CN101115490A - 药物活性化合物、它们的制备方法、包含它们的组合物及它们的应用 - Google Patents
药物活性化合物、它们的制备方法、包含它们的组合物及它们的应用 Download PDFInfo
- Publication number
- CN101115490A CN101115490A CNA2006800046348A CN200680004634A CN101115490A CN 101115490 A CN101115490 A CN 101115490A CN A2006800046348 A CNA2006800046348 A CN A2006800046348A CN 200680004634 A CN200680004634 A CN 200680004634A CN 101115490 A CN101115490 A CN 101115490A
- Authority
- CN
- China
- Prior art keywords
- general formula
- iii
- metal
- chemical compound
- preferred
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims description 93
- 239000000203 mixture Substances 0.000 title claims description 21
- 238000004519 manufacturing process Methods 0.000 title description 2
- 229910052751 metal Inorganic materials 0.000 claims abstract description 88
- 239000002184 metal Substances 0.000 claims abstract description 88
- 239000003814 drug Substances 0.000 claims abstract description 31
- 239000007787 solid Substances 0.000 claims abstract description 31
- 238000010438 heat treatment Methods 0.000 claims abstract description 29
- 239000000463 material Substances 0.000 claims description 90
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 59
- 229910001868 water Inorganic materials 0.000 claims description 51
- 238000002360 preparation method Methods 0.000 claims description 45
- 150000001450 anions Chemical class 0.000 claims description 43
- 201000005991 hyperphosphatemia Diseases 0.000 claims description 14
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 claims description 13
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 12
- 241001465754 Metazoa Species 0.000 claims description 11
- 239000003937 drug carrier Substances 0.000 claims description 11
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 10
- 238000001179 sorption measurement Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 abstract description 7
- 150000002736 metal compounds Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 48
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 38
- 229910019142 PO4 Inorganic materials 0.000 description 36
- 239000010452 phosphate Substances 0.000 description 34
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 32
- 239000011777 magnesium Substances 0.000 description 31
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 23
- 229910052749 magnesium Inorganic materials 0.000 description 23
- 229910052742 iron Inorganic materials 0.000 description 19
- 239000000047 product Substances 0.000 description 19
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 17
- 238000001354 calcination Methods 0.000 description 17
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 16
- 238000005406 washing Methods 0.000 description 15
- 239000008194 pharmaceutical composition Substances 0.000 description 14
- 238000001035 drying Methods 0.000 description 13
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- 239000011230 binding agent Substances 0.000 description 11
- 238000001914 filtration Methods 0.000 description 11
- 238000003756 stirring Methods 0.000 description 11
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 10
- 229910052799 carbon Inorganic materials 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 239000010410 layer Substances 0.000 description 9
- 239000011734 sodium Substances 0.000 description 9
