CA2318744A1 - Genetic immunization with nonstructural proteins of hepatitis c virus - Google Patents
Genetic immunization with nonstructural proteins of hepatitis c virus Download PDFInfo
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- CA2318744A1 CA2318744A1 CA002318744A CA2318744A CA2318744A1 CA 2318744 A1 CA2318744 A1 CA 2318744A1 CA 002318744 A CA002318744 A CA 002318744A CA 2318744 A CA2318744 A CA 2318744A CA 2318744 A1 CA2318744 A1 CA 2318744A1
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- 229940021993 prophylactic vaccine Drugs 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 210000003314 quadriceps muscle Anatomy 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 102000055501 telomere Human genes 0.000 description 1
- 108091035539 telomere Proteins 0.000 description 1
- 210000003411 telomere Anatomy 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000006514 viral protein processing Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7315698P | 1998-01-30 | 1998-01-30 | |
| US60/073,156 | 1998-01-30 | ||
| PCT/US1999/001823 WO1999038880A1 (en) | 1998-01-30 | 1999-01-28 | Genetic immunization with nonstructural proteins of hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2318744A1 true CA2318744A1 (en) | 1999-08-05 |
Family
ID=22112053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002318744A Abandoned CA2318744A1 (en) | 1998-01-30 | 1999-01-28 | Genetic immunization with nonstructural proteins of hepatitis c virus |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1056762A4 (ko) |
| JP (1) | JP2002501737A (ko) |
| KR (2) | KR20060057653A (ko) |
| CN (3) | CN100335637C (ko) |
| AU (1) | AU746258B2 (ko) |
| BR (1) | BR9908540A (ko) |
| CA (1) | CA2318744A1 (ko) |
| IL (1) | IL137458A0 (ko) |
| WO (1) | WO1999038880A1 (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562346B1 (en) * | 1999-10-27 | 2003-05-13 | Chiron Corporation | Activation of HCV-specific T cells |
| ATE376558T1 (de) * | 1999-11-24 | 2007-11-15 | Novartis Vaccines & Diagnostic | Neues nichtstrukturelles hcv polypeptid |
| US6986892B1 (en) | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
| US7598362B2 (en) | 2001-10-11 | 2009-10-06 | Merck & Co., Inc. | Hepatitis C virus vaccine |
| FR2855758B1 (fr) | 2003-06-05 | 2005-07-22 | Biomerieux Sa | Composition comprenant la polyproteine ns3/ns4 et le polypeptide ns5b du vhc, vecteurs d'expression incluant les sequences nucleiques correspondantes et leur utilisation en therapeutique |
| WO2013062507A1 (en) * | 2011-10-24 | 2013-05-02 | The Trustees Of The University Of Pennsylvania | Improved hcv vaccines and methods for using the same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE270326T1 (de) * | 1990-04-04 | 2004-07-15 | Chiron Corp | Protease von hepatitis-c-virus |
| AU675702B2 (en) * | 1993-01-26 | 1997-02-13 | Leslie R. Coney | Compositions and methods for delivery of genetic material |
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| IL118364A0 (en) * | 1995-05-22 | 1996-09-12 | Bionova Corp | A hepatitis C virus-derived composition methods for the preparation thereof and assays for the detection of hepatitis C virus |
| CA2250723C (en) * | 1996-05-24 | 2012-07-17 | Chiron Corporation | Multiple epitope fusion protein |
| JP2002500502A (ja) * | 1996-06-11 | 2002-01-08 | メルク エンド カンパニー インコーポレーテッド | 合成ｃ型肝炎遺伝子 |
| DE69838513T2 (de) * | 1997-12-11 | 2008-07-03 | Smithkline Beecham Corp. | Verkürztes hepatitis-c-virus protein nsb5 und methoden, um antivirale substanzen zu identifizieren |
-
1999
- 1999-01-28 CN CNB998024813A patent/CN100335637C/zh not_active Expired - Fee Related
- 1999-01-28 JP JP2000529347A patent/JP2002501737A/ja not_active Withdrawn
- 1999-01-28 CA CA002318744A patent/CA2318744A1/en not_active Abandoned
- 1999-01-28 EP EP99904381A patent/EP1056762A4/en not_active Withdrawn
- 1999-01-28 AU AU24786/99A patent/AU746258B2/en not_active Ceased
- 1999-01-28 CN CNA2007101398938A patent/CN101126095A/zh active Pending
- 1999-01-28 KR KR1020067008960A patent/KR20060057653A/ko not_active IP Right Cessation
- 1999-01-28 KR KR1020007008307A patent/KR100628411B1/ko not_active IP Right Cessation
- 1999-01-28 CN CNA2007101384653A patent/CN101126094A/zh active Pending
- 1999-01-28 WO PCT/US1999/001823 patent/WO1999038880A1/en not_active Application Discontinuation
- 1999-01-28 BR BR9908540-2A patent/BR9908540A/pt not_active Application Discontinuation
- 1999-01-28 IL IL13745899A patent/IL137458A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2478699A (en) | 1999-08-16 |
| CN101126095A (zh) | 2008-02-20 |
| JP2002501737A (ja) | 2002-01-22 |
| KR20060057653A (ko) | 2006-05-26 |
| EP1056762A1 (en) | 2000-12-06 |
| WO1999038880A1 (en) | 1999-08-05 |
| KR20010086226A (ko) | 2001-09-10 |
| CN1289339A (zh) | 2001-03-28 |
| IL137458A0 (en) | 2001-07-24 |
| BR9908540A (pt) | 2000-11-28 |
| KR100628411B1 (ko) | 2006-09-28 |
| CN100335637C (zh) | 2007-09-05 |
| AU746258B2 (en) | 2002-04-18 |
| EP1056762A4 (en) | 2003-07-23 |
| CN101126094A (zh) | 2008-02-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |