CN101151066B - 使用口服饮食补充剂调节人的角质组织的美观性 - Google Patents
使用口服饮食补充剂调节人的角质组织的美观性 Download PDFInfo
- Publication number
- CN101151066B CN101151066B CN2006800100164A CN200680010016A CN101151066B CN 101151066 B CN101151066 B CN 101151066B CN 2006800100164 A CN2006800100164 A CN 2006800100164A CN 200680010016 A CN200680010016 A CN 200680010016A CN 101151066 B CN101151066 B CN 101151066B
- Authority
- CN
- China
- Prior art keywords
- dietary supplement
- consumer
- oral
- therapeutic method
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 96
- 239000002537 cosmetic Substances 0.000 title abstract description 9
- 230000001105 regulatory effect Effects 0.000 title abstract description 5
- 239000006041 probiotic Substances 0.000 claims abstract description 38
- 235000018291 probiotics Nutrition 0.000 claims abstract description 38
- 210000004209 hair Anatomy 0.000 claims abstract description 37
- 230000000529 probiotic effect Effects 0.000 claims abstract description 37
- 239000000203 mixture Substances 0.000 claims description 43
- 210000004905 finger nail Anatomy 0.000 claims description 30
- 241000894006 Bacteria Species 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 21
- 239000011782 vitamin Substances 0.000 claims description 17
- 229940088594 vitamin Drugs 0.000 claims description 16
- 229930003231 vitamin Natural products 0.000 claims description 16
- 235000013343 vitamin Nutrition 0.000 claims description 16
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 15
- 238000002560 therapeutic procedure Methods 0.000 claims description 14
- 239000002775 capsule Substances 0.000 claims description 13
- 229910052751 metal Inorganic materials 0.000 claims description 13
- 239000002184 metal Substances 0.000 claims description 13
- 239000003963 antioxidant agent Substances 0.000 claims description 12
- 230000003078 antioxidant effect Effects 0.000 claims description 12
- 235000006708 antioxidants Nutrition 0.000 claims description 12
- 235000013406 prebiotics Nutrition 0.000 claims description 12
- 239000011785 micronutrient Substances 0.000 claims description 11
- 235000013369 micronutrients Nutrition 0.000 claims description 11
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 11
- 230000003203 everyday effect Effects 0.000 claims description 10
- 210000004761 scalp Anatomy 0.000 claims description 7
- 235000012054 meals Nutrition 0.000 claims description 5
- 235000013399 edible fruits Nutrition 0.000 claims description 4
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- 229920001202 Inulin Polymers 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 229940029339 inulin Drugs 0.000 claims description 2
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 description 46
- 239000000047 product Substances 0.000 description 37
- 230000000699 topical effect Effects 0.000 description 28
- -1 ascorbyl ester Chemical class 0.000 description 22
- 229930003270 Vitamin B Natural products 0.000 description 21
- 150000001875 compounds Chemical class 0.000 description 21
- 235000019156 vitamin B Nutrition 0.000 description 21
- 239000011720 vitamin B Substances 0.000 description 21
- 239000003795 chemical substances by application Substances 0.000 description 20
- 241001597008 Nomeidae Species 0.000 description 16
- 150000003839 salts Chemical class 0.000 description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 15
- 230000036541 health Effects 0.000 description 13
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 11
- 230000009286 beneficial effect Effects 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- 229940011671 vitamin b6 Drugs 0.000 description 10
- 241000186660 Lactobacillus Species 0.000 description 9
- 230000002354 daily effect Effects 0.000 description 9
- 235000004626 essential fatty acids Nutrition 0.000 description 9
- 229940039696 lactobacillus Drugs 0.000 description 9
- 239000000843 powder Substances 0.000 description 9
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 8
- 239000003826 tablet Substances 0.000 description 8
- 230000032683 aging Effects 0.000 description 7
- 239000012228 culture supernatant Substances 0.000 description 7
- 229930003799 tocopherol Natural products 0.000 description 7
- 235000010384 tocopherol Nutrition 0.000 description 7
- 229960001295 tocopherol Drugs 0.000 description 7
- 239000011732 tocopherol Substances 0.000 description 7
- 235000013305 food Nutrition 0.000 description 6
- 150000002337 glycosamines Chemical class 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 5
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 5
- 229930003268 Vitamin C Natural products 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000006071 cream Substances 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 230000002779 inactivation Effects 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 235000019154 vitamin C Nutrition 0.000 description 5
- 239000011718 vitamin C Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 206010040954 Skin wrinkling Diseases 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229940029329 intrinsic factor Drugs 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 230000000474 nursing effect Effects 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- NHZMQXZHNVQTQA-UHFFFAOYSA-N pyridoxamine Chemical compound CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 description 4
- 238000007665 sagging Methods 0.000 description 4
- 241000186016 Bifidobacterium bifidum Species 0.000 description 3
- 208000001840 Dandruff Diseases 0.000 description 3
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 3
