CN101011468A - Yixinningshen tablet and its preparation method - Google Patents
Yixinningshen tablet and its preparation method Download PDFInfo
- Publication number
- CN101011468A CN101011468A CN 200710010164 CN200710010164A CN101011468A CN 101011468 A CN101011468 A CN 101011468A CN 200710010164 CN200710010164 CN 200710010164 CN 200710010164 A CN200710010164 A CN 200710010164A CN 101011468 A CN101011468 A CN 101011468A
- Authority
- CN
- China
- Prior art keywords
- hours
- time
- add
- ganoderma
- tenghehuan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a method for preparing relieving mental stress tablet, which comprises 9-11g panaxoside, 995-1005g albizia flower, 495-505g schisandra fruit, and 495-505g lucid ganoderma; breaks the schisandra fruit into rough powder, adding 75% alcohol to be immerged for 30min, refluxing and extracting for two times while the first time costs 2.5h and the second time costs 2h, combining the extractive and recycling alcohol, concentrating into dense paste; adding water into albizia flower and lucid ganoderma to be boiled for two times, while the first costs 2h and the second costs 1.5h; filtering, combining the fluid liquors, concentrating into dense paste, combining the dense pastes, drying and breaking into fine powder, adding panaxoside, and 80-100g amidon, or adding 15-20g calcium sulfate, 10-15g pre-gelatinized amidon, and 55-65g amidon; using 35-55% alcohol or 8-15% syrup to prepare particles, drying, and adding 0.5-1% dolomol and 1% French chalk, mixing uniformly, pressing into 1000 tablets or 600 tablets, coating sugar package or film. The invention has high drug utilization without side effect.
Description
Technical field
The present invention relates to Chinese patent medicine, particularly relate to a kind ofly treat cardiopalmus, be insomnia, the YIXING NINHSHEN PIAN and the preparation method of forgetful neurasthenia.
Background technology
Neurasthenia is common clinically a kind of disease, and its pathogenic factor is by the initiation that influences each other of several paathogenic factors, causes the excitement and the process of inhibition obstacle of normal brain activity nerve, and clinical manifestation is cardiopalmus, be insomnia, forgetful.Theory of Chinese medical science is thought the genus deficiency of both the heart and spleen, and how stagnation of QI due to depression of the liver is pondered over too because of overstrain, and damage heart spleen is hindered in heart hematozemia then, deficiency of both the heart and spleen then god become homeless foster, so show dizziness and tinnitus, shortness of breath and palpitation, insomnia and dreamful sleep.The treatment of many at present employing chemical synthetic drugs, this disease is delayed touching long period medication, and used chemical synthetic drug side effect is big, lacks specific aim in addition, so to treatment cardiopalmus, be insomnia, neurasthenia curative effect such as forgetful is obvious inadequately, long-term prescription can bring financial burden to the patient.
Summary of the invention
The objective of the invention is at the problems referred to above, a kind of treatment cardiopalmus is provided, is insomnia, forgetful effective, YIXING NINHSHEN PIAN that has no side effect and preparation method.
The technical scheme that adopts is:
YIXING NINHSHEN PIAN is by stem and leaf of Radix Ginseng total saponins, TENGHEHUAN, Fructus Schisandrae Chinensis, Ganoderma, adds appropriate amount of auxiliary materials and makes tablet.Its compatibility is stem and leaf of Radix Ginseng total saponins 9-11g, TENGHEHUAN 995-1005g, Fructus Schisandrae Chinensis 495-505g, Ganoderma 495-505g.
The preparation method of YIXING NINHSHEN PIAN is got stem and leaf of Radix Ginseng total saponins 9-11g, TENGHEHUAN 995-1005g, Fructus Schisandrae Chinensis 495-505g, Ganoderma 495-505g are standby.More than four the flavor, get Fructus Schisandrae Chinensis powder and be broken into coarse powder, add 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaims ethanol, is concentrated into the thick paste shape, get TENGHEHUAN and Ganoderma two flavors, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is concentrated into the thick paste shape, gets above-mentioned thick paste, merge, drying is ground into fine powder, adds stem and leaf of Radix Ginseng total saponins and starch 80-100g or adds calcium sulfate 15-20g, pregelatinized Starch 10-15g, starch 55-65g, syrup with 35-55% ethanol or 8-15% is granulated drying.Add the magnesium stearate of grain amount 0.5-1% and 1% Pulvis Talci behind the granulate, mixing is pressed into 1000 or 600, sugar coating or bag film-coat.
The side separates:
Reuse stem and leaf of Radix Ginseng total saponins among the we and go into heart spleen channel, the excitement and the inhibition dual regulation that have human body immunity improving power to reach nervus centralis are its principal agent.With the nourishing kidney of Fructus Schisandrae Chinensis heart tonifying, nervus centralis there is the strong accessory drugs that act as.It is adjuvant drug that Ganoderma has the digestive function of raising and analgesic activity.TENGHEHUAN is gone into heart spleen channel, spleen reinforcing is calmed the nerves and blood resolving depression, calmness, pain relieving are messenger drug.
The present invention adopts the Yixinningshen Chinese medicine preparation of stem and leaf of Radix Ginseng total saponins, Fructus Schisandrae Chinensis, TENGHEHUAN, the preparation of Ganoderma Chinese medicine, but tonifying QI to produce body fluid, and tranquilizing by nourishing the heart is used for shortness of breath and palpitation, dreaminess insomnia, the neurasthenia of hypomnesis.Have convenient drug administration, rapid-action, drug utilization degree height, constant product quality, the advantage that has no side effect.
Pharmacological effect is learned experiment:
This pharmacological effect is learned experiment and is provided by Shenyang Pharmaceutical University.
1, experiment purpose
Observing calmness, hypnosis, resisting fatigue, the immunity of YIXING NINHSHEN PIAN reconciles and anti-aging effects.
2, zoopery
Kunming mouse, body weight 18-22g, the male and female dual-purpose, Shenyang Pharmaceutical University experimental animal center provides.
3, experimental project
(1) YIXING NINHSHEN PIAN is to the influence of spontaneous activity in mice;
(2) YIXING NINHSHEN PIAN is to the pentobarbital sodium in mice influence of the length of one's sleep;
(3) YIXING NINHSHEN PIAN is to the influence of mouse memory acquisition;
(4) YIXING NINHSHEN PIAN is to the influence of mouse memory reproduction;
(5) YIXING NINHSHEN PIAN is to mice reticuloendothelial system phagocytic function and to the influence of engulfing the ability of cleaning up of inertia carbon granule in the blood flow;
(6) YIXING NINHSHEN PIAN is to the influence of sheep red blood cell (SRBC) induced mice hemolytic antibody content;
(7) YIXING NINHSHEN PIAN is to the influence of mice low temperature antifatigue effect;
(8) YIXING NINHSHEN PIAN is to the influence of mouse red blood cell catalase activity;
(9) YIXING NINHSHEN PIAN is to the active influence of rats'liver SOD.
4, experimental result
The YIXING NINHSHEN PIAN pharmacodynamics is thought: can significantly suppress the spontaneous activity of mice, be certain dose-effect interdependence its mouse oral administration 0.2,0.6 and 1.8g (sheet is heavy)/kg.0.2 and 0.6g/kg dosage can significant prolongation pentobarbital sodium length of one's sleep.0.6 and 1.8g/kg dosage has the improvement effect to Anisodine induced mice dysmnesia, the memory represents obstacle that ethanol the is caused effect that also is significantly improved.Can significantly strengthen mice low temperature antifatigue effect to its mouse oral administration 0.6 and 1.2g/kg.0.6 reach the phagocytic function that 1.8g/kg dosage can strengthen the mice reticuloendothelial system, and the antagonist generation has certain promotion.YIXING NINHSHEN PIAN 0.6 and 1.8g/kg dosage can also improve the mice activity of catalase.Can significantly improve the activity of rats'liver SOD to rat oral administration 0.3 and 0.6g/kg.
Can think that according to experimental result YIXING NINHSHEN PIAN has the effect of calmness, hypnosis, raising learning capacity and memory ability.Also have resisting fatigue, regulate the effect of immunologic function.Has certain anti-aging effects in addition.
Toxicity test
Provide by Liaoning Research Institute of Traditional Chinese Medicine.
