicant exposure chamber, exhaustor and gas sampling bag that a cover combines with the toxicant exposure chamber;
By controlling miniature air supply motor and dismantled and assembled toxicant exposure chamber, realize contamination pattern that different time dosage changes and repeatedly, repeatedly, for a long time, remote on-the-spot exposure experiment;
By the various combination and different contamination patterns of small-sized removable contamination device, carry out the performance evaluation of gas on-site exposure to toxicant experiment, toxicologic study and harmful gas protective gear.
2. gas exposure device as claimed in claim 1 and method is characterized in that, its miniature air supply motor carries out the Long-distance Control of gas flow rate, flow and contamination time for the grade speed regulating control is arranged by the miniature adjustable motor of supplying gas.
3. gas exposure device as claimed in claim 1 and method is characterized in that, its gas exposure chamber is transparent IVC Mus case.
4. gas exposure device as claimed in claim 1 and method is characterized in that, its gas exposure chamber has multiple utilitarian function, but integral disassembly, assembly, switching, move and change, and can add foodstuff and drinking-water.
5. gas exposure device as claimed in claim 1 and method is characterized in that, gas-filtering device can be installed in its gas exposure chamber air inlet, gas outlet, carries out gas filtration processing and preventer performance evaluation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810045039XA CN101243995A (en) | 2008-03-21 | 2008-03-21 | Experimental device and method for gas on-site exposure to toxicant |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA200810045039XA CN101243995A (en) | 2008-03-21 | 2008-03-21 | Experimental device and method for gas on-site exposure to toxicant |
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| CNA200810045039XA Pending CN101243995A (en) | 2008-03-21 | 2008-03-21 | Experimental device and method for gas on-site exposure to toxicant |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172336A (en) * | 2011-03-11 | 2011-09-07 | 山西农业大学 | Simple dynamic sulfur dioxide gas toxicant exposure experimental device |
| CN102715888A (en) * | 2012-05-28 | 2012-10-10 | 公安部四川消防研究所 | Non-destructive monitoring system for animal exposure on fire scene |
| US20130047704A1 (en) * | 2011-08-24 | 2013-02-28 | Korea Institute Of Science And Technology | Multi-functional vehicle for measuring air pollution |
| CN103505302B (en) * | 2012-06-26 | 2015-05-20 | 郑州大学第一附属医院 | Experimental device for inducing pulmonary arterial hypertension of mouse |
| CN110749728A (en) * | 2019-08-22 | 2020-02-04 | 青岛大学 | Chicken embryo diesel engine tail gas contamination method |
-
2008
- 2008-03-21 CN CNA200810045039XA patent/CN101243995A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172336A (en) * | 2011-03-11 | 2011-09-07 | 山西农业大学 | Simple dynamic sulfur dioxide gas toxicant exposure experimental device |
| US20130047704A1 (en) * | 2011-08-24 | 2013-02-28 | Korea Institute Of Science And Technology | Multi-functional vehicle for measuring air pollution |
| CN102715888A (en) * | 2012-05-28 | 2012-10-10 | 公安部四川消防研究所 | Non-destructive monitoring system for animal exposure on fire scene |
| CN103505302B (en) * | 2012-06-26 | 2015-05-20 | 郑州大学第一附属医院 | Experimental device for inducing pulmonary arterial hypertension of mouse |
| CN110749728A (en) * | 2019-08-22 | 2020-02-04 | 青岛大学 | Chicken embryo diesel engine tail gas contamination method |
| CN110749728B (en) * | 2019-08-22 | 2023-06-30 | 青岛大学 | Method for contaminating tail gas of chick embryo diesel engine |
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Open date: 20080820 |