CN101228429B - 原位热诱发的抗原修复及染色设备和方法 - Google Patents

原位热诱发的抗原修复及染色设备和方法 Download PDF

Info

Publication number
CN101228429B
CN101228429B CN2006800266738A CN200680026673A CN101228429B CN 101228429 B CN101228429 B CN 101228429B CN 2006800266738 A CN2006800266738 A CN 2006800266738A CN 200680026673 A CN200680026673 A CN 200680026673A CN 101228429 B CN101228429 B CN 101228429B
Authority
CN
China
Prior art keywords
microslide
reagent
reaction cabin
support component
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800266738A
Other languages
English (en)
Chinese (zh)
Other versions
CN101228429A (zh
Inventor
利·H·安格罗斯
托马斯·L·拜尔斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN101228429A publication Critical patent/CN101228429A/zh
Application granted granted Critical
Publication of CN101228429B publication Critical patent/CN101228429B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0059—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit
    • A61F2007/0063—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit for cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/0085—Devices for generating hot or cold treatment fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00138—Slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Thermal Sciences (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN2006800266738A 2005-05-24 2006-05-24 原位热诱发的抗原修复及染色设备和方法 Expired - Fee Related CN101228429B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68404705P 2005-05-24 2005-05-24
US60/684,047 2005-05-24
US60/689,386 2005-06-06
US68938605P 2005-06-10 2005-06-10
US73074405P 2005-10-27 2005-10-27
US60/730,744 2005-10-27
PCT/US2006/020156 WO2006127852A2 (en) 2005-05-24 2006-05-24 In situ heat induced antigen recovery and staining apparatus and method

Publications (2)

Publication Number Publication Date
CN101228429A CN101228429A (zh) 2008-07-23
CN101228429B true CN101228429B (zh) 2013-04-10

Family

ID=37452811

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800266738A Expired - Fee Related CN101228429B (zh) 2005-05-24 2006-05-24 原位热诱发的抗原修复及染色设备和方法

Country Status (9)

Country Link
US (6) US8361388B2 (https=)
EP (1) EP1888739B1 (https=)
JP (1) JP5335420B2 (https=)
CN (1) CN101228429B (https=)
AU (1) AU2006249956A1 (https=)
BR (1) BRPI0609898A2 (https=)
CA (1) CA2609453C (https=)
MX (1) MX2007014655A (https=)
WO (1) WO2006127852A2 (https=)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006249956A1 (en) 2005-05-24 2006-11-30 Angros, Lee H In situ heat induced antigen recovery and staining apparatus and method
CA3138078C (en) * 2007-10-02 2024-02-13 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
US20090139311A1 (en) 2007-10-05 2009-06-04 Applied Biosystems Inc. Biological Analysis Systems, Devices, and Methods
WO2010025425A1 (en) 2008-08-29 2010-03-04 Angros Lee H Multiplexed microscope slide staining apparatus
FR2938062B1 (fr) * 2008-11-05 2014-02-28 Biomerieux Sa Dispositif de preparation et/ou de traitement d'un echantillon biologique
US8067241B2 (en) * 2009-08-26 2011-11-29 General Electric Company Method and apparatus for antigen retrieval process
WO2012048154A1 (en) 2010-10-06 2012-04-12 Biocare Medical, Llc Methods and systems for efficient processing of biological samples
EP2468862A1 (en) * 2010-12-23 2012-06-27 Qiagen GmbH Method and kit for processing wax-embedded biological samples
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples
US8932543B2 (en) * 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
EP2780453B1 (en) * 2011-11-17 2017-03-29 Rheonix, Inc. Microfluidic apparatus, method, and applications
WO2014001531A2 (en) * 2012-06-29 2014-01-03 Victorious Medical Systems Aps A system and a dip tank for washing and target retrieval of tissue samples mounted on microscope slides
US10228382B2 (en) 2012-11-01 2019-03-12 Leica Biosystems Melbourne Pty Ltd Fluid transport system and method for treating one or more tissue samples on a slide
CN111089980B (zh) * 2013-12-13 2023-08-15 文塔纳医疗系统公司 生物样本的自动化组织学处理及相关的技术
JP6302066B2 (ja) 2013-12-13 2018-03-28 ベンタナ メディカル システムズ， インコーポレイテッド 顕微鏡スライドを熱処理する自動化された処理システムおよび方法
CN105980828B (zh) 2013-12-13 2021-12-17 文塔纳医疗系统公司 用于生物标本组织处理的染色试剂和其它液体及关联技术
US10634590B2 (en) 2014-03-11 2020-04-28 Emd Millipore Corporation IHC, tissue slide fluid exchange disposable and system
CN104744588A (zh) * 2015-04-03 2015-07-01 福州大学 一种用于制备抗体的抗原预处理方法
WO2016190111A1 (ja) 2015-05-26 2016-12-01 オリンパス株式会社 検体染色装置および検体染色方法
US10640882B2 (en) * 2015-07-23 2020-05-05 Shoei Chemical Inc. Method for producing nanocrystals and nanocrystal production device
CN105987839B (zh) * 2016-06-03 2018-09-28 浙江世纪康大医疗科技股份有限公司 一种edta-柠檬酸抗原修复液
CN105987840B (zh) * 2016-06-03 2018-09-28 浙江世纪康大医疗科技股份有限公司 一种柠檬酸抗原修复液
US11460383B2 (en) 2016-06-16 2022-10-04 Nanocytomics, LLC Automated staining system
CN106124288A (zh) * 2016-06-18 2016-11-16 张阳康 一种熔样装置
EP3559627A1 (en) * 2016-12-20 2019-10-30 Diapath S.p.A. Disposable container for stains or reagents for staining machines of biological material and staining system comprising said container
CN106769985B (zh) * 2016-12-30 2021-03-02 湖南微灵仪器有限公司 固体表面吸附红外检测可视化系统
EP3714251B1 (en) 2017-11-21 2024-04-03 Ventana Medical Systems, Inc. Contactless mixing using modulated air jets
EP3824266B1 (en) 2018-07-16 2022-11-23 Ventana Medical Systems, Inc. Automated slide staining system and method for processing a specimen
EP3824265B1 (en) 2018-07-16 2024-02-14 Ventana Medical Systems, Inc. Automated staining system
EP3823754B1 (en) 2018-07-16 2025-11-19 Ventana Medical Systems, Inc. Automated slide processing systems, consumable stainer units, and related technologies
CN109556929A (zh) * 2018-10-18 2019-04-02 广州安必平医药科技股份有限公司 反应仓、抗原修复仪及其使用方法
CN109540802B (zh) * 2018-12-13 2021-06-04 东北大学 一种生物体液中葡萄糖浓度的光声检测装置及方法
AU2019396833B2 (en) 2018-12-14 2024-08-01 Leica Biosystems Melbourne Pty Ltd Reagent cassette
US11724261B1 (en) 2019-05-13 2023-08-15 Integrated Dna Technologies, Inc. Synthesizer system with inflatable seal and valve arrangement
CN113785184B (zh) * 2019-05-14 2025-02-28 文塔纳医疗系统公司 包括生物学样品处理腔室的系统
CN110411810A (zh) * 2019-09-04 2019-11-05 深圳褀氏生物医疗电子有限公司 一种免疫组化染色机及免疫组化染色方法
CN211235173U (zh) * 2019-11-26 2020-08-11 莱卡生物系统努斯洛赫有限责任公司 一种组织处理设备
WO2021138606A1 (en) * 2019-12-31 2021-07-08 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
US20210299668A1 (en) * 2020-03-30 2021-09-30 Singular Genomics Systems, Inc. Sequencing system with preheating
EP4158305B1 (en) * 2020-05-27 2025-01-08 Agilent Technologies, Inc. Apparatus and method for processing biological samples
CN114305860B (zh) * 2022-03-10 2022-05-17 广州三森健康产业科技有限公司 一种多功能带有热循环的蒸汽眼罩
US20230392196A1 (en) * 2022-06-06 2023-12-07 Applied Materials, Inc. RNA retrieval process for preparing formalin-fixed, paraffin-embedded (FFPE) tissue samples for in situ hybridization
CN115323805B (zh) * 2022-08-31 2024-04-05 湖州倍亨纺织有限公司 一种提升聚乳酸染色牢度的热熔染色方法
CN115755366A (zh) * 2022-11-21 2023-03-07 四川大学华西医院 一种适用于多免疫标记辅助克罗恩病诊断的载玻片装置及其组件
CN116499842A (zh) * 2023-03-14 2023-07-28 厦门通灵生物医药科技有限公司 一种用于载片标本独立染色的支架以及染色装置
CN117571429B (zh) * 2023-10-13 2024-06-14 浙江莱阅病理诊断科技有限公司 一种免疫组化染色模块及染色方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439649A (en) * 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
US6534008B1 (en) * 1999-07-08 2003-03-18 Lee Angros In situ heat induced antigen recovery and staining apparatus and method
US6783733B2 (en) * 1998-02-27 2004-08-31 Cytologix Corporation Random access slide stainer with independent slide heating regulation