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 3
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 235000013361 beverage Nutrition 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 235000021466 carotenoid Nutrition 0.000 description 3
- 150000001747 carotenoids Chemical class 0.000 description 3
- DVSZKTAMJJTWFG-UHFFFAOYSA-N docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCCC=CC=CC=CC=CC=CC=CC(O)=O DVSZKTAMJJTWFG-UHFFFAOYSA-N 0.000 description 3
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 3
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 3
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 3
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 description 3
- 229950006780 n-acetylglucosamine Drugs 0.000 description 3
- 235000001968 nicotinic acid Nutrition 0.000 description 3
- 239000011664 nicotinic acid Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 235000020665 omega-6 fatty acid Nutrition 0.000 description 3
- 229940033080 omega-6 fatty acid Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 2
- MRAMPOPITCOOIN-VIFPVBQESA-N (2r)-n-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide Chemical compound CCOCCCNC(=O)[C@H](O)C(C)(C)CO MRAMPOPITCOOIN-VIFPVBQESA-N 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- MSWZFWKMSRAUBD-CBPJZXOFSA-N 2-amino-2-deoxy-D-mannopyranose Chemical compound N[C@@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-CBPJZXOFSA-N 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 241000239290 Araneae Species 0.000 description 2
- 241000186018 Bifidobacterium adolescentis Species 0.000 description 2
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 description 2
- 241001608472 Bifidobacterium longum Species 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- 108010016626 Dipeptides Proteins 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 241000186605 Lactobacillus paracasei Species 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- 206010043189 Telangiectasia Diseases 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000001166 anti-perspirative effect Effects 0.000 description 2
- 239000003213 antiperspirant Substances 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 235000013734 beta-carotene Nutrition 0.000 description 2
- 239000011648 beta-carotene Substances 0.000 description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 2
- 229960002747 betacarotene Drugs 0.000 description 2
- 229940009289 bifidobacterium lactis Drugs 0.000 description 2
- 229940009291 bifidobacterium longum Drugs 0.000 description 2
- 229940036350 bisabolol Drugs 0.000 description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000019504 cigarettes Nutrition 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 210000004709 eyebrow Anatomy 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 235000013350 formula milk Nutrition 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 2
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 2
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 229960002733 gamolenic acid Drugs 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000003648 hair appearance Effects 0.000 description 2
- 210000003780 hair follicle Anatomy 0.000 description 2
- 230000003814 hair luster Effects 0.000 description 2
- 230000003752 improving hair Effects 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000003780 keratinization Effects 0.000 description 2
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 2
- HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 2
- 229940012843 omega-3 fatty acid Drugs 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 229940055726 pantothenic acid Drugs 0.000 description 2
- 235000019161 pantothenic acid Nutrition 0.000 description 2
- 239000011713 pantothenic acid Substances 0.000 description 2
- IJTNSXPMYKJZPR-UHFFFAOYSA-N parinaric acid Chemical compound CCC=CC=CC=CC=CCCCCCCCC(O)=O IJTNSXPMYKJZPR-UHFFFAOYSA-N 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 235000008151 pyridoxamine Nutrition 0.000 description 2
- 239000011699 pyridoxamine Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 229910052711 selenium Inorganic materials 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 210000004003 subcutaneous fat Anatomy 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000009056 telangiectasis Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000003813 thin hair Effects 0.000 description 2
- 210000004906 toe nail Anatomy 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 description 1
- WSGCRSMLXFHGRM-DEVHWETNSA-N (2s)-2-[[(2s)-6-amino-2-[[(2s,3r)-2-[[(2s,3r)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid Chemical group CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O WSGCRSMLXFHGRM-DEVHWETNSA-N 0.000 description 1
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 description 1
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 description 1
- MVQVNTPHUGQQHK-UHFFFAOYSA-N 3-pyridinemethanol Chemical compound OCC1=CC=CN=C1 MVQVNTPHUGQQHK-UHFFFAOYSA-N 0.000 description 1
- HXACOUQIXZGNBF-UHFFFAOYSA-N 4-pyridoxic acid Chemical compound CC1=NC=C(CO)C(C(O)=O)=C1O HXACOUQIXZGNBF-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 235000007173 Abies balsamea Nutrition 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 239000004857 Balsam Substances 0.000 description 1
- CNOPDZWOYFOHGN-BQYQJAHWSA-N Beta-Ionol Chemical compound CC(O)\C=C\C1=C(C)CCCC1(C)C CNOPDZWOYFOHGN-BQYQJAHWSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 241000186012 Bifidobacterium breve Species 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 108010087806 Carnosine Proteins 0.000 description 1
