CN101010105A - 甘油支化的聚乙二醇人生长激素缀合物、其制备方法及其使用方法 - Google Patents
甘油支化的聚乙二醇人生长激素缀合物、其制备方法及其使用方法 Download PDFInfo
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US60594504P | 2004-08-31 | 2004-08-31 | |
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CN101010105A true CN101010105A (zh) | 2007-08-01 |
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EP (1) | EP1789092A2 (fr) |
JP (1) | JP2008511610A (fr) |
KR (1) | KR20070042567A (fr) |
CN (1) | CN101010105A (fr) |
AP (1) | AP2007003919A0 (fr) |
AR (1) | AR050851A1 (fr) |
AU (1) | AU2005278903A1 (fr) |
BR (1) | BRPI0515118A (fr) |
CA (1) | CA2577999A1 (fr) |
CR (1) | CR8942A (fr) |
EA (1) | EA200700380A1 (fr) |
EC (1) | ECSP077281A (fr) |
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MA (1) | MA28908B1 (fr) |
MX (1) | MX2007002441A (fr) |
NL (1) | NL1029828C2 (fr) |
NO (1) | NO20071322L (fr) |
PE (1) | PE20060654A1 (fr) |
TN (1) | TNSN07078A1 (fr) |
TW (1) | TW200621291A (fr) |
UY (1) | UY29088A1 (fr) |
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Cited By (3)
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CN101831067A (zh) * | 2010-05-31 | 2010-09-15 | 王二新 | 聚乙二醇脂类缀合物及其在制备药物中的应用 |
CN102367290A (zh) * | 2011-04-26 | 2012-03-07 | 刘超 | 链官能化的多级支化聚乙二醇及其合成方法 |
WO2014110867A1 (fr) * | 2013-01-17 | 2014-07-24 | 厦门赛诺邦格生物科技有限公司 | Polyéthylèneglycol ramifié monofonctionnel et substance de type biologique modifiée par celui-ci |
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DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
JP2002534119A (ja) | 1999-01-14 | 2002-10-15 | ボルダー バイオテクノロジー, インコーポレイテッド | 自由システイン残基を有するタンパク質の生産方法 |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
EP1834963A1 (fr) * | 2006-03-13 | 2007-09-19 | Siegfried Ltd. | Conjugues de proteines et de dipolymeres et leurs procedes de preparation |
US20090117077A1 (en) * | 2006-05-12 | 2009-05-07 | Dong-A Pharm. Co., Ltd. | Polyethylene glycol-interferon alpha conjugate |
JP2008069073A (ja) * | 2006-09-12 | 2008-03-27 | Yokohama Tlo Co Ltd | ラクトフェリン複合体及びその製造方法 |
KR101079993B1 (ko) * | 2006-11-17 | 2011-11-04 | 동아제약주식회사 | 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체 |
CL2008002399A1 (es) | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
WO2010011096A2 (fr) * | 2008-07-23 | 2010-01-28 | Hanmi Pharmaceutical Co., Ltd. | Complexe de polypeptide comprenant un polymère non-peptidylique ayant trois extrémités fonctionnelles |
MY156568A (en) | 2008-07-31 | 2016-03-15 | Pharmaessentia Corp | Peptide-polymer conjugates |
SI2340271T1 (sl) * | 2008-10-10 | 2019-08-30 | Polyactiva Pty Ltd. | Konjugati polimer-bioaktivnega sredstva |
US8535655B2 (en) | 2008-10-10 | 2013-09-17 | Polyactiva Pty Ltd. | Biodegradable polymer—bioactive moiety conjugates |
CA2739078C (fr) * | 2008-10-10 | 2017-01-03 | The Bionic Ear Institute | Conjugues polymere biodegradable - fractions bioactives |
US8680050B2 (en) | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
DK2393828T3 (en) | 2009-02-03 | 2017-01-23 | Amunix Operating Inc | Extended recombinant polypeptides and compositions comprising same |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
CN102612376A (zh) | 2009-08-06 | 2012-07-25 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内功效的生长激素 |
EP2446898A1 (fr) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de l'hormone de croissance pour améliorer la réponse immunitaire chez des patients immunodéprimés |
