CN101204531A - Medicament composite for ANFH - Google Patents
Medicament composite for ANFH Download PDFInfo
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- CN101204531A CN101204531A CNA2007100603507A CN200710060350A CN101204531A CN 101204531 A CN101204531 A CN 101204531A CN A2007100603507 A CNA2007100603507 A CN A2007100603507A CN 200710060350 A CN200710060350 A CN 200710060350A CN 101204531 A CN101204531 A CN 101204531A
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Abstract
The invention discloses a medicine combination used for treating caput femoris necrosis. The medicine combination is made from the following ingredients with the weight account: 10-20 proportion astragalus root, 10-20 proportion chiretta, 8-16 proportion salvia root, 8-16 proportion cooked rehmannia root, 8-16 proportion white peony root, 8-16 proportion slenderstyle acanthopanax bark, 8-16 proportion Chinese flowering quince, 8-16 proportion dodder seed, 8-16 proportion barbary wolfberry fruit, 10-20 proportion dragon bone, 10-20 proportion oyster shell, 8-16 proportion tall gastrodia tuber, 8-16 proportion dipsacus root, 8-16 proportion gynura segetum, 8-16 proportion corydalis tablet of corydalis tuber, 8-16 proportion wheat powder, 8-16 proportion common clubmoss herb, 8-16 proportion tortoise plastron, 8-16 proportion trionycis carapax, 8-16 proportion black-striped snake, 0.5-1.5 proportion manchurian wildginger, 8-16 proportion common aucklandia root, 0.05-0.15 proportion succinin, 0.05-0.15 proportion saffron and 0.5-1.5 proportion dragon's blood.The invention has a relative good treating effect for caput femoris necrosis; total clinical effective rate can reach 98 percent; cure rate can reach 85.6 percent.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of femur head necrosis.
Background technology
The femur head necrosis full name is an aseptic necrosis of femoral head, or ischemic necrosis of femoral head, is that the local blood fortune of femoral head that causes owing to multiple reason is bad, thereby causes a kind of pathological changes of the further ischemia of osteocyte, necrosis, bone trabecula fracture, collapse of the femoral head.Be familiar with this disease of femur head necrosis first so far from world medical circle in 1888, femur head necrosis changes frequently-occurring disease, commonly encountered diseases into by rare disease.Especially since the appearance and extensive use thereof of steroid hormone, the sickness rate of femur head necrosis rises gradually.The Fracture of femur that caused such as vehicle accident, and the number of excessive drinking in addition increases, and all makes this patient's quantity increase severely.According to incompletely statistics, about 3,000 ten thousand people of this patient are suffered from the whole world at present, and China has 4,000,000 people approximately.Up-to-date investigation shows, this disease do not have an obvious sex difference, any age all can be ill, and had hormone to use the probability showed increased of history, hip trauma history, excessive drinking history, relevant disease history person morbidity.
This disease can betide any age, but it is maximum with 31-60 year, beginning shows as hip joint or its dull pain, the dull pain in joint on every side more, the activity postemphasis, further develop the dysfunction that can cause hip joint, have a strong impact on patient's quality of life and work capacity,, also can cause lifelong deformity if treatment is untimely.
The method of treatment femur head necrosis has a lot, as operation or chemicals injection etc., but existing method, what have costs an arm and a leg, and just suiting the medicine to the illness of having alleviated, and long-term effect is undesirable.In order to remove vast femoral head patient's misery as early as possible, the necessary medicine of developing a kind of determined curative effect, short treating period, cure rate height, relapse rate is low, price is low treatment femur head necrosis.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, the pharmaceutical composition of a kind of determined curative effect, short treating period, cure rate height, relapse rate is low, price is low treatment femur head necrosis is provided.
Technical scheme of the present invention is summarized as follows:
A kind of pharmaceutical composition for the treatment of femur head necrosis, form by following component by weight:
Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Salviae Miltiorrhizae 8-16 part, Radix Rehmanniae Preparata 8-16 part, Radix Paeoniae Alba 8-16 part, Cortex Acanthopancis 8-16 part, Fructus Chaenomelis 8-16 part, Semen Cuscutae 8-16 part, Fructus Lycii 8-16 part, Os Draconis 10-20 part, Concha Ostreae 10-20 part, Rhizoma Gastrodiae 8-16 part, Radix Dipsaci 8-16 part, Radix Notoginseng 8-16 part, Rhizoma Corydalis 8-16 part, Rhizoma Drynariae 8-16 part, Herba Lycopodii 8-16 part, Carapax et Plastrum Testudinis 8-16 part, Carapax Trionycis 8-16 part, Zaocys 8-16 part, Herba Asari 0.5-1.5 part, Radix Aucklandiae 8-16 part, succinum 0.05-0.15 part, Stigma Croci 0.05-0.15 part, Sanguis Draxonis 0.5-1.5 part.