- 208000035484 Cellulite Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 241000235035 Debaryomyces Species 0.000 description 1
- 229920001174 Diethylhydroxylamine Polymers 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- CEAGUSGLAUVBEQ-UHFFFAOYSA-N Forosamine Natural products CC1CC(N(C)C)CC(O)O1 CEAGUSGLAUVBEQ-UHFFFAOYSA-N 0.000 description 1
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 206010020112 Hirsutism Diseases 0.000 description 1
- 244000018716 Impatiens biflora Species 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 241001446187 Kermes Species 0.000 description 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 241001468157 Lactobacillus johnsonii Species 0.000 description 1
- 241001406038 Lactobacillus johnsonii NCC 533 Species 0.000 description 1
- 241000186604 Lactobacillus reuteri Species 0.000 description 1
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 description 1
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 206010049752 Peau d'orange Diseases 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- NRCMAYZCPIVABH-UHFFFAOYSA-N Quinacridone Chemical compound N1C2=CC=CC=C2C(=O)C2=C1C=C1C(=O)C3=CC=CC=C3NC1=C2 NRCMAYZCPIVABH-UHFFFAOYSA-N 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 241001489223 Saccharomycodes Species 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Natural products OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 208000026062 Tissue disease Diseases 0.000 description 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- GLEVLJDDWXEYCO-UHFFFAOYSA-N Trolox Chemical compound O1C(C)(C(O)=O)CCC2=C1C(C)=C(C)C(O)=C2C GLEVLJDDWXEYCO-UHFFFAOYSA-N 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241000235017 Zygosaccharomyces Species 0.000 description 1
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 description 1
- UDRYFKCHZFVZGJ-UHFFFAOYSA-N [5-hexadecanoyloxy-4-(hexadecanoyloxymethyl)-6-methylpyridin-3-yl]methyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC1=CN=C(C)C(OC(=O)CCCCCCCCCCCCCCC)=C1COC(=O)CCCCCCCCCCCCCCC UDRYFKCHZFVZGJ-UHFFFAOYSA-N 0.000 description 1
- QAKVQPVSNCRRGJ-UHFFFAOYSA-N [I].C(CCC)NC(O)=O Chemical compound [I].C(CCC)NC(O)=O QAKVQPVSNCRRGJ-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- IJTNSXPMYKJZPR-WVRBZULHSA-N alpha-parinaric acid Natural products CCC=C/C=C/C=C/C=CCCCCCCCC(=O)O IJTNSXPMYKJZPR-WVRBZULHSA-N 0.000 description 1
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 239000000058 anti acne agent Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940124340 antiacne agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229940067599 ascorbyl glucoside Drugs 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- CNOPDZWOYFOHGN-UHFFFAOYSA-N beta-ionol Natural products CC(O)C=CC1=C(C)CCCC1(C)C CNOPDZWOYFOHGN-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229940093797 bioflavonoids Drugs 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000006208 butylation Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 description 1
- 229940025250 camphora Drugs 0.000 description 1
- 239000010238 camphora Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 229940044199 carnosine Drugs 0.000 description 1
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- SVURIXNDRWRAFU-OGMFBOKVSA-N cedrol Chemical compound C1[C@]23[C@H](C)CC[C@H]3C(C)(C)[C@@H]1[C@@](O)(C)CC2 SVURIXNDRWRAFU-OGMFBOKVSA-N 0.000 description 1
- 229940026455 cedrol Drugs 0.000 description 1
- PCROEXHGMUJCDB-UHFFFAOYSA-N cedrol Natural products CC1CCC2C(C)(C)C3CC(C)(O)CC12C3 PCROEXHGMUJCDB-UHFFFAOYSA-N 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 239000008294 cold cream Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 239000004064 cosurfactant Substances 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 239000003398 denaturant Substances 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 description 1
- FVCOIAYSJZGECG-UHFFFAOYSA-N diethylhydroxylamine Chemical compound CCN(O)CC FVCOIAYSJZGECG-UHFFFAOYSA-N 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- BZCOSCNPHJNQBP-OWOJBTEDSA-N dihydroxyfumaric acid Chemical compound OC(=O)C(\O)=C(/O)C(O)=O BZCOSCNPHJNQBP-OWOJBTEDSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 238000009967 direct dyeing Methods 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- 150000004141 diterpene derivatives Chemical class 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- ADFCQWZHKCXPAJ-GFCCVEGCSA-N equol Chemical compound C1=CC(O)=CC=C1[C@@H]1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-GFCCVEGCSA-N 0.000 description 1
- 235000019126 equol Nutrition 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- HCZKYJDFEPMADG-UHFFFAOYSA-N erythro-nordihydroguaiaretic acid Natural products C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 210000000720 eyelash Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 235000021001 fermented dairy product Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- SZGAAHDUAFVZSS-SFYZADRCSA-N forosamine Chemical compound C[C@@H](O)[C@@H](N(C)C)CCC=O SZGAAHDUAFVZSS-SFYZADRCSA-N 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 229960001911 glucosamine hydrochloride Drugs 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 235000003969 glutathione Nutrition 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000000118 hair dye Substances 0.000 description 1
- 239000008266 hair spray Substances 0.000 description 1