Medicine: the YIXING NINHSHEN PIAN suspension contains crude drug 8.6g for oral, 10% liquid asepsis preparation injection for intravenous.
Animal: Kunming hybridization white mice.
Method: get 20g ± 20 of 2g body weight white mice and make acute toxicity testing, get 80 of 80-120g body weight rat and make long term toxicity test, every day heavy dose of filling appetite clothes and intravenous injection.Acute experiment was observed seven days, and none example is dead as a result, and average weight increases by 19.6%.Long term toxicity test was observed 90 days, conclusion is rat to be grown have no effect, routine blood test, before routine urinalysis and liver, kidney function test are tested and experiment back no significant difference, the check pathological section result shows the rat heart, liver, lung, kidney main organs all harmless, pathologic all do not occur and change, illustrate that this poison of drug reaction is extremely light.
Clinical observation on the therapeutic effect
(1) source of data
100 examples are observed by Liaoning academy of traditional Chinese medicine, and clinical observation patient major part is the out-patient, and the minority case is an inpatient, and patient age is 17-58 year, and male 46 people account for 46%; Women 54 people account for 54%.
(2) observation cures mainly
Shortness of breath and palpitation, the dreaminess insomnia, hypomnesis, dizziness is main, and the tcm clinical practice typing is based on the deficiency of both the heart and spleen type, and caused by hepatic stagnation qi stagnation is for taking second place, and the course of disease is more than 1 month.
(3) curative effect determinate standard
Clinical recovery: recover normal the length of one's sleep, or day length of one's sleep 〉=6 hour, other simultaneous phenomenon disappears substantially;
Produce effects: sleep is clearly better, and increase 〉=3 hours the length of one's sleep, and other simultaneous phenomenon major part disappears substantially or obviously alleviates;
Effectively: sleep takes a turn for the better, and is increased in the length of one's sleep between 2-3 hour, and other simultaneous phenomenon reduces or alleviates;
Invalid: the insomnia situation is not improved, or increases the weight of.
(4) observed result
Recovery from illness: 10 examples 10%
Produce effects: 46 examples 46%
Effectively: 37 examples 37%
Invalid: 7 examples 7%
Total effective rate 93%.
Function with cure mainly
Tonifying QI to produce body fluid, tranquilizing by nourishing the heart is used for shortness of breath and palpitation, dreaminess insomnia, hypomnesis, diseases such as neurasthenia.
The specific embodiment
Embodiment one
YIXING NINHSHEN PIAN and preparation method are got stem and leaf of Radix Ginseng total saponins 10g, TENGHEHUAN 1000g, Fructus Schisandrae Chinensis 500g, Ganoderma 500g is broken into coarse powder with Fructus Schisandrae Chinensis powder, add 75% ethanol warm macerating 30 minutes, reflux, extract, secondary, 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, be concentrated into the thick paste shape, get TENGHEHUAN and Ganoderma two flavors, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, be concentrated into the thick paste shape, get above-mentioned thick paste, merge, dry, be ground into fine powder, add stem and leaf of Radix Ginseng total saponins and starch 90g, mixing, granulate drying with 35% ethanol or 10% syrup.Add the magnesium stearate of grain amount 0.8% and 1% Pulvis Talci behind the granulate, mixing is pressed into 1000 of the slice, thin pieces of the heavy 0.3g of substrate, and sugar coating is made coated tablet.
Usage and dosage: oral, one time 5,3 times on the one.
Embodiment two
Embodiment two and embodiment one are basic identical, and difference is that the adjuvant that adds is calcium sulfate 16g, pregelatinized Starch 14g, starch 60g, and mixing is granulated drying with 40% ethanol or 10 syrup.Add the magnesium stearate of grain amount 0.5% and 1% Pulvis Talci behind the granulate, mixing is pressed into 1000 of the slice, thin pieces of the heavy 0.3g of substrate, and the bag film-coat is made every and heavily is the 0.31g Film coated tablets.
Usage and dosage: oral, one time 5,3 times on the one.