Preferably: 15 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts in Radix Rehmanniae Preparata, 12 parts of the Radix Paeoniae Albas, 12 parts of Cortex Acanthopanciss, 12 parts of Fructus Chaenomeliss, 12 parts of Semen Cuscutae, 12 parts of Fructus Lycii, 15 parts of Os Draconis, 15 parts of Concha Ostreaes, 12 parts in Rhizoma Gastrodiae, 12 parts of Radix Dipsaci, 12 parts of Radix Notoginseng, 12 parts of Rhizoma Corydalis, 12 parts of Rhizoma Drynariae, 12 parts of Herba Lycopodiis, 12 parts of Carapax et Plastrum Testudiniss, 12 parts of Carapax Trionycis, 12 parts of Zaocys, 1 part of Herba Asari, 12 parts of the Radix Aucklandiae, 0.1 part of succinum, 0.1 part of Stigma Croci, 1 part of Sanguis Draxonis.
A kind of pharmaceutical composition for the treatment of femur head necrosis of the present invention according to the process of Chinese medicine preparation of routine, can be prepared into any medicament commonly used, as pill, drop pill, powder, tablet, capsule and oral liquid etc.
A kind of pharmaceutical composition for the treatment of femur head necrosis of the present invention, have that QI invigorating is enriched blood, invigorating the kidney and strengthening the bones, life essence-filling, marrow-benefitting, blood circulation promoting and blood stasis dispelling, the bone resorption of giving a piece of bad advice, new bone formation, bone trabecula is rebuild, and femur head necrosis is had therapeutical effect preferably, and clinical total effective rate reaches 98%, cure rate reaches 85.6%, drug safety.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of pharmaceutical composition for the treatment of femur head necrosis comprises following component:
The Radix Astragali 15 grams, Radix Angelicae Sinensis 15 grams, Radix Salviae Miltiorrhizae 12 grams, Radix Rehmanniae Preparata 12 grams, the Radix Paeoniae Alba 12 grams, Cortex Acanthopancis 12 grams, Fructus Chaenomelis 12 grams, Semen Cuscutae 12 grams, Fructus Lycii 12 grams, Os Draconis 15 grams, Concha Ostreae 15 grams, Rhizoma Gastrodiae 12 grams, Radix Dipsaci 12 grams, Radix Notoginseng 12 grams, Rhizoma Corydalis 12 grams, Rhizoma Drynariae 12 grams, Herba Lycopodii 12 grams, Carapax et Plastrum Testudinis 12 grams, Carapax Trionycis 12 grams, Zaocys 12 grams, Herba Asari 1 gram, the Radix Aucklandiae 12 grams, succinum 0.1 gram, Stigma Croci 0.1 gram, Sanguis Draxonis 1 gram.
A kind of pharmaceutical composition for the treatment of femur head necrosis of the present invention according to the process of Chinese medicine preparation of routine, can be prepared into any medicament commonly used, as pill, drop pill, powder, tablet, capsule and oral liquid etc.
The preparation method of pill of the present invention is: choose medical material according to said ratio, oven dry is pulverized, and making pellets by mixing medical powder with honey, every ball weigh 10 grams.
Can also be: the succinum in the above-mentioned prescription, Stigma Croci, Sanguis Draxonis are plucked elected, add the beeswax that is equivalent to Stigma Croci 100 times of weight in addition, make powder or pill; Remaining other component decocts with water into solution.Powder and solution are used.
Embodiment 2
A kind of pharmaceutical composition for the treatment of femur head necrosis comprises following component:
The Radix Astragali 10 grams, Radix Angelicae Sinensis 10 grams, Radix Salviae Miltiorrhizae 16 grams, Radix Rehmanniae Preparata 8 grams, the Radix Paeoniae Alba 16 grams, Cortex Acanthopancis 16 grams, Fructus Chaenomelis 16 grams, Semen Cuscutae 8 grams, Fructus Lycii 8 grams, Os Draconis 20 grams, Concha Ostreae 10 grams, Rhizoma Gastrodiae 8 grams, Radix Dipsaci 16 grams, Radix Notoginseng 16 grams, Rhizoma Corydalis 8 grams, Rhizoma Drynariae 16 grams, Herba Lycopodii 8 grams, Carapax et Plastrum Testudinis 8 grams, Carapax Trionycis 8 grams, Zaocys 16 grams, Herba Asari 0.5 gram, the Radix Aucklandiae 16 grams, succinum 0.05 gram, Stigma Croci 0.15 gram, Sanguis Draxonis 1.5 grams.