- 230000003741 hair volume Effects 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229960004337 hydroquinone Drugs 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- ADFCQWZHKCXPAJ-UHFFFAOYSA-N indofine Natural products C1=CC(O)=CC=C1C1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-UHFFFAOYSA-N 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- SVURIXNDRWRAFU-UHFFFAOYSA-N juniperanol Natural products C1C23C(C)CCC3C(C)(C)C1C(O)(C)CC2 SVURIXNDRWRAFU-UHFFFAOYSA-N 0.000 description 1
- CXORMDKZEUMQHX-UHFFFAOYSA-N kermesic acid Chemical compound O=C1C2=C(O)C(O)=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C CXORMDKZEUMQHX-UHFFFAOYSA-N 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 229940001882 lactobacillus reuteri Drugs 0.000 description 1
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 210000000088 lip Anatomy 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 229960003951 masoprocol Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- NYGZLYXAPMMJTE-UHFFFAOYSA-M metanil yellow Chemical group [Na+].[O-]S(=O)(=O)C1=CC=CC(N=NC=2C=CC(NC=3C=CC=CC=3)=CC=2)=C1 NYGZLYXAPMMJTE-UHFFFAOYSA-M 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229930003658 monoterpene Natural products 0.000 description 1
- 150000002773 monoterpene derivatives Chemical class 0.000 description 1
- 235000002577 monoterpenes Nutrition 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229960004738 nicotinyl alcohol Drugs 0.000 description 1
- 125000000018 nitroso group Chemical group N(=O)* 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940100691 oral capsule Drugs 0.000 description 1
- FJCFFCXMEXZEIM-UHFFFAOYSA-N oxiniacic acid Chemical compound OC(=O)C1=CC=C[N+]([O-])=C1 FJCFFCXMEXZEIM-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 108010027628 palmitoyl-lysyl-threonyl-threonyl-lysyl-serine Proteins 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 229940023735 panthenyl ethyl ether Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003711 photoprotective effect Effects 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- CGIHFIDULQUVJG-UHFFFAOYSA-N phytantriol Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C(O)CO CGIHFIDULQUVJG-UHFFFAOYSA-N 0.000 description 1
- CGIHFIDULQUVJG-VNTMZGSJSA-N phytantriol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@](C)(O)[C@H](O)CO CGIHFIDULQUVJG-VNTMZGSJSA-N 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229950001046 piroctone Drugs 0.000 description 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 1
- 235000002378 plant sterols Nutrition 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- DQMZLTXERSFNPB-UHFFFAOYSA-N primidone Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NCNC1=O DQMZLTXERSFNPB-UHFFFAOYSA-N 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001915 proofreading effect Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- FGVVTMRZYROCTH-UHFFFAOYSA-N pyridine-2-thiol N-oxide Chemical compound [O-][N+]1=CC=CC=C1S FGVVTMRZYROCTH-UHFFFAOYSA-N 0.000 description 1
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 description 1
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 description 1
- 229960001327 pyridoxal phosphate Drugs 0.000 description 1
- 229960002026 pyrithione Drugs 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 150000004492 retinoid derivatives Chemical class 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 description 1
- 229960004245 silymarin Drugs 0.000 description 1
- 235000017700 silymarin Nutrition 0.000 description 1
- 231100000051 skin sensitiser Toxicity 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- KUUVQVSHGLHAKZ-UHFFFAOYSA-N thionine Chemical compound C=1C=CC=CSC=CC=1 KUUVQVSHGLHAKZ-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q99/00—Subject matter not provided for in other groups of this subclass
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
调节人的角质组织(例如,皮肤、毛发和/或指甲)。更具体地讲,本发明涉及通过口服包含益生菌的饮食补充剂来调节人的角质组织的美观性。
Description
技术领域
本发明涉及调节人的角质组织(例如,皮肤、毛发和/或指甲)。更具体地讲,本发明涉及通过口服包含益生菌的饮食补充剂来调节人的角质组织的外观和/或健康。
发明背景
人的角质组织(例如,皮肤、毛发和/或指甲)易受多种内在和外在因素的侵害。外在因素包括环境污染、风吹、日晒、低湿度、紫外线辐射(例如,由于暴露在阳光下)等。内在因素包括实足年龄和身体引起的其它生化变化。此外,饮食和营养可对毛发、皮肤和指甲的外观具有非常重要的影响。在当今社会,许多人的饮食缺乏营养物质和/或在营养物质上不均衡,从而导致角质组织的外观没有达到最佳。这些外在和内在因素以及不充足的饮食会导致毛发的外观无生气且暗淡而不是迷人有光泽,造成皮肤瑕疵,并且致使指甲缺乏吸引力、易断和易破损。
因此,许多消费者的角质组织不是像所期望的那样看上去迷人和/或健康。因此,需要向消费者提供一种可获得更健康的和/或更迷人的角质组织的方法。
发明概述
本发明为消费者提供了一种方法。所述方法可获得外观更迷人和/或更健康的角质组织(例如,皮肤、毛发和/或指甲)。具体地讲,本发明提供了使用饮食补充剂来调节人的角质组织的外观和/或健康的方法。更具体地讲,本发明涉及口服包含益生菌和/或其培养上清液的饮食补充剂。更具体地讲,本发明涉及口服包含乳酸菌和/或其培养上清液的饮食补充剂。优选地,应服用安全有效量的益生菌。
在另一个方面,本发明提供了用于告知消费者口服饮食补充剂可调节角质组织吸引力和/或健康的方法。在另一个方面,本发明提供了一种营销方法。在另一个方面,本发明还涉及一种商业制品。
发明详述
尽管本说明书以由特别指出并清楚地要求保护本发明的权利要求书作出结论,但据信通过以下说明可更好地理解本发明。
除非另外指明,本文使用的所有百分比和比率均按总组合物的重量计,并且所有的测量均在25℃进行。
本文所用术语“角质组织”是指作为人最外保护层的含角蛋白层,其包括但不限于皮肤、黏膜、嘴唇、毛发、脚趾甲、手指甲、表皮、头皮等。
本文所用术语“口服”是指用口摄取本发明的组合物。
本文所用术语“口腔可接受的”是指所描述的组合物或组分适用于人用口摄取,而没有不适当的毒性、不相容性、不稳定性、变应性反应等。
本文所用术语“有效量”是指化合物或组合物的量足以显著引起积极的角质组织有益效果,优选积极的角质组织外观、健康、运动或感觉有益效果。该有益效果包括独立的或组合的有益效果。这意味着当组合物以正常频率和正常量施用时,制剂中益生菌的量和/或浓度足以调节一种或多种非期望的角质组织病症(例如,皮肤皱纹)。例如,施用的量足以抑制或增强发生于角质组织中的一些生物化学功能。取决于产品类型、施用的角质组织病症类型等因素,益生菌的量可能发生变化。
本文所用术语“安全有效量”是指在技术人员合理的判断范围内,化合物或组合物足以产生显著的积极有益效果、优选积极的角质组织外观、健康、运动或感觉有益效果的量。该有益效果包括独立的或组合的有益效果,同时该量又足够低以避免严重的副反应,即提供合理的效险比。
本发明的饮食补充剂可用于调节角质组织(例如,毛发、皮肤或指甲)病症。本文所用术语“调节”是指维持或改善健康和/或外观,包括调节角质组织视觉上的、触觉上的和运动方面的性质,还可包括预防性调节和/或治疗性调节。由于内在因素和/或外在因素可诱发或导致身体的各种病症,因此通常需要对角质组织病症,尤其是人的皮肤、毛发或指甲病症进行调节。实例包括:环境损伤、辐射暴露(包括紫外线辐射)、实足年龄、更年期状况(如更年期后皮肤、毛发或指甲的变化)、压力、疾病、失调等。例如,“调节皮肤、毛发或指甲病症”包括预防性调节和/或治疗性调节皮肤、毛发或指甲病症,并且可包括一种或多种以下有益效果:增厚皮肤、毛发或指甲(例如,构造皮肤的表皮和/或真皮和/或皮下[例如,皮下脂肪或肌肉]层,和在应用处构造指甲和发干的角质层)以减少萎缩;增加真皮-表皮边界(也称为网缘)的卷曲;防止皮肤或毛发弹性的损失(例如功能性皮肤蛋白的损失、破坏和/或失活)例如弹性组织变性、松垂、皮肤损失或毛发变形的反冲;防止黑色素或非黑色素改变皮肤、毛发或指甲的颜色,例如眼袋、疹斑(例如,由如红斑痤疮引起的不均匀红色)(以下称作为“红斑”)、肤色灰黄(灰白色)、由毛细管扩张或蛛形血管引起的褪色、以及毛发变灰。调节也包括平滑、软化(例如软化皮肤)和减少皮肤和/或头皮的脱落。调节可包括延缓、最小化、防止、改善和/或消除非期望的角质组织病症。所述病症是视觉、感觉或其它途径可察觉的。例如,调节可包括调节老化迹象。
