CN101115481A - 苯基取代的吡咯烷酮类化合物 - Google Patents

苯基取代的吡咯烷酮类化合物 Download PDF

Info

Publication number
CN101115481A
CN101115481A CNA2006800033348A CN200680003334A CN101115481A CN 101115481 A CN101115481 A CN 101115481A CN A2006800033348 A CNA2006800033348 A CN A2006800033348A CN 200680003334 A CN200680003334 A CN 200680003334A CN 101115481 A CN101115481 A CN 101115481A
Authority
CN
China
Prior art keywords
hiv
alkyl
unsubstituted
chemical compound
replacement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800033348A
Other languages
English (en)
Chinese (zh)
Inventor
吴报根
T·N·源
D·A·艾理斯
贺晓晖
B·M·阿纳克勒里奥
杨鲲泳
崔夏洵
王志成
T·马尔希杰
贺耘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IRM LLC
Original Assignee
IRM LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IRM LLC filed Critical IRM LLC
Publication of CN101115481A publication Critical patent/CN101115481A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2006800033348A 2005-01-28 2006-01-30 苯基取代的吡咯烷酮类化合物 Pending CN101115481A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64802705P 2005-01-28 2005-01-28
US60/648,027 2005-01-28

Publications (1)

Publication Number Publication Date
CN101115481A true CN101115481A (zh) 2008-01-30

Family

ID=36741146

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800033348A Pending CN101115481A (zh) 2005-01-28 2006-01-30 苯基取代的吡咯烷酮类化合物

Country Status (11)

Country Link
US (1) US20080287516A1 (enExample)
EP (1) EP1841425A4 (enExample)
JP (1) JP2008528624A (enExample)
KR (2) KR100896889B1 (enExample)
CN (1) CN101115481A (enExample)
AU (1) AU2006209245A1 (enExample)
BR (1) BRPI0606123A2 (enExample)
CA (1) CA2594915A1 (enExample)
MX (1) MX2007009137A (enExample)
RU (1) RU2371433C2 (enExample)
WO (1) WO2006081554A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101979378A (zh) * 2010-10-13 2011-02-23 中国科学院上海有机化学研究所 一种手性γ-内酰胺化合物的合成方法
CN101747253B (zh) * 2008-12-02 2013-01-16 中国人民解放军军事医学科学院毒物药物研究所 三取代的手性内酰胺类衍生物及其制备方法和用途
CN110506037A (zh) * 2017-03-31 2019-11-26 爱瑞制药公司 芳基环丙基-氨基-异喹啉酰胺化合物

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2477604A1 (en) 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
CA2593816A1 (en) * 2005-01-28 2006-08-03 Irm Llc Synthesis of aryl pyrrolidones
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
WO2006084033A1 (en) 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
JP5164510B2 (ja) * 2006-10-06 2013-03-21 日本曹達株式会社 含窒素複素環化合物および有害生物防除剤
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
WO2009132051A1 (en) 2008-04-21 2009-10-29 Signum Biosciences, Inc. Compounds, compositions and methods for making the same
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2834451T3 (es) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
US9238643B2 (en) 2010-09-06 2016-01-19 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Amide compounds
CN110396085B (zh) 2013-03-15 2024-11-15 爱尔康公司 联合治疗
CN109640966A (zh) 2016-08-31 2019-04-16 爱瑞制药公司 眼用组合物
WO2019046467A1 (en) 2017-08-29 2019-03-07 Rutgers, The State University Of New Jersey INDAZOLES THERAPEUTIC
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU797219A1 (ru) * 1979-05-08 1995-07-25 Ленинградский государственный педагогический институт им.А.И.Герцена N-карбамоилметил-4-фенил-2-пирролидон, обладающий гипотензивной активностью
TW448172B (en) * 1996-03-08 2001-08-01 Pharmacia & Upjohn Co Llc Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
WO2004037784A2 (en) * 2002-10-21 2004-05-06 Irm Llc Pyrrolidones with anti-hiv activity

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101747253B (zh) * 2008-12-02 2013-01-16 中国人民解放军军事医学科学院毒物药物研究所 三取代的手性内酰胺类衍生物及其制备方法和用途
CN101979378A (zh) * 2010-10-13 2011-02-23 中国科学院上海有机化学研究所 一种手性γ-内酰胺化合物的合成方法
CN110506037A (zh) * 2017-03-31 2019-11-26 爱瑞制药公司 芳基环丙基-氨基-异喹啉酰胺化合物

Also Published As

Publication number Publication date
MX2007009137A (es) 2007-09-12
WO2006081554A2 (en) 2006-08-03
WO2006081554A3 (en) 2006-12-14
AU2006209245A1 (en) 2006-08-03
RU2371433C2 (ru) 2009-10-27
BRPI0606123A2 (pt) 2009-06-02
JP2008528624A (ja) 2008-07-31
US20080287516A1 (en) 2008-11-20
KR20070103404A (ko) 2007-10-23
CA2594915A1 (en) 2006-08-03
RU2007132259A (ru) 2009-03-10
EP1841425A2 (en) 2007-10-10
KR100896889B1 (ko) 2009-05-14
EP1841425A4 (en) 2009-02-18
KR20090028846A (ko) 2009-03-19

Similar Documents

Publication Publication Date Title
CN101115481A (zh) 苯基取代的吡咯烷酮类化合物
US7601742B2 (en) Pyrrolidones with anti-HIV activity
US20040152755A1 (en) Oxindoles with anti-HIV activity
KR100713960B1 (ko) 피롤 치환 2-인돌리논 단백질 인산화 효소 저해제
CN100560073C (zh) 用于治疗病毒感染的n4-酰基胞嘧啶核苷
Nugent et al. Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV
KR100802368B1 (ko) 세포 증식의 억제제로서의 이미다졸로-5-일-2-아닐리노-피리미딘
JP2021534213A (ja) 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ−シヌクレインタンパク質を標的とするタンパク質分解
SK11332003A3 (sk) Deriváty 3-(4-amidopyrol-2-ylmetylidén)-2-indolinónu ako inhibítory proteínkinázy
Homerin et al. Pyroglutamide-based P2X7 receptor antagonists targeting inflammatory bowel disease
CA2325935A1 (en) Heterocyclic families of compounds for the modulation of tyrosine protein kinase
CA2383623A1 (en) 3-methylidenyl-2-indolinone modulators of protein kinase
CA2410509A1 (en) Indolinone derivatives as protein kinase/phosphatase inhibitors
CA2368041A1 (en) Indolinone compounds as kinase inhibitors
KR100958337B1 (ko) 트롬보포이에틴 활성 조절 화합물 및 방법
US20030100555A1 (en) Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US20040152719A1 (en) Quinolones with anti-HIV activity
IE913159A1 (en) Benzodiazepines
TW201412720A (zh) 三（雜）芳基吡唑及其應用
CN112724148B (zh) 一种咪唑并哒嗪类化合物及修饰后的双亲功能分子及其应用
CN116715634B (zh) 一种化合物、药物组合物及在制备血管舒张药物中的应用
JPH08208612A (ja) ウレア化合物、及びその化合物を有効成分とする抗ヒト免疫不全症ウイルス剤

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20080130