CN101010087B - 用于制备金属有机盐的高收率和快速的合成方法 - Google Patents

用于制备金属有机盐的高收率和快速的合成方法 Download PDF

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Publication number
CN101010087B
CN101010087B CN2005800226577A CN200580022657A CN101010087B CN 101010087 B CN101010087 B CN 101010087B CN 2005800226577 A CN2005800226577 A CN 2005800226577A CN 200580022657 A CN200580022657 A CN 200580022657A CN 101010087 B CN101010087 B CN 101010087B
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CN
China
Prior art keywords
strontium
acid
salts
salt
glutamate
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Expired - Fee Related
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CN2005800226577A
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English (en)
Chinese (zh)
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CN101010087A (zh
Inventor
斯蒂芬·克里斯戈
延斯·E·T·安德森
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Osteologix AS
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Osteologix AS
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Priority claimed from PCT/DK2004/000328 external-priority patent/WO2004098619A2/en
Priority claimed from PCT/DK2004/000326 external-priority patent/WO2004098617A2/en
Priority claimed from PCT/DK2004/000327 external-priority patent/WO2004098618A2/en
Application filed by Osteologix AS filed Critical Osteologix AS
Publication of CN101010087A publication Critical patent/CN101010087A/zh
Application granted granted Critical
Publication of CN101010087B publication Critical patent/CN101010087B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/08—Malonic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2005800226577A 2004-05-06 2005-05-05 用于制备金属有机盐的高收率和快速的合成方法 Expired - Fee Related CN101010087B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
PCT/DK2004/000328 WO2004098619A2 (en) 2003-05-07 2004-05-06 Treating cartilage / bone conditions with water-soluble strontium salts
DKPCT/DK2004/000326 2004-05-06
DKPCT/DK2004/000328 2004-05-06
PCT/DK2004/000326 WO2004098617A2 (en) 2003-05-07 2004-05-06 Controlled release composition containing a strontium salt
DKPCT/DK2004/000327 2004-05-06
PCT/DK2004/000327 WO2004098618A2 (en) 2003-05-07 2004-05-06 Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions
DKPA200401708 2004-11-05
DKPA200401708 2004-11-05
PCT/DK2005/000307 WO2005108339A2 (en) 2004-05-06 2005-05-05 High yield and rapid syntheses methods for producing metallo-organic salts

Publications (2)

Publication Number Publication Date
CN101010087A CN101010087A (zh) 2007-08-01
CN101010087B true CN101010087B (zh) 2012-06-27

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CN2005800226577A Expired - Fee Related CN101010087B (zh) 2004-05-06 2005-05-05 用于制备金属有机盐的高收率和快速的合成方法

Country Status (8)