CN104877127B (zh) | 2015-06-23 | 2017-11-10 | 厦门赛诺邦格生物科技股份有限公司 | 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质 |
EA037151B1 (ru) | 2014-11-06 | 2021-02-11 | Фармаэссентия Корпорейшн | Способ лечения с использованием пегилированного интерферона |
CN111727063A (zh) * | 2017-12-29 | 2020-09-29 | 豪夫迈·罗氏有限公司 | 用于提供聚乙二醇化蛋白质组合物的方法 |
JP7137625B2 (ja) * | 2017-12-29 | 2022-09-14 | エフ.ホフマン-ラ ロシュ アーゲー | Peg化タンパク質組成物を提供するための方法 |
ES2905105T3 (es) | 2017-12-29 | 2022-04-07 | Hoffmann La Roche | Procedimiento para proporcionar una composición de proteína PEGilada |
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AU2147192A (en) * | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
JP3092531B2 (ja) * | 1996-11-05 | 2000-09-25 | 日本油脂株式会社 | コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法 |
DE69838552T2 (de) * | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
JP3921781B2 (ja) * | 1998-02-12 | 2007-05-30 | 日本油脂株式会社 | カルボキシル基含有ポリオキシアルキレン化合物 |
JP2002534119A (ja) * | 1999-01-14 | 2002-10-15 | ボルダー バイオテクノロジー, インコーポレイテッド | 自由システイン残基を有するタンパク質の生産方法 |
JP2005525302A (ja) * | 2001-11-20 | 2005-08-25 | ファルマシア・コーポレーション | 化学的に修飾されたヒト成長ホルモンコンジュゲート |
BR0314172A (pt) * | 2002-09-09 | 2005-07-26 | Nektar Therapeutics Al Corp | Polìmero solúvel em água, composição, forma de hidrato ou acetal, composto,composição, usos do composto e do conjugado, e, processo para preparar o conjugado |
JP4412461B2 (ja) * | 2002-11-20 | 2010-02-10 | 日油株式会社 | 修飾された生体関連物質、その製造方法および中間体 |
MXPA05007165A (es) * | 2002-12-31 | 2005-09-21 | Nektar Therapeutics Al Corp | Reactivos polimericos que comprnden una cetona o un grupo funcional relacionado. |
EA011351B1 (ru) * | 2003-05-23 | 2009-02-27 | Нектар Терапеутикс Ал, Корпорейшн | Полимерные реагенты, способы их получения, а также содержащие их конъюгаты и фармацевтические препараты |
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2005
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- 2005-08-25 AP AP2007003919A patent/AP2007003919A0/xx unknown
- 2005-08-25 CA CA002577999A patent/CA2577999A1/fr not_active Abandoned
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101831067A (zh) * | 2010-05-31 | 2010-09-15 | 王二新 | 聚乙二醇脂类缀合物及其在制备药物中的应用 |
CN102367290A (zh) * | 2011-04-26 | 2012-03-07 | 刘超 | 链官能化的多级支化聚乙二醇及其合成方法 |
CN102367290B (zh) * | 2011-04-26 | 2013-05-08 | 厦门赛诺邦格生物科技有限公司 | 链官能化的多级支化聚乙二醇及其合成方法 |
WO2014110867A1 (fr) * | 2013-01-17 | 2014-07-24 | 厦门赛诺邦格生物科技有限公司 | Polyéthylèneglycol ramifié monofonctionnel et substance de type biologique modifiée par celui-ci |
Also Published As
Publication number | Publication date |
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ECSP077281A (es) | 2007-03-29 |
NO20071322L (no) | 2007-05-29 |
EA200700380A1 (ru) | 2007-10-26 |
WO2006024953A3 (fr) | 2007-01-18 |
NL1029828A1 (nl) | 2006-03-01 |
PE20060654A1 (es) | 2006-08-12 |
MX2007002441A (es) | 2007-05-04 |
TW200621291A (en) | 2006-07-01 |
NL1029828C2 (nl) | 2006-10-20 |
BRPI0515118A (pt) | 2008-07-01 |
UY29088A1 (es) | 2006-03-31 |
CR8942A (es) | 2007-08-16 |
IL181085A0 (en) | 2007-07-04 |
AP2007003919A0 (en) | 2007-02-28 |
MA28908B1 (fr) | 2007-10-01 |
AU2005278903A1 (en) | 2006-03-09 |
ZA200701802B (en) | 2008-08-27 |
KR20070042567A (ko) | 2007-04-23 |
WO2006024953A2 (fr) | 2006-03-09 |
EP1789092A2 (fr) | 2007-05-30 |
GT200500235A (es) | 2006-03-21 |
CA2577999A1 (fr) | 2006-03-09 |
AR050851A1 (es) | 2006-11-29 |
JP2008511610A (ja) | 2008-04-17 |
TNSN07078A1 (fr) | 2008-06-02 |
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