CN101126095A - 采用丙型肝炎病毒非结构蛋白进行的基因免疫 - Google Patents

采用丙型肝炎病毒非结构蛋白进行的基因免疫 Download PDF

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Publication number
CN101126095A
CN101126095A CNA2007101398938A CN200710139893A CN101126095A CN 101126095 A CN101126095 A CN 101126095A CN A2007101398938 A CNA2007101398938 A CN A2007101398938A CN 200710139893 A CN200710139893 A CN 200710139893A CN 101126095 A CN101126095 A CN 101126095A
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China
Prior art keywords
cell
virus
nucleic acid
hcv
hepatitis
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Pending
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CNA2007101398938A
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English (en)
Chinese (zh)
Inventor
J·万德斯
J·恩克
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General Hospital Corp
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General Hospital Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/29Hepatitis virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CNA2007101398938A 1998-01-30 1999-01-28 采用丙型肝炎病毒非结构蛋白进行的基因免疫 Pending CN101126095A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7315698P 1998-01-30 1998-01-30
US60/073,156 1998-01-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB998024813A Division CN100335637C (zh) 1998-01-30 1999-01-28 采用丙型肝炎病毒非结构蛋白进行的基因免疫

Publications (1)

Publication Number Publication Date
CN101126095A true CN101126095A (zh) 2008-02-20

Family

ID=22112053

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA2007101398938A Pending CN101126095A (zh) 1998-01-30 1999-01-28 采用丙型肝炎病毒非结构蛋白进行的基因免疫
CNB998024813A Expired - Fee Related CN100335637C (zh) 1998-01-30 1999-01-28 采用丙型肝炎病毒非结构蛋白进行的基因免疫
CNA2007101384653A Pending CN101126094A (zh) 1998-01-30 1999-01-28 采用丙型肝炎病毒非结构蛋白进行的基因免疫

Family Applications After (2)

Application Number Title Priority Date Filing Date
CNB998024813A Expired - Fee Related CN100335637C (zh) 1998-01-30 1999-01-28 采用丙型肝炎病毒非结构蛋白进行的基因免疫
CNA2007101384653A Pending CN101126094A (zh) 1998-01-30 1999-01-28 采用丙型肝炎病毒非结构蛋白进行的基因免疫

Country Status (9)

Country Link
EP (1) EP1056762A4 (ko)
JP (1) JP2002501737A (ko)
KR (2) KR20060057653A (ko)
CN (3) CN101126095A (ko)
AU (1) AU746258B2 (ko)
BR (1) BR9908540A (ko)
CA (1) CA2318744A1 (ko)
IL (1) IL137458A0 (ko)
WO (1) WO1999038880A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562346B1 (en) * 1999-10-27 2003-05-13 Chiron Corporation Activation of HCV-specific T cells
US6986892B1 (en) 1999-11-24 2006-01-17 Chiron Corporation Immunogenic Hepatitis C virus non-structural polypeptides
KR100788812B1 (ko) * 1999-11-24 2007-12-27 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 신규한 hcv 비구조 폴리펩티드
CN1582337B (zh) 2001-10-11 2011-12-14 默沙东公司 丙型肝炎病毒疫苗
FR2855758B1 (fr) 2003-06-05 2005-07-22 Biomerieux Sa Composition comprenant la polyproteine ns3/ns4 et le polypeptide ns5b du vhc, vecteurs d'expression incluant les sequences nucleiques correspondantes et leur utilisation en therapeutique
CA2851336C (en) * 2011-10-24 2021-01-12 The Trustees Of The University Of Pennsylvania Improved hcv vaccines and methods for using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69133402T2 (de) * 1990-04-04 2004-11-11 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Protease von hepatitis-c-virus
US5593972A (en) * 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
AU675702B2 (en) * 1993-01-26 1997-02-13 Leslie R. Coney Compositions and methods for delivery of genetic material
IL118364A0 (en) * 1995-05-22 1996-09-12 Bionova Corp A hepatitis C virus-derived composition methods for the preparation thereof and assays for the detection of hepatitis C virus
AU719929B2 (en) * 1996-05-24 2000-05-18 Grifols Worldwide Operations Limited Multiple epitope fusion protein
JP2002500502A (ja) * 1996-06-11 2002-01-08 メルク エンド カンパニー インコーポレーテッド 合成c型肝炎遺伝子
EP1037974B1 (en) * 1997-12-11 2007-10-03 SmithKline Beecham Corporation Hepatitis c virus ns5b truncated protein and methods thereof to identify antiviral compounds

Also Published As

Publication number Publication date
KR100628411B1 (ko) 2006-09-28
CN100335637C (zh) 2007-09-05
EP1056762A1 (en) 2000-12-06
AU746258B2 (en) 2002-04-18
CA2318744A1 (en) 1999-08-05
WO1999038880A1 (en) 1999-08-05
CN101126094A (zh) 2008-02-20
IL137458A0 (en) 2001-07-24
BR9908540A (pt) 2000-11-28
AU2478699A (en) 1999-08-16
KR20060057653A (ko) 2006-05-26
CN1289339A (zh) 2001-03-28
EP1056762A4 (en) 2003-07-23
KR20010086226A (ko) 2001-09-10
JP2002501737A (ja) 2002-01-22

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Open date: 20080220