本文所用术语“松垂”是指皮肤的松弛、下垂或类似病症,真皮弹性蛋白、肌肉和/或皮下脂肪的损失、破坏、改变和/或异常会引发所述病症。
本文所用术语“光滑”和“软化”是指改变角质组织的表面以改进触感。
术语“角质组织老化迹象”或“老化迹象”包括但不限于由角质组织老化引起的所有外表可见的和触觉可发觉的迹象以及任何其它或大或小的效果。这些迹象可由内在因素或外在因素诱导或引起,例如实足年龄和/或环境侵害。引起这些迹象的过程包括但不限于组织不连续的发展例如皱纹和粗深皱纹、细纹、皮肤细纹、裂纹、肿块、粗大毛孔(例如,与附属组织相关的如汗腺导管、皮脂腺或毛囊)、不平或粗糙、皮肤弹性丧失(功能性皮肤弹性蛋白的损失和/或失活)、松垂(包括眼周和面部浮肿)、皮肤紧致丧失、皮肤紧实丧失、皮肤变形后反冲丧失、变色(包括眼袋)、疹斑、灰黄、皮肤区域色素沉着如老年斑和雀斑、角质化、异常分化、过度角质化、弹性组织变性、胶原破裂、以及其它在角质层、真皮、表皮、皮肤脉管系统(例如毛细管扩张或蛛形血管)和皮下组织(例如脂肪和/或肌肉),尤其是那些最靠近皮肤的组织中的组织学变化。
本文所用术语“益生菌”的涵盖面足够广,包括一种或多种益生菌,一种或多种其培养上清液和/或其混合物。
本发明的饮食补充剂更详细地描述于下文中。
A.调节使用的饮食补充剂
人的角质组织的外观和/或健康
依照本发明,所述饮食补充剂适于口腔给药并可口服。在优选的实施摄生法中,所述饮食补充剂为胶囊形式(如旨在被吞咽或咀嚼的那些)、片剂形式(如旨在被吞咽或咀嚼的那些)、粉末形式(如粉末可被加入到水、牛奶或其他液体中)、液体形式(如即饮型或适于稀释到其他饮料中)、或营养食品形式。例如,所述饮食补充剂的形式可为营养粑(如粗粉或小吃)、饼干、蜜饯(如太妃糖、饴糖、果子冻、软质巧克力、咀嚼物如水果糖、口香糖)、糖浆或饮料(如即饮型或浓缩物形式或粉末形式)。
本文所用术语“饮食补充剂”的涵盖面足够广,其不仅包括单剂型而且包括彼此联合使用的多剂型。例如,在一个实施摄生法中,饮食补充剂是胶囊(例如包含益生乳酸菌和其培养上清液的胶囊)。在另一个实施摄生法中,饮食补充剂是两种胶囊(例如,一种包含益生乳酸菌,另一种包含其培养上清液)。在另一个实施摄生法中,饮食补充剂包含一种饮料,所述饮料包含益生乳酸菌。它与一种也包含益生乳酸菌的胶囊一起服用。本文所用的“与...一起服用”或“与...一起使用”是指由同一使用者同时口服或不同时口服。
根据饮食补充剂的形式,可有多种食物摄取疗法。例如,如果饮食补充剂为胶囊或片剂形式,则优选每日与一餐或多餐一起服用。例如,每日可与早餐、中餐和/或晚餐一起服用胶囊或片剂。更优选地,有在受治疗者的整个一生中口服使用的本发明的饮食补充剂胶囊或片剂形式,优选每日服用。尽管有益效果在各种不同最大使用期(例如,五年、十年或二十年)后仍能获得,但优选的是在受治疗者的整个一生中长期持续口服本发明胶囊状或片剂状饮食补充剂。
与口服本发明饮食补充剂相组合,可任选地将适用于局部应用的产品施用到毛发、皮肤和/或指甲上,以作为组合治疗摄生法的一部分。在一个实施摄生法中,除了为增进毛发、皮肤和/或指甲的健康和/或吸引力而口服饮食补充剂以外,还可将一种或多种局部用产品施用到毛发、皮肤和/或指甲上以用于同样的目的。在另一个实施摄生法中,没有使用组合的治疗摄生法。相反,将饮食补充剂口服,而局部用产品却没有同样用于改善毛发、皮肤和/或指甲外观的目的(如增加毛发光泽和/或降低指甲破损和/或脆度)。
在一个实施摄生法中,饮食补充剂每日至少服用一次。在一个具体的实施摄生法中,饮食补充剂在晚上睡觉前服用。在另一个实施摄生法中,饮食补充剂在每日晚上睡觉前服用。优选地,应服用安全有效量的饮食补充剂。
本文的饮食补充剂包含:(1)益生菌,和(2)任选地一种或多种任选组分。
1. 益生菌
在以下描述中,“NCC”是指Nestle Culture Collection(NestleResearch Center,Vers-chez-les-Blanc,Lausanne,Switzerland)。
依照本发明,受试组合物包含至少一种益生菌作为活性剂。在一个具体的实施摄生法中,益生菌包含益生乳酸菌和/或其培养上清液。
益生菌是非病原的和非产毒素的生物体,通过胃和小肠后仍保持活性。通过宿主的连续摄取,它们最后存在于肠内的量可达到很大的程度,因此能与其它潜在的病原菌竞争营养物质和/或肠胃壁上的附着位点,降低它们的数量并减少或防止感染。
已经发现了多种益生菌微生物,据报导它们通过产生毒素、代谢副产物、短链脂肪酸等影响肠道。然而,益生菌也能影响到远离其存在区域的人体其它部分。例如,参见公布于2003年8月28日的WO 03/070203A1。该专利描述了类胡萝卜素与乳酸菌组合使用引起的光保护作用。
在本发明的一个实施摄生法中,益生菌选自乳酸菌,具体地讲选自乳酸杆菌和/或双歧杆菌,更具体地讲选自约氏乳杆菌、罗伊氏乳杆菌、鼠李糖乳杆菌、类干酪乳杆菌、干酪乳杆菌或两歧双歧杆菌、短双歧杆菌、长双歧杆菌、动物双岐杆菌、乳双歧杆菌、婴儿双歧杆菌、青春双岐杆菌、假链双歧杆菌或它们的混合物。依照一个实施摄生法菌株约氏乳杆菌NCC 533、类干酪乳杆菌NCC 2461、青春双岐杆菌NCC 251和长双歧杆菌NCC 490按照布达佩斯条约,将样品于1992年6月30日,1999年1月12日,1999年4月15日,1999年3月15日分别寄存于巴斯德研究所(28rue du Docteur Roux,F-75024 Paris cedex 15),寄存号CNCMI-1225,CNCM I-2116,CNCM I-2168和CNCM I-2170,各2个。其它可用的菌株包括乳双歧杆菌(ATCC27536),由Hansen(Chr.Hansen A/S,10-12 Boege Alle,P.O.Box 407,DK-2970 Hoersholm,Danemark)提供。
本发明所述的益生菌微生物可包括活性形式、失活形式、半活性或半失活形式,和获取自活性或失活微生物的片段(例如冻干粉末)。最优选地,益生菌包含活益生菌微生物。产品也可包括微生物的培养上清液,任选其浓缩形式。它也可被包括于胶囊包封形式。
当使用益生菌培养基的上清液时,上清液可以被同量使用,或者在引入产品之前经过一个或多个纯化步骤以浓缩或分离活性成分/代谢物。本领域技术人员熟知纯化化合物与检测获得部分活性的方法和技术。
在一个实施摄生法中,益生菌可存在于载体中,其量为至少105cfu/g口服用载体,更具体地讲为约105至约1015cfu/g口服用载体,更具体地讲为约107至约1012cfu/g口服用载体。
在一个实施摄生法中,日剂量为约0.00001g至约1g,更具体地讲为约0.0001g至约0.5g,更具体地讲为约0.0005g至约0.1g益生菌。
2.任选组分
a.口服用载体
载体可以是任何食物或药物产品,或者是口服营养补充剂或口服组合物,其中可包括益生菌微生物。食物或药物载体的实施例是牛奶、酸奶、凝乳、干酪、发酵乳制品、牛奶发酵产品、冰淇淋、谷类发酵产品、奶粉、婴儿配方食物或片剂、悬浮液、干口服补充剂、湿口服补充剂、干管食物。
口服营养补充剂可以在胶囊、软胶囊、片剂、糊剂或锭剂、树胶、或可饮用的溶液或乳液中。制备载体的方法包括那些本领域常见的方法。依照本发明的组合物还可包含例如生物活性分子或酵母提取物。在一个实施摄生法中,所述酵母为任何食品级酵母,其选自子囊菌亚门或半知菌亚门。在一个具体的实施摄生法中,所述酵母选自德巴利氏酵母属、克鲁弗氏酵母属、酵母菌属、西洋蓍酵母、接合酵母属、假丝酵母属、深红酵母和/或面包酵母。这些酵母以干或冻干提取物的形式使用。在一个实施摄生法中,它可存在于口服用载体中,其量为至少105cfu/g口服用载体,更具体地讲为约105至约1015cfu/g口服用载体,更具体地讲为约107至约1012cfu/g口服用载体。所述量取决于具体酵母的种类和活性。
b.益生元
本发明的饮食补充剂还可包含益生元。本文所用术语“益生元”和“多种益生元”的涵盖面足够广,其包括一种益生元或多于一种以上的益生元的混合物。本文所用的“益生元”是指在其上培养细菌(即,益生菌)的基质。在一个实施摄生法中,日剂量为约0.00001g至约1g,更优选为约0.0001g至约0.5g,甚至更优选为约0.0005g至约0.1g益生元。
益生元的实例包括纤维、菊粉、果寡糖、果糖、以及它们的混合物。
c.其它任选组分
依照本发明的饮食补充剂可任选地包含任何适宜的任选组分。这些任选组分可包括但不限于,糖胺(例如氨基糖)多不饱和脂肪酸、抗氧化剂、维生素、微量营养金属、益生菌、益生元、以及它们的组合。本文所用术语“任选组分”和“多种任选组分”可替换使用,表示一种任选组分或多于一种以上的任选组分的混合物。
1.多不饱和脂肪酸
所述饮食补充剂可包含安全有效量的多不饱和脂肪酸。多不饱和脂肪酸基本上为多烯酸(即,包含至少两个碳-碳双键)。本文所用术语“多不饱和脂肪酸”和“多种多不饱和脂肪酸”可替换使用,表示一种多不饱和脂肪酸或多于一种以上的多不饱和脂肪酸的混合物。本文所用术语“多不饱和脂肪酸”的涵盖面足够广,包括甘油一酯、甘油二酯和甘油三酯、必需脂肪酸、脂肪酸的盐、以及必需脂肪酸的盐。
如果使用的话,优选地本文所用的多不饱和脂肪酸为必需脂肪酸。本文所用术语“必需脂肪酸”和“多种必需脂肪酸”可替换使用,表示一种必需脂肪酸或多于一种以上的必需脂肪酸的混合物。由于身体不能制造它们,本文所用“必需脂肪酸”是指饮食所必需的脂肪,并且其被分类为ω-3脂肪酸或ω-6脂肪酸。如果使用的话,日剂量优选为至少约0.1g至约3g,更优选为约0.75g至约2.5g,甚至更优选为约1g至约2g必需脂肪酸。
用于本文的Ω-3脂肪酸的实施例包括α-亚麻酸、十八碳四烯酸(stearidonic acid)、二十碳五烯酸(EPA)、二十二碳六烯酸(DHA)、以及它们的混合物。优选地,Ω-3脂肪酸是EPA、DHA、或它们的混合物。
用于本文的Ω-6脂肪酸的实施例包括亚油酸、γ-亚麻酸、花生四烯酸、以及它们的混合物。优选地,Ω-6脂肪酸是γ-亚麻酸。
2. 抗氧化剂
本发明的饮食补充剂可包含安全有效量的抗氧化剂。本文所用术语“抗氧化剂”和“多种抗氧化剂”可替换使用,表示一种抗氧化剂或多于一种以上的抗氧化剂的混合物。如果使用的话, 日剂量优选为约0.00001g至约1g,更优选为约0.0001g至约0.5g,甚至更优选为约0.0005g至约0.1g抗氧化剂。
可使用抗氧化剂,如酯-C+、抗坏血酸(维生素C)及其盐、脂肪酸的抗坏血酸酯、抗坏血酸衍生物(例如,抗坏血酸磷酸镁)、生育酚(维生素E)、生育酚山梨酸酯、生育酚乙酸酯、生育酚其它酯、丁基化羟基苯甲酸及其盐、6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-羧酸(以商品名Trolox市售)、没食子酸及其烷基酯,尤其是没食子酸丙酯、尿酸及其盐和烷基酯、山梨酸及其盐、硫辛酸、胺(例如,N,N-二乙基羟基胺、氨基-胍)、巯基化合物(例如,谷胱甘肽)、二羟基富马酸及其盐、氧哺氨酸甜菜硷、精氨酸氧哺氨酸、去甲二氢愈创木酸、生物类黄酮、赖氨酸、蛋氨酸、脯氨酸、过氧化物岐化酶、西利马林、混合胡萝卜素(即,β-胡萝卜素、叶黄素、番茄红素)、绿茶提取物、葡萄皮/种子提取物、黑色素和迷迭香提取物。优选的抗氧化剂选自生育酚乙酸酯、生育酚的其它酯,更优选生育酚乙酸酯。
3.维生素
本发明的饮食补充剂可包含安全有效量的维生素。本文所用术语“维生素”和“多种维生素”可替换使用,表示一种维生素或多于一种以上的维生素的混合物。此外,本文所用术语“维生素”或“多种维生素”的涵盖面足够广,包括维生素原(如β-胡萝卜素)。如果使用的话,日剂量优选为约0.00001g至约1g,更优选为约0.0001g至约0.5g,甚至更优选为约0.0005g至约0.1g维生素。
用于本文的维生素的实施例包括维生素A、维生素B、维生素C、维生素D、维生素E、维生素K;它们的衍生物;以及它们的混合物。
a)维生素B
用于本文的维生素B化合物的实施例包括维生素B1、维生素B2、维生素B3、维生素B5、维生素B6、维生素B12、维生素B15、它们的衍生物、以及它们的混合物。
例如,可以使用安全有效量的维生素B3化合物。当使用维生素B3化合物时,维生素B3化合物的日剂量优选为约0.00001g至约1g,更优选为约0.0001g至约0.5g,甚至更优选为约0.0005g至约0.1g。
本文所用的“维生素B3化合物”是指具有下式结构的化合物:
其中R为-CONH2(即烟酰铵)、-COOH(即烟酸)或-CH2OH(即烟醇);其衍生物;和任意前述化合物的盐。
