CN101085339A - Traditional Chinese medicine composition for curing chronic nephritis - Google Patents

Abstract

The invention relates to a Chinese medicinal composition for treating chronic nephritis, which is prepared from more than ten kinds of Chinese medicinal herbs including Chinese ephedra, cassia twig, poria peel coix seed.

Description

A kind of Chinese medicine composition for the treatment of chronic nephritis

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of chronic nephritis, is that a kind of chronic nephritis for the treatment of is the Chinese medicine composition of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

The one group of immune disease that is primary in glomerule that chronic glomerulonephritis (abbreviation chronic nephritis) is made up of multiple reason, multiple histological type.Clinical characters is onset concealment, and the course of disease is tediously long, asymptomatic stage that can be for some time, and routine urianlysis has albuminuria, hematuria and cylinderuria in various degree, and most patient has edema, hypertension and the renal function injury of varying degree.The chronic nephritis sickness rate is higher, is more common in person between twenty and fifty, and the male is more than the women.Along with the development of the state of an illness, the patient can renal failure occur after 2～3 years or 20～30 years, be China's main diseases of causing chronic renal failure because of, account for 64.6%, become the principal disease that influences health of people.Chronic nephritis belongs to categories such as Chinese medicine " edema ", " lumbago ", " headache ", " dizzy ", " asthenia ".Chronic nephritis is clinical to serve as main performance with edema, dizzy, albuminuria, hematuria etc., although clinical manifestation is not quite similar, analyzes with regard to its disease evolution process, and its common etiology and pathogenesis characteristics are all arranged.The clinical manifestation of primary disease is: edema, hypertension, urine abnormal change, renal insufficiency, anemia.The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation such as insufficiency of QI of the lung and kidney, deficiency of spleen-YANG and kidneyYANG, the hepatic and renal YIN deficiency and deficiency of both QI and YIN clinically, obtains very good effect.Chinese medicine not only can alleviate patient's clinical symptoms, and can improve laboratory checking index, can protect and stablize renal function, delays the arrival of renal failure.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic nephritis.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.5～6 parts of 1.5～6 parts of Fructus Forsythiaes of 1.5～6 portions of Semen Phaseolis of Semen Coicis

1.0～4 parts of 1.0～4 parts of Radix Saposhnikoviaes of 1.0～4 parts of CORTEX ZINGIBERIS RHIZOMAE of Cortex Sclerotii Poriae

0.1～2 part of 1.0～4 portions of Rhizoma Et Radix Notopterygii of 1.0～4 parts of Pericarpium Arecae of Cortex Mori

0.1～1 part in 0.1～2 portion of Herba Ephedrae of 0.1～2 part of Ramulus Cinnamomi of stir-baked SEMEN ARMENIACAE AMARUM.

The weight proportion of each raw material of optimization formula of the present invention is:

2.5～3.5 parts of 2.5～3.5 parts of Fructus Forsythiaes of 2.5～3.5 portions of Semen Phaseolis of Semen Coicis

1.5～2.5 parts of 1.5～2.5 parts of Radix Saposhnikoviaes of 1.5～2.5 parts of CORTEX ZINGIBERIS RHIZOMAE of Cortex Sclerotii Poriae

0.5～1.5 part of 1.5～2.5 portions of Rhizoma Et Radix Notopterygii of 1.5～2.5 parts of Pericarpium Arecae of Cortex Mori

0.3～0.7 part in 0.5～1.5 portion of Herba Ephedrae of 0.5～1.5 part of Ramulus Cinnamomi of stir-baked SEMEN ARMENIACAE AMARUM.

The weight proportion of each raw material of optimum formula of the present invention is:

3 parts of 3 parts of Fructus Forsythiaes of 3 portions of Semen Phaseolis of Semen Coicis

2 parts of 2 parts of Radix Saposhnikoviaes of 2 parts of CORTEX ZINGIBERIS RHIZOMAE of Cortex Sclerotii Poriae

1 part of 2 portions of Rhizoma Et Radix Notopterygii of 2 parts of Pericarpium Arecae of Cortex Mori

0.5 part in 1 portion of Herba Ephedrae of 1 part of Ramulus Cinnamomi of stir-baked SEMEN ARMENIACAE AMARUM.

