CN101234117A - 一对新的人参皂苷元和它们的混合体的医药用途 - Google Patents
一对新的人参皂苷元和它们的混合体的医药用途 Download PDFInfo
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- CN101234117A CN101234117A CNA2008100104414A CN200810010441A CN101234117A CN 101234117 A CN101234117 A CN 101234117A CN A2008100104414 A CNA2008100104414 A CN A2008100104414A CN 200810010441 A CN200810010441 A CN 200810010441A CN 101234117 A CN101234117 A CN 101234117A
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Abstract
Description
MCF-7 | HepG2 | A549 | Du145 | Colon205 | HL-60 | |
25Rmdt | 13.52 | 12.43 | 33.57 | 11.43 | 10.81 | 7.13 |
25Smdt | 8.34 | 8.32 | 35.62 | 11.83 | 14.2 | 8.48 |
25Rmdt∶25Smdt(1∶ | 10.17 | 9.03 | 33.80 | 10.61 | 11.39 | 7.47 |
组别 | 剂量 | 动物数 | 动物体重(g) | 瘤重 | 抑瘤率 |
mg/kg/d | (n) | 给药前 | 给药后 | (g) | (%) | |
荷瘤对照组A | - | 10 | 20.2±2.25 | 22.10±2.28 | 0.99±0.36 | - |
25Smdt | 10 | 10 | 20.7±1.89 | 21.89±2.12 | 0.46±0.22* | 53.5 |
25Rmdt25Rmdt∶25Smdt(1∶1)人参皂苷-Rg3原人参二醇紫杉醇 | 1010101010 | 1010101010 | 20.1±2.0920.9±1.6220.0±2.1820.8±1.8220.6±1.98 | 21.42±1.0821.68±2.3021.36±2.2521.89±1.6921.90±2.07 | 0.44±0.12*0.45±0.46*0.60±0.28*0.55±0.20*0.47±0.36* | 55.454.439.444.452.5 |
组别 | 剂量mg/kg/d | 给药量mL/g | 动物数(n) | 平均存活期(d) | 延长存活期(d) |
荷瘤对照组A | - | 0.01 | 10 | 15.0 | - |
25Smdt | 10 | 0.01 | 10 | 22.4 | 7.4 |
25Rmdt25Rmdt∶25Smdt(1∶1)人参皂苷-Rg3原人参二醇紫杉醇 | 1010101010 | 0.010.010.010.010.01 | 1010101010 | 22.622.020.220.821.9 | 7.67.05.25.86.9 |
组别 | 剂量mg/kg/d | 动物数(n) | 动物体重(g) | 瘤重(g) | 抑瘤率(%) | |
给药前 | 给药后 | |||||
荷瘤对照组A | - | 10 | 20.6±1.20 | 22.90±2.06 | 1.16±0.42 | - |
25Smdt | 10 | 10 | 19.9±2.26 | 21.06±2.48 | 0.52±0.22* | 55.5 |
25Rmdt25Rmdt∶25Smdt(1∶1)人参皂苷-Rg3原人参二醇紫杉醇 | 1010101010 | 1010101010 | 20.6±1.7620.2±2.7820.7±2.5919.8±2.6220.6±2.68 | 21.22±2.0821.48±1.6722.02±1.8821.58±2.0221.90±2.96 | 0.53±0.32*0.61±0.46*0.69±0.28*0.62±0.20*0.54±0.36* | 54.455.440.446.453.5 |
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CN2008100104414A CN101234117B (zh) | 2008-02-20 | 2008-02-20 | 一对人参皂苷元和它们的混合体的医药用途 |
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CN2008100104414A CN101234117B (zh) | 2008-02-20 | 2008-02-20 | 一对人参皂苷元和它们的混合体的医药用途 |
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CN2010105527179A Division CN101984973A (zh) | 2008-02-20 | 2008-02-20 | 20(R)-25-甲氧基-达玛烷-3β,12β,20-三醇的医药用途 |
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CN101234117A true CN101234117A (zh) | 2008-08-06 |
CN101234117B CN101234117B (zh) | 2012-11-07 |
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Cited By (6)
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CN104258101A (zh) * | 2014-09-25 | 2015-01-07 | 廖昕琳 | 一种具有抗化疗功能的药膳包及其制备方法 |
CN104666309A (zh) * | 2013-11-29 | 2015-06-03 | 沈阳药科大学 | 达玛烷型皂苷元抗肝纤维化的医药用途 |
CN105348352A (zh) * | 2015-09-30 | 2016-02-24 | 辽宁新中现代医药有限公司 | 一对新的人参皂苷元混合体的拆分方法 |
CN109575099A (zh) * | 2018-11-19 | 2019-04-05 | 沈阳药科大学 | 达玛烷皂苷元衍生物及其制备方法和应用 |
CN111686117A (zh) * | 2020-07-09 | 2020-09-22 | 延边大学 | 一种ad-1对抗dss诱导的小鼠急性结肠炎的应用 |
CN111825735A (zh) * | 2019-04-18 | 2020-10-27 | 辽宁新中现代医药有限公司 | 达玛烷皂苷元和齐墩果烷皂苷元衍生物及其制备和应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1939311B (zh) * | 2006-10-01 | 2011-07-20 | 沈阳药科大学 | 一种新的人参皂苷苷元衍生物制剂及其用途 |
-
2008
- 2008-02-20 CN CN2008100104414A patent/CN101234117B/zh not_active Expired - Fee Related
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104666309A (zh) * | 2013-11-29 | 2015-06-03 | 沈阳药科大学 | 达玛烷型皂苷元抗肝纤维化的医药用途 |
CN104258101A (zh) * | 2014-09-25 | 2015-01-07 | 廖昕琳 | 一种具有抗化疗功能的药膳包及其制备方法 |
CN104258101B (zh) * | 2014-09-25 | 2018-02-02 | 廖昕琳 | 一种具有抗化疗功能的药膳包及其制备方法 |
CN105348352A (zh) * | 2015-09-30 | 2016-02-24 | 辽宁新中现代医药有限公司 | 一对新的人参皂苷元混合体的拆分方法 |
CN109575099A (zh) * | 2018-11-19 | 2019-04-05 | 沈阳药科大学 | 达玛烷皂苷元衍生物及其制备方法和应用 |
CN109575099B (zh) * | 2018-11-19 | 2021-10-15 | 沈阳药科大学 | 达玛烷皂苷元衍生物及其制备方法和应用 |
CN111825735A (zh) * | 2019-04-18 | 2020-10-27 | 辽宁新中现代医药有限公司 | 达玛烷皂苷元和齐墩果烷皂苷元衍生物及其制备和应用 |
CN111825735B (zh) * | 2019-04-18 | 2023-06-02 | 辽宁新中现代医药有限公司 | 达玛烷皂苷元和齐墩果烷皂苷元衍生物及其制备和应用 |
CN111686117A (zh) * | 2020-07-09 | 2020-09-22 | 延边大学 | 一种ad-1对抗dss诱导的小鼠急性结肠炎的应用 |
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