- -1 sulfate radical Chemical class 0.000 description 9
- 229910002091 carbon monoxide Inorganic materials 0.000 description 8
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 8
- 235000019341 magnesium sulphate Nutrition 0.000 description 8
- 235000011121 sodium hydroxide Nutrition 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000013078 crystal Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 125000000129 anionic group Chemical group 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000003128 head Anatomy 0.000 description 6
- 239000000376 reactant Substances 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 239000002671 adjuvant Substances 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 241000282326 Felis catus Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 239000007767 bonding agent Substances 0.000 description 4
- 238000005266 casting Methods 0.000 description 4
- 150000001768 cations Chemical class 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 238000002354 inductively-coupled plasma atomic emission spectroscopy Methods 0.000 description 4
- 210000000088 lip Anatomy 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
- 238000002441 X-ray diffraction Methods 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000000975 co-precipitation Methods 0.000 description 3
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical group [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
- 239000011229 interlayer Substances 0.000 description 3
- 238000005304 joining Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000007873 sieving Methods 0.000 description 3
- 239000007892 solid unit dosage form Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 210000000433 stratum disjunctum Anatomy 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- 229910020068 MgAl Inorganic materials 0.000 description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000004927 clay Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000002485 combustion reaction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 229910000765 intermetallic Inorganic materials 0.000 description 2
- 238000000643 oven drying Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000003578 releasing effect Effects 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 229910052596 spinel Inorganic materials 0.000 description 2
- 239000011029 spinel Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- 229930182844 L-isoleucine Natural products 0.000 description 1
- 239000004395 L-leucine Substances 0.000 description 1
- 235000019454 L-leucine Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229910015905 MWCO 2 Inorganic materials 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229910003023 Mg-Al Inorganic materials 0.000 description 1
- 229910019094 Mg-S Inorganic materials 0.000 description 1
- 229910017916 MgMn Inorganic materials 0.000 description 1