Embodiment three
Embodiment three and embodiment one are basic identical, and difference is that the adjuvant that adds is calcium sulfate 18g, pregelatinized Starch 12g, starch 58g, and mixing is granulated drying with 45% ethanol or 10% syrup.Add the magnesium stearate of grain amount 0.5% and 1% Pulvis Talci behind the granulate, mixing is pressed into 600 of the slice, thin pieces of the heavy 0.5g of substrate, and the bag film-coat is made every and heavily is the 0.52g Film coated tablets.
Usage and dosage: oral, one time 3,3 times on the one.
Claims (3)
1, YIXING NINHSHEN PIAN is characterized in that appropriate amount of auxiliary materials is made tablet by stem and leaf of Radix Ginseng total saponins, TENGHEHUAN, Fructus Schisandrae Chinensis, Ganoderma, and its compatibility is stem and leaf of Radix Ginseng total saponins 9-11g, TENGHEHUAN 995-1005g, Fructus Schisandrae Chinensis 495-505g, Ganoderma 495-505g.
2, the preparation method of YIXING NINHSHEN PIAN according to claim 1 is characterized in that getting stem and leaf of Radix Ginseng total saponins 9-11g, TENGHEHUAN 995-1005g, Fructus Schisandrae Chinensis 495-505g, Ganoderma 495-505g is standby, more than four the flavor, get Fructus Schisandrae Chinensis powder and be broken into coarse powder, add 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid,, reclaim ethanol, be concentrated into the thick paste shape, get TENGHEHUAN and Ganoderma two flavors, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter merging filtrate, be concentrated into the thick paste shape, get above-mentioned thick paste, merge drying, be ground into fine powder, add stem and leaf of Radix Ginseng total saponins and starch 80-100g, granulate drying with the syrup of 35-55% ethanol or 8-15%, add the magnesium stearate of granule 0.5-1% and 1% Pulvis Talci behind the granulate, mixing is pressed into 1000, sugar coating, get specification, the coated tablet of the heavy 0.3g of its sheet.
3, the preparation method of YIXING NINHSHEN PIAN according to claim 2 is characterized in that getting stem and leaf of Radix Ginseng total saponins 10g, TENGHEHUAN 1000g, Fructus Schisandrae Chinensis 500g, Ganoderma 500g is broken into coarse powder with Fructus Schisandrae Chinensis powder, add 75% ethanol warm macerating 30 minutes, reflux, extract, secondary, 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, be concentrated into the thick paste shape, get TENGHEHUAN and Ganoderma two flavors, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is concentrated into the thick paste shape, get above-mentioned thick paste, merge, drying is ground into fine powder, add stem and leaf of Radix Ginseng total saponins and add calcium sulfate 15-20g, pregelatinized Starch 10-15g, starch 55-65g, syrup with 35-55% ethanol or 8-15% is granulated drying, mixing, dry, add the magnesium stearate of grain amount 0.5-1% and 1% Pulvis Talci behind the granulate, mixing is pressed into 1000 or 600, the bag film-coat, getting specification is every heavy 0.31g Film coated tablets or every heavy 0.52g Film coated tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710010164 CN101011468A (en) | 2007-01-24 | 2007-01-24 | Yixinningshen tablet and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710010164 CN101011468A (en) | 2007-01-24 | 2007-01-24 | Yixinningshen tablet and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101011468A true CN101011468A (en) | 2007-08-08 |
Family
ID=38699304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200710010164 Pending CN101011468A (en) | 2007-01-24 | 2007-01-24 | Yixinningshen tablet and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101011468A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103039996A (en) * | 2012-12-28 | 2013-04-17 | 杨石 | Health food with function of improving sleep |
| CN105878707A (en) * | 2014-10-11 | 2016-08-24 | 王成全 | Wuling Anmian Powder |
| CN106668282A (en) * | 2016-12-30 | 2017-05-17 | 辽宁上药好护士药业（集团）有限公司 | Application of heart-invigorating and calming tablet in preparation of medicine for curing heart diseases |
| CN106728289A (en) * | 2016-12-30 | 2017-05-31 | 辽宁上药好护士药业（集团）有限公司 | Application of the Yixinningshen tablet in treatment diplocardia medicine is prepared |
