CN101104002A - Application of fly maggot protein powder in preparing anti-fatigue and immunity-improving product - Google Patents
Application of fly maggot protein powder in preparing anti-fatigue and immunity-improving product Download PDFInfo
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- CN101104002A CN101104002A CNA2007102010370A CN200710201037A CN101104002A CN 101104002 A CN101104002 A CN 101104002A CN A2007102010370 A CNA2007102010370 A CN A2007102010370A CN 200710201037 A CN200710201037 A CN 200710201037A CN 101104002 A CN101104002 A CN 101104002A
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Abstract
The invention discloses an application of flyblow albumen powder in the preparation of products for fatigue resistance and immunity enhancement. The flyblow albumen powder is made of an engineer fly third-instar young. Compared with the prior art, the flyblow albumen powder of the invention is rich in various nutrient contents; with low fat, low cholesterol, reasonable trophic structure and less meat fiber, the invention which is easy for absorption can improve the immunological competence and anti-aging capacity and achieve multiple effects, such as prevention of diseases, nutrition and health care, and body recovery, foreshowing a good application prospect as medicine or health care product for fatigue resistance and immunity enhancement.
Description
Technical field: the present invention relates to the application of Flyblow albumen powder in the product of preparation resisting fatigue, enhancing immunity, belong to insect resources and utilize technical field.
Background technology: housefly is the important medical insecticide, can propagate the various human animal diseases and self is not ill.This true prompting housefly has very strong immunologic mechanism.Research for the various disease-resistant mechanism of Musca domestica larva began already as far back as the twentieth century middle period, and deepen continuously and expand, pushed the research of Musca domestica larva to diversification and high-technicalization from the angle of microbiology, parasitology, cellular immunology, agricultural sciences.
Musca domestica larva contains protein, unsaturated fatty acid, mineral and multivitamin, is a kind of rare high-quality nutrient protein.Housefly is as the object of culturing exploitation, the technology that the internal energy large-scale farming housefly of state produces the fly larvae larva is ripe, mostly with fowl and animal excrement and Testa Tritici as breeding feed, gained fly larvae larva be mainly used in feed additive and keep fowls, the high-quality animal proteinum of aquatic products, but utilize the research of fly larvae larva albumen exploitation health product or pharmaceutical preparations also few.The protide health product of having developed at present mostly are the vegetable protein group food, the single big dead angle that becomes plant source protein as the health product use of nutritional labeling.With the health product or the medicine of Musca domestica larva albumen exploitation becoming a new generation, and constantly diversification, human health is had great importance.
Summary of the invention:
The objective of the invention is to: the application of Flyblow albumen powder in the product of preparation resisting fatigue, enhancing immunity is provided.The present invention is that the Flyblow albumen powder that raw material is made has carried out the research of enhance immunity and antifatigue effect to the engineering fly maggot of raising with the Maotai distiller grains by animal experiment, for Flyblow albumen powder is applied to medicine or field of health care products provides theoretical foundation.
The present invention constitutes like this: the application of Flyblow albumen powder in the product of preparation resisting fatigue, enhancing immunity.
Described Flyblow albumen powder is that the engineering fly third-instar larvae that the Maotai distiller grains are raised is cleaned, pulverizes, dried and make.
Described product is medicine or health product.
Specifically, Flyblow albumen powder and an amount of pharmaceutic adjuvant are prepared into pharmaceutical preparation according to conventional method.
For example: get Flyblow albumen powder, add appropriate amount of starch, Pulvis Talci mixing, after sieving, make tablet according to a conventional method.
Perhaps, add an amount of pharmaceutic adjuvant, be prepared into pharmaceutical preparation according to conventional method with Flyblow albumen powder and the combination of other medicinal ingredient.
For example: get Flyblow albumen powder 1000g, soybean protein powder 150g, add appropriate amount of auxiliary materials, mixing, oven dry, sterilization, packing is made electuary or capsule.
Can also with Flyblow albumen powder separately or with other combinations of substances, be prepared into health product according to conventional method.
