CN101128474A - 用于治疗病毒感染的三环核苷前药 - Google Patents

用于治疗病毒感染的三环核苷前药 Download PDF

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Publication number
CN101128474A
CN101128474A CNA2006800063907A CN200680006390A CN101128474A CN 101128474 A CN101128474 A CN 101128474A CN A2006800063907 A CNA2006800063907 A CN A2006800063907A CN 200680006390 A CN200680006390 A CN 200680006390A CN 101128474 A CN101128474 A CN 101128474A
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CN
China
Prior art keywords
group
substituted
alkyl
bond
hydrogen
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800063907A
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English (en)
Chinese (zh)
Inventor
杰西·D·凯歇尔
克里斯托弗·唐·罗伯茨
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Genelabs Technologies Inc
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Genelabs Technologies Inc
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Filing date
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Publication of CN101128474A publication Critical patent/CN101128474A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2006800063907A 2005-02-28 2006-02-28 用于治疗病毒感染的三环核苷前药 Pending CN101128474A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65746305P 2005-02-28 2005-02-28
US60/657,463 2005-02-28

Publications (1)

Publication Number Publication Date
CN101128474A true CN101128474A (zh) 2008-02-20

Family

ID=36570903

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2006800063894A Pending CN101142226A (zh) 2005-02-28 2006-02-28 用于治疗病毒感染的三环核苷化合物
CNA2006800063907A Pending CN101128474A (zh) 2005-02-28 2006-02-28 用于治疗病毒感染的三环核苷前药

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNA2006800063894A Pending CN101142226A (zh) 2005-02-28 2006-02-28 用于治疗病毒感染的三环核苷化合物

Country Status (18)

Country Link
US (4) US7534771B2 (OSRAM)
EP (2) EP1853617A1 (OSRAM)
JP (2) JP2008531703A (OSRAM)
KR (2) KR20070106781A (OSRAM)
CN (2) CN101142226A (OSRAM)
AP (2) AP2007004128A0 (OSRAM)
AR (1) AR058419A1 (OSRAM)
AU (2) AU2006218704A1 (OSRAM)
BR (2) BRPI0607770A2 (OSRAM)
CA (2) CA2597683A1 (OSRAM)
EA (2) EA200701850A1 (OSRAM)
HR (2) HRP20070436A2 (OSRAM)
IL (2) IL184955A0 (OSRAM)
MX (2) MX2007010463A (OSRAM)
NO (2) NO20074613L (OSRAM)
TW (1) TW200640474A (OSRAM)
WO (2) WO2006093987A1 (OSRAM)
ZA (1) ZA200707410B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104321334A (zh) * 2012-03-15 2015-01-28 伯尔尼大学 三环核苷及由其制备的低聚化合物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104321334A (zh) * 2012-03-15 2015-01-28 伯尔尼大学 三环核苷及由其制备的低聚化合物

Also Published As

Publication number Publication date
MX2007010460A (es) 2007-11-08
US20060194749A1 (en) 2006-08-31
AP2007004128A0 (en) 2007-08-31
JP2008531704A (ja) 2008-08-14
AP2007004118A0 (en) 2007-08-31
IL184954A0 (en) 2007-12-03
US20090253648A1 (en) 2009-10-08
US7524825B2 (en) 2009-04-28
KR20070106767A (ko) 2007-11-05
US20060252715A1 (en) 2006-11-09
AR058419A1 (es) 2008-02-06
US7534771B2 (en) 2009-05-19
HRP20070435A2 (hr) 2008-02-29
EP1853617A1 (en) 2007-11-14
TW200640474A (en) 2006-12-01
EP1853618A1 (en) 2007-11-14
CN101142226A (zh) 2008-03-12
EA200701850A1 (ru) 2008-02-28
JP2008531703A (ja) 2008-08-14
US20090208457A1 (en) 2009-08-20
MX2007010463A (es) 2007-11-08
CA2597683A1 (en) 2006-09-08
CA2597685A1 (en) 2006-09-08
NO20074915L (no) 2007-11-20
WO2006093987A1 (en) 2006-09-08
KR20070106781A (ko) 2007-11-05
NO20074613L (no) 2007-11-27
BRPI0607769A2 (pt) 2009-10-06
ZA200707410B (en) 2008-10-29
IL184955A0 (en) 2007-12-03
BRPI0607770A2 (pt) 2009-06-13
HRP20070436A2 (hr) 2008-02-29
HRP20070435A9 (en) 2008-09-30
EA200701849A1 (ru) 2008-02-28
AU2006218704A1 (en) 2006-09-08
AU2006218705A1 (en) 2006-09-08
WO2006093986A1 (en) 2006-09-08

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