| CN110812415A (en) * | 2019-12-27 | 2020-02-21 | 辽宁上药好护士药业（集团）有限公司 | Preparation method of heart-benefiting and mind-tranquilizing composition for improving sleep |
-
2007
- 2007-01-24 CN CN 200710010164 patent/CN101011468A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103039996A (en) * | 2012-12-28 | 2013-04-17 | 杨石 | Health food with function of improving sleep |
| CN105878707A (en) * | 2014-10-11 | 2016-08-24 | 王成全 | Wuling Anmian Powder |
| CN106668282A (en) * | 2016-12-30 | 2017-05-17 | 辽宁上药好护士药业（集团）有限公司 | Application of heart-invigorating and calming tablet in preparation of medicine for curing heart diseases |
| CN106728289A (en) * | 2016-12-30 | 2017-05-31 | 辽宁上药好护士药业（集团）有限公司 | Application of the Yixinningshen tablet in treatment diplocardia medicine is prepared |
| CN106668282B (en) * | 2016-12-30 | 2020-03-27 | 辽宁上药好护士药业（集团）有限公司 | Application of heart-benefiting mind-tranquilizing tablet in preparation of medicine for treating heart diseases |
| CN106728289B (en) * | 2016-12-30 | 2020-04-14 | 辽宁上药好护士药业（集团）有限公司 | Application of heart-benefiting mind-tranquilizing tablet in preparation of medicine for treating diplocardia |
| CN110812415A (en) * | 2019-12-27 | 2020-02-21 | 辽宁上药好护士药业（集团）有限公司 | Preparation method of heart-benefiting and mind-tranquilizing composition for improving sleep |
| CN110812415B (en) * | 2019-12-27 | 2021-10-12 | 辽宁上药好护士药业（集团）有限公司 | Preparation method of heart-benefiting and mind-tranquilizing composition for improving sleep |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102428832B (en) | Fungal pharmaceutical mycoplasm with blood sugar lowering efficacy and preparation method thereof | |
| CN101011468A (en) | Yixinningshen tablet and its preparation method | |
| CN103211257A (en) | Apple vinegar health care beverage for reducing blood sugar and preparation method thereof | |
| CN102145120B (en) | Traditional Chinese medicine composition suitable for treating Type II diabetes | |
| CN102228484A (en) | Chinese medicinal preparation Jinshuibao oral liquid and preparation method thereof | |
| CN110251591A (en) | A kind of pharmaceutical composition and its preparation method and application that aided blood pressure-lowering is hypoglycemic | |
| CN103211996B (en) | Preparation method of traditional Chinese medicine for treating diabetes mellitus | |
| CN1977884B (en) | Medicinal composition for treating diabetes and its preparing method | |
| CN102631492B (en) | Chinese medicinal composition for improving immunity and resisting fatigue | |
| CN101559139A (en) | Prescription of pure traditional Chinese medicine preparation for preventing and curing neurasthenia insomnia and preparation method thereof | |
| CN102805818A (en) | Hypoglycemic drug and preparation method thereof | |
| CN101129431A (en) | Traditional Chinese medicine composition for preventing and controlling cardiovascular disease and relative disease, method of preparing the same and application of the same | |
| CN102631486B (en) | Health care composition | |
| CN102631506B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN103230552A (en) | Traditional Chinese medicine for treating diabetes mellitus | |
| CN102579801B (en) | Traditional Chinese medicine preparation for treating diabetic syndrome and preparation method of same | |
| CN102631487B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN107669860A (en) | A kind of Chinese medicine composition and its application with blood sugar reducing function | |
| CN109010444A (en) | A kind of Chinese medicine composition and preparation method containing Herb Gynostemmae Pentaphylli extract | |
| CN107137621A (en) | It is a kind of to treat Chinese medicine composition of high fat of blood and its preparation method and application | |
| CN101953917B (en) | Chinese medicinal composition for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof | |
| CN101129493B (en) | Antineoplastic anti-AIDS pharmaceutical composition and method of preparing the same | |
| CN102068555A (en) | Medicinal composition for improving sleep and preparation method thereof | |
| CN101961340A (en) | Application of pedunculoside in preparing medicine for treating coronary heart disease | |
| CN102631393B (en) | Health care composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |