CN101048165B - 用于制备二膦酸盐的方法 - Google Patents

用于制备二膦酸盐的方法 Download PDF

Info

Publication number
CN101048165B
CN101048165B CN2005800371320A CN200580037132A CN101048165B CN 101048165 B CN101048165 B CN 101048165B CN 2005800371320 A CN2005800371320 A CN 2005800371320A CN 200580037132 A CN200580037132 A CN 200580037132A CN 101048165 B CN101048165 B CN 101048165B
Authority
CN
China
Prior art keywords
methyl
sodium salt
salt monohydrate
amyl group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800371320A
Other languages
English (en)
Chinese (zh)
Other versions
CN101048165A (zh
Inventor
弗里德里希·贝茨
贝恩德·容汉斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN101048165A publication Critical patent/CN101048165A/zh
Application granted granted Critical
Publication of CN101048165B publication Critical patent/CN101048165B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
CN2005800371320A 2004-10-29 2005-10-25 用于制备二膦酸盐的方法 Expired - Fee Related CN101048165B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04105407 2004-10-29
EP04105407.3 2004-10-29
PCT/EP2005/011404 WO2006045578A2 (en) 2004-10-29 2005-10-25 Process for the preparation of ibandronate

Publications (2)

Publication Number Publication Date
CN101048165A CN101048165A (zh) 2007-10-03
CN101048165B true CN101048165B (zh) 2010-12-01

Family

ID=36097233

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800371320A Expired - Fee Related CN101048165B (zh) 2004-10-29 2005-10-25 用于制备二膦酸盐的方法

Country Status (13)

Country Link
US (1) US7214818B2 (enExample)
EP (1) EP1807090B9 (enExample)
JP (1) JP4560548B2 (enExample)
KR (1) KR100880061B1 (enExample)
CN (1) CN101048165B (enExample)
AT (1) ATE497769T1 (enExample)
CA (1) CA2585027C (enExample)
DE (1) DE602005026310D1 (enExample)
ES (1) ES2359415T3 (enExample)
IL (1) IL182690A (enExample)
MX (1) MX2007005114A (enExample)
TW (1) TWI293304B (enExample)
WO (1) WO2006045578A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093416A (zh) * 2011-03-17 2011-06-15 南京恒生制药厂 一种合成伊班膦酸钠的方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007000087A (es) * 2004-06-23 2007-11-06 Teva Pharma Acido ibandronico solido y cristalino.
WO2007074475A2 (en) * 2005-12-27 2007-07-05 Natco Pharma Limited Novel polymorphic forms of ibandronate
NZ573137A (en) * 2006-06-23 2011-03-31 Cipla Ltd Process for the synthesis of ibandronate sodium
EP2041148A1 (en) * 2006-07-03 2009-04-01 Generics Ýuk¨Limited Novel process for the preparation of bisphosphonic acids
EP2046342A4 (en) * 2006-07-28 2011-05-04 Reddys Lab Ltd Dr CRYSTALLINE FORM WITH IBANDRONIC ACID AND PROCESS FOR PREPARING THE SAME
EP2009016A3 (en) * 2006-11-16 2009-02-25 Teva Pharmaceutical Industries Ltd Process for preparing crystalline form of ibandronate sodium
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
DK2144919T3 (en) * 2007-04-11 2015-12-14 Hoffmann La Roche The multistage SYNTHESIS OF Ibandronate
WO2008131160A1 (en) * 2007-04-19 2008-10-30 Dr. Reddy's Laboratories Ltd. Ibandronate sodium polymorphs
US20090042839A1 (en) * 2007-08-09 2009-02-12 Sharon Avhar-Maydan Crystalline forms of ibandronate sodium
US20090075944A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched ibandronate
WO2009093258A2 (en) * 2008-01-24 2009-07-30 Fleming Laboratories Limited A new and improved process for the preparation of ibandronate sodium monohydrate
EP2180003A1 (en) 2008-10-21 2010-04-28 Zentiva, k.s. Preparation of ibandronate trisodium
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
EP2192126B1 (en) 2008-11-26 2013-03-27 Synthon B.V. Process for making zoledronic acid
CN101863919B (zh) * 2010-07-05 2011-11-23 武汉同源药业有限公司 一种化合物伊班膦酸钠的制备方法
CN103012155A (zh) * 2012-11-29 2013-04-03 张家港市大伟助剂有限公司 一种n-甲基戊胺的制备方法
CN103396332A (zh) * 2013-08-19 2013-11-20 四川协力制药有限公司 3—[（n—甲基—n—戊基）氨基]丙酸盐酸盐的制备方法
CN104628768A (zh) * 2015-03-06 2015-05-20 江苏正大清江制药有限公司 一种伊班膦酸钠的制备方法
CN114524925B (zh) * 2020-11-23 2023-11-14 华润化学材料科技股份有限公司 钛系催化剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919321A (en) * 1966-11-08 1975-11-11 Hoffmann La Roche Halo-substituted-5H-dibenzo{8 a,d{9 cyclohepten-5-ones
US4220611A (en) 1978-06-29 1980-09-02 Sandoz, Inc. Polyoxyalkylene bridged phosphate esters
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3808074A1 (de) 1988-03-11 1989-09-21 Henkel Kgaa Verfahren zur herstellung von azacycloalkan-2,2-diphosphonsaeuren
DE3822650A1 (de) 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4922007A (en) 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PE20011065A1 (es) 2000-02-01 2001-11-21 Procter & Gamble Proceso para fabricar bisfosfonatos geminales
CA2657002A1 (en) 2002-05-17 2003-11-27 Teva Pharmaceutical Industries Ltd. Use of aromatic hydrocarbons and silicone fluids for making disphosphonic acids