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645690A (en) 1968-01-22 1972-02-29 Beckman Instruments Inc Automated chemical analyzer
US3574064A (en) * 1968-05-09 1971-04-06 Aerojet General Co Automated biological reaction instrument
JPS5335420B2 (https=) 1971-12-25 1978-09-27
US3853092A (en) 1973-10-25 1974-12-10 Corning Glass Works Apparatus for nutating and staining a microscope slide
US4296070A (en) 1980-06-16 1981-10-20 Eastman Kodak Company Slide distributor for a chemical analyzer
US4510119A (en) 1982-05-07 1985-04-09 Centocor, Inc. Diagnostic test bead transfer apparatus
JPH076992B2 (ja) 1985-06-21 1995-01-30 富士写真フイルム株式会社 化学分析装置
DE3786087T2 (de) 1986-02-07 1993-09-16 Fuji Photo Film Co Ltd Geraet fuer chemische analysen.
US5154889A (en) 1986-08-07 1992-10-13 Fuji Photo Film Co., Ltd. Chemical analysis apparatus
US4847208A (en) 1987-07-29 1989-07-11 Bogen Steven A Apparatus for immunohistochemical staining and method of rinsing a plurality of slides
US5089233A (en) 1989-06-12 1992-02-18 Eastman Kodak Company Processing apparatus for a chemical reaction pack
US5209903A (en) 1989-09-06 1993-05-11 Toa Medical Electronics, Co., Ltd. Synthetic apparatus for inspection of blood
US5346672A (en) * 1989-11-17 1994-09-13 Gene Tec Corporation Devices for containing biological specimens for thermal processing
US5250262A (en) 1989-11-22 1993-10-05 Vettest S.A. Chemical analyzer
US5225325A (en) 1990-03-02 1993-07-06 Ventana Medical Systems, Inc. Immunohistochemical staining method and reagents therefor
US6472217B1 (en) 1990-03-02 2002-10-29 Ventana Medical Systems, Inc. Slide aqueous volume controlling apparatus
US5595707A (en) 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
US5425918A (en) 1990-07-18 1995-06-20 Australian Biomedical Corporation Apparatus for automatic tissue staining for immunohistochemistry
US5244787A (en) 1991-01-31 1993-09-14 Biogenex Laboratories Antigen retrieval in formalin-fixed tissues using microwave energy
US5273905A (en) 1991-02-22 1993-12-28 Amoco Corporation Processing of slide mounted material
DE4117833C2 (de) 1991-05-29 1993-10-07 Medite Ges Fuer Medizintechnik Verfahren und Vorrichtung zur Färbung von auf Objektträgern angeordneten histologischen Präparaten
US5696887A (en) 1991-08-05 1997-12-09 Biotek Solutions, Incorporated Automated tissue assay using standardized chemicals and packages
US5355439A (en) 1991-08-05 1994-10-11 Bio Tek Instruments Method and apparatus for automated tissue assay
US5232664A (en) 1991-09-18 1993-08-03 Ventana Medical Systems, Inc. Liquid dispenser
FI915731A0 (fi) 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
US5578452A (en) 1992-01-16 1996-11-26 Biogenex Laboratories Enhancement of immunochemical staining in aldehyde-fixed tissues
US6180061B1 (en) 1992-05-11 2001-01-30 Cytologix Corporation Moving platform slide stainer with heating elements
US5947167A (en) 1992-05-11 1999-09-07 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5645114A (en) 1992-05-11 1997-07-08 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5316452A (en) 1992-05-11 1994-05-31 Gilbert Corporation Dispensing assembly with interchangeable cartridge pumps
US6632598B1 (en) 1994-03-11 2003-10-14 Biogenex Laboratories Deparaffinization compositions and methods for their use
US6451551B1 (en) 1994-03-11 2002-09-17 Biogenex Laboratories Releasing embedding media from tissue specimens
US5525514A (en) 1994-04-06 1996-06-11 Johnson & Johnson Clinical Diagnostics, Inc. Wash detection method for dried chemistry test elements
AUPN038995A0 (en) 1995-01-05 1995-01-27 Australian Biomedical Corporation Limited Method and apparatus for human or animal cell sample treatment
EP0729021A1 (de) * 1995-02-25 1996-08-28 Roche Diagnostics GmbH Vorrichtung zur Bearbeitung von Proben auf Objektträgern