前述维生素B3化合物的示例性衍生物包括烟酸酯,包括烟酸的非血管舒张性酯(例如,烟酸生育酚酯)、烟基氨基酸、羧酸烟基醇酯、烟酸N-氧化物和烟酰胺N-氧化物。
适合的维生素B3化合物的实施例是本领域所熟知的,并且可购自多个来源,例如,Sigma Chemical Company(St.Louis,MO)、ICNBiomedicals,Inc.(Irvin,CA)和Aldrich Chemical Company(Milwaukee,WI)。
维生素化合物可作为基本上纯的物质使用,或者作为通过合适的物理和/或化学分离手段从天然(例如,植物)来源获得的提取物来使用。
又例如,可以使用安全有效量的维生素B6化合物。本文所用的维生素B6化合物包括吡哆素、吡哆素的酯(例如,吡哆素三棕榈酸酯)、吡哆素的胺(吡哆胺)、吡哆素的盐(例如,吡哆素盐酸盐)以及其衍生物,包括吡哆胺、吡哆醛、磷酸吡哆醛和吡哆酸。更优选地,维生素B6选自由下列物质组成的组:吡哆素、吡哆素的酯和吡哆素的盐。最优选地,维生素B6为吡哆素盐酸盐。
维生素B6来源于合成或天然,并且基本上可作为纯化合物或化合物的混合物来使用(例如天然源的提取物或合成物质的混合物)。维生素B6通常存在于许多食品中,尤其是酵母、肝脏和谷类。本文所用术语“维生素B6”包括这些物质的异构体和互变异构体,并且可商购自Sigma Chemical Co.,St.而合成。
当维生素B6化合物存在于本发明中时,维生素B6化合物日剂量优选为约0.00001g至约1g,更优选为约0.0001g至约0.5g,并且甚至更优选为约0.0005g至约0.1g。
4.微量营养金属
本发明的饮食补充剂还可包含微量营养金属。本文所用术语“微量营养金属”和“多种微量营养金属”可替换使用,表示一种微量营养金属或多于一种以上的微量营养金属的混合物。本文所用的“微量营养金属”是指可向哺乳动物体内提供常态总营养所需营养物质的金属。如果使用的话,日剂量优选为约0.00001g至约1g,更优选为约0.0001g至约0.5g,甚至更优选为约0.0005g至约0.1g微量营养金属。
可用于本文的微量营养金属的实施例包括铁、锌、硒、铜、锰;它们的衍生物;它们的盐;以及它们的混合物。优选地,微量营养金属是铜、硒、锌以及它们的混合物。
5.糖胺(氨基糖)
本文所用术语“糖胺”是指六碳糖的胺衍生物。本文所用术语“糖胺”的涵盖面足够广,不仅包括糖胺,而且包括其可药用的盐。此外,术语“糖胺”和“多种糖胺”可替换使用,表示一种糖胺或多于一种以上的糖胺的混合物。
如果使用的话,糖胺日剂量优选为约0.1g至约3g,更优选为约0.75g至约2.5g,更优选为约1g至约2g。
可用于本发明的糖胺的实施例包括但不限于葡糖胺、N-乙酰基葡糖胺、甘露糖胺、N-乙酰基甘露糖胺、半乳糖胺、N-乙酰基半乳糖胺;它们的衍生物;它们的盐;以及它们的混合物。优选地,该糖胺是葡糖胺。优选的葡糖胺包括N-乙酰基葡糖胺、葡糖胺和葡糖胺盐酸盐。另外,可使用两种或多种糖胺的组合。
B.调节人类消费者角质组织的方法,营销饮食补充剂的方法,商业
制品,和个人护理套盒
在另一方面,本发明提供了用于调节人的角质组织病症的方法。所述方法包括以下步骤:
(1)制造人类消费者可用的包含益生菌的口服饮食补充剂;
(2)告知所述消费者,口服所述饮食补充剂可调节所述消费者的角质组织;
(3)所述消费者获得所述口服饮食补充剂;和
(4)所述消费者口服所述饮食补充剂。
在另一方面,本发明提供了一种用于调节人的角质组织的饮食补充剂的营销方法。所述方法包括以下步骤:
(1)制造人类消费者可用的包含益生菌的口服饮食补充剂;和
(2)告知所述消费者,口服所述饮食补充剂可调节所述消费者的角质组织;
另一方面,本发明提供一种商业制品。所述商业制品包括:
(1)包含益生菌的口服饮食补充剂;
(2)容纳所述饮食补充剂的容器;和
(3)与所述饮食补充剂有关的信息,其中所述信息告知人类消费者:口服所述饮食补充剂可调节所述消费者的角质组织。
在另一方面,本发明可提供一种个人护理套盒。所述个人护理套盒包括:
(1)包含益生菌的饮食补充剂;
(2)局部用产品,其中所述局部用产品适于局部应用于角质组织;和
(3)任选地,指导消费者使用饮食补充剂和局部用产品作为摄生法的一部分的信息。
可以任何适宜的方式向消费者提供所述饮食补充剂。例如,其可通过从零售渠道销售或通过由目录或因特网购买来提供。此外,可使用任何适宜的传播方式来告知消费者口服所述饮食补充剂可调节消费者的角质组织。例如,资讯可以是印刷材料形式(如包装标记、印刷广告)、因特网传播的电子信息方式、或电视或广播传播的播送信息方式。例如,所述资讯可告知消费者:施用所述饮食补充剂可改善毛发健康、毛发光亮度、毛发光泽或毛发光彩,或可改善指甲健康、指甲强度,或可降低指甲脆度或破损。在一个实施摄生法中,所述资讯告知消费者:施用所述饮食补充剂可减少老化痕迹、抗老化、逆转老化和/或防止老化。在一个具体的实施摄生法中,所述资讯告知消费者:施用所述饮食补充剂可改善消费者的美容状况和/或吸引力。
在一个具体的实施摄生法中,所述资讯可告知消费者:口服所述饮食补充剂可实现预防和/或校正哺乳动物、尤其是人类毛囊皮脂腺单元的机能性失调,并且更具体地讲可用于治疗油性和/或高脂溢性头皮、毛发纤细、多毛症和/或秃头症。在另一个实施摄生法中,所述资讯可告知消费者:口服所述饮食补充剂可增加毛发尤其是人的毛发的密度,和/或减少毛发直径不均匀性,和/或改善它们的生长(如增加生长速率),和/或预防和/或降低和/或延缓毛发损失。在另一个实施摄生法中,所述资讯还可告知消费者:口服所述饮食补充剂可增加毛发体积。
本文所用术语“毛发直径不均匀性”是指头皮特定区域内毛发直径的显著变化;一些毛发具有100um范围内的生理直径,而最邻近那些毛发的另一些毛发具有较小的直径(如纤细毛发)。因此,“减少毛发直径不均匀性”是指增加纤细毛发的直径。“增加密度”是指增加每平方厘米皮肤或头皮上的毛发数目。
所述消费者可以任何适宜的方式获得所述饮食补充剂。例如,所述消费者可购买饮食补充剂,可从饮食补充剂买方处获得所述饮食补充剂,可以免费样品的形式获得饮食补充剂,或可以购买别的物品时附带或组合的礼物形式获得饮食补充剂。本文所用术语“消费者”是指人类消费者,它的涵盖面足够广,包括所述饮食补充剂的购买者和潜在购买者。
任何可从其中分配、呈现、展示或储存所述饮食补充剂的容器均是适宜的。合适的容器包括但不限于瓶、盒、袋、小袋、管子和倒头瓶。
个人护理套盒可以是任何合适的形式。例如,它可以是包装于一个一体化包装中的两个分离容器(例如,一个容器包含饮食补充剂而另一个包含局部用产品)的形式。它也可以是两个一起使用的分离容器的形式。
任选地,所述套盒包含指导消费者使用饮食补充剂和局部用产品作为摄生法的一部分(例如,使用两种产品作为健康和/或美容摄生法的一部分、时间表、治疗等)的信息。例如,资讯可告知消费者饮食补充剂和局部用产品应分别每日使用(例如同时或不同时),分别夜间使用等。信息也可任选地通知消费者摄生法能调节人的角质组织。例如,信息可通知消费者摄生法能调节人毛发、皮肤和/或指甲的健康和/或外观。
套盒可包含任何适用的局部用产品。局部用产品是那些适于局部应用于角质组织的个人护理组合物。例如,合适的局部用产品可包括霜膏、凝胶、洗剂、乳液、胶体、溶液、悬浮液、油膏剂、乳、喷剂、胶囊、片剂、液体、棒、固体、粉末、粉盒、铅笔、喷雾制剂、粉刷制剂、织物、擦拭物等。
局部用产品的非限制性实施例可无限制地包括:唇膏、睫毛膏、胭脂、粉底、腮红、眼线、唇线、唇彩、扑面粉或爽身粉、指甲油、摩丝、喷剂、定型凝胶、指甲调理剂、沐浴凝胶、洗发剂、护发剂、清洗霜、毛发染料和染色产品、免洗型护发剂、防晒剂、唇香膏、皮肤调理剂、冷面霜、润湿剂、毛发喷剂、肥皂、身体磨砂膏、脱皮剂、收敛剂、脱毛剂和烫发液、抗头皮屑制剂、防汗或止汗组合物、剃须、须前和须后产品、补水剂、除臭剂、冷霜、清洁剂、润肤凝胶和洗剂。
此外,局部用产品可通过使用贴剂或其它递送装置局部施用。递送装置可包括但不限于那些能被加热或冷却的装置以及那些利用离子电渗疗法或超声波的装置。
例如,局部用产品能通过例如施用组合物施用。组合物的形式包括皮肤露剂、爽肤水、乳液、霜膏、凝胶、泡沫、油膏剂、糊剂、浆液、喷剂、调理剂、滋补剂、化妆品、唇膏、粉底、指甲油、须后水等。所述组合物旨在留于皮肤或其它角质组织上(即“免洗型”组合物)。在角质组织(如皮肤)上施用组合物后,在一个实施摄生法中,其在皮肤上敷用优选至少约15分钟,更优选至少约30分钟,甚至更优选至少约1小时,甚至更优选至少几个小时,如最多约12小时。在一个实施摄生法中,局部用产品敷用过夜。在另一个实施摄生法中,局部用产品全天敷用。可以处理面部、毛发和/或指甲的任何表面部位(例如,面部、嘴唇、眼下部位、眼皮、头皮、颈、躯干、臂、手、腿、脚、手指甲、脚趾甲、头发、睫毛、眉毛等)。
可使用任何合适的方法来施用局部用产品。例如,可使用手掌和/或手指或装置或工具来完成局部用产品的施用(例如棉球、药签、衬垫、涂药笔、喷雾涂敷器等)。确保至少将最小含量的局部用产品连续涂敷在角质组织上的另一个方法是使用贴剂来施用化合物,如贴到脸上。这种方法尤其可用于有问题的皮肤区域。该皮肤区域需要更多的强化治疗(如面部鱼尾纹区域、眉心纹、眼下区域、上唇等)。该贴剂可以是吸留的、半吸留的或不吸留的,并且可以是粘性的或非粘性的。该局部用产品可被包含在贴剂中或在使用贴剂前涂敷到皮肤上。该贴剂还可包括附加的活性物质,如用于放热反应的化学引发剂,如描述于PCT申请WO 9701313,和授予Wu等人的美国专利5,821,250、5,981,547和5,972,957中的那些。贴剂也可包含电能量源(例如电池)以例如增加组合物和活性剂的递送(例如离子电渗疗法)。可保留贴剂在角质组织上任何合适的时间。例如,至少为约5分钟,更优选至少约15分钟,还更优选至少约30分钟,甚至更优选至少约1小时,甚至更优选晚上作为夜间治疗的一种形式,或者在另一个实施摄生法中全天。
局部用产品可包含任何适用的期望物质。例如,这些物质可选自糖胺(如N-乙酰基葡糖胺)、维生素B3化合物、脱氢乙酸钠、脱氢乙酸及其盐、植物甾醇、大豆衍生物(如雌马酚和其它异黄酮)、烟酰胺、植烷三醇、金合欢醇、红没药醇、水杨酸化合物、去氧苯比妥、二烷酰基羟脯氨酸化合物、类黄酮、N-酰氨基酸化合物、类视色素(如维生素C、抗坏血酸、抗坏血酸基葡糖苷、抗坏血酸棕榈酸酯、抗坏血酸磷酸镁、抗坏血酸磷酸钠)、颗粒物质、防晒活性物质、抗蜂窝炎剂、二叔丁对甲酚、叔丁对甲氧酚、它们的衍生物、以及它们的组合。其它实施例包括阳离子聚合物、护发剂(烃油、脂肪族酯、硅氧烷)、去头皮屑剂、悬浮剂、粘度调节剂、染料、非挥发性溶剂或稀释剂(水溶性和水不溶性的)、珠光助剂、泡沫促进剂、表面活性剂或非离子助表面活性剂、灭虱剂、pH调节剂、香料、防腐剂、螯合剂、蛋白质、紫外线吸收剂、颜料、其它氨基酸和其它维生素。
例如,可用于本文的局部用产品可包含一种或多种维生素和/或氨基酸,例如:水溶性维生素,如维生素B1、B2、B6、B12、C、泛酸、泛基乙基醚、泛醇、生物素和它们的衍生物;水溶性氨基酸,如天冬酰胺、丙氨酸、吲哚、谷氨酸和它们的盐;水不溶性维生素,如维生素A、D、E和它们的衍生物;水不溶性氨基酸,如酪氨酸、色胺和它们的盐。
局部用产品也可包含一种或多种颜料物质,如无机的、亚硝基、单偶氮、重氮基、类胡萝卜素、三苯甲烷、三芳基甲烷、氧杂蒽、喹啉、噁嗪、吖嗪、蒽醌、靛青类、硫堇靛青类、喹吖啶酮、酞菁、植物的、天然的颜料,包括:水溶性组分,如具有C.I.命名的那些。局部用产品还可包含可用作化妆品杀虫剂和去头皮屑剂的抗微生物剂,其包括:水溶性组分,如羟甲辛吡酮乙醇胺;水不溶性组分,如3,4,4′-三氯碳酰苯胺(三氯生)、三氯卡班和1-氧-2-巯基吡啶锌。
此外,局部用产品可包含肽,例如那些公开于美国专利6,492,326中的肽,该专利公布于2002年12月10日,授予Robinson等人(例如,五肽如赖氨酸-苏氨酸-苏氨酸-赖氨酸-丝氨酸,以及它们的衍生物)。优选的五肽衍生物为棕榈酰-赖氨酸-苏氨酸-苏氨酸-赖氨酸-丝氨酸,商购自Sederma,France。另一种优选可用的任选二肽是肌肽。其它适用的肽可包括二肽、三肽、四肽、五肽、或六肽和/或它们的衍生物。
局部用产品也可包括任何其它适用的物质,例如那些常规使用于给定产品类型的成分。CTFA Cosmetic Ingredient Handbook,第十版(由Cosmetic,Toiletry,and Fragrance Association,Inc.,Washington,D.C.公布)(2004)(以下称为“CTFA”),描述了多种能添加到本文局部用产品中的非限制性物质。这些成分种类的实施例包括,但不限于:研磨剂,吸收剂,美容组分例如芳香剂、颜料、染色/着色剂、精油、皮肤增感剂、收敛剂等(例如丁香油、薄荷醇、樟脑、桉树油、丁子香酚、乳酸薄荷酯、金缕梅馏出液),抗痤疮剂,抗结块剂,消泡剂,抗微生物剂(丁基氨基甲酸碘丙酯),抗氧化剂,粘合剂,生物添加剂,缓冲剂、增量剂、螯合剂、化学添加剂,着色剂,化妆收敛剂,化妆杀虫剂,变性剂,药物收敛剂,润肤剂,外用镇痛剂,成膜剂或材料如有助于组合物成膜性和直接性染色的聚合物(如二十碳烯与乙烯基吡咯烷酮的共聚物),不透明剂,pH调节剂,推进剂,还原剂,多价螯合剂,皮肤漂白和增亮剂(如对苯二酚、曲酸、维生素C、维生素C磷酸镁盐、维生素C葡萄糖苷、维生素B6),皮肤调理剂(如湿润剂和闭塞剂),皮肤抚慰剂/或愈合剂及衍生物(如泛酰醇和衍生物如乙基泛酰醇、芦荟、泛酸及其衍生物、尿囊素、红没药醇以及甘草酸二钾盐),皮肤处理剂(如维生素D化合物、单萜、双萜和三萜、β-紫罗兰醇、雪松醇),增稠剂,和维生素,以及它们的衍生物。