- 229910019397 Mg—S Inorganic materials 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- PLZNPHDJGFDNRM-UHFFFAOYSA-M O.[Na+].[O-][PH2]=O Chemical compound O.[Na+].[O-][PH2]=O PLZNPHDJGFDNRM-UHFFFAOYSA-M 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 229920002494 Zein Polymers 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 229940048053 acrylate Drugs 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002156 adsorbate Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229960003767 alanine Drugs 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 150000001399 aluminium compounds Chemical class 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- PZZYQPZGQPZBDN-UHFFFAOYSA-N aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 229940115440 aluminum sodium silicate Drugs 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 229960005261 aspartic acid Drugs 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229910001593 boehmite Inorganic materials 0.000 description 1
- 229910052599 brucite Inorganic materials 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000005588 carbonic acid salt group Chemical group 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- CEZCCHQBSQPRMU-UHFFFAOYSA-L chembl174821 Chemical compound [Na+].[Na+].COC1=CC(S([O-])(=O)=O)=C(C)C=C1N=NC1=C(O)C=CC2=CC(S([O-])(=O)=O)=CC=C12 CEZCCHQBSQPRMU-UHFFFAOYSA-L 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- HPXRVTGHNJAIIH-PTQBSOBMSA-N cyclohexanol Chemical class O[13CH]1CCCCC1 HPXRVTGHNJAIIH-PTQBSOBMSA-N 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- PSHMSSXLYVAENJ-UHFFFAOYSA-N dilithium;[oxido(oxoboranyloxy)boranyl]oxy-oxoboranyloxyborinate Chemical compound [Li+].[Li+].O=BOB([O-])OB([O-])OB=O PSHMSSXLYVAENJ-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000000451 gelidium spp. gum Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 235000011167 hydrochloric acid Nutrition 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 229910001701 hydrotalcite Inorganic materials 0.000 description 1
- 229960001545 hydrotalcite Drugs 0.000 description 1
- FAHBNUUHRFUEAI-UHFFFAOYSA-M hydroxidooxidoaluminium Chemical compound O[Al]=O FAHBNUUHRFUEAI-UHFFFAOYSA-M 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000009616 inductively coupled plasma Methods 0.000 description 1
- 239000010842 industrial wastewater Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 229910000358 iron sulfate Inorganic materials 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229910052746 lanthanum Inorganic materials 0.000 description 1
- FZLIPJUXYLNCLC-UHFFFAOYSA-N lanthanum atom Chemical compound [La] FZLIPJUXYLNCLC-UHFFFAOYSA-N 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- HZRMTWQRDMYLNW-UHFFFAOYSA-N lithium metaborate Chemical compound [Li+].[O-]B=O HZRMTWQRDMYLNW-UHFFFAOYSA-N 0.000 description 1
- 208000020442 loss of weight Diseases 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229910003455 mixed metal oxide Inorganic materials 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229960005190 phenylalanine Drugs 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000429 sodium aluminium silicate Substances 0.000 description 1
- 235000012217 sodium aluminium silicate Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical group [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compounds Of Iron (AREA)
Abstract
Description
实施例 | 温度℃ | PO4结合 | 可溶性Mg的释放 | 表面吸附的水 | 混合性金属种类 | |||
批次A% | 批次B% | 批次Ammol/l | 批次Bmmol/l | 批次A% | 批次B% | 批次A(指定为通式I在34°θ的峰)XRD-次据 | ||