Country Link
US (2) US7589235B2 (https=)
EP (1) EP1744770A2 (https=)
JP (1) JP4954867B2 (https=)
KR (1) KR20110124317A (https=)
CN (1) CN101010087B (https=)
AU (1) AU2005240257B2 (https=)
CA (1) CA2565840A1 (https=)
WO (1) WO2005108339A2 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1622630B1 (en) * 2003-05-07 2012-08-29 Osteologix A/S Strontium combinations for the prophylaxis/treatment of cartilage and/or bone conditions
AU2004237437B2 (en) * 2003-05-07 2011-01-20 Osteologix A/S Controlled release composition containing a strontium salt
ES2275218T3 (es) 2003-05-07 2007-06-01 Osteologix A/S Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
US20080167513A1 (en) 2004-02-26 2008-07-10 Osteologlx A/S Strontium-Containing Compounds for Use in the Prevention or Treatment of Necrotic Bone Conditions
SI2153870T1 (sl) 2004-11-26 2014-05-30 Ucl Business Plc Sestavki, ki obsegajo ornitin in fenilacetat ali fenilbutirat, za zdravljenje hepatitične encefalopatije
KR100878140B1 (ko) * 2007-01-29 2009-01-12 한미약품 주식회사 아토바스타틴의 스트론튬염 또는 이의 수화물, 및 이를포함하는 약학 조성물
CN101327203B (zh) * 2007-06-19 2011-03-30 惠州市昆泰精细化工有限公司 没食子酸螯合物组合物及其应用
HUE035921T2 (en) 2009-04-03 2018-05-28 Ocera Therapeutics Inc L-ornithine phenyl acetate and methods of making thereof
CN104434894A (zh) 2009-06-08 2015-03-25 Ucl商业有限公司 使用l-鸟氨酸苯乙酸盐治疗门静脉高压和恢复肝功能
FR2963837B1 (fr) * 2010-08-10 2012-08-31 Air Liquide Traitement a niveaux multiples pour optimiser une ou plusieurs unites de separation de fluides
US8946473B2 (en) 2010-10-06 2015-02-03 Ocera Therapeutics, Inc. Methods of making L-ornithine phenyl acetate
EP2530068A1 (en) 2011-05-31 2012-12-05 Lacer, S.A. New strontium salts, synthesis and use thereof in the treatment of osteoporosis
CN103173845B (zh) * 2012-01-12 2015-06-03 江苏爱特恩高分子材料有限公司 一种对苯二甲酸金属盐晶须的生产方法与应用
RU2564858C1 (ru) * 2014-06-04 2015-10-10 Закрытое акционерное общество "ЭКОС-1" Способ получения безводного формиата стронция
ES2769000T3 (es) 2014-11-24 2020-06-24 Ucl Business Ltd Tratamiento de enfermedades asociadas con la activación de células estrelladas hepáticas utilizando terapias reductoras de amoníaco
JP6464475B2 (ja) * 2015-03-02 2019-02-06 清水建設株式会社 放射性ストロンチウムの分析方法
WO2017031131A1 (en) 2015-08-18 2017-02-23 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate
US10463636B2 (en) 2016-09-30 2019-11-05 Deanna J. Nelson Pharmaceutical quality strontium L-lactate
CN106699781B (zh) * 2016-12-16 2018-11-16 商丘师范学院 基于衣康酸-吡嗪混合配体的锌(ii)荧光材料及制备方法
MX389665B (es) 2017-05-11 2025-03-20 Ocera Therapeutics Inc Procesos para producir fenilacetato de l-ornitina
US10472596B2 (en) 2017-06-27 2019-11-12 Ecolab Usa Inc. Non-phosphorous transition metal control in laundry applications
CN108047155A (zh) * 2017-11-29 2018-05-18 浙江震元制药有限公司 一种双芳基取代的异恶唑化合物的定向制备方法及用途
US11499952B2 (en) * 2018-05-11 2022-11-15 Premex, Inc. Process for quantification of metal amino acid chelates in solutions and solids
KR102833111B1 (ko) * 2018-09-25 2025-07-10 폰세 드 리온 헬스 데지그네이티드 액티비티 컴퍼니 칼슘 알파-케토글루타레이트의 제조 방법
CN109444277B (zh) * 2018-10-29 2021-05-11 郑州大学第一附属医院 代谢标志物在制备胶质瘤诊断试剂盒方面的应用
CN109622238B (zh) * 2018-12-18 2020-07-17 商洛学院 一种用于从金红石重选中矿中浮选回收金红石的药剂组合
CN110668934A (zh) * 2019-10-14 2020-01-10 惠州市志海新威科技有限公司 一种酒石酸锌的制备方法及其在稳定剂中的应用
CN114479098B (zh) * 2021-12-17 2023-05-23 广东石油化工学院 一种可控微介孔金属有机框架hkust-1材料及其制备方法和应用
CN117205363A (zh) * 2023-08-24 2023-12-12 中鼎凯瑞科技成都有限公司 基于没食子酸复合盐的自凝固复合骨植入物及其制备方法