For example: get Flyblow albumen powder, sieve, oven dry after the sterilization, is made electuary or capsule according to a conventional method.
Perhaps: get Flyblow albumen powder 1000g, Radix Astragali 150g, pulverize, sieve, add appropriate amount of auxiliary materials, mixing, oven dry, tablet, electuary or capsule are made in sterilization.
Said medicine preparation or health product can be prepared into suitable administration form or the dosage form that can be used as human according to methods known in the art, route of administration can be intestinal or non-intestinal, as oral, muscle, subcutaneous, nasal cavity, oral mucosa, skin, peritoneum or rectum etc.Form of administration is tablet, capsule, drop pill, aerosol, pill, powder, solution, suspensoid, Emulsion, granule, liposome, transdermal agent, buccal tablet, inspection agent, unguentum, patch, injection, lyophilized injectable powder etc. for example.Can be ordinary preparation, slow releasing preparation, controlled release preparation and various particulate delivery system.
When making tablet, can be extensive use of various adjuvant well known in the art: for example diluent and absorbent, as starch, dextrin, lactose, mannitol, sucrose, glucose, carbamide, microcrystalline Cellulose etc.; Wetting agent and binding agent are as water, glycerol, Polyethylene Glycol, ethanol, propanol, starch slurry, dextrin, syrup, Mel, glucose solution, sodium carboxymethyl cellulose, methylcellulose, polyvinylpyrrolidone etc.; Disintegrating agent is as dry starch, laminaran, sodium bicarbonate and citric acid, polyoxyethylene sorbitol fatty acid ester, dodecyl sodium sulfate, methylcellulose, ethyl cellulose etc.; The disintegrate inhibitor is as sucrose, glyceryl tristearate, hydrogenation wet goods; Absorption enhancer is as quaternary ammonium salt, sodium lauryl sulphate etc.; Lubricant is as Pulvis Talci, corn starch, stearate, boric acid, Polyethylene Glycol etc.Tablet further can also be made coated tablet, for example sugar coated tablet, thin membrane coated tablet, ECT, or double-layer tablet, multilayer tablet.When making pill, can be extensive use of various adjuvant well known in the art: for example diluent and absorbent, as glucose, lactose, starch, cocoa butter, nitrogenize vegetable oil, polyvinylpyrrolidone etc.; Binding agent such as arabic gum, gelatin, ethanol, Mel, liquid sugar, rice paste or batter etc.; Disintegrating agent is as agar powder, dry starch, alginate, dodecyl sodium sulfate, methylcellulose, ethyl cellulose etc.If make capsule, the effective ingredient Flyblow albumen powder is mixed with above-mentioned various carriers, and the mixture that will obtain thus places hard ' Yanming ' capsules for clearing or soft capsule.Also the effective ingredient Flyblow albumen powder can be made microcapsule, be suspended in and form suspensoid in the aqueous medium, in the hard capsule of also can packing into or make injection and use.If make injection preparation, as solution, Emulsion, lyophilized injectable powder and suspensoid, can use this area all diluent commonly used, for example water, ethanol, Polyethylene Glycol, 1, ammediol, Polyoxyethylene Sorbitol Fatty Acid Esters etc.In addition, ooze injection, can in injection preparation, add proper amount of sodium chloride, glucose or glycerol, in addition, can also add conventional cosolvent, buffer agent, pH regulator agent etc. in order to prepare etc.As needs, also can in pharmaceutical preparation or health product, add coloring agent, antiseptic, spice, correctives, sweeting agent or other adjuvant.
In order to verify Flyblow albumen powder at the action effect aspect enhancing immunity and the resisting fatigue, the applicant has carried out series of experimental research, and is specific as follows:
One, Flyblow albumen powder is to the Immune Effects of normal mouse and immunosuppressed mice:
1 experiment material
1.1 the medicine Flyblow albumen powder is provided by Guizhou Kun'en Bioengineering Co., Ltd..Experiment is faced the time spent and is made into desired concn with distilled water.
