CN101134012A - 以混聚酸酐为中小分子药物载体制备可注射给药制剂的方法和应用 - Google Patents
以混聚酸酐为中小分子药物载体制备可注射给药制剂的方法和应用 Download PDFInfo
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- CN101134012A CN101134012A CNA2006101120561A CN200610112056A CN101134012A CN 101134012 A CN101134012 A CN 101134012A CN A2006101120561 A CNA2006101120561 A CN A2006101120561A CN 200610112056 A CN200610112056 A CN 200610112056A CN 101134012 A CN101134012 A CN 101134012A
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- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
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Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
乳化剂(%) | 方法 | 混加物(%) | 药物的包载率(%) | 混聚酸酐颗粒的收率(%) |
VETPGS*(0.015%) | 单乳 | ------- | 12.85% | 60.91% |
VETPGS(0.03%) | 单乳 | ------- | 26.23% | 88.42% |
PVA**(1%) | 单乳 | ------- | 48.29% | 75.81% |
PVA(1.5%) | 单乳 | ------- | 27.54% | 78.97% |
PVA(2%) | 单乳 | ------- | 14.89% | 77.45% |
PVA(1%) | 单乳 | 胆固醇(5%) | 72.96% | 69.64% |
PVA(1%) | 单乳 | 胆固醇(10%) | 99.19% | 77.60% |
PVA(1%) | 双乳 | 普鲁兰(5%) | 48.47% | 86.36% |
PVA(1%) | 双乳 | 普鲁兰(10%) | 90.99% | 69.63% |
PVA(1%) | 双乳 | 普鲁兰(15%) | 95.02% | 66.03% |
PVA(1%) | 双乳 | 聚乙二醇(PEG,5%) | 66.41% | 70.25% |
PVA(1%) | 双乳 | 聚乙二醇(10%) | 90.21% | 69.53% |
PVA(1%) | 双乳 | 明胶(2%) | 88.51% | 89.53% |
PVA(1%) | 单乳 | IPM(5%) | 21.77% | 99.80% |
PVA(1%) | 单乳 | DPPC(0.01%) | 45.75% | 82.25% |
PVA(1%) | 单乳 | DPPC(0.02%) | 44.52% | 78.21% |
无 | 单乳 | DPPC(0.05%) | 65.81% | 90.02% |
无 | 喷雾干燥 | ------- | 87.17% | 75.45% |
无 | 喷雾干燥 | IPM(5%) | 81.62% | 73.25% |
无 | 喷雾干燥 | 普鲁兰(5%) | 75.16% | 78.32% |
无 | 喷雾干燥 | 胆固醇(5%) | 91.71% | 80.21% |
Claims (13)
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102552948A (zh) * | 2010-12-10 | 2012-07-11 | 财团法人工业技术研究院 | 可控制释放的组合物及其制造方法 |
CN106389341A (zh) * | 2016-09-06 | 2017-02-15 | 湖南中南制药有限责任公司 | 五氟利多聚酸酐微丸和五氟利多长效控释片及其制备方法 |
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2006
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102552948A (zh) * | 2010-12-10 | 2012-07-11 | 财团法人工业技术研究院 | 可控制释放的组合物及其制造方法 |
CN102552948B (zh) * | 2010-12-10 | 2015-08-26 | 财团法人工业技术研究院 | 可控制释放的组合物及其制造方法 |
CN106389341A (zh) * | 2016-09-06 | 2017-02-15 | 湖南中南制药有限责任公司 | 五氟利多聚酸酐微丸和五氟利多长效控释片及其制备方法 |
CN106389341B (zh) * | 2016-09-06 | 2020-03-10 | 湖南中南制药有限责任公司 | 五氟利多聚酸酐微丸和五氟利多长效控释片及其制备方法 |
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