US5551487A (en) 1995-03-10 1996-09-03 Hewlett-Packard Company Micro-dispenser for preparing assay plates
US5645200A (en) * 1995-07-14 1997-07-08 Mcdowell Bros. Garment hanger
US6127188A (en) * 1995-10-06 2000-10-03 Mj Research, Inc. Method and apparatus for controlling evaporation in histological procedures
AUPN923596A0 (en) 1996-04-12 1996-05-09 Australian Biomedical Corporation Limited Method and apparatus for treatment of human or animal cell samples
US5939251A (en) * 1996-07-12 1999-08-17 Hu; Min Apparatus and method for simplifying the processes in creating a sealed space on slides to conduct molecular biological reactions therein
US5839091A (en) 1996-10-07 1998-11-17 Lab Vision Corporation Method and apparatus for automatic tissue staining
US5804141A (en) 1996-10-15 1998-09-08 Chianese; David Reagent strip slide treating apparatus
US5958341A (en) 1996-12-23 1999-09-28 American Registry Of Pathology Apparatus for efficient processing of tissue samples on slides
US5734999A (en) * 1997-01-24 1998-04-07 John J. Nicholas Safety device for swimming pools
US5948359A (en) 1997-03-21 1999-09-07 Biogenex Laboratories Automated staining apparatus
US6489171B1 (en) 1997-04-18 2002-12-03 Cell Marque Corporation Chemical dispensing system and method
US5985214A (en) 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
US5922604A (en) 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US5882601A (en) 1997-06-18 1999-03-16 Merck & Co., Ltd. Deflected septum seal access port
US6093574A (en) 1997-08-11 2000-07-25 Ventana Medical Systems Method and apparatus for rinsing a microscope slide
KR20010023070A (ko) 1997-08-20 2001-03-26 더 유니버시티 오브 마이애미 고품질의 연속적인 재료 처리, 조직 고정-탈수-지방제거-함침 방법
US6649368B1 (en) 1997-10-24 2003-11-18 Cell Marque Corporation Composition and method for treating tissue samples
WO1999034190A1 (en) 1997-12-23 1999-07-08 Dako A/S Cartridge device for processing a sample mounted on a surface of a support member
US6269846B1 (en) 1998-01-13 2001-08-07 Genetic Microsystems, Inc. Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
US6582962B1 (en) 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US20030211630A1 (en) 1998-02-27 2003-11-13 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
JP3847559B2 (ja) 1998-02-27 2006-11-22 ベンタナ・メデイカル・システムズ・インコーポレーテツド 独立スライド加熱器を有する自動化分子病理学装置
US6096271A (en) 1998-02-27 2000-08-01 Cytologix Corporation Random access slide stainer with liquid waste segregation
US6855559B1 (en) 1998-09-03 2005-02-15 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6660228B1 (en) * 1998-03-02 2003-12-09 Cepheid Apparatus for performing heat-exchanging, chemical reactions
US6495106B1 (en) 1998-03-24 2002-12-17 Biogenex Laboratories Automated staining apparatus
ID23331A (id) 1998-03-31 2000-04-05 American Cyanamid Co Komposisi insektisida semprot yang memiliki kemanjuran kuat
AU766614B2 (en) 1998-09-03 2003-10-23 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6948843B2 (en) 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
DE69937747T2 (de) 1998-10-28 2008-12-04 Covaris, Inc., Woburn Vorrichtung und verfahren zur kontrolle einer akustischen behandlung
US6544798B1 (en) 1999-02-26 2003-04-08 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6245297B1 (en) 1999-04-16 2001-06-12 Pe Corporation (Ny) Apparatus and method for transferring small volumes of substances
US6673620B1 (en) 1999-04-20 2004-01-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
US6773676B2 (en) 1999-04-27 2004-08-10 Agilent Technologies, Inc. Devices for performing array hybridization assays and methods of using the same
JP2001004506A (ja) * 1999-06-24 2001-01-12 Shichiro Miyazawa 電子顕微鏡試料作製装置及び電子顕微鏡試料作製方法
US7951612B2 (en) 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US8298485B2 (en) 1999-07-08 2012-10-30 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US7897106B2 (en) 1999-07-08 2011-03-01 Lee Angros Situ heat induced antigen recovery and staining apparatus and method
CA2376969A1 (en) 1999-07-21 2001-02-01 Dako A/S A method of controlling the temperature of a specimen in or on a solid support member
US6403036B1 (en) 1999-09-29 2002-06-11 Ventana Medical Systems, Inc. Temperature monitoring system for an automated biological reaction apparatus
US6358473B1 (en) 1999-10-05 2002-03-19 Albert Coello Microscope slide heater
US6403931B1 (en) 1999-10-07 2002-06-11 Ventana Medical Systems, Inc. Slide heater calibrator and temperature converter apparatus and method
US6403037B1 (en) * 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
US6783934B1 (en) * 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
US6943035B1 (en) 2000-05-19 2005-09-13 Genetix Limited Liquid dispensing apparatus and method
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US7025933B2 (en) 2000-07-06 2006-04-11 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
EP1524028B1 (de) 2001-05-25 2008-09-24 Tecan Trading AG Vorrichtung und Verfahrenseinheit zum Bereitstellen eines Hybridisierraums
JP3797418B2 (ja) * 2001-05-29 2006-07-19 茂樹 並松 抗原賦活化法及びその抗原賦活剤
JP2003057156A (ja) * 2001-08-17 2003-02-26 Aloka Co Ltd サンプル処理装置
US7270785B1 (en) 2001-11-02 2007-09-18 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US7378058B2 (en) 2002-01-30 2008-05-27 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
WO2003089140A1 (en) 2002-04-15 2003-10-30 Ventana Medical Systems, Inc. Automated high volume slide staining system
EP1499872B1 (en) 2002-04-26 2015-11-18 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US20040029184A1 (en) 2002-08-09 2004-02-12 Pickcell Laboratories B.V. Method for antigen retrieval and submersion fluid compositions for use therein
KR101090570B1 (ko) * 2002-12-09 2011-12-08 산요덴키 바이오메디칼 가부시키가이샤 인큐베이터
US7875245B2 (en) 2003-05-14 2011-01-25 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7584019B2 (en) 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US7850912B2 (en) 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7354705B2 (en) * 2003-01-30 2008-04-08 Schering Corporation Methods for cancer prognosis and diagnosis
USD495425S1 (en) 2003-03-24 2004-08-31 Vision Biosystems, Limited Cover tile
US20050079517A1 (en) * 2003-06-19 2005-04-14 Michael Goncharko Controlled evaporation, temperature control and packaging for optical inspection of biological samples
US7273591B2 (en) * 2003-08-12 2007-09-25 Idexx Laboratories, Inc. Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same
DE202004001263U1 (de) 2004-01-28 2004-11-18 E-BENK TECH CO., LTD., Junghe Stativ
US7615370B2 (en) 2004-07-08 2009-11-10 Tecan Trading Ag System having device for preventing air bubbles in a hybridization chamber and corresponding method
DE202004012163U1 (de) 2004-07-08 2004-10-07 Tecan Trading Ag System mit Einrichtung zum Verhindern von Luftblasen in einer Hybridisierkammer
US7867443B2 (en) 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
AU2012247048B2 (en) 2005-05-24 2014-11-27 Angros, Lee H In situ heat induced antigen recovery and staining apparatus and method
AU2006249956A1 (en) * 2005-05-24 2006-11-30 Angros, Lee H In situ heat induced antigen recovery and staining apparatus and method
RU2439572C2 (ru) 2005-05-24 2012-01-10 Ли Х. АНГРОС АППАРАТ ДЛЯ ВЫЗВАННОГО ТЕПЛОВОЙ ОБРАБОТКОЙ ВОССТАНОВЛЕНИЯ АНТИГЕНА in situ И ОКРАШИВАНИЯ И СПОСОБ
US7875242B2 (en) 2006-10-17 2011-01-25 Preyas Sarabhai Shah Slide stainer with multiple heater stations
US20090093028A1 (en) * 2007-10-05 2009-04-09 Joy Doran Peterson Apparatus and methods for treating biomass