1.2 the reagent india ink, India Ink Tuache nach burri 3D 065.Cyclophosphamide (Cy), Hengrui Medicine Co., Ltd., Jiangsu Prov. produces, lot number 05110621.Sheep red blood cell (SRBC) is provided by the Guiyang Medical College Experimental Animal Center.Complement: pooled serum (20 ℃ of preservations of 3 male 2 female healthy guinea pigs, face the dilution in 1: 10 of time spent normal saline), A Shi liquid (glucose 2.05g, sodium citrate 0.80g, sodium chloride 0.42g, distilled water 100ml, aseptic filtration), Dou Shi reagent (sodium bicarbonate 1.0g, potassium cyanide 0.05g, high-potassium ferricyanide 0.2g, distilled water 1000ml).
1.3 key instrument μ-Quant scanning enzyme mark spectrophotometer: U.S. Bio-Tek company; Digital display thermostat water bath HH-2: state China Electrical Appliances Co., Ltd; DJ-1000J electronic balance: Chinese-foreign joint Asia-Pacific electronic balance.
1.4 animal: Kunming mouse, male and female half and half, body weight 16-18g is provided by the Guiyang Medical College Experimental Animal Center.
1.5 statistical method is carried out the data statistics credit and is analysed with designing t check in groups.
2 methods
2.1 grouping and modeling
2.1.1 Flyblow albumen powder is got 40 of mices to the influence of normal mouse, male and female half and half, body weight 16-18g is divided into 4 groups at random, every group 10, be respectively dosage group (4g/kg), egg albumen powder high dose group (6g/kg) in blank group, egg albumen powder low dose group (2g/kg), the egg albumen powder.The basic, normal, high dosage group of Flyblow albumen powder is irritated the stomach Flyblow albumen powder, and the blank group is irritated stomach equivalent distilled water, every day 1 time, continuous 7 days.
2.1.2 preventive administration is got 40 of mices, male and female half and half, and body weight 16-18g is divided into 4 groups at random, 10 every group, is respectively blank group, Cy model group, Flyblow albumen powder low (4g/kg), high dose group (6g/kg).Except that the blank group, the equal ip cyclophosphamide of all the other each treated animals 60mg/kg, every day 1 time, continuous 4 days.Flyblow albumen powder is low, high dose group is irritated the stomach Flyblow albumen powder, and blank group and Cy model group are irritated stomach equivalent distilled water, every day 1 time, continuous 7 days.
2.1.3 therapeutic administration mice is got 10 at random as the blank group, all the other 20 equal ip cyclophosphamide 60mg/kg, every day 1 time, continuous 4 days.After model causes, be divided into Cy treatment model group, fly maggot protein treated powder group (6g/kg) at random, 10 every group.Fly maggot protein treated powder group administration every day 1 time, blank group and Cy treatment model group are irritated stomach equivalent distilled water, every day 1 time, continuous 7 days.
2.2 immunologic function index determining
2.2.1 influence to serum hemolysin content
Yu Give medicine the 2nd day, every Mus lumbar injection 20% hematocrit sheep red blood cell (SRBC) (SRBC) normal saline cell suspension 0.2ml carries out immunity, Ji Xu Give medicine 5 days, 1h behind Yi Give medicine behind the Zui, get blood from the mouse orbit venous plexus, centrifugalize serum is got serum with 500 times of normal saline dilutions, gets dilute serum 1ml then and puts in the test tube, add 10%SRBC suspension 0.5ml, put in the ice bath, the guinea pig serum 1ml that adds again with normal saline dilution in 1: 10 mixes, and other establishes the not blank of increase serum.Behind the insulation 10min, put cessation reaction in the ice bath immediately in 37 ℃ of waters bath with thermostatic control of dislocation.With the centrifugal 10min of 2000r/min, get supernatant 1ml, add Dou Shi reagent 3ml, mixing was placed 10 minutes, got supernatant and marked spectrophotometer 540nm place colorimetric with 96 orifice plates in the scanning enzyme, surveyed absorbance (OD).Other gets 10%SRBC suspension 0.25ml, adds Dou Shi reagent 3.75ml, and the same mensuration OD value is as half hemolysis value.Serum hemolysin content is with half hemolysis value (HC
50) expression.Be calculated as follows: HC
50OD value * extension rate during the OD value of=sample/SRBC HD50
2.2.2 to the exponential influence of carbon clearance
Grouping and administration are all the same.Behind last administration 1h, the india ink 0.1ml/10g of every caudal vein injection dilution.Each Mus respectively behind the injection india ink 2min and 12min (stopwatch record) respectively get blood 20 μ L with disposable blood taking tube eye socket, be blown into immediately and fill 2ml0.1%Na
2CO
3In the test tube of solution, pressure-vaccum fully to wash out the blood that the blood sampling tube wall adheres to, shakes up for several times, marks spectrophotometer 600nm place colorimetric, photometry density value (OD) in the scanning enzyme behind the 15min.And after blood sampling for the second time, mice is put to death with taking off the cervical vertebra method, weigh, liver is got in dissection, spleen is weighed, by formula calculate mice phagocytic index α=
3√ K * body weight/(liver weight+spleen heavy) (K=(1gOD wherein
1-1gOD
2)/(t
2-t
1), OD
1, OD
2Be respectively 2 and the 12min optical density, t
1=2, t
2=12).
