CN101116669B - 20(r)-人参皂苷组合物及其应用 - Google Patents
20(r)-人参皂苷组合物及其应用 Download PDFInfo
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- CN101116669B CN101116669B CN2006100110948A CN200610011094A CN101116669B CN 101116669 B CN101116669 B CN 101116669B CN 2006100110948 A CN2006100110948 A CN 2006100110948A CN 200610011094 A CN200610011094 A CN 200610011094A CN 101116669 B CN101116669 B CN 101116669B
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- ginsenoside
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- CKUVNOCSBYYHIS-SUEBGMEDSA-N (2r,3r,4s,5s,6r)-2-[[(3s,5r,8r,9r,10r,12r,13r,14r,17s)-12-hydroxy-17-[(2r)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O([C@H]1CC[C@]2(C)[C@H]3C[C@@H](O)[C@H]4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@@H]4[C@](C)(O)CCC=C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CKUVNOCSBYYHIS-SUEBGMEDSA-N 0.000 title claims abstract description 39
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- 239000003814 drug Substances 0.000 claims abstract description 31
- 229940079593 drug Drugs 0.000 claims abstract description 19
- UWGVFBVJCVDUPT-UHFFFAOYSA-N Ginsenoside III Chemical compound C1CC(C2(CCC3C(C)(C)C(OC4C(C(O)C(O)C(CO)O4)OC4C(C(O)C(O)C(CO)O4)O)CCC3(C)C2CC2O)C)(C)C2C1C(C)(CCC(=O)C(=C)C)OC1OC(CO)C(O)C(O)C1O UWGVFBVJCVDUPT-UHFFFAOYSA-N 0.000 claims abstract description 16
- IITVYETYQBNPRC-UHFFFAOYSA-N Ginsenoside III Natural products CC(=C)C(=O)CCC(C)(OC1OC(CO)C(O)C(O)C1OC2OC(CO)C(O)C(O)C2O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7O)C(C)(C)C6CCC45C IITVYETYQBNPRC-UHFFFAOYSA-N 0.000 claims abstract description 15
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- RWXIFXNRCLMQCD-CZIWJLDFSA-N (20R)-ginsenoside Rg3 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1CC[C@]2(C)[C@H]3C[C@@H](O)[C@H]4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@@H]4[C@](C)(O)CCC=C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RWXIFXNRCLMQCD-CZIWJLDFSA-N 0.000 abstract 1
- CKUVNOCSBYYHIS-UHFFFAOYSA-N (20R)-ginsenoside Rg3 Natural products CC(C)=CCCC(C)(O)C1CCC(C2(CCC3C4(C)C)C)(C)C1C(O)CC2C3(C)CCC4OC1OC(CO)C(O)C(O)C1O CKUVNOCSBYYHIS-UHFFFAOYSA-N 0.000 abstract 1
- XIRZPICFRDZXPF-GCIIHGAUSA-N 20(R)-Ginsenoside Rg3 Natural products CC(=CCC[C@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]3[C@@]4(C)CC[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@H]6O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]6O)C(C)(C)[C@@H]4[C@@H](O)C[C@@]23C)C XIRZPICFRDZXPF-GCIIHGAUSA-N 0.000 abstract 1
- CKUVNOCSBYYHIS-LGYUXIIVSA-N 20(R)-Ginsenoside Rh2 Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@H]1C(C)(C)[C@H]2[C@@](C)([C@H]3[C@](C)([C@@]4(C)[C@H]([C@H](O)C3)[C@@H]([C@](O)(CC/C=C(\C)/C)C)CC4)CC2)CC1 CKUVNOCSBYYHIS-LGYUXIIVSA-N 0.000 abstract 1
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- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 6
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- CKUVNOCSBYYHIS-IRFFNABBSA-N (20S)-ginsenoside Rh2 Chemical compound O([C@H]1CC[C@]2(C)[C@H]3C[C@@H](O)[C@H]4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@@H]4[C@@](C)(O)CCC=C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CKUVNOCSBYYHIS-IRFFNABBSA-N 0.000 description 1
- UUTKICFRNVKFRG-WDSKDSINSA-N (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSCN1C(=O)[C@H]1NC(=O)CC1 UUTKICFRNVKFRG-WDSKDSINSA-N 0.000 description 1
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
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- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 description 1
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- 241001529936 Murinae Species 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
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- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- PPWHTZKZQNXVAE-UHFFFAOYSA-N Tetracaine hydrochloride Chemical compound Cl.CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 PPWHTZKZQNXVAE-UHFFFAOYSA-N 0.000 description 1
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- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (2)
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CN2006100110948A CN101116669B (zh) | 2006-08-02 | 2006-08-02 | 20(r)-人参皂苷组合物及其应用 |
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CN2006100110948A CN101116669B (zh) | 2006-08-02 | 2006-08-02 | 20(r)-人参皂苷组合物及其应用 |
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CN101116669A CN101116669A (zh) | 2008-02-06 |
CN101116669B true CN101116669B (zh) | 2010-12-08 |
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CN2006100110948A Expired - Fee Related CN101116669B (zh) | 2006-08-02 | 2006-08-02 | 20(r)-人参皂苷组合物及其应用 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103908459B (zh) * | 2013-01-09 | 2018-02-02 | 上海中医药大学 | 三七皂苷Ft1的医药用途 |
CN104644654A (zh) * | 2013-11-20 | 2015-05-27 | 富力 | 20(R)-人参皂苷Rg3在制备乳腺增生药物中的应用及其药物 |
CN104814972A (zh) * | 2015-04-16 | 2015-08-05 | 云南普优生物科技有限公司 | 一种含有人参皂苷的药物组合物 |
CN105832780A (zh) * | 2016-05-25 | 2016-08-10 | 朱国平 | 能增强人体免疫力且具有抗癌作用的药物组合物及其制备方法 |
US11000537B2 (en) * | 2018-10-17 | 2021-05-11 | Amorepacific Corporation | Composition comprising novel ginsenoside |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1425381A (zh) * | 2002-12-28 | 2003-06-25 | 杨淑玲 | 人参皂苷单体配伍治疗癌症的产品 |
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CN1425381A (zh) * | 2002-12-28 | 2003-06-25 | 杨淑玲 | 人参皂苷单体配伍治疗癌症的产品 |
Non-Patent Citations (4)
Title |
---|
Qiu Feng etc..A new dammarane glycoside |
Qiu, Feng etc..A new dammarane glycoside, ginsenoside III fromtheflower-buds of Panax ginseng C.A. Meyer.CA131:308837.2002, * |
封颖璐等.人参皂苷与肿瘤.国外医学肿瘤学分册32 9.2005,32(9),665-668. |
封颖璐等.人参皂苷与肿瘤.国外医学肿瘤学分册32 9.2005,32(9),665-668. * |
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