CN101163466B - 2-(2-硝基-4-三氟甲基苯甲酰)-1,3-环己二酮在治疗帕金森病中的用途 - Google Patents

2-(2-硝基-4-三氟甲基苯甲酰)-1,3-环己二酮在治疗帕金森病中的用途 Download PDF

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Publication number
CN101163466B
CN101163466B CN2006800133878A CN200680013387A CN101163466B CN 101163466 B CN101163466 B CN 101163466B CN 2006800133878 A CN2006800133878 A CN 2006800133878A CN 200680013387 A CN200680013387 A CN 200680013387A CN 101163466 B CN101163466 B CN 101163466B
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China
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alkyl
compound
alkoxy
inhibitor
effective amount
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Expired - Fee Related
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CN2006800133878A
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Chinese (zh)
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CN101163466A (zh
Inventor
约翰·欧内斯特·多伊
尼克拉斯·克里斯皮尼亚恩·斯特奇斯
金·扎卡里·特拉维斯
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Syngenta Ltd
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Zeneca Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
CN2006800133878A 2005-02-28 2006-02-27 2-(2-硝基-4-三氟甲基苯甲酰)-1,3-环己二酮在治疗帕金森病中的用途 Expired - Fee Related CN101163466B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0504103.3A GB0504103D0 (en) 2005-02-28 2005-02-28 Novel method
GB0504103.3 2005-02-28
PCT/GB2006/000684 WO2006090177A1 (en) 2005-02-28 2006-02-27 USE OF 2-(2-NITRO-4-TRIFLUOROMETHYLBENZOYL)-l,3- CYCLOHEXANEDIONE IN THE TREATMENT OF PARKINSON'S DISEASE

Publications (2)

Publication Number Publication Date
CN101163466A CN101163466A (zh) 2008-04-16
CN101163466B true CN101163466B (zh) 2011-12-07

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CN2006800133878A Expired - Fee Related CN101163466B (zh) 2005-02-28 2006-02-27 2-(2-硝基-4-三氟甲基苯甲酰)-1,3-环己二酮在治疗帕金森病中的用途

Country Status (17)

Country Link
US (1) US20090326072A1 (https=)
EP (1) EP1853241B1 (https=)
JP (1) JP2008531665A (https=)
CN (1) CN101163466B (https=)
AT (1) ATE524171T1 (https=)
AU (1) AU2006217650B2 (https=)
BR (1) BRPI0609177A2 (https=)
CA (1) CA2598517A1 (https=)
DK (1) DK1853241T3 (https=)
ES (1) ES2374761T3 (https=)
GB (1) GB0504103D0 (https=)
IL (1) IL185410A0 (https=)
MX (1) MX2007010480A (https=)
PT (1) PT1853241E (https=)
RU (1) RU2420272C2 (https=)
WO (1) WO2006090177A1 (https=)
ZA (1) ZA200707486B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101669432B1 (ko) 2007-08-27 2016-10-26 다트 뉴로사이언스 (케이만) 엘티디. 치료적 이속사졸 화합물
WO2009086303A2 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2010054273A1 (en) * 2008-11-06 2010-05-14 Synosia Therapeutics Treatment of restless leg syndrome and sleep disorders
RS54632B1 (sr) 2011-06-23 2016-08-31 Swedish Orphan Biovitrum International Ab Tečna farmaceutska kompozicija koja sadrži nitizinon
CN103622942A (zh) * 2013-11-04 2014-03-12 江苏大学 左旋多巴/卡比多巴复方缓释混悬剂及其制备方法
JP2018521077A (ja) * 2015-07-29 2018-08-02 タケダ ゲー・エム・ベー・ハーＴａｋｅｄａ ＧｍｂＨ 糖尿病性腎症を治療するためのｐｄｅ４阻害剤
ITUB20160650A1 (it) 2016-02-11 2017-08-11 Dipharma S A Formulazioni farmaceutiche solide stabili contenenti 2-(2-nitro-4-trifluorometilbenzoil)-1,3-cicloesandione
US9783485B1 (en) 2016-11-30 2017-10-10 Dipharma S.A. Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof
TW202543611A (zh) * 2024-03-27 2025-11-16 美商費斯製藥有限公司 Ｈｐｄ抑制劑組成物及使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780127A (en) * 1982-03-25 1988-10-25 Stauffer Chemical Company Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides
US5092919A (en) * 1991-01-15 1992-03-03 Imperial Chemical Industries Plc Certain 2-(2'-methyl-3',4'-trisubstituted benzoyl)-1,3-cyclohexanediones