Embodiment 3
A kind of pharmaceutical composition for the treatment of femur head necrosis comprises following component:
The Radix Astragali 20 grams, Radix Angelicae Sinensis 20 grams, Radix Salviae Miltiorrhizae 8 grams, Radix Rehmanniae Preparata 16 grams, the Radix Paeoniae Alba 8 grams, Cortex Acanthopancis 8 grams, Fructus Chaenomelis 8 grams, Semen Cuscutae 16 grams, Fructus Lycii 8 grams, Os Draconis 10 grams, Concha Ostreae 20 grams, Rhizoma Gastrodiae 16 grams, Radix Dipsaci 8 grams, Radix Notoginseng 8 grams, Rhizoma Corydalis 16 grams, Rhizoma Drynariae 8 grams, Herba Lycopodii 16 grams, Carapax et Plastrum Testudinis 16 grams, Carapax Trionycis 16 grams, Zaocys 8 grams, Herba Asari 1.5 grams, the Radix Aucklandiae 8 grams, succinum 0.15 gram, Stigma Croci 0.05 gram, Sanguis Draxonis 0.5 gram.
Experimental example
Unified diagnosis and criterion of therapeutical effect according to the State shares head necrosis, we adopt the method for completely random contrast, 320 routine patients have been carried out observation of curative effect, wherein there are 83 routine patients to do operation at large hospital, wherein, boring decompression 57 examples, bone grafting operation 21 examples, artificial femoral head replacement's 1 example, moving 4 examples of femoral head rotation.The short-term effect of operative treatment is better, but therapeutic effect at a specified future date is not ideal, and the small number of patients postoperative also osteonecrosis sign can occur.
One, clinical data
1. case is selected
Among the patient of 1300 examples of accepting for medical treatment, select 320 examples, outpatient service 281 examples wherein, 39 examples of being in hospital, to the classical symptom of femur head necrosis, sign etc. before treatment all through X line pathological staging and main indications, CT examination, nuclear magnetic resonance check, prove position, size, the distortion of osteonecrosis district of femur head necrosis on inspection and subside the symptom of arthrostenosis.
2. physical data
Case 320 examples, wherein male 272 examples, women 48 examples, these patients, the age-based branch: 1-10 year 5 examples, 12-20 year 3 examples, 21-40 year 115 examples, 41-60 year 169 examples, 28 examples more than 61 years old, the course of disease is the longest 13 years, the shortest 9 months, ill 1 year with 72 interior examples, 131 examples of 1-6,7-10 104 examples, 11 years above 13 examples.320 routine patients are pressed marcus by stages, routine routine V-VI118 example of III-IV phases 189 of I-II phases 13.
Two. Therapeutic Method:
The pill of choosing the patient to use a kind of pharmaceutical composition for the treatment of femur head necrosis of the present invention to make according to the state of an illness, usage every day three times, each ball (10 gram), warm boiled water, three months is a course of treatment.I-II phase patient obeys 1-2 the course of treatment, and III-IV phase patient obeys 2-4 the course of treatment, and V-VI phase patient obeys 3-5 the course of treatment.
Three. efficacy analysis
1. cure: pain disappears around the hip joint, and function is improved normal, walks not have and walks lamely, 4 words tests (bend, stretch, open up, revolve) (-), the X-ray prompting: the femur head necrosis district all absorbs, and area of new bone forms, the perichondrium tissue repair, 2 kilometers of walkings are asymptomatic, can participate in manual labor and work.
2. produce effects: pain disappears, and function is improved, and does not have limpings substantially with oning foot, and 4 words are tested (-), and there is absorption in the osteonecrosis district, area of new bone formation, and the perichondrium tissue repair, 2 kilometers buttocks acid precipitation of walking, nothing is ached.
3. take a turn for the better: pain disappears substantially, and function makes moderate progress, rare limping, and osteonecrosis is most of to be absorbed.
4. curative effect is not obvious: can control the development of osteonecrosis district, symptom can be alleviated, and function has improvement, but not obvious.
Four. therapeutic outcome:
| Patient's sum | Cure number | The produce effects number | Good revolution | Not obvious | |
| Chinese medicine expectant treatment group | 237 | 214 | 15 | 8 | 0 |
| Postoperative prescription on individual diagnosis group | 83 | 60 | 11 | 6 | 6 |
Clinical total effective rate reaches 98%, and cure rate reaches 85.6%.
Claims (2)
1. a pharmaceutical composition for the treatment of femur head necrosis is characterized in that being made up of following component by weight: Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Salviae Miltiorrhizae 8-16 part, Radix Rehmanniae Preparata 8-16 part, Radix Paeoniae Alba 8-16 part, Cortex Acanthopancis 8-16 part, Fructus Chaenomelis 8-16 part, Semen Cuscutae 8-16 part, Fructus Lycii 8-16 part, Os Draconis 10-20 part, Concha Ostreae 10-20 part, Rhizoma Gastrodiae 8-16 part, Radix Dipsaci 8-16 part, Radix Notoginseng 8-16 part, Rhizoma Corydalis 8-16 part, Rhizoma Drynariae 8-16 part, Herba Lycopodii 8-16 part, Carapax et Plastrum Testudinis 8-16 part, Carapax Trionycis 8-16 part, Zaocys 8-16 part, Herba Asari 0.5-1.5 part, Radix Aucklandiae 8-16 part, succinum 0.05-0.15 part, Stigma Croci 0.05-0.15 part, Sanguis Draxonis 0.5-1.5 part.
2. a kind of pharmaceutical composition for the treatment of femur head necrosis according to claim 1 is characterized in that the parts by weight of described each component are: 15 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts in Radix Rehmanniae Preparata, 12 parts of the Radix Paeoniae Albas, 12 parts of Cortex Acanthopanciss, 12 parts of Fructus Chaenomeliss, 12 parts of Semen Cuscutae, 12 parts of Fructus Lycii, 15 parts of Os Draconis, 15 parts of Concha Ostreaes, 12 parts in Rhizoma Gastrodiae, 12 parts of Radix Dipsaci, 12 parts of Radix Notoginseng, 12 parts of Rhizoma Corydalis, 12 parts of Rhizoma Drynariae, 12 parts of Herba Lycopodiis, 12 parts of Carapax et Plastrum Testudiniss, 12 parts of Carapax Trionycis, 12 parts of Zaocys, 1 part of Herba Asari, 12 parts of the Radix Aucklandiae, 0.1 part of succinum, 0.1 part of Stigma Croci, 1 part of Sanguis Draxonis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710060350A CN101204531B (en) | 2007-12-19 | 2007-12-19 | Medicament composite for ANFH |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710060350A CN101204531B (en) | 2007-12-19 | 2007-12-19 | Medicament composite for ANFH |
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| Publication Number | Publication Date |
|---|---|
| CN101204531A true CN101204531A (en) | 2008-06-25 |
| CN101204531B CN101204531B (en) | 2010-05-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200710060350A Expired - Fee Related CN101204531B (en) | 2007-12-19 | 2007-12-19 | Medicament composite for ANFH |
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| Country | Link |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953941A (en) * | 2010-10-22 | 2011-01-26 | 赵洪社 | Chinese medicinal liquor for treating femoral head necrosis |
| CN104107302A (en) * | 2013-04-20 | 2014-10-22 | 沈阳市骨科医院 | Femoral-head recovering tablet |
| CN105943719A (en) * | 2016-04-28 | 2016-09-21 | 谭永胜 | Externally-applied Chinese herbal medicine and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142896B (en) * | 2013-03-29 | 2014-08-06 | 刘新宇 | Medicine for treating osteonecrosis of femoral head |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055242C (en) * | 1998-06-30 | 2000-08-09 | 钱应敏 | Chinese medicine for curing aseptic necrosis of head of femur |
-
2007
- 2007-12-19 CN CN200710060350A patent/CN101204531B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953941A (en) * | 2010-10-22 | 2011-01-26 | 赵洪社 | Chinese medicinal liquor for treating femoral head necrosis |
| CN101953941B (en) * | 2010-10-22 | 2011-08-31 | 赵洪社 | Chinese medicinal liquor for treating femoral head necrosis |
| CN104107302A (en) * | 2013-04-20 | 2014-10-22 | 沈阳市骨科医院 | Femoral-head recovering tablet |
| CN105943719A (en) * | 2016-04-28 | 2016-09-21 | 谭永胜 | Externally-applied Chinese herbal medicine and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101204531B (en) | 2010-05-19 |
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Granted publication date: 20100519 Termination date: 20131219 |