abcdefghijkm | 未煅烧1502002503003504004505006007501000 | 51.150.949.657.761.766.065.266.064.042.828.517.6 | 43.246.255.951.554.864.761.261.884.658.345.213.0 | 7.47.36.93.32.00.70.71.50.86.010.713.3 | 8.87.04.23.12.60.90.71.10.38.414.619.5 | 3.121.110.960.240.520.000.250.000.961.09-- | 4.720.430.730.600.460.230.610.820.961.11-- | 000210021001700160016001600000 |
用于煅烧试验的金属化合物的组成 | ||||
实施例 | 摩尔比MII∶MIII | 阴离子类型 | 制备方法 | |
A | Mg和Fe | 2 | 碳酸根 | M1 |
B | Mg和Fe | 4 | 碳酸根 | M1 |
1 | Mg和Fe | 2 | 碳酸根 | M2 |
2 | Mg和Fe | 3 | 碳酸根 | M3 |
3 | Mg和Fe | 4 | 碳酸根 | M2 |
4 | Mg和Fe | 2 | 碳酸根 | M4 |
5 | Mg和Fe | 4 | 碳酸根 | M5 |
6 | Mg和Al | 3 | 碳酸根 | M6 |
7 | Mg和Fe | 3 | 氯 | M7 |
开始批次 | 温度℃ | 煅烧时间 | 作为氧化物表示的重量百分数 | ||||||
%Na2O | %MgO | %Fe2O3 | %H2O | %CO2 | %SO3 | %CO3 | |||
A | u | 1.98 | 29.71 | 28.39 | 28.92 | 7.97 | 3.03 | 10.9 | |
A | 300 | 3小时 | 2.44 | 35.49 | 33.74 | 17.88 | 7.79 | 2.66 | 10.6 |
A | 500 | 3小时 | 1.64 | 42.28 | 41.78 | 6.19 | 1.87 | 6.25 | 2.6 |
A | 600 | 3小时 | 3.19 | 45.81 | 43.64 | 3.65 | 0.36 | 3.36 | 0.5 |
A | 1000 | 3小时 | 3.25 | 47.14 | 45.08 | 0.00 | 0.00 | 4.61 | 0.0 |
B | u | 1.74 | 37.06 | 18.64 | 31.40 | 8.02 | 3.14 | 10.9 | |
B | 300 | 3小时 | |||||||
B | 500 | 3小时 | 1.89 | 2.6 | |||||
B | 600 | 3小时 | 0.24 | 0.3 | |||||
B | 1000 | 3小时 | 0.00 | 0.0 | |||||
1 | u | 0.05 | 28.08 | 28.72 | 34.82 | 6.47 | 1.86 | 8.8 | |
1 | 300 | 3小时 | 0.05 | 30.82 | 31.07 | 29.54 | 6.60 | 1.92 | 9.0 |
1 | 500 | 3小时 | 0.05 | 37.23 | 38.00 | 20.96 | 1.11 | 2.65 | 1.5 |
1 | 750 | 3小时 | 0.00 | 0.0 | |||||
2 | u | 0.05 | 32.78 | 22.43 | 36.47 | 6.82 | 1.45 | 9.3 | |
2 | 500 | 3小时 | 0.05 | 53.81 | 36.63 | 5.69 | 0.51 | 3.31 | 0.7 |
3 | u | 0.05 | 37.26 | 19.31 | 34.07 | 6.99 | 2.32 | 9.5 | |
3 | 200 | 3小时 | 0.05 | 43.63 | 22.64 | 22.77 | 8.17 | 2.74 | 11.1 |
3 | 500 | 3小时 | 0.05 | 59.12 | 31.03 | 5.00 | 1.00 | 3.80 | 1.4 |
4 | u | 20.91 | 17.70 | 17.21 | 15.77 | 7.85 | 20.56 | 10.7 | |
4 | 300 | 3小时 | 22.35 | 20.13 | 19.10 | 8.50 | 8.04 | 21.88 | 11.0 |
4 | 500 | 3小时 | 26.75 | 23.17 | 22.44 | 4.16 | 3.28 | 20.20 | 4.5 |
4 | 750 | 3小时 | 0.83 | 1.1 | |||||
5 | u | 0.05 | 40.14 | 20.70 | 29.39 | 7.98 | 1.74 | 10.9 | |
5 | 200 | 3小时 | 0.05 | 42.91 | 21.89 | 24.56 | 8.75 | 1.84 | 11.9 |
5 | 500 | 3小时 | 0.05 | 57.01 | 29.54 | 9.00 | 1.93 | 2.48 | 2.6 |
6 | u | ||||||||
6 | 300 | 3小时 | |||||||
6 | 500 | 3小时 | |||||||
6 | 750 | 3小时 | |||||||
7 | u | 0.05 | 35.62 | 24.85 | |||||
7 | 500 | 3小时 | |||||||
7 | 750 | 3小时 | |||||||
2 | 500 | 5分钟 | 0.09 | 43.34 | 42.84 | 8.94 | 2.09 | 2.70 | 2.8 |
2 | 500 | 16小时 | 1.34 | 45.41 | 44.83 | 4.33 | 1.25 | 2.84 | 1.7 |
温度℃ | 煅烧时间 | 通式常数[MII (1-a)MIII ωObAn- c.zH2O] | PO4结合 | 释放Mg | |||||
%重量 | mmol/l | ||||||||
a | b | c | z | ∑cn/a | |||||
A | u | x0.33 | - | y0.17 | m1.47 | - | 51.1 | 7.4 | |
A | 300 | 3小时 | 0.32 | 1.03 | 0.14 | 0.76 | 0.84 | 61.7 | 2.0 |
A | 500 | 3小时 | 0.33 | 1.11 | 0.06 | 0.22 | 0.34 | 64.0 | 0.8 |
A | 600 | 3小时 | 0.32 | 1.15 | 0.01 | 0.12 | 0.07 | 42.8 | 6.0 |
A | 1000 | 3小时 | 0.33 | 1.15 | 0.01 | 0.00 | 0.09 | 17.6 | 13.3 |
B | u | x0.20 | - | y0.16 | - | - | 43.2 | 8.8 | |
B | 300 | 3小时 | 54.8 | 2.6 | |||||
B | 500 | 3小时 | 84.6 | 0.3 | |||||
B | 600 | 3小时 | 58.3 | 8.4 | |||||
B | 100 | 3小时 | 13.0 | 19.5 | |||||
1 | u | x0.34 | - | y0.14 | m1.83 | - | 67.6 | 6.0 | |
1 | 300 | 3小时 | 0.34 | 1.04 | 0.13 | 1.42 | 0.77 | 73.2 | 0.2 |
1 | 500 | 3小时 | 0.34 | 1.15 | 0.02 | 0.83 | 0.11 | 80.0 | 0.4 |
1 | 750 | 3小时 | 51.0 | 12.1 | |||||
2 | u | x0.26 | - | y0.14 | m1.85 | - | 59.7 | 7.8 | |
2 | 500 | 3小时 | 0.26 | 1.12 | 0.01 | 0.18 | 0.09 | 79.4 | 0.3 |
3 | u | x0.21 | - | y0.14 | m1.62 | - | 51.7 | 5.9 | |
3 | 200 | 3小时 | 0.21 | 0.97 | 0.14 | 0.93 | 1.33 | 64.8 | 1.7 |
3 | 500 | 3小时 | 0.21 | 1.08 | 0.02 | 0.15 | 0.20 | 91.3 | 0.1 |
4 | u | x0.33 | - | y0.62 | m1.34 | - | 28.3 | 2.8 | |
4 | 300 | 3小时 | 0.32 | 0.59 | 0.57 | 0.64 | 3.55 | 30.7 | 3.5 |
4 | 500 | 3小时 | 0.33 | 0.82 | 0.34 | 0.27 | 2.10 | 17.1 | 1.4 |
4 | 750 | 3小时 | 10.6 | 0.5 | |||||
5 | u | x0.21 | - | y0.14 | m1.30 | - | 66.2 | 3.4 | |
5 | 200 | 3小时 | 0.20 | 0.95 | 0.15 | 1.02 | 1.45 | 67.6 | 1.6 |
5 | 500 | 3小时 | 0.21 | 1.08 | 0.02 | 0.28 | 0.24 | 87.1 | 0.0 |
6 | u | - | 42.8 | 8.13 | |||||
6 | 300 | 3小时 | 47.6 | 3.32 | |||||
6 | 500 | 3小时 | 94.2 | 0 | |||||
6 | 750 | 3小时 | 71.7 | 1.87 | |||||
7 | u | x0.26 | - | 44.3 | 6.55 | ||||
7 | 500 | 3小时 | 72.6 | 0.36 | |||||
7 | 750 | 3小时 | 64.1 | 0.71 | |||||
2 | 500 | 5分钟 | 0.33 | 1.14 | 0.03 | 0.31 | 0.18 | 84.6 | 0.15 |
2 | 500 | 16小时 | 0.33 | 1.15 | 0.02 | 0.14 | 0.10 | 73.5 | 1.05 |
磷酸盐结合剂 | 煅烧温度 | PO4结合 | PO4结合 | Mg释放 | Mg释放 |
pH=4 | pH=7 | pH=4 | pH=7 | ||
% | % | mmol/l | Mmol/l | ||
实施例1 | 500℃,3小时 | 81 | 79 | 0.07 | 0.06 |
实施例1 | 未煅烧 | 56 | 57 | 0.32 | 0.16 |
Claims (33)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510713549.XA CN105412150B (zh) | 2005-02-10 | 2006-02-09 | 药物活性化合物、它们的制备方法、包含它们的组合物及它们的应用 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0502787.5 | 2005-02-10 | ||
GBGB0502787.5A GB0502787D0 (en) | 2005-02-10 | 2005-02-10 | Pharmaceuticlly active compounds, their manufacture, compositions containing them and their use |
PCT/GB2006/000452 WO2006085079A2 (en) | 2005-02-10 | 2006-02-09 | Pharmaceutically active phosphate binders, their manufacture, compositions containing them and their use |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510713549.XA Division CN105412150B (zh) | 2005-02-10 | 2006-02-09 | 药物活性化合物、它们的制备方法、包含它们的组合物及它们的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101115490A true CN101115490A (zh) | 2008-01-30 |
CN101115490B CN101115490B (zh) | 2015-12-09 |
Family
ID=34356109
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510713549.XA Expired - Fee Related CN105412150B (zh) | 2005-02-10 | 2006-02-09 | 药物活性化合物、它们的制备方法、包含它们的组合物及它们的应用 |
CN200680004634.8A Expired - Fee Related CN101115490B (zh) | 2005-02-10 | 2006-02-09 | 药物活性化合物、它们的制备方法、包含它们的组合物及它们的应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510713549.XA Expired - Fee Related CN105412150B (zh) | 2005-02-10 | 2006-02-09 | 药物活性化合物、它们的制备方法、包含它们的组合物及它们的应用 |
Country Status (20)
Country | Link |
---|---|
US (2) | US20080206358A1 (zh) |
EP (2) | EP1850859B1 (zh) |
JP (2) | JP5328157B2 (zh) |
KR (3) | KR20140066756A (zh) |
CN (2) | CN105412150B (zh) |
AR (2) | AR053678A1 (zh) |
AU (1) | AU2006213922B2 (zh) |
BR (1) | BRPI0606923B1 (zh) |
CA (1) | CA2597124C (zh) |
ES (1) | ES2599152T3 (zh) |
GB (1) | GB0502787D0 (zh) |
IL (1) | IL184448A (zh) |
MX (1) | MX2007009688A (zh) |
MY (1) | MY150070A (zh) |
NO (2) | NO341846B1 (zh) |
NZ (1) | NZ556600A (zh) |
RU (1) | RU2420297C2 (zh) |
TW (1) | TWI461201B (zh) |
WO (1) | WO2006085079A2 (zh) |
ZA (1) | ZA200706160B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109152794A (zh) * | 2016-03-30 | 2019-01-04 | 贝勒大学 | 包含在哺乳动物组织中增加氧水平的包合物的聚氧化金属氢氧化物 |
CN110357165A (zh) * | 2009-08-03 | 2019-10-22 | 欧普科爱尔兰环球控股有限公司 | 制备混合金属化合物的方法 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9720061D0 (en) * | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
MY157620A (en) | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
GB0714670D0 (en) * | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
GB0720220D0 (en) * | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
GB201001779D0 (en) * | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
GB201005931D0 (en) | 2010-04-09 | 2010-05-26 | Isis Innovation | Immune modulation |
AU2019363816A1 (en) | 2018-10-25 | 2021-05-13 | Eirgen Pharma Ltd. | Methods of treatment with mixed metal compounds |
RU2758671C1 (ru) * | 2020-12-08 | 2021-11-01 | Федеральное государственное бюджетное учреждение науки Институт физики прочности и материаловедения Сибирского отделения Российской академии наук (ИФПМ СО РАН) | СПОСОБ ПОЛУЧЕНИЯ НАНОСТРУКТУРНЫХ ДВОЙНЫХ ГИДРОКСИДОВ НА ОСНОВЕ АЛЮМИНИЯ И ЩЕЛОЧНОЗЕМЕЛЬНЫХ МЕТАЛЛОВ, ТАКИХ КАК МАГНИЙ ИЛИ КАЛЬЦИЙ, ОБЛАДАЮЩИХ СВОЙСТВОМ ПОВЫШАТЬ pH КЛЕТОЧНОЙ СРЕДЫ, И НАНОСТРУКТУРЫ, ПОЛУЧЕННЫЕ ДАННЫМ СПОСОБОМ |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2838930C2 (de) * | 1978-09-07 | 1980-07-03 | Chemische Werke Huels Ag, 4370 Marl | Wäßriges Behandlungsmittel für Holz und Holzwerkstoffe und dessen Verwendung |
US4514389A (en) * | 1981-05-06 | 1985-04-30 | Kyowa Chemical Industry Co. Ltd. | Gastric antacid and method for controlling pH of gastric juice |
JPS606619A (ja) * | 1983-06-27 | 1985-01-14 | Kyowa Chem Ind Co Ltd | 鉄分欠乏症処置剤及びその製法 |
US4566986A (en) * | 1984-08-31 | 1986-01-28 | Waldmann John J | Flocculating agents and processes for making them |
US5153156A (en) * | 1989-04-18 | 1992-10-06 | Aristech Chemical Corporation | Process for making efficient anionic clay catalyst, catalysts made thereby, and method of making isophorone |
US5246899A (en) * | 1991-08-16 | 1993-09-21 | Amoco Corporation | Simplified preparation of hydrotalcite-type clays |
NL9201907A (nl) * | 1992-11-02 | 1994-06-01 | Tno | Peristaltisch mengende reactor en peristaltische kleppenpomp. |
US5506248A (en) * | 1993-08-02 | 1996-04-09 | Bristol-Myers Squibb Company | Pharmaceutical compositions having good dissolution properties |
GB9506126D0 (en) * | 1995-03-25 | 1995-05-10 | Johnson Matthey Plc | Pharmaceutical composition and method |
GB9720061D0 (en) * | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
US6720005B1 (en) * | 2000-07-07 | 2004-04-13 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Coated, platform-generating tablet |
WO2003003809A2 (en) * | 2001-07-05 | 2003-01-16 | Marantech Holding, Llc | Methods of using electron active compounds for managing conditions afflicting mammals |
US20040161474A1 (en) * | 2002-05-24 | 2004-08-19 | Moerck Rudi E. | Rare earth metal compounds methods of making, and methods of using the same |
JP4348426B2 (ja) * | 2002-08-29 | 2009-10-21 | 独立行政法人産業技術総合研究所 | 高選択性脱リン剤及びその製造方法 |
US7381428B2 (en) * | 2003-08-26 | 2008-06-03 | Shire International Licensing B.V. | Stabilized lanthanum carbonate compositions |
EP1696889A1 (en) * | 2003-08-28 | 2006-09-06 | Ranbaxy Laboratories, Ltd. | Pharmaceutical compositions of benzimidazole and processes for their preparation |
MY157620A (en) * | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
-
2005
- 2005-02-10 GB GBGB0502787.5A patent/GB0502787D0/en not_active Ceased