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439649A (en) * 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
US6783733B2 (en) * 1998-02-27 2004-08-31 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US6534008B1 (en) * 1999-07-08 2003-03-18 Lee Angros In situ heat induced antigen recovery and staining apparatus and method

Also Published As

Publication number Publication date
WO2006127852A3 (en) 2007-03-29
US20200326266A1 (en) 2020-10-15
US20140024134A1 (en) 2014-01-23
US20110150725A1 (en) 2011-06-23
US8361388B2 (en) 2013-01-29
WO2006127852A8 (en) 2009-10-08
CN101228429A (zh) 2008-07-23
BRPI0609898A2 (pt) 2011-10-11
US8541244B2 (en) 2013-09-24
WO2006127852A2 (en) 2006-11-30
AU2006249956A1 (en) 2006-11-30
US9719895B2 (en) 2017-08-01
US20160274007A1 (en) 2016-09-22
CA2609453C (en) 2014-07-08
MX2007014655A (es) 2008-04-02
US20110229978A1 (en) 2011-09-22
JP2009506300A (ja) 2009-02-12
US20170328820A1 (en) 2017-11-16
JP5335420B2 (ja) 2013-11-06
US11585737B2 (en) 2023-02-21
EP1888739A4 (en) 2012-07-18
HK1120110A1 (en) 2009-03-20
CA2609453A1 (en) 2006-11-30
EP1888739B1 (en) 2021-08-11
EP1888739A2 (en) 2008-02-20
US10697868B2 (en) 2020-06-30
US9354145B2 (en) 2016-05-31

Similar Documents

Publication Publication Date Title
CN101228429B (zh) 原位热诱发的抗原修复及染色设备和方法
US7951612B2 (en) In situ heat induced antigen recovery and staining apparatus and method
US11668629B2 (en) In situ heat induced antigen recovery and staining apparatus and method
US7897106B2 (en) Situ heat induced antigen recovery and staining apparatus and method
US8298485B2 (en) In situ heat induced antigen recovery and staining apparatus and method
AU2017202159B2 (en) In situ heat induced antigen recovery and staining apparatus and method
AU2012247048B2 (en) In situ heat induced antigen recovery and staining apparatus and method
HK1120110B (en) In situ heat induced antigen recovery and staining apparatus and method

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1120110

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1120110

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130410