CN119874570A (zh) * 2024-12-16 2025-04-25 天津理工大学 碱土金属甲基磺酸盐化合物及其晶体、制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL77097C (https=) 1952-04-29
US3478083A (en) * 1966-02-01 1969-11-11 Abbott Lab Nor-androstene steroid derivatives
SE340807B (https=) 1966-05-06 1971-12-06 Astra Ab
US4056567A (en) 1976-03-08 1977-11-01 Lever Brothers Company Chemical processes for preparing citric acid
DE2913592C2 (de) * 1979-04-04 1988-11-10 Chemische Werke München Otto Bärlocher GmbH, 8000 München Verfahen zur Herstellung von Metallseifen
DE3735264C1 (de) * 1987-10-17 1988-08-25 Degussa Verfahren zur Herstellung von Erdalkalimetallsalzen der L-2-Pyrrolidon-5-carbonsaeure
FR2651497B1 (fr) * 1989-09-01 1991-10-25 Adir Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2658816A1 (fr) * 1990-02-27 1991-08-30 Adir Nouveaux sels de metaux alcalinoterreux d'oxa-polyacides leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2665896A1 (fr) * 1990-08-16 1992-02-21 Rhone Poulenc Chimie Carboxylates metalliques, leur preparation et compositions supraconductrices obtenues a partir de ceux-ci.
JP3566984B2 (ja) * 1994-06-02 2004-09-15 帝人株式会社 骨形成促進剤
FR2749759B1 (fr) * 1996-06-17 1999-11-26 Adir Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
GB9814316D0 (en) 1998-07-02 1998-09-02 Smithkline Beecham Plc Novel compounds
DE19837522A1 (de) * 1998-08-19 2000-02-24 Clariant Gmbh Verwendung von Metall-Carboxylaten und -Sulfonaten als Ladungssteuermittel
US6232497B1 (en) * 1998-12-23 2001-05-15 Skw Trostberg Aktiengesellschaft Method for producing alkali metal and alkaline earth metal pyruvates
NO20014746D0 (no) * 2001-09-28 2001-09-28 Clas M Kjoelberg Smertelindrende middel
FR2844795B1 (fr) 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
EP1622630B1 (en) 2003-05-07 2012-08-29 Osteologix A/S Strontium combinations for the prophylaxis/treatment of cartilage and/or bone conditions
ES2275218T3 (es) 2003-05-07 2007-06-01 Osteologix A/S Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
AU2004237437B2 (en) 2003-05-07 2011-01-20 Osteologix A/S Controlled release composition containing a strontium salt
US20080167513A1 (en) * 2004-02-26 2008-07-10 Osteologlx A/S Strontium-Containing Compounds for Use in the Prevention or Treatment of Necrotic Bone Conditions
CA2570503A1 (en) * 2004-06-17 2005-12-29 Osteologix A/S A method of improving the medical treatment of pain
US20090035315A1 (en) * 2004-06-17 2009-02-05 Stephan Christgau Method of Improving Treatments in Rheumatic and Arthritic Diseases
EP1855654A1 (en) 2005-02-28 2007-11-21 Osteologix A/S Tablets comprising a high load of strontium
JP2009500358A (ja) * 2005-07-06 2009-01-08 オステオロジックス エイ／エス ストロンチウムの有機塩を製造するための高収率合成法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
B. Briggman, Å. Oskarsson.The crystal structures of calcium malonate dihydrate and strontium malonate.《Acta Crystallographica Section B》.1977,第33卷(第6期),1900–1906. *

Also Published As

Publication number Publication date
KR20110124317A (ko) 2011-11-16
CA2565840A1 (en) 2005-11-17
AU2005240257A1 (en) 2005-11-17
US20070282127A1 (en) 2007-12-06
US20090291926A1 (en) 2009-11-26
US8183409B2 (en) 2012-05-22
JP2007536288A (ja) 2007-12-13
JP4954867B2 (ja) 2012-06-20
US7589235B2 (en) 2009-09-15
EP1744770A2 (en) 2007-01-24
WO2005108339A2 (en) 2005-11-17
AU2005240257B2 (en) 2011-11-24
CN101010087A (zh) 2007-08-01
WO2005108339A3 (en) 2005-12-29

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