CN101142225B - 具有抗炎活性的大环内酯 - Google Patents

具有抗炎活性的大环内酯 Download PDF

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Publication number
CN101142225B
CN101142225B CN2006800081835A CN200680008183A CN101142225B CN 101142225 B CN101142225 B CN 101142225B CN 2006800081835 A CN2006800081835 A CN 2006800081835A CN 200680008183 A CN200680008183 A CN 200680008183A CN 101142225 B CN101142225 B CN 101142225B
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CN
China
Prior art keywords
compound
group
alkyl
formula
inflammatory
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Expired - Fee Related
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CN2006800081835A
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English (en)
Chinese (zh)
Other versions
CN101142225A (zh
Inventor
奥格珍·卡利克
马丁纳·博斯纳
尼古拉·马杰诺维克
杜布拉夫科·杰利克
苏利曼·阿利霍齐克
范杰·维拉
佐里卡·马鲁西克-伊斯图克
维斯纳·伊拉科维克
贝里斯拉夫·博斯恩杰克
博斯卡·赫瓦西克
玛丽杰·托马斯科维克
维斯纳·穆尼克
瓦妮莎·艾维蒂克
安滕·赫坦克
戈兰·克拉戈尔
玛丽杰·勒杰克
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Glaxo Group Ltd
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Glaxo Group Ltd
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Publication of CN101142225A publication Critical patent/CN101142225A/zh
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Publication of CN101142225B publication Critical patent/CN101142225B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2006800081835A 2005-01-13 2006-01-13 具有抗炎活性的大环内酯 Expired - Fee Related CN101142225B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64384105P 2005-01-13 2005-01-13
US60/643,841 2005-01-13
US71582805P 2005-09-09 2005-09-09
US60/715,828 2005-09-09
PCT/IB2006/001238 WO2006087644A2 (en) 2005-01-13 2006-01-13 Macrolides with anti-inflammatory activity

Publications (2)

Publication Number Publication Date
CN101142225A CN101142225A (zh) 2008-03-12
CN101142225B true CN101142225B (zh) 2011-09-07

Family

ID=36916830

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800081835A Expired - Fee Related CN101142225B (zh) 2005-01-13 2006-01-13 具有抗炎活性的大环内酯

Country Status (18)

Country Link
US (2) US8080529B2 (https=)
EP (1) EP1851236B1 (https=)
JP (1) JP5036558B2 (https=)
KR (1) KR20070105993A (https=)
CN (1) CN101142225B (https=)
AT (1) ATE476438T1 (https=)
AU (1) AU2006215315B2 (https=)
CA (1) CA2594820A1 (https=)
CY (1) CY1110866T1 (https=)
DE (1) DE602006015919D1 (https=)
DK (1) DK1851236T3 (https=)
HR (1) HRP20100549T1 (https=)
IL (1) IL184438A (https=)
NO (1) NO20074162L (https=)
PL (1) PL1851236T3 (https=)
PT (1) PT1851236E (https=)
RS (1) RS51479B (https=)
WO (1) WO2006087644A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011518799A (ja) * 2008-04-23 2011-06-30 グラクソ グループ リミテッド ２’−ｏ，３’−ｎ−橋かけマクロライド
CN101423539B (zh) * 2008-12-09 2011-04-27 山东大学 4″,11-二氨基甲酸酯阿奇霉素衍生物、制备方法及其药物组合物
TW201038277A (en) * 2009-01-30 2010-11-01 Glaxosmithkline Zagreb Anti-inflammatory macrolide
WO2011018510A1 (en) 2009-08-13 2011-02-17 Basilea Pharmaceutica Ag New macrolides and their use
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
US9982005B2 (en) * 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
AU2014252462A1 (en) 2013-04-10 2015-10-01 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
GB201520419D0 (en) * 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
KR20220156570A (ko) * 2020-03-12 2022-11-25 조에티스 서비시즈 엘엘씨 면역조절성 유레아 아잘라이드
WO2022128054A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammatory conditions of human skin (iv)
CN114858953B (zh) * 2022-05-20 2023-11-21 大连工业大学 一种动物源食品中红霉素及降解产物的检测试剂盒及检测方法
GB202404587D0 (en) 2024-03-28 2024-05-15 Epiendo Pharmaceuticals Ehf Chemical forms

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0895999A1 (en) * 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126344A2 (en) * 1983-05-20 1984-11-28 Abbott Laboratories Tripeptide esters of therapeutic agents
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
HRP980189B1 (en) 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
RU2330858C2 (ru) * 2002-07-08 2008-08-10 Глаксомитклайн Истраживацки Центар Загреб Д.О.О. Новые соединения, составы и способы лечения воспалительных заболеваний и состояний
GB0310986D0 (en) 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
EP1841776B1 (en) 2005-01-13 2008-12-31 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Decladinosyl-macrolides with anti-inflammatory activity
JP5065910B2 (ja) 2005-01-14 2012-11-07 グラクソ グループ リミテッド ビオチンおよび光親和性基を含む、マクロライド標的同定用のマクロライド化合物
TW201038277A (en) 2009-01-30 2010-11-01 Glaxosmithkline Zagreb Anti-inflammatory macrolide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0895999A1 (en) * 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics

Also Published As

Publication number Publication date
CN101142225A (zh) 2008-03-12
IL184438A0 (en) 2008-12-29
NO20074162L (no) 2007-09-18
AU2006215315B2 (en) 2012-02-16
PT1851236E (pt) 2010-10-25
KR20070105993A (ko) 2007-10-31
RS51479B (sr) 2011-04-30
WO2006087644A2 (en) 2006-08-24
JP2008526950A (ja) 2008-07-24
DK1851236T3 (da) 2010-11-22
JP5036558B2 (ja) 2012-09-26
EP1851236B1 (en) 2010-08-04
WO2006087644A3 (en) 2007-03-15
CA2594820A1 (en) 2006-08-24
PL1851236T3 (pl) 2011-05-31
US20120058963A1 (en) 2012-03-08
US20080221046A1 (en) 2008-09-11
AU2006215315A1 (en) 2006-08-24
US8080529B2 (en) 2011-12-20
ATE476438T1 (de) 2010-08-15
DE602006015919D1 (de) 2010-09-16
IL184438A (en) 2011-12-29
HK1112920A1 (en) 2008-09-19
HRP20100549T1 (hr) 2010-11-30
EP1851236A2 (en) 2007-11-07
CY1110866T1 (el) 2015-06-10

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Effective date: 20110422

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Free format text: CORRECT: ADDRESS; FROM: ZAGREB, CROATIA TO: MIDDLESEX, THE UK

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Effective date of registration: 20110422

Address after: British Meader Sykes

Applicant after: Glaxo Group Ltd.

Address before: Croatia Zagreb

Applicant before: Glaxosmithkline Istrazivacki C.

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Termination date: 20140113