CN101163585A - 能释放活性组分、促进其被吸收，并能用作医疗救助用品或用来制作与健康或患病肌肤直接接触的衣服或结构的透气保湿的多层技术复合物 - Google Patents

能释放活性组分、促进其被吸收，并能用作医疗救助用品或用来制作与健康或患病肌肤直接接触的衣服或结构的透气保湿的多层技术复合物 Download PDF

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CN101163585A
CN101163585A CNA2006800089659A CN200680008965A CN101163585A CN 101163585 A CN101163585 A CN 101163585A CN A2006800089659 A CNA2006800089659 A CN A2006800089659A CN 200680008965 A CN200680008965 A CN 200680008965A CN 101163585 A CN101163585 A CN 101163585A
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埃米利奥·伯蒂尼
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    • A41D31/00—Materials specially adapted for outerwear
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    • A41D31/30—Antimicrobial, e.g. antibacterial
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Abstract

本发明涉及一种尤其用于制造医疗救助用品、服装和医用品的多层技术复合物，该复合物包含至少两层(2，3)，其第一层(2)与皮肤接触，是一种棉织物(经过或多或少的弹性处理)或丝织品或加入了壳聚糖、银或另一种抗菌物质或活性组分的织物，第二层外层(3)由半渗透膜如5－80微米厚的聚氨酯组成，该膜具有相当大的弹性以确保为使用者提供舒适感。可充填活性组分的受体被掺到织物(2)中并由聚氨酯膜保护。

