CN101218217A - 具有改善性质的新的1,4－苯并硫氮杂䓬－1,1－二氧化物衍生物、制备它们的方法、包含所述化合物的药物以及它们的用途 - Google Patents

具有改善性质的新的1,4－苯并硫氮杂䓬－1,1－二氧化物衍生物、制备它们的方法、包含所述化合物的药物以及它们的用途 Download PDF

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Publication number
CN101218217A
CN101218217A CNA2006800250068A CN200680025006A CN101218217A CN 101218217 A CN101218217 A CN 101218217A CN A2006800250068 A CNA2006800250068 A CN A2006800250068A CN 200680025006 A CN200680025006 A CN 200680025006A CN 101218217 A CN101218217 A CN 101218217A
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CN
China
Prior art keywords
compound
inhibitors
agonists
medicament
compounds
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Pending
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CNA2006800250068A
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English (en)
Chinese (zh)
Inventor
W·弗里克
H·格隆比克
H·霍耶尔
H-L·舍费尔
S·泰斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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Filing date
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Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Publication of CN101218217A publication Critical patent/CN101218217A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CNA2006800250068A 2005-07-15 2006-07-13 具有改善性质的新的1,4－苯并硫氮杂䓬－1,1－二氧化物衍生物、制备它们的方法、包含所述化合物的药物以及它们的用途 Pending CN101218217A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005033100A DE102005033100B3 (de) 2005-07-15 2005-07-15 Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, diese Verbindung enthaltene Arzneimittel und Verfahren zu deren Herstellung
DE102005033100.9 2005-07-15

Publications (1)

Publication Number Publication Date
CN101218217A true CN101218217A (zh) 2008-07-09

Family

ID=37575930

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800250068A Pending CN101218217A (zh) 2005-07-15 2006-07-13 具有改善性质的新的1,4－苯并硫氮杂䓬－1,1－二氧化物衍生物、制备它们的方法、包含所述化合物的药物以及它们的用途

Country Status (20)

Country Link
US (1) US20080207592A1 (https=)
EP (1) EP1907370B1 (https=)
JP (1) JP2009501178A (https=)
KR (1) KR20080027841A (https=)
CN (1) CN101218217A (https=)
AR (2) AR058433A1 (https=)
AT (1) ATE423774T1 (https=)
AU (1) AU2006272043A1 (https=)
BR (1) BRPI0613041A2 (https=)
CA (1) CA2614697A1 (https=)
DE (2) DE102005033100B3 (https=)
IL (1) IL188606A0 (https=)
MA (1) MA29620B1 (https=)
MX (1) MX2008000355A (https=)
NO (1) NO20080728L (https=)
NZ (1) NZ565293A (https=)
RU (1) RU2008105741A (https=)
TW (1) TW200745070A (https=)
WO (1) WO2007009656A2 (https=)
ZA (1) ZA200710360B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN109415329A (zh) * 2016-06-27 2019-03-01 葛兰素史克知识产权第二有限公司 合成方法

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DE102007005045B4 (de) 2007-01-26 2008-12-18 Sanofi-Aventis Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
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EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
ES2687027T3 (es) 2010-11-04 2018-10-23 Albireo Ab Inhibidores de ibat para el tratamiento de enfermedades hepáticas
DK2637646T3 (en) 2010-11-08 2016-08-29 Albireo Ab PHARMACEUTICAL COMBINATION CONTAINING AN IBAT inhibitor and a bile acid binder
WO2012120051A1 (de) 2011-03-08 2012-09-13 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683702B1 (de) 2011-03-08 2014-12-24 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
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CN109415329B (zh) * 2016-06-27 2023-05-12 葛兰素史克知识产权第二有限公司 合成方法

Also Published As

Publication number Publication date
NO20080728L (no) 2008-02-08
WO2007009656A3 (de) 2007-04-19
NZ565293A (en) 2010-01-29
IL188606A0 (en) 2008-04-13
US20080207592A1 (en) 2008-08-28
BRPI0613041A2 (pt) 2010-12-14
EP1907370B1 (de) 2009-02-25
MX2008000355A (es) 2008-03-07
TW200745070A (en) 2007-12-16
KR20080027841A (ko) 2008-03-28
RU2008105741A (ru) 2009-08-20
AR058433A1 (es) 2008-02-06
ZA200710360B (en) 2008-11-26
DE502006002956D1 (de) 2009-04-09
JP2009501178A (ja) 2009-01-15
EP1907370A2 (de) 2008-04-09
AR055076A1 (es) 2007-08-01
ATE423774T1 (de) 2009-03-15
DE102005033100B3 (de) 2007-01-25
WO2007009656A2 (de) 2007-01-25
CA2614697A1 (en) 2007-01-25
MA29620B1 (fr) 2008-07-01
AU2006272043A1 (en) 2007-01-25

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