Drug action mechanism among the present invention is as follows:

The Semen Coicis property of medicine is sweet, light, is slightly cold.Return spleen, stomach, lung meridian.Has the dampness removing spleen invigorating, arthralgia relieving by relaxing muscles and tendons, the effect of clearing away heat and discharging pus.Can treat edema, beriberi, dribbling urination, damp-warm diseases is had loose bowels, leukorrhagia, rheumatic arthralgia, the contracture of muscle arteries and veins, lung abscess, acute appendicitis, verruca plana etc.(the 3725th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Semen Phaseoli property of medicine is sweet, sour, is slightly cold.GUIXIN, small intestinal, spleen channel.Has the inducing diuresis to remove edema jaundice eliminating, the effect of heat-clearing and toxic substances removing eliminating carbuncle.Can treat edema, beriberi, jaundice, gonorrhea is had blood in stool, toxic swelling skin infection, scall etc.(the 1443rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Fructus Forsythiae property of medicine hardship is slightly cold.Return lung, the heart, gallbladder meridian.Has heat-clearing and toxic substances removing, the effect of dispersing swelling and dissipating binds.Can treat anemopyretic cold, epidemic febrile disease, pyretic stranguria urine retention, carbuncle, toxic swelling, scrofula, goiter, sore throat etc.(the 1554th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Cortex Sclerotii Poriae is flat, and sweet in the mouth, light is nontoxic.Effect with inducing diuresis to remove edema.It is full to treat the water damp-edema, dysuria etc.(the 2156th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

CORTEX ZINGIBERIS RHIZOMAE property of medicine suffering, cold.Return spleen, lung meridian.Effect with line water detumescence.Can treat edema from the beginning of, dysuria etc.(the 927th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Saposhnikoviae nature and flavor suffering, sweet, temperature.Return bladder, liver, spleen channel.Have inducing diaphoresis to dispel wind, win and wet, the effect of relieving convulsion.Can treat headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus etc.(the 117th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Cortex Mori nature and flavor are sweet, hot, and are cold.Return lung, spleen channel.Has eliminating pathogen from the lung for relieving asthma, the effect of inducing diuresis to remove edema.Cure mainly the fullness in the chest that lung-heat or diseases caused by retention of fluid stop lung and breath with cough hemoptysis, edema, beriberi, dysuria etc.(the 2787th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Pericarpium Arecae property of medicine suffering, tepor.Return spleen, stomach, large intestine, small intestine meridian.Has therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the effect of line water detumescence.It is vexed to treat breast abdominal distention, edema, beriberi, dysuria etc.(the 178th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Et Radix Notopterygii property of medicine suffering, hardship, temperature.Return bladder, kidney channel.Has diffusing exterior cold, wind-damp dispelling, sharp joint, analgesic effect.Can treat affection of exogenous wind-cold, it is lossless to have a headache, anemofrigid-damp arthralgia, edema due to wind pathogen edema, sore swollen toxin etc.(the 1621st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Stir-baked SEMEN ARMENIACAE AMARUM property of medicine hardship, tepor, mild toxicity.Return lung, large intestine channel.Has lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, the effect of loosening bowel to relieve constipation.Can treat exogenous cough's dyspnea with fullness of the chest, dryness of the intestine constipation etc.(the 1526th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Ramulus Cinnamomi property of medicine suffering, sweet, temperature.Return bladder, the heart, lung meridian.Has expelling cold and relieving exterior syndrome, warming the meridian, the effect of activating yang.Can treat exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea ， mass in the abdomen caking, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria etc.(the 2522nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Herba Ephedrae property of medicine suffering, little hardship, temperature.Return lung, urinary bladder channel.Has relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema.Can treat chill exterior syndrome, cough and asthma, edema due to wind pathogen, dysuria, rheumatic arthralgia, numbness of the skin, rubella pruritus, carbuncle of yin nature sucutaneous nodule etc.(Shanghai science tech publishing house second edition the 3094th is write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Semen Coicis, Fructus Forsythiae, Herba Ephedrae, Ramulus Cinnamomi and Cortex Mori; With Cortex Sclerotii Poriae, CORTEX ZINGIBERIS RHIZOMAE, Pericarpium Arecae and Radix Saposhnikoviae is ministerial drug; With stir-baked SEMEN ARMENIACAE AMARUM, Rhizoma Et Radix Notopterygii and Semen Phaseoli is adjuvant.All medicines are harmonious, and are total to the tool diffusing lung, relieving exterior syndrome, the effect of inducing diuresis to remove edema.The treatment chronic nephritis has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of Pharmacopoeia of People's Republic of China, utilizes the comprehensive function treatment chronic nephritis of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat chronic nephritis, and the prevention of chronic nephritis is also had good effect, and the treatment chronic nephritis has determined curative effect, has no side effect taking convenience, cheap characteristics.