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FREIFELDER M.Local Anesthetics Ⅶ.Monoalkylamino-4-alkoxy-3-amino-benzoates and 3-alkoxy-4-aminobenzoates.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY80 16.1958,80(16),P4321,第一栏,方法A. *
GALIN F Z.Sulphur ylides.2.S,N-Transmethylation upon treatmentofazomethines withdimethylcarboethoxymethylidinesulphurane,generated underphase transfer conditions.BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR, DIVISION OF CHEMICAL SCIENCE37 4.1988,37(4),P709表1,P711第8-12行,参考文献11. *
WIDLER L.Highly potent geminal bisphosphonates. Frompamidronatedisodium (Aredia) to zoledronic acid (Zometa).JOURNAL OF MEDICINAL CHEMISTRY45 17.2002,45(17),P3724 表5,方法A;P3723 表1,方法A. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093416A (zh) * 2011-03-17 2011-06-15 南京恒生制药厂 一种合成伊班膦酸钠的方法
CN102093416B (zh) * 2011-03-17 2013-07-24 南京恒生制药有限公司 一种合成伊班膦酸钠的方法

Also Published As

Publication number Publication date
TWI293304B (en) 2008-02-11
TW200621792A (en) 2006-07-01
IL182690A0 (en) 2007-09-20
CN101048165A (zh) 2007-10-03
KR20070070246A (ko) 2007-07-03
ATE497769T1 (de) 2011-02-15
WO2006045578A2 (en) 2006-05-04
KR100880061B1 (ko) 2009-01-22
EP1807090B9 (en) 2011-11-09
EP1807090B1 (en) 2011-02-09
MX2007005114A (es) 2007-06-26
DE602005026310D1 (de) 2011-03-24
CA2585027C (en) 2010-05-18
JP4560548B2 (ja) 2010-10-13
WO2006045578A3 (en) 2006-08-17
US7214818B2 (en) 2007-05-08
ES2359415T3 (es) 2011-05-23
IL182690A (en) 2011-07-31
JP2008517964A (ja) 2008-05-29
CA2585027A1 (en) 2006-05-04
US20060094898A1 (en) 2006-05-04
EP1807090A2 (en) 2007-07-18

Similar Documents

Publication Publication Date Title
CN101048165B (zh) 用于制备二膦酸盐的方法
JP2008517964A5 (enExample)
WO2007083240A2 (en) An improved process for the preparation of bisphosphonic acids
CN101111505A (zh) 伊班膦酸盐多晶型物b
US8450488B2 (en) Process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid and hemipentahydrate monosodium salt thereof
US7662990B2 (en) Process for preparing ibandronate
FI92704B (fi) Menetelmä terapeuttisesti käyttökelpoisten aromaattisesti substituoitujen alkyyliaminoalkaanidifosfonihappojen valmistamiseksi
US20090198062A1 (en) Novel process
WO2007023342A2 (en) Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof
US8076483B2 (en) Process for the preparation of pure risedronic acid or salts
PL213599B1 (pl) Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego
CA2590046A1 (en) Process for preparing a pure polymorphic form of 3-pyridyl-1-hydroxyethylidine-1,1-bisphosphonic acid sodium salt

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20101201

Termination date: 20171025