实施例
实施例1-饮食补充剂
将包含500mg益生菌的饮食补充剂制备成胶囊形式。所述饮食补充剂以每日一个胶囊的量口服。
实施例2-商业制品
将实施例1中的饮食补充剂装入到瓶子中并供给零售渠道来销售。电视广告包含的信息告知消费者:口服所述饮食补充剂可改善消费者毛发的光亮度、光彩和光泽。
实施例3-商业制品
将实施例1中的饮食补充剂装入到小袋中并供给零售渠道来销售。杂志中印刷广告包含的信息告知消费者:口服所述饮食补充剂可降低消费者指甲的破损和脆度。
实施例4-商业制品
将实施例1中的饮食补充剂装入到小袋中并供给零售渠道来销售。杂志中印刷广告包含的信息告知消费者:口服所述饮食补充剂可通过增加消费者毛发的光泽和降低消费者指甲的破损来改善毛发和指甲的外观。
实施例5-商业制品
将实施例1中的饮食补充剂装入到小袋中并供给零售渠道来销售。杂志中印刷广告包含的信息告知消费者:口服所述饮食补充剂有助于减少衰老迹象。
本文引用的所有公布文献均因此全文引入本文以供参考。任何文献的引用不可解释为对其作为本发明的现有技术的认可。
尽管已用具体实施摄生法来说明和描述了本发明,但对于本领域的技术人员显而易见的是,在不背离本发明的精神和保护范围的情况下可作出许多其它的变化和修改。因此,有意识地在附加的权利要求书中包括属于本发明范围内的所有这些变化和修改。
Claims (13)
1.一种用于调节人的角质组织美观性的非治疗方法,其中所述方法包括以下步骤:
(1)为消费者提供包含活性益生菌的口服饮食补充剂,其中益生菌的量为至少105cfu/g口服用载体;
(2)告知所述消费者:口服所述饮食补充剂可调节所述消费者的角质组织;
(3)所述消费者获得所述口服饮食补充剂;和
(4)所述消费者口服所述饮食补充剂。
2.如权利要求1所述的非治疗方法,其中所述人的角质组织为人的皮肤。
3.如权利要求1所述的非治疗方法,其中所述告知还包括告知所述消费者:所述饮食补充剂包含活性益生菌。
4.如权利要求3所述的非治疗方法,其中所述饮食补充剂还包含选自纤维、菊粉、果寡糖、果糖以及它们的混合物的益生元。
5.如权利要求4所述的非治疗方法,其中所述告知还包括告知所述消费者:所述饮食补充剂包含益生元。
6.如权利要求1所述的非治疗方法,其中所述告知包括告知所述消费者:所述饮食补充剂可调节所述消费者的毛发的外观。
7.如权利要求1所述的非治疗方法,其中所述告知包括告知所述消费者:所述饮食补充剂可调节所述消费者的皮肤的外观。
8.如权利要求1所述的非治疗方法,其中所述告知包括告知所述消费者:所述饮食补充剂可调节所述消费者的指甲的外观。
9.如权利要求1所述的非治疗方法,其中所述告知包括告知所述消费者:所述饮食补充剂可调节所述消费者的头皮的外观。
10.如权利要求1所述的非治疗方法,其中所述口服饮食补充剂还包括选自下述的任选组分:糖胺、多不饱和脂肪酸、抗氧化剂、维生素、微量营养金属、以及它们的组合。
11.如权利要求1所述的非治疗方法,其中每日至少服用一次所述口服饮食补充剂。
12.如权利要求11所述的非治疗方法,其中在每日晚上睡觉前服用所述口服饮食补充剂。
13.如权利要求1所述的非治疗方法,其中所述口服饮食补充剂为胶囊或片剂形式,和每日与一餐或多餐一起服用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66602905P | 2005-03-29 | 2005-03-29 | |
US60/666,029 | 2005-03-29 | ||
PCT/US2006/009779 WO2006104730A1 (en) | 2005-03-29 | 2006-03-15 | Use of an orally administered dietary supplement for regulating the cosmetic appearance of human keratinous tissue |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101151066A CN101151066A (zh) | 2008-03-26 |
CN101151066B true CN101151066B (zh) | 2013-02-13 |
Family
ID=36624234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800100164A Active CN101151066B (zh) | 2005-03-29 | 2006-03-15 | 使用口服饮食补充剂调节人的角质组织的美观性 |
Country Status (4)
Country | Link |
---|---|
US (4) | US20060269508A1 (zh) |
EP (1) | EP1871485B1 (zh) |
CN (1) | CN101151066B (zh) |
WO (1) | WO2006104730A1 (zh) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1917960A1 (en) * | 2006-11-06 | 2008-05-07 | Nestec S.A. | Improved biological effects of rosmarinic acid |
TW201444815A (zh) * | 2007-06-13 | 2014-12-01 | 大塚製藥股份有限公司 | 含雌馬酚(equol)之萃取物、其製造方法、雌馬酚萃取方法及含雌馬酚之食品(二) |
WO2009035484A1 (en) * | 2007-06-15 | 2009-03-19 | Nguyen Lethu T | Lip gloss |
US20090047229A1 (en) * | 2007-06-15 | 2009-02-19 | Coty S.A.S | Lip gloss |
US8236289B2 (en) * | 2007-06-15 | 2012-08-07 | Coty S.A.S. | Lip gloss |
US20090324521A1 (en) * | 2007-07-27 | 2009-12-31 | Jonathan Robert Cetti | Personal Care Article For Sequentially Dispensing Compositions With Variable Concentrations Of Hydrophobic Benefit Materials |
EP2022471A1 (en) * | 2007-08-07 | 2009-02-11 | KPSS-Kao Professional Salon Services GmbH | Conditioning composition for hair |
EP2022468A1 (en) * | 2007-08-07 | 2009-02-11 | KPSS-Kao Professional Salon Services GmbH | Conditioning composition for hair |
FR2920304B1 (fr) | 2007-09-04 | 2010-06-25 | Oreal | Utilisation cosmetique de lysat bifidobacterium species pour le traitement de la secheresse. |
FR2920305B1 (fr) | 2007-09-04 | 2010-07-30 | Oreal | Utilisation d'un lysat de bifidobacterium species pour le traitement de peaux sensibles. |
FR2938437B1 (fr) * | 2008-11-19 | 2020-03-27 | Société des Produits Nestlé S.A. | Utilisation cosmetique de microorganisme pour le traitement des peaux grasses |
ES2677905T3 (es) | 2008-07-29 | 2018-08-07 | L'oreal | Uso cosmético y dermatológico de microorganismos probióticos Lactobacillus paracasei para el tratamiento de trastornos grasos del cuero cabelludo |
US20110091431A1 (en) * | 2009-10-09 | 2011-04-21 | Prothera, Inc. | Compositions and methods comprising pediococcus for reducing at least one symptom associated with autism spectrum disease in a person diagnosed with an autism spectrum disease |
FR2953408B1 (fr) * | 2009-12-08 | 2013-02-08 | Oreal | Microorganismes probiotiques a titre d'actif pour l'eclat du teint de la peau |
FR2953407B1 (fr) | 2009-12-08 | 2013-06-14 | Oreal | Microorganismes probiotiques a titre d'actif contre les alterations du microrelief |
US20130004463A1 (en) * | 2010-01-06 | 2013-01-03 | Kabushiki Kaisha Yakult Honsha | Dna damage repair promoter for oral application, and elastase activity inhibitor for oral application |
US20150224074A1 (en) * | 2010-05-25 | 2015-08-13 | Eric Kuhrts | Stable formulations of fatty acids |
US20130245118A1 (en) * | 2010-07-02 | 2013-09-19 | Eric H. Kuhrts | Stable fatty acid-containing formulations |
WO2012092628A2 (en) * | 2010-12-31 | 2012-07-05 | Incube Labs, Llc | Patches and methods for the transdermal delivery of agents to treat hair loss |
US10626545B2 (en) * | 2011-03-18 | 2020-04-21 | University Of Limerick | Embedding nanoparticles in thermoplastic polymers |
FR2982150B1 (fr) * | 2011-11-09 | 2016-05-20 | Oreal | Acide gras mono-insature pour le soin des ongles |
FR2996128B1 (fr) | 2012-09-28 | 2015-01-02 | Inneov Lab | Utilisation d'une association de taurine ou un de ses derives, et d'extrait de raisins pour ameliorer la qualite des ongles. |
FR2996136B1 (fr) * | 2012-09-28 | 2015-01-02 | Inneov Lab | Utilisation d'une association d'au moins un acide gras polyinsature et d'au moins un carotenoide pour ameliorer la qualite des ongles. |