For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment chronic nephritis; Treatment chronic nephritis patient 18 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.8 examples of fully recovering account for 44.44%, and 7 examples that take a turn for the better account for 38.89%, and more 3 examples do not account for 16.67%, and total effective rate reaches 83.33%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

3 parts of 3 parts of Fructus Forsythiaes of 3 portions of Semen Phaseolis of Semen Coicis

2 parts of 2 parts of Radix Saposhnikoviaes of 2 parts of CORTEX ZINGIBERIS RHIZOMAE of Cortex Sclerotii Poriae

1 part of 2 portions of Rhizoma Et Radix Notopterygii of 2 parts of Pericarpium Arecae of Cortex Mori

0.5 part in 1 portion of Herba Ephedrae of 1 part of Ramulus Cinnamomi of stir-baked SEMEN ARMENIACAE AMARUM.

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment chronic nephritis that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.

Claims (3)

1, a kind of Chinese medicine composition for the treatment of chronic nephritis is characterized in that it is made by the following weight proportion raw material:

1.5～6 parts of 1.5～6 parts of Fructus Forsythiaes of 1.5～6 portions of Semen Phaseolis of Semen Coicis

1.0～4 parts of 1.0～4 parts of Radix Saposhnikoviaes of 1.0～4 parts of CORTEX ZINGIBERIS RHIZOMAE of Cortex Sclerotii Poriae

0.1～2 part of 1.0～4 portions of Rhizoma Et Radix Notopterygii of 1.0～4 parts of Pericarpium Arecae of Cortex Mori

0.1～1 part in 0.1～2 portion of Herba Ephedrae of 0.1～2 part of Ramulus Cinnamomi of stir-baked SEMEN ARMENIACAE AMARUM.

2, a kind of Chinese medicine composition for the treatment of chronic nephritis according to claim 1, wherein the weight proportion of each raw material is:

2.5～3.5 parts of 2.5～3.5 parts of Fructus Forsythiaes of 2.5～3.5 portions of Semen Phaseolis of Semen Coicis

1.5～2.5 parts of 1.5～2.5 parts of Radix Saposhnikoviaes of 1.5～2.5 parts of CORTEX ZINGIBERIS RHIZOMAE of Cortex Sclerotii Poriae

0.5～1.5 part of 1.5～2.5 portions of Rhizoma Et Radix Notopterygii of 1.5～2.5 parts of Pericarpium Arecae of Cortex Mori

0.3～0.7 part in 0.5～1.5 portion of Herba Ephedrae of 0.5～1.5 part of Ramulus Cinnamomi of stir-baked SEMEN ARMENIACAE AMARUM.

3, a kind of Chinese medicine composition for the treatment of chronic nephritis according to claim 1, wherein the weight proportion of each raw material is:

3 parts of 3 parts of Fructus Forsythiaes of 3 portions of Semen Phaseolis of Semen Coicis

2 parts of 2 parts of Radix Saposhnikoviaes of 2 parts of CORTEX ZINGIBERIS RHIZOMAE of Cortex Sclerotii Poriae

1 part of 2 portions of Rhizoma Et Radix Notopterygii of 2 parts of Pericarpium Arecae of Cortex Mori

0.5 part in 1 portion of Herba Ephedrae of 1 part of Ramulus Cinnamomi of stir-baked SEMEN ARMENIACAE AMARUM.