3 results
3.1 Flyblow albumen powder is to normal effect of immunologic function
Experimental result shows, each dosage group mice HC
50All be higher than the blank group, difference has significance (p＜0.05).Middle dosage group drug effect is best, but the high dose group effect is not good than low, middle dosage group, illustrates that when low dosage, drug effect strengthens with the increase of dosage, and after having arrived doses, drug effect and dosage there is no dependence.Each dosage group mice α all is lower than the blank group, but difference does not have significance (p＞0.05).Show that Flyblow albumen powder can significantly improve normal mouse HC
50, strengthen its humoral immune function; And normal mouse α is not had influence, promptly the phagocytic function to macrophage does not have influence.See Table 1.
Table 1 Flyblow albumen powder is to normal effect of immunologic function (X ± S)
| Group | Number of animals | Dosage (g/kg) | HC 50 | |
| The blank group | 10 | -- | 134.86±14.13 | 5.113±1.071 |
| The egg albumen powder low dose group | 10 | 2 | 157.67±11.94 ** | 4.505±0.862 △ |
| Dosage group in the egg albumen powder | 10 | 4 | 165.50±12.71 ** | 4.966±1.570 △ |
| The egg albumen powder high dose group | 10 | 6 | 148.85±11.72 * | 4.737±2.238 △ |
Compare with the blank group,
*P＜0.05,
*P＜0.01,
△P＞0.05, as follows.
3.2 Flyblow albumen powder is to the influence of immunologic hypofunction mice
3.2.1 Flyblow albumen powder is to the preventive effect of immunologic hypofunction mice
Experimental result shows, model group mice HC
50, α all is lower than the blank group, difference has significance (p＜0.01), shows the modeling success.Each dosage group mice HC
50Compare with model group, difference does not have significance (p＞0.05).Each dosage group mice α all is higher than model group, and difference has significance (p＜0.05); Wherein, high dose group mice α is significantly higher than model group (p＜0.01), and compares with the blank group, and difference does not have significance (p＞0.05).Show that Flyblow albumen powder is to immunologic hypofunction mice HC
50Do not have influence, promptly the phagocytic function to macrophage does not have influence; But can significantly improve immunologic hypofunction mice α, promptly the low mice of humoral immune function that CY is caused has protective effect.See Table 2.
Table 2 Flyblow albumen powder is to the preventive effect of immunologic hypofunction mice (X ± S)
| Group | Number of animals | Dosage (g/kg) | HC 50 | |
| The blank group | 10 | -- | 135.41±50.8 | 5.057±1.205 |
| The Cy model group | 10 | -- | 84.05±12.61 ** | 2.075±1.005 ** |
| Egg albumen powder prevention low dose group | 10 | 4 | 86.64±10.83 ▲ | 3.226±1.214 |
| Egg albumen powder prevention high dose group | 10 | 6 | 84.88±13.30 ▲ | 5.013±1.015 △ |
Compare with model group,
P＜0.05,
P＜0.01,
▲P＞0.05, as follows.