Description

能释放活性组分、促进其被吸收，并能用作医疗救助用品或用来制作与健康或患病肌肤直接接触的衣服或结构的透气保湿的多层技术复合物
本发明涉及一种能释放活性组分、促进其被吸收，并特别能用作医疗工具或用来制作与健康或患病肌肤直接接触的衣服或结构的透气保湿的多层技术复合物。
发明背景
纺织工业尤其重视市场需求；用于特定功能的材料的需求，如具有与健康和患病皮肤接触功能的纺织纤维和织物的需求尤其在最近几年显为增加。
实践证明目前使用的材料并不是完全令人满意。
发明内容
本发明的目的是提供一种能保证特定透气性的多层技术复合物，以便确保皮肤的最佳润湿性以及活性组分发挥作用的理想条件。
本发明的另一个目的是提供这样一种多层复合物，该复合物可与化妆品或药品配方联合使用或掺混使用，帮助其被吸收和优化其性能。
本发明的另一个目的是提供一种多层复合物，其柔软、舒适并可能抗菌，可再填以活性组分。
按照本发明，这些目的可由所附的独立权利要求1的特征来达到。
本发明也涉及包含这里所述的多层复合物的医疗装置以及这些材料作为润湿剂在皮肤病学和化妆品中的用途。
从属权利要求描述了本发明的优选实施例。
发明详述
按照本发明的多层技术复合物主要包含至少两层。第一层与皮肤接触，是一种织物，第二层外层由半透膜形成。
第一层与皮肤接触，可由加入了壳聚糖、银或其它抗菌物质或活性组分的棉(经过或多或少的弹性处理)、丝织品或织物构成。
第二层由半透膜材料构成，优选由5-80微米厚的聚氨酯构成，该膜具有相当大的弹性以确保为使用者提供舒适感。所述膜可以是无孔的，这样，若有活性组分，也不会透到外部。这样，活性组分不会被浪费，并且由于其没有到达外表面，就不会弄脏床单、衣服或其它包扎用品。
所述膜可通过渗透作用透气，因此不会形成闭塞的包扎用品。
附图所示的是按照本发明的两层技术复合物的部分横截面示意图，该材料整体表示为1，包含一个例如由棉，丝织物或其它纤维制品的织物构成的第一层内层2，以及一个由聚氨酯构成的第二层即外层3，这两层紧紧地相互粘结，优选通过热压过程，并使用为达到这个目的而特别设计的非过敏性胶水的微粒，测得的该微粒直径在0.15-0.7mm之间，以规则的间隔布置微粒，这样可计算出每平方厘米有60-180个点。胶点的规则间隙提供了胶粘表面和自由表面的合适比例。
该结构优选包含可再填充的受体，该受体包含润湿剂或更具体的治疗活性组分，如环糊精、微型海绵物、脂质体和纳米粒子。
若应用于皮肤(棉和/或其它材料层接触表皮，聚氨酯膜在外表面)，根据皮肤的角质层的完整性和皮肤屏障的客观参数，本发明的多层技术复合物改善皮肤的屏障和润湿作用；换句话说，它起到润湿物质的作用。这些性质可通过使用非侵入方法如透皮水分流失(TEWL)测量和角质层测量来证实。
若在施以润湿物质和/或活性组分之后使用，则可以促进它们的活性和渗透性。
使用上述类型的复合物得到了好的结果，特别是，已经进行了该材料对于一些皮肤生理参数的显著的、新的作用的研究。
该研究在15个受验者上进行。该多层复合物“原样”应用到不同的两处皮肤上：前臂的手掌表面和前腹区域。复合物被连续八小时留在该位置来模拟代替消费者使用的内衣和睡衣的产品。应用八小时之后，进行一些仪器测试来观察皮肤上发生的变化。特别是测量透皮水分流失(TEWL)，并且通过皮肤表面湿度测量仪测量角质层的液体含量。TEWL测量在特定物质的表面上蒸发的水蒸汽量，皮肤表面湿度测量是基于探测随着特定身体水含量变化的电容量的一项技术。所有这些测试使用纯棉织物(空白对照剂)，通过相同的步骤作为对照标准，以其上未放置任何产品的皮肤作为负的对照标准。结果表明，在施用8小时的测试产品到皮肤表面之后，可维持透过薄膜正常的皮肤透气，其TEWL指数可与棉的指数相比，并具有可与棉或作为对照标准的皮肤相比的增加(统计显著的)的角质层水含量。
该发现证实了本产品的独特的透气性及其能增加皮肤润湿性的能力。其它薄膜在可透气的同时不能增加润湿性。在重复同样测试步骤的随后的研究中，施用润湿膏于产品和皮肤的界面上。结果更为显著(包括统计)；保持了高透气性(通过产品的TEWL)，并具有极好地润湿皮肤的效果。这足以支持使用具有润湿配方的该产品来处理以皮肤的干燥为特征的不同皮肤情况，如扩散性干燥，特应性皮炎，牛皮癣等。除了使用具有化妆品或制药配方的该产品之外，在制药和化妆品工业中用于活性组分受控释放的材料，如环糊精、微型海绵物、脂质体、纳米粒子和双性缩胺酸，可混合到成品中来增加所述配方的功效。
众所周知，在皮肤药理学中很多活性组分的释放和经皮渗透发生在最佳皮肤润湿条件下；当皮肤脱水时，这些技术在线性控制释放方面上经常出现问题，因此不能被充分利用于治疗目的。根据本发明的含有所述低释放粒子(环糊精、微型海绵物、脂质体等)的多层复合物的一些实际应用可以是其与活性物质结合来处理由脂肪团，局部消炎物质(皮质酮、NSAIDs、植物保护剂、甘草次酸、维生素和抗氧化物质)，或处理脱皮性皮炎(尿素、维生素D衍生物、类视黄醇等)引起的缺陷。
此外，各种各样的防腐和抗菌活性组分，如双氯苯双胍己烷、三氯生、十一碳烯酸、咪菌酮和其它咪唑衍生物可被添加到具有该多层复合物的控制-释放体系，并通常用来处理脓疱皮炎、酵母感染和真菌等。包含在多层体系中的银(以各种形式)也提供杀菌的预防作用，被用来避免和控制各种紊乱的细菌和/或真菌感染，如特异性皮炎，各种类型的下肢的溃疡损伤，与一些代谢和发炎紊乱有关的皮肤并发症，通常如糖尿病、结缔组织疾病和血管疾病。
特别指出的是，它可用于用在疾病上或身体需要处理的部位的衣服，如有袖或无袖T-恤、裤子、睡衣、外套、手套、帽子、面罩、包扎用品、长袜、护膝、衬裤等，以处理各种皮肤和其它疾病，如接触性皮炎、牛皮癣、扭伤和脱臼、关节问题等。
总的来说，按照本发明的所述多层技术复合物通过渗透实现透气功能，可将汗液输送到聚氨酯薄膜的外部，因此可防止浸渍，同时，它延长和优化了所有活性或润湿组分(如闭塞一样的效应)的功能，这样活性组分就不会释放到外部，通过这样的方法，膜的外表面不受影响，并且被褥、被单、包扎用品等等不会被弄脏，因此即使患有重大疾病的病人也不需中断其正常活动。
如前所述，该多层复合物可用来制作有袖或无袖T-裇、裤子、睡衣、外套、手套、帽子、面罩和包扎用品。
再次通过胶点或网式粘结，使用热压过程可粘结一层具有美感或应用功能的第三外层到该多层技术织物上。

Claims (20)

1.效果特别有效的用于医疗救助和服装的多层技术复合物，其包含至少两层，其第一层(2)与皮肤接触，是一种织物，以及第二层即外层(3)由半透膜形成。
2.如权利要求1所述的多层复合物，其特征在于所述与皮肤接触的第一层织物(2)是棉或丝。
3.如权利要求2所述的多层复合物，其特征在于所述棉或其它织物经弹性处理。
4.如前述权利要求中任一项所述的多层复合物，其特征在于壳聚糖、银(以各种形式)或抗菌剂加入到所述织物(2)中。
5.如前述权利要求中任一项所述的多层复合物，其特征在于所述织物(2)中掺入选自环糊精、纳米粒子、微型海绵物和生物肽的受体。
6.如前述权利要求中任一项所述的多层复合物，其特征在于所述形成第二层即外层(3)的半透膜由弹性聚氨酯构成。
7.如前述权利要求中任一项所述的多层复合物，其特征在于所述形成第二层即外层(3)的半透膜与织物层(2)的粘结使受体(环糊精、纳米粒子、微型海绵物和生物肽)集中和固定。
8.如权利要求6所述的多层复合物，其中所述聚氨酯膜能通过渗透作用透气并且不产生闭塞效应。
9.如权利要求6所述的多层复合物，其中所述聚氨酯膜能通过渗透作用透气，因而促进了皮肤的润湿度和恢复皮肤屏障作用。
10.如权利要求5和6所述的多层复合物，其中所述聚氨酯膜能在内层(与皮肤接触)保留活性组分，该组分自由存在或粘结到受体上，并且不允许其透过或分散到外部。
11.如权利要求5所述的多层复合物，其中所述聚氨酯膜的厚度为5-80微米。
12.如前述权利要求中任一项所述的多层复合物，其中所述层(2，3)使用直径0.15-0.7mm的非过敏性胶水(4)的微粒通过热压过程紧密粘结在一起。
13.如前述权利要求中任一项所述的多层复合物，其特征在于包含选自环糊精、微型海绵物、脂质体、纳米粒子和生物肽的受体，所述受体可再填充润湿或治疗活性组分。
14.如权利要求13所述的多层复合物，其在治疗由脂肪团、局部消炎物质、可的松、NSAIDs、植物保护剂、甘草次酸、维生素或抗氧化物质引起的损伤中与活性物质结合使用，或在脱皮性皮炎中与活性物质，如尿素、维生素D衍生物和类视黄醇结合使用。
15.如前述权利要求中任一项所述的多层复合物，其特征在于包含选自双氯苯双胍己烷、三氯生、十一碳烯酸、咪菌酮和咪唑衍生物的通常用来处理脓疹皮炎、酵母感染和真菌的防腐和抗菌活性组分。
16.如前述权利要求中任一项所述的多层复合物，其特征在于包含至少一个具有美感或应用功能的附加第三外层。
17.如权利要求16所述的多层复合物，其中所述附加外层使用热压过程通过胶点或网式粘结进行粘合。
18.如前述权利要求中任一项所述的复合物，其用来制作有袖或无袖T-恤、裤子、睡衣、外套、手套、帽子、面罩、包扎用品、长袜、护膝、衬裤和常规服装。
19.使用前述权利要求中任一项所述的多层复合物制作的医疗救助用品或衣服。
20.如权利要求1-18所述的复合物作为皮肤润湿剂的用途。
CNA2006800089659A 2005-03-22 2006-03-20 能释放活性组分、促进其被吸收，并能用作医疗救助用品或用来制作与健康或患病肌肤直接接触的衣服或结构的透气保湿的多层技术复合物 Pending CN101163585A (zh)

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US11491254B2 (en) 2017-11-08 2022-11-08 Coloplast A/S Adhesive wafer with a neutralizer matrix
US11911310B2 (en) 2017-11-08 2024-02-27 Coloplast A/S Adhesive wafer with a neutralizer matrix

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JP2008538705A (ja) 2008-11-06
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