CN101128193B - 抗自由基剂 - Google Patents

抗自由基剂 Download PDF

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Publication number
CN101128193B
CN101128193B CN2005800485961A CN200580048596A CN101128193B CN 101128193 B CN101128193 B CN 101128193B CN 2005800485961 A CN2005800485961 A CN 2005800485961A CN 200580048596 A CN200580048596 A CN 200580048596A CN 101128193 B CN101128193 B CN 101128193B
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CN
China
Prior art keywords
acid
alkyl
carbon atom
hydroxyl
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2005800485961A
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English (en)
Chinese (zh)
Other versions
CN101128193A (zh
Inventor
沃纳·巴斯乔恩
奥利弗·赖克
塞巴斯蒂安·蒙吉亚特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority claimed from PCT/EP2005/055475 external-priority patent/WO2006066987A1/en
Publication of CN101128193A publication Critical patent/CN101128193A/zh
Application granted granted Critical
Publication of CN101128193B publication Critical patent/CN101128193B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Hydrogenated Pyridines (AREA)
CN2005800485961A 2004-12-22 2005-10-24 抗自由基剂 Active CN101128193B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04106821.4 2004-12-22
EP04106821 2004-12-22
PCT/EP2005/055475 WO2006066987A1 (en) 2004-12-22 2005-10-24 Anti-radical agents

Publications (2)

Publication Number Publication Date
CN101128193A CN101128193A (zh) 2008-02-20
CN101128193B true CN101128193B (zh) 2011-11-16

Family

ID=34930109

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800485961A Active CN101128193B (zh) 2004-12-22 2005-10-24 抗自由基剂

Country Status (3)

Country Link
KR (1) KR101312422B1 (es)
CN (1) CN101128193B (es)
ES (1) ES2349415T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010051138A2 (en) * 2008-10-06 2010-05-06 Pharma Cosmetix Research, Llc Skin treatments containing carboxylic acid-substituted idebenone derivatives and methods of preparation and use thereof
KR20180063179A (ko) * 2015-10-07 2018-06-11 조엘 후이젠가 인간의 노화에 따른 노쇠의 방어 및 회복을 위한 생체 경로의 복구
CN105806830B (zh) * 2015-12-10 2019-01-29 北京联众泰克科技有限公司 一种稳定的hrp酶促化学发光底物液、其制备方法及应用
CN110200981A (zh) * 2019-06-06 2019-09-06 中国药科大学 五环三萜皂苷的医药用途及其药物组合物

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857572A (en) * 1985-11-13 1989-08-15 Ciba-Geigy Corporation Substituted phenols as stabilizers
WO1992022290A1 (en) * 1991-06-18 1992-12-23 Oklahoma Medical Research Foundation Use of spin trapping for the treatment of diseases associated with oxidation of lipids and proteins
WO1996040127A1 (en) * 1995-06-07 1996-12-19 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Nitroxides as protectors against oxidative stress
US5840734A (en) * 1997-05-06 1998-11-24 Thomas Jefferson University Use of tempol in the prevention of photoaging
US6403627B1 (en) * 1991-06-18 2002-06-11 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
US20040024025A1 (en) * 1998-06-26 2004-02-05 Georgetown University Compositions and methods for inducing cell death
US20050065182A1 (en) * 2003-09-23 2005-03-24 Papazoglou Elisabeth S. Method and compositions for chronic wound care

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000025731A1 (en) * 1998-11-02 2000-05-11 Ciba Specialty Chemicals Holding Inc. Stabilisation of body-care and household products

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857572A (en) * 1985-11-13 1989-08-15 Ciba-Geigy Corporation Substituted phenols as stabilizers
WO1992022290A1 (en) * 1991-06-18 1992-12-23 Oklahoma Medical Research Foundation Use of spin trapping for the treatment of diseases associated with oxidation of lipids and proteins
US6403627B1 (en) * 1991-06-18 2002-06-11 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
WO1996040127A1 (en) * 1995-06-07 1996-12-19 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Nitroxides as protectors against oxidative stress
US5840734A (en) * 1997-05-06 1998-11-24 Thomas Jefferson University Use of tempol in the prevention of photoaging
US20040024025A1 (en) * 1998-06-26 2004-02-05 Georgetown University Compositions and methods for inducing cell death
US20050065182A1 (en) * 2003-09-23 2005-03-24 Papazoglou Elisabeth S. Method and compositions for chronic wound care

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
H.G.S.Rathore, et al.Sythesis and pharmacological activities of new 3-phenyl-3(N,N-substituted aminomethyl)-2(3H)-benzofuranones.Journal of the Indian Chemical Society61.1984,61556-558. *
Simeng Suy, et al.Nitroxides tempol and tempo inducedivergent signal transduction pathways in MDA-MB 231breast cancer cells.Journal of Biology Chemistry273 28.1998,273(28),17871-17878.
Simeng Suy, et al.Nitroxides tempol and tempo inducedivergent signal transduction pathways in MDA-MB 231breast cancer cells.Journal of Biology Chemistry273 28.1998,273(28),17871-17878. *

Also Published As

Publication number Publication date
KR101312422B1 (ko) 2013-09-30
ES2349415T3 (es) 2011-01-03
KR20070090919A (ko) 2007-09-06
CN101128193A (zh) 2008-02-20

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