3.2.2 Flyblow albumen powder is to the therapeutical effect of immunologic hypofunction mice
Experimental result shows, model group mice HC
50, α all is lower than the blank group, difference has significance (p＜0.01), shows the modeling success.Treatment group mice HC
50Compare with model group, difference does not have significance (p＞0.05).Treatment group mice α is lower than the blank group, and difference does not have significance (p＞0.05); Compare with model group, treatment group mice α is higher than model group, and difference has significance (p＜0.01).Show that Flyblow albumen powder is to immunologic hypofunction mice HC
50Do not have influence, promptly the phagocytic function to macrophage does not have influence; But can significantly improve immunologic hypofunction mice α, promptly the low mice of humoral immune function that CY is caused has therapeutical effect.See Table 3.
Table 3 Flyblow albumen powder is to the therapeutical effect of immunologic hypofunction mice (X ± S)
| Group | Number of animals | Dosage (g/kg) | HC 50 | |
| The blank group | 10 | -- | 126.43±13.51 | 5.104±1.945 |
| The Cy model group | 10 | -- | 87.55±11.23 ** | 2.334±1.023 ** |
| Egg albumen powder treatment group | 10 | 6 | 89.38±10.19 ▲ | 4.201±1.315 △ |
Two, Flyblow albumen powder is to the antifatigue effect of mice:
Experiment material is the same.
Experimental technique: get mice and be divided into 3 groups at random, be respectively blank group, egg albumen powder low dose group (4g/kg), egg albumen powder high dose group (6g/kg); Low dose group administration every day 1 time, high dose group administration every day 2 times, continuous 15 days; Claim the mice body weight after the last administration behind the 30min, tie up plasticine, mice is placed in the depth of water 20cm pond 20 ℃ of water temperatures, record mice swimming time with 10% body weight in Mus tail end.The result is carried out statistical analysis with the SPSS12.0 statistical software, and the result is as follows
| Group | Number of animals | Swimming time (min) |
| Blank group (female) | 5 | 32.56±7.85 |
| Blank group (hero) | 5 | 36.8±5.24 |
| Egg albumen powder low dose group (female) | 5 | 58.25±10.52 |
| Egg albumen powder low dose group (hero) | 5 | 66.23±8.36 |
| Egg albumen powder high dose group (female) | 5 | 98.38±7.92 |
| Egg albumen powder high dose group (hero) | 5 | 109.50±5.82 |
Egg albumen powder low dose group and egg albumen powder high dose group compare with the blank group respectively, P＜0.01.Show that Flyblow albumen powder has the obvious anti-fatigue effect.
Compared with prior art, the engineering fly maggot that the used Flyblow albumen powder of the present invention is raised by the Maotai distiller grains prepares and gets, be rich in various nutritional labelings, low fat, low cholesterol, trophic structure is reasonable, and fleshy fiber is few, be easy to again absorb, can improve the immunocompetence and the defying age ability of human body, can reach multiple effects such as prevent disease, nourishing healthy, rehabilitation health, aspect the medicine of resisting fatigue, enhancing immunity or health product, have a good application prospect.
The specific embodiment:
Embodiments of the invention 1: get Flyblow albumen powder 1000g, add appropriate amount of starch, Pulvis Talci mixing, after sieving, make tablet according to a conventional method.Said preparation is oral, 2g/ time, every day 3 times, is used for the auxiliary treatment of immunocompromised person or other disease.
Embodiments of the invention 2: get Flyblow albumen powder 1000g, soybean protein powder 150g, add appropriate amount of auxiliary materials, mixing, oven dry, sterilization, packing is made electuary or capsule.Said preparation is oral, and 2g/ time, be used for the auxiliary treatment of immunocompromised person or other diseases every day 3 times, antifatigue effect is arranged.
Embodiments of the invention 3: get Flyblow albumen powder 1000g, sieve, oven dry after the sterilization, is made electuary or capsule according to a conventional method.Said preparation is oral, and 1.5g/ time, be used to improve Abwehrkraft des Koepers every day 3 times, control is because of the disease due to the hypoimmunity.