FR2999932B1 (fr) * | 2012-12-21 | 2020-01-31 | Société des Produits Nestlé S.A. | Utilisation de microorganismes probiotiques comme agent favorisant la synthese de melanine |
FR3005411B1 (fr) | 2013-05-07 | 2016-09-30 | Laboratoires Inneov | Association d'actifs pour une administration par voie orale pour ameliorer la qualite des ongles. |
FR3030253B1 (fr) * | 2014-12-18 | 2018-03-02 | Nutricos Technologies | Composition pour ameliorer l'aspect cellulitique de la peau |
GB202115797D0 (en) * | 2021-11-03 | 2021-12-15 | Iiaa Ltd | Compositions comprising probiotic and postbiotic strains of bacteria |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1545936A (zh) * | 2003-12-01 | 2004-11-17 | 上海交大昂立股份有限公司 | 一种含有活性益生菌的食用组合物及其制备方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5821250A (en) * | 1996-02-01 | 1998-10-13 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US6492326B1 (en) * | 1999-04-19 | 2002-12-10 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
US6284802B1 (en) * | 1999-04-19 | 2001-09-04 | The Procter & Gamble Company | Methods for regulating the condition of mammalian keratinous tissue |
US20020119237A1 (en) * | 2000-12-22 | 2002-08-29 | Hevey Maurice O. | Medium and method for delivery of edible materials subject to degradation by oxidation and hydrolysis |
AUPS057102A0 (en) * | 2002-02-15 | 2002-03-07 | Vri Biomedical Ltd | Compositions and methods for treatment of skin disorders |
DE60317646T2 (de) | 2002-02-21 | 2008-10-30 | Société des Produits Nestlé S.A. | Photoprotektive oral verabreichbare zusammensetzung für die haut |
DE60305159T2 (de) | 2002-02-21 | 2007-03-15 | Société des Produits Nestlé S.A. | Oral verabreichbare zusammensetzung zum schutz der haut vor licht |
BR0314142A (pt) * | 2002-09-09 | 2005-06-28 | Nestec Sa | Composição administrável oralmente para melhoria da qualidade do cabelo ou da pele |
US20040156923A1 (en) * | 2002-10-23 | 2004-08-12 | Davenport David F. | Method and nutraceutical composition for mammals |
US20050123500A1 (en) * | 2003-01-31 | 2005-06-09 | The Procter & Gamble Company | Means for improving the appearance of mammalian hair and nails |
JP2006524187A (ja) * | 2003-01-31 | 2006-10-26 | ザ プロクター アンド ギャンブル カンパニー | 哺乳類のケラチン組織の外観を改善する手段 |
US20050010476A1 (en) * | 2003-07-07 | 2005-01-13 | Nubella, Inc. | Consumer specific marketing tool method and apparatus |
WO2005030230A1 (en) * | 2003-09-30 | 2005-04-07 | Probiomics Limited | Compositions and methods for treatment or prevention of psoriasis and related disorders |
WO2005085287A1 (en) * | 2004-03-03 | 2005-09-15 | En-N-Tech, Inc. | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions |
FR2872047B1 (fr) | 2004-06-23 | 2007-06-15 | Oreal | Composition pour peaux sensibles associant cation mineral et probiotique(s) |
EP1642570A1 (fr) | 2004-10-04 | 2006-04-05 | L'oreal | Composition cosmétique et/ou dermatologique pour peaux sensibles |
-
2006
- 2006-03-10 US US11/372,637 patent/US20060269508A1/en not_active Abandoned
- 2006-03-15 WO PCT/US2006/009779 patent/WO2006104730A1/en active Application Filing
- 2006-03-15 CN CN2006800100164A patent/CN101151066B/zh active Active
- 2006-03-15 EP EP06738796.9A patent/EP1871485B1/en not_active Revoked
-
2009
- 2009-12-08 US US12/633,054 patent/US20100086521A1/en not_active Abandoned
-
2011
- 2011-01-07 US US12/986,324 patent/US20110106730A1/en not_active Abandoned
- 2011-01-07 US US12/986,316 patent/US20110104135A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1545936A (zh) * | 2003-12-01 | 2004-11-17 | 上海交大昂立股份有限公司 | 一种含有活性益生菌的食用组合物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
US20110104135A1 (en) | 2011-05-05 |
US20060269508A1 (en) | 2006-11-30 |
EP1871485A1 (en) | 2008-01-02 |
CN101151066A (zh) | 2008-03-26 |
EP1871485B1 (en) | 2014-04-23 |
US20100086521A1 (en) | 2010-04-08 |
US20110106730A1 (en) | 2011-05-05 |
WO2006104730A1 (en) | 2006-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101151066B (zh) | 使用口服饮食补充剂调节人的角质组织的美观性 | |
US11801216B2 (en) | Enhanced toothpaste and kits | |
CA2697735C (en) | Use of a combination of hesperidin and of a microorganism for influencing the barrier function of the skin | |
ES2639023T3 (es) | Lactobacillus paracasei para tratar manchas de senescencia y/o melasma | |
CN101166512A (zh) | 包含二肽的个人护理组合物 | |
TW200307555A (en) | Orally administrable composition for the photoprotection of the skin | |
FR2938437A1 (fr) | Utilisation cosmetique de microorganisme pour le traitement des peaux grasses | |
JP6106141B2 (ja) | クコの実の乳酸菌発酵物、該発酵物を含む化粧品、飲食品、医薬品、並びにdna修復促進剤 | |
CN101773463A (zh) | 一种富硒纳米珍珠粉配方及其生产方法 | |
JP2008239547A (ja) | 植物由来の賦活化剤及び細胞外マトリックス産生促進剤 | |
SG181510A1 (en) | Probiotic microorganisms as active agents against changes in the skin's microrelief | |
JP2008156330A (ja) | 賦活化剤及び抗老化剤 | |
WO2010096564A2 (en) | Dietary supplements containing polyunsaturated omega-3 fatty acids and probiotic bacteria with potential gastrointestinal and dermatological benefits | |
KR20190048152A (ko) | 유산균의 유크림 발효액을 유효성분으로 포함하는 화장료 조성물 | |
WO2019159588A1 (ja) | アンチポリューション剤及び皮膚外用組成物 | |
JP2011173921A (ja) | 発酵物組成物、化粧品組成物及びそれらの製造方法 | |
CN105916391A (zh) | 用于改善头发品质的口服施用的基于多不饱和脂肪酸和类胡萝卜素的组合物 | |
CN103998020B (zh) | 用于指甲护理的单不饱和脂肪酸 | |
CN101780026B (zh) | 眼影眼线粉块及其制备方法 | |
JP2008239548A (ja) | 細胞賦活化剤 | |
JP5216228B2 (ja) | 細胞外マトリックス産生向上剤 | |
JP5048246B2 (ja) | スキンケア用の内服組成物 | |
JP6799767B2 (ja) | ウロリチン類を含有するメラニン産生抑制剤 | |
CN101005821A (zh) | 以α-糖基甘草酸作为有效成分的保湿剂及其用途 | |
JPWO2015015815A1 (ja) | 繊維芽細胞賦活剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |