CN101102772A - 一种含有石杉碱甲、乙复合成分的蛇足石杉组合物及其制备方法 - Google Patents

一种含有石杉碱甲、乙复合成分的蛇足石杉组合物及其制备方法 Download PDF

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CN101102772A
CN101102772A CNA2005800470129A CN200580047012A CN101102772A CN 101102772 A CN101102772 A CN 101102772A CN A2005800470129 A CNA2005800470129 A CN A2005800470129A CN 200580047012 A CN200580047012 A CN 200580047012A CN 101102772 A CN101102772 A CN 101102772A
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huperzine
composition
huperzia serrata
extract
solution
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CN100566714C (zh
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谢德隆
谢家骏
王军
黄新生
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Shanghai Tianci Life Science Development Co ltd
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Xie Jiajun
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
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  • Microbiology (AREA)
  • Mycology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明涉及天然药物技术领域，具体涉及蛇足石杉的生物碱提取物。本发明提供了一种蛇足石杉生物碱组合物及其制备方法。本发明的蛇足石杉组合物包含石杉碱甲和石杉碱乙，其中石杉碱甲和石杉碱乙的总含量以重量％表示为总生物碱的50％-99％，两者的重量比为1∶0.5-5。本发明蛇足石杉生物碱组合物具有良好的治疗效果，且安全性更高。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CNB2005800470129A 2004-11-26 2005-11-24 一种含有石杉碱甲、乙复合成分的蛇足石杉组合物及其制备方法 Active CN100566714C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNB2004100846331A CN100441200C (zh) 2004-11-26 2004-11-26 石杉碱甲、乙复合成分的蛇足石杉提取物及其制备方法
CN200410084633.1 2004-11-26
PCT/CN2005/001992 WO2006056129A1 (fr) 2004-11-26 2005-11-24 Compositions d'alcaloides d'huperzia serrata comportant de l'huperzine a et de l'huperzine b et preparation de ces compositions

Publications (2)

Publication Number Publication Date
CN101102772A true CN101102772A (zh) 2008-01-09
CN100566714C CN100566714C (zh) 2009-12-09

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CNB2004100846331A Active CN100441200C (zh) 2004-11-26 2004-11-26 石杉碱甲、乙复合成分的蛇足石杉提取物及其制备方法
CNB2005800470129A Active CN100566714C (zh) 2004-11-26 2005-11-24 一种含有石杉碱甲、乙复合成分的蛇足石杉组合物及其制备方法

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US (1) US8574633B2 (zh)
CN (2) CN100441200C (zh)
WO (1) WO2006056129A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109613156A (zh) * 2018-09-06 2019-04-12 万邦德制药集团股份有限公司 一种石杉碱甲及石杉碱甲注射液有关物质的检测方法

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US8778986B1 (en) * 2007-01-25 2014-07-15 University Of South Florida Treatment of glycogen synthase kinase-based disease
CN101658544B (zh) * 2008-08-30 2012-07-18 浙江万邦药业股份有限公司 千层塔控释片及其制造方法
CN102603730A (zh) * 2011-01-25 2012-07-25 苏州宝泽堂医药科技有限公司 一种从伸筋草中提取石松碱的方法
CA2867891C (en) 2012-03-19 2021-09-14 Buck Institute For Research On Aging App specific bace inhibitors (asbis) and uses thereof
CN102872016A (zh) * 2012-03-22 2013-01-16 北京阜康仁生物制药科技有限公司 一种药物组合物
CN103667070A (zh) * 2013-08-08 2014-03-26 浙江医药高等专科学校 蛇足石杉植物内生真菌及其在制备石杉碱甲中的应用
CN103462940A (zh) * 2013-09-17 2013-12-25 浙江省医学科学院 一种石杉碱甲微乳型巴布剂
CN103705548B (zh) * 2014-01-10 2015-11-04 吉首大学 一种活体提取蛇足石杉生物总碱的方法
KR101784413B1 (ko) * 2015-04-14 2017-10-12 대구가톨릭대학교산학협력단 석송강 추출물 또는 이로부터 분리된 화합물을 포함하는 알츠하이머병의 예방 또는 치료용 조성물-ⅰ
PT3106160T (pt) * 2015-06-15 2020-01-30 Neuralia Composição de combinação compreendendo huperzina
CN105061310B (zh) * 2015-08-31 2018-01-12 桂林三宝生物科技有限公司 一种从千层塔中提取石杉碱甲的方法
CN108314651A (zh) * 2018-05-14 2018-07-24 上海华堇生物技术有限责任公司 一种石杉碱甲的新制备方法
CN110372592B (zh) * 2019-07-11 2022-06-28 中国科学院昆明植物研究所 14-羟基玉柏石松醇碱及其药物组合物与其制备方法和应用
CN111349046B (zh) * 2020-03-13 2022-03-15 西北大学 一种生物碱、晶体、制备方法及应用
CN112457251B (zh) * 2020-11-30 2022-04-15 湖南华诚生物资源股份有限公司 从千层塔提取物中分离多种高含量生物碱单体的方法
CN112402466B (zh) * 2020-11-30 2022-04-19 湖南华诚生物资源股份有限公司 从千层塔提取物中分离总生物碱的方法

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CN1047732A (zh) 1990-04-28 1990-12-12 黄斌夫 双层三环四带轮窑
CN1037359C (zh) 1993-10-07 1998-02-11 化学工业部化工机械研究院 高温合金炉管的回收再生技术
CN1047732C (zh) * 1995-04-10 1999-12-29 浙江省医学科学院 石杉碱透皮吸收贴片
CN1279065A (zh) * 1999-07-06 2001-01-10 青岛科达生物工程有限公司 一种治疗记忆障碍和老年痴呆的药物组合物
WO2001032115A1 (en) * 1999-11-04 2001-05-10 Xel Herbaceuticals Transdermal administration of huperzine
CN1101381C (zh) * 2000-01-21 2003-02-12 浙江大学 乙酰胆碱酯酶抑制剂石杉碱甲的提取方法
ITRM20010218A1 (it) * 2001-04-23 2002-10-23 Sigma Tau Healthscience Spa Composizione per la prevenzione o il trattamento dei disturbi dell'apprendimento in bambini affetti da deficit dell'attenzione ed iperattivi
CN1207285C (zh) * 2002-03-28 2005-06-22 河南竹林众生制药股份有限公司 从中草药千层塔中提取石杉碱甲的方法
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109613156A (zh) * 2018-09-06 2019-04-12 万邦德制药集团股份有限公司 一种石杉碱甲及石杉碱甲注射液有关物质的检测方法

Also Published As

Publication number Publication date
CN100441200C (zh) 2008-12-10
CN100566714C (zh) 2009-12-09
WO2006056129A1 (fr) 2006-06-01
US8574633B2 (en) 2013-11-05
CN1644208A (zh) 2005-07-27
US20070286911A1 (en) 2007-12-13

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