Embodiments of the invention 4: get Flyblow albumen powder 1000g, Radix Astragali 150g, pulverize, sieve, add appropriate amount of auxiliary materials, mixing, oven dry, tablet, electuary or capsule are made in sterilization.Said preparation is oral, and 1.8g/ time, be used to improve Abwehrkraft des Koepers every day 3 times, control is because of the disease due to the hypoimmunity.
Claims (10)
1. the application of Flyblow albumen powder in the product of preparation resisting fatigue, enhancing immunity.
2. according to the application of the described Flyblow albumen powder of claim 1, it is characterized in that: described Flyblow albumen powder is that the engineering fly third-instar larvae that the Maotai distiller grains are raised is cleaned, pulverizes, dried and make.
3. according to the application of the described Flyblow albumen powder of claim 1, it is characterized in that: described product is medicine or health product.
4. according to the application of claim 1,2 or 3 described Flyblow albumen powders, it is characterized in that: Flyblow albumen powder and an amount of pharmaceutic adjuvant are prepared into pharmaceutical preparation according to conventional method.
5. according to the application of the described Flyblow albumen powder of claim 4, it is characterized in that: get Flyblow albumen powder, add appropriate amount of starch, Pulvis Talci mixing, after sieving, make tablet according to a conventional method.
6. according to the application of claim 1,2 or 3 described Flyblow albumen powders, it is characterized in that: with Flyblow albumen powder and the combination of other medicinal ingredient, add an amount of pharmaceutic adjuvant, be prepared into pharmaceutical preparation according to conventional method.
7. according to the application of the described Flyblow albumen powder of claim 6, it is characterized in that: get Flyblow albumen powder 1000g, soybean protein powder 150g, add appropriate amount of auxiliary materials, mixing, oven dry, sterilization, packing is made electuary or capsule
8. according to the application of claim 1,2 or 3 described Flyblow albumen powders, it is characterized in that: with Flyblow albumen powder separately or with other combinations of substances, be prepared into health product according to conventional method.
9. according to the application of the described Flyblow albumen powder of claim 8, it is characterized in that: get Flyblow albumen powder, sieve, oven dry after the sterilization, is made electuary or capsule according to a conventional method.
10. according to the application of the described Flyblow albumen powder of claim 8, it is characterized in that: get Flyblow albumen powder 1000g, Radix Astragali 150g, pulverize, sieve, add appropriate amount of auxiliary materials, mixing, oven dry, tablet, electuary or capsule are made in sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007102010370A CN101104002A (en) | 2007-07-10 | 2007-07-10 | Application of fly maggot protein powder in preparing anti-fatigue and immunity-improving product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007102010370A CN101104002A (en) | 2007-07-10 | 2007-07-10 | Application of fly maggot protein powder in preparing anti-fatigue and immunity-improving product |
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| Publication Number | Publication Date |
|---|---|
| CN101104002A true CN101104002A (en) | 2008-01-16 |
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ID=38998209
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007102010370A Pending CN101104002A (en) | 2007-07-10 | 2007-07-10 | Application of fly maggot protein powder in preparing anti-fatigue and immunity-improving product |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104738645A (en) * | 2015-03-05 | 2015-07-01 | 陈学沛 | Health powder capable of increasing human body resistance |
| CN105707403A (en) * | 2015-11-09 | 2016-06-29 | 南通蛇类治疗研究所 | Technology for producing complex element selenium-enriched germanium-enriched fly larva protein powder by using livestock dung |
-
2007
- 2007-07-10 CN CNA2007102010370A patent/CN101104002A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104738645A (en) * | 2015-03-05 | 2015-07-01 | 陈学沛 | Health powder capable of increasing human body resistance |
| CN105707403A (en) * | 2015-11-09 | 2016-06-29 | 南通蛇类治疗研究所 | Technology for producing complex element selenium-enriched germanium-enriched fly larva protein powder by using livestock dung |
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Application publication date: 20080116 |