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3130935B2 (ja) * 1991-06-24 2001-01-31 ゼネカ リミテッド 医薬組成物
FR2777781B1 (fr) * 1998-04-24 2004-04-09 Rhone Poulenc Rorer Sa Associations riluzole et l-dopa pour le traitement de la maladie de parkinson
US20050288187A1 (en) * 2002-07-03 2005-12-29 Hanauske-Abel Hartmut M Inhibitor development for 4-hydroxyphenylpyruvate dioxygenase, employing tyrosinemia 1 as a model for human diseases mediated by 2-oxoacid utilizing dioxygenases
WO2005007096A2 (en) * 2003-07-11 2005-01-27 Merck & Co., Inc. Treatment of movement disorders with a metabotropic glutamate 4 receptor positive allosteric modulator
NZ574153A (en) * 2006-08-18 2011-12-22 Syngenta Ltd Use of hppd inhibitors in the treatment of depression and/or withdrawal symptoms associated with addictive drugs
WO2010054273A1 (en) * 2008-11-06 2010-05-14 Synosia Therapeutics Treatment of restless leg syndrome and sleep disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780127A (en) * 1982-03-25 1988-10-25 Stauffer Chemical Company Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides
US5092919A (en) * 1991-01-15 1992-03-03 Imperial Chemical Industries Plc Certain 2-(2'-methyl-3',4'-trisubstituted benzoyl)-1,3-cyclohexanediones

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Meilan Huang et al.3D-QSAR Studies on 4-hydroxyphenylpyruvate DioxygenaseInhibitors by Comparative Molecular Field Analysis (CoMFA).Bioorganic Medicinal Chemistry Letters 12.2002,(12),2271-2275.
Meilan Huang et al.3D-QSAR Studies on 4-hydroxyphenylpyruvate DioxygenaseInhibitors by Comparative Molecular Field Analysis (CoMFA).Bioorganic Medicinal Chemistry Letters 12.2002,(12),2271-2275. *
李开顺等.帕金森病的药物治疗进展.中国药师2 4.1999,2(4),208-210.
李开顺等.帕金森病的药物治疗进展.中国药师2 4.1999,2(4),208-210. *
陈涛等.多巴胺受体激动剂与帕金森病.国外医学.老年医学分册23 2.2002,23(2),64-68.
陈涛等.多巴胺受体激动剂与帕金森病.国外医学.老年医学分册23 2.2002,23(2),64-68. *
黄美兰等.两类HPPD酶抑制剂的比较分子场分析研究.化学学报60 9.2002,60(9),1558-1563.
黄美兰等.两类HPPD酶抑制剂的比较分子场分析研究.化学学报60 9.2002,60(9),1558-1563. *

Also Published As

Publication number Publication date
CN101163466A (zh) 2008-04-16
PT1853241E (pt) 2012-01-11
DK1853241T3 (da) 2012-01-16
RU2420272C2 (ru) 2011-06-10
GB0504103D0 (en) 2005-04-06
HK1110211A1 (en) 2008-07-11
AU2006217650A1 (en) 2006-08-31
AU2006217650B2 (en) 2011-06-09
ES2374761T3 (es) 2012-02-21
CA2598517A1 (en) 2006-08-31
ZA200707486B (en) 2009-02-25
IL185410A0 (en) 2008-08-07
MX2007010480A (es) 2008-02-07
RU2007131934A (ru) 2009-02-27
JP2008531665A (ja) 2008-08-14
US20090326072A1 (en) 2009-12-31
ATE524171T1 (de) 2011-09-15
EP1853241A1 (en) 2007-11-14
WO2006090177A1 (en) 2006-08-31
BRPI0609177A2 (pt) 2010-02-23
EP1853241B1 (en) 2011-09-14

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