-
2006
- 2006-02-06 US US11/815,845 patent/US20080206358A1/en not_active Abandoned
- 2006-02-09 AU AU2006213922A patent/AU2006213922B2/en not_active Ceased
- 2006-02-09 KR KR1020147009809A patent/KR20140066756A/ko not_active Application Discontinuation
- 2006-02-09 MY MYPI20060564A patent/MY150070A/en unknown
- 2006-02-09 RU RU2007133720/15A patent/RU2420297C2/ru not_active IP Right Cessation
- 2006-02-09 CN CN201510713549.XA patent/CN105412150B/zh not_active Expired - Fee Related
- 2006-02-09 EP EP06709690.9A patent/EP1850859B1/en active Active
- 2006-02-09 CN CN200680004634.8A patent/CN101115490B/zh not_active Expired - Fee Related
- 2006-02-09 KR KR1020137024757A patent/KR101491531B1/ko active IP Right Grant
- 2006-02-09 KR KR1020077017214A patent/KR20070082918A/ko not_active IP Right Cessation
- 2006-02-09 NZ NZ556600A patent/NZ556600A/en not_active IP Right Cessation
- 2006-02-09 ES ES06709690.9T patent/ES2599152T3/es active Active
- 2006-02-09 CA CA2597124A patent/CA2597124C/en not_active Expired - Fee Related
- 2006-02-09 ZA ZA200706160A patent/ZA200706160B/xx unknown
- 2006-02-09 EP EP16174070.9A patent/EP3120855A1/en not_active Withdrawn
- 2006-02-09 WO PCT/GB2006/000452 patent/WO2006085079A2/en active Application Filing
- 2006-02-09 MX MX2007009688A patent/MX2007009688A/es active IP Right Grant
- 2006-02-09 BR BRPI0606923-1A patent/BRPI0606923B1/pt not_active IP Right Cessation
- 2006-02-09 TW TW095104355A patent/TWI461201B/zh not_active IP Right Cessation
- 2006-02-09 JP JP2007554635A patent/JP5328157B2/ja not_active Expired - Fee Related
- 2006-02-10 AR ARP060100490A patent/AR053678A1/es not_active Application Discontinuation
-
2007
- 2007-07-05 IL IL184448A patent/IL184448A/en not_active IP Right Cessation
- 2007-09-05 NO NO20074504A patent/NO341846B1/no not_active IP Right Cessation
-
2011
- 2011-10-11 US US13/270,358 patent/US20120093943A1/en not_active Abandoned
-
2013
- 2013-05-20 JP JP2013106271A patent/JP2013209401A/ja active Pending
-
2016
- 2016-11-15 AR ARP160103488A patent/AR106699A2/es unknown
-
2017
- 2017-11-08 NO NO20171769A patent/NO20171769A1/no not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110357165A (zh) * | 2009-08-03 | 2019-10-22 | 欧普科爱尔兰环球控股有限公司 | 制备混合金属化合物的方法 |
CN110357165B (zh) * | 2009-08-03 | 2022-05-13 | 欧普科爱尔兰环球控股有限公司 | 制备混合金属化合物的方法 |
CN109152794A (zh) * | 2016-03-30 | 2019-01-04 | 贝勒大学 | 包含在哺乳动物组织中增加氧水平的包合物的聚氧化金属氢氧化物 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101115490B (zh) | 药物活性化合物、它们的制备方法、包含它们的组合物及它们的应用 | |
CN101827602B (zh) | 用于治疗高磷酸盐血症的混合金属化合物 | |
JP6333926B2 (ja) | 混合金属化合物 | |
JP4584830B2 (ja) | ランタンオキシカーボネートを製造する方法、組成物、哺乳類の高リン血症の処置の方法、およびリン酸塩を結合する方法 | |
NO342570B1 (no) | Granulært material, fremgangsmåte for dets fremstilling, samt enhetsdose for oral administrering. | |
CN100526219C (zh) | 稀土金属化合物、其制造方法及其使用方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: SETTOC ROMA DEVELOPMENT CORPORATION Free format text: FORMER OWNER: INEOS SILICAS LTD. Effective date: 20120206 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20120206 Address after: Michael, Babaduosisheng Applicant after: Cytochroma Developments Inc. Address before: British diesel Applicant before: Ineos Healthcare Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151209 Termination date: 20200209 |