CA2594915A1 - Phenyl-substituted pyrrolidones - Google Patents
Phenyl-substituted pyrrolidones Download PDFInfo
- Publication number
- CA2594915A1 CA2594915A1 CA002594915A CA2594915A CA2594915A1 CA 2594915 A1 CA2594915 A1 CA 2594915A1 CA 002594915 A CA002594915 A CA 002594915A CA 2594915 A CA2594915 A CA 2594915A CA 2594915 A1 CA2594915 A1 CA 2594915A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- unsubstituted
- hiv
- alkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- -1 Phenyl-substituted pyrrolidones Chemical class 0.000 title claims abstract description 116
- 150000001875 compounds Chemical class 0.000 claims abstract description 133
- 238000000034 method Methods 0.000 claims abstract description 60
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 37
- 125000000217 alkyl group Chemical group 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 34
- 229910052757 nitrogen Inorganic materials 0.000 claims description 30
- 229910052739 hydrogen Inorganic materials 0.000 claims description 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 15
- 229910052736 halogen Inorganic materials 0.000 claims description 15
- 150000002367 halogens Chemical class 0.000 claims description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 9
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 5
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
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- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64802705P | 2005-01-28 | 2005-01-28 | |
| US60/648,027 | 2005-01-28 | ||
| PCT/US2006/003217 WO2006081554A2 (en) | 2005-01-28 | 2006-01-30 | Phenyl-substituted pyrrolidones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2594915A1 true CA2594915A1 (en) | 2006-08-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002594915A Abandoned CA2594915A1 (en) | 2005-01-28 | 2006-01-30 | Phenyl-substituted pyrrolidones |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080287516A1 (enExample) |
| EP (1) | EP1841425A4 (enExample) |
| JP (1) | JP2008528624A (enExample) |
| KR (2) | KR100896889B1 (enExample) |
| CN (1) | CN101115481A (enExample) |
| AU (1) | AU2006209245A1 (enExample) |
| BR (1) | BRPI0606123A2 (enExample) |
| CA (1) | CA2594915A1 (enExample) |
| MX (1) | MX2007009137A (enExample) |
| RU (1) | RU2371433C2 (enExample) |
| WO (1) | WO2006081554A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| AU2006209241B2 (en) * | 2005-01-28 | 2009-10-22 | Irm Llc | Synthesis of aryl pyrrolidones |
| EP1843734A4 (en) | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | COMPOSITIONS AND METHOD FOR INTENSIFYING COGNITIVE FUNCTIONS |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| JP5164510B2 (ja) * | 2006-10-06 | 2013-03-21 | 日本曹達株式会社 | 含窒素複素環化合物および有害生物防除剤 |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| CN102014897B (zh) | 2008-04-21 | 2015-08-05 | 西格纳姆生物科学公司 | 化合物、组合物和其制备方法 |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| CN101747253B (zh) * | 2008-12-02 | 2013-01-16 | 中国人民解放军军事医学科学院毒物药物研究所 | 三取代的手性内酰胺类衍生物及其制备方法和用途 |
| ES2672624T3 (es) | 2009-05-01 | 2018-06-15 | Aerie Pharmaceuticals, Inc. | Inhibidores de mecanismo doble para el tratamiento de enfermedades |
| US9238643B2 (en) | 2010-09-06 | 2016-01-19 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Amide compounds |
| CN101979378B (zh) * | 2010-10-13 | 2012-06-27 | 中国科学院上海有机化学研究所 | 一种手性γ-内酰胺化合物的合成方法 |
| PT3811943T (pt) | 2013-03-15 | 2023-03-15 | Aerie Pharmaceuticals Inc | Composto para uso no tratamento de distúrbios oculares |
| MX2019002396A (es) | 2016-08-31 | 2019-07-08 | Aerie Pharmaceuticals Inc | Composiciones oftalmicas. |
| BR112019020078A2 (pt) * | 2017-03-31 | 2020-04-28 | Aerie Pharmaceuticals Inc | compostos e composições farmacêuticas à base de arilciclopropil-amino-isoquinolinil amida e métodos de uso dos mesmos |
| US11186549B2 (en) | 2017-08-29 | 2021-11-30 | Rutgers, The State University Of New Jersey | Therapeutic indazoles |
| CA3112391A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU797219A1 (ru) * | 1979-05-08 | 1995-07-25 | Ленинградский государственный педагогический институт им.А.И.Герцена | N-карбамоилметил-4-фенил-2-пирролидон, обладающий гипотензивной активностью |
| TW448172B (en) * | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| US7495016B2 (en) * | 2002-10-21 | 2009-02-24 | Irm Llc | Pyrrolidones with anti-HIV activity |
-
2006
- 2006-01-30 BR BRPI0606123-0A patent/BRPI0606123A2/pt not_active IP Right Cessation
- 2006-01-30 RU RU2007132259/04A patent/RU2371433C2/ru not_active IP Right Cessation
- 2006-01-30 KR KR1020077017487A patent/KR100896889B1/ko not_active Expired - Fee Related
- 2006-01-30 CA CA002594915A patent/CA2594915A1/en not_active Abandoned
- 2006-01-30 CN CNA2006800033348A patent/CN101115481A/zh active Pending
- 2006-01-30 JP JP2007553324A patent/JP2008528624A/ja active Pending
- 2006-01-30 AU AU2006209245A patent/AU2006209245A1/en not_active Abandoned
- 2006-01-30 KR KR1020097004694A patent/KR20090028846A/ko not_active Ceased
- 2006-01-30 EP EP06734052A patent/EP1841425A4/en not_active Withdrawn
- 2006-01-30 MX MX2007009137A patent/MX2007009137A/es not_active Application Discontinuation
- 2006-01-30 US US11/814,480 patent/US20080287516A1/en not_active Abandoned
- 2006-01-30 WO PCT/US2006/003217 patent/WO2006081554A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006081554A2 (en) | 2006-08-03 |
| KR100896889B1 (ko) | 2009-05-14 |
| KR20070103404A (ko) | 2007-10-23 |
| EP1841425A4 (en) | 2009-02-18 |
| RU2007132259A (ru) | 2009-03-10 |
| MX2007009137A (es) | 2007-09-12 |
| US20080287516A1 (en) | 2008-11-20 |
| RU2371433C2 (ru) | 2009-10-27 |
| WO2006081554A3 (en) | 2006-12-14 |
| KR20090028846A (ko) | 2009-03-19 |
| JP2008528624A (ja) | 2008-07-31 |
| EP1841425A2 (en) | 2007-10-10 |
| BRPI0606123A2 (pt) | 2009-06-02 |
| AU2006209245A1 (en) | 2006-08-03 |
| CN101115481A (zh) | 2008-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |