CN101010087B - 用于制备金属有机盐的高收率和快速的合成方法 - Google Patents

用于制备金属有机盐的高收率和快速的合成方法 Download PDF

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Publication number
CN101010087B
CN101010087B CN2005800226577A CN200580022657A CN101010087B CN 101010087 B CN101010087 B CN 101010087B CN 2005800226577 A CN2005800226577 A CN 2005800226577A CN 200580022657 A CN200580022657 A CN 200580022657A CN 101010087 B CN101010087 B CN 101010087B
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CN
China
Prior art keywords
strontium
acid
salts
salt
glutamate
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Expired - Fee Related
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CN2005800226577A
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English (en)
Chinese (zh)
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CN101010087A (zh
Inventor
斯蒂芬·克里斯戈
延斯·E·T·安德森
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Osteologix AS
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Osteologix AS
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Priority claimed from PCT/DK2004/000328 external-priority patent/WO2004098619A2/en
Priority claimed from PCT/DK2004/000327 external-priority patent/WO2004098618A2/en
Priority claimed from PCT/DK2004/000326 external-priority patent/WO2004098617A2/en
Application filed by Osteologix AS filed Critical Osteologix AS
Publication of CN101010087A publication Critical patent/CN101010087A/zh
Application granted granted Critical
Publication of CN101010087B publication Critical patent/CN101010087B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/08—Malonic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2005800226577A 2004-05-06 2005-05-05 用于制备金属有机盐的高收率和快速的合成方法 Expired - Fee Related CN101010087B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
PCT/DK2004/000328 WO2004098619A2 (en) 2003-05-07 2004-05-06 Treating cartilage / bone conditions with water-soluble strontium salts
DKPCT/DK2004/000328 2004-05-06
PCT/DK2004/000327 WO2004098618A2 (en) 2003-05-07 2004-05-06 Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions
DKPCT/DK2004/000326 2004-05-06
PCT/DK2004/000326 WO2004098617A2 (en) 2003-05-07 2004-05-06 Controlled release composition containing a strontium salt
DKPCT/DK2004/000327 2004-05-06
DKPA200401708 2004-11-05
DKPA200401708 2004-11-05
PCT/DK2005/000307 WO2005108339A2 (en) 2004-05-06 2005-05-05 High yield and rapid syntheses methods for producing metallo-organic salts

Publications (2)

Publication Number Publication Date
CN101010087A CN101010087A (zh) 2007-08-01
CN101010087B true CN101010087B (zh) 2012-06-27

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CN2005800226577A Expired - Fee Related CN101010087B (zh) 2004-05-06 2005-05-05 用于制备金属有机盐的高收率和快速的合成方法

Country Status (8)

Country Link
US (2) US7589235B2 (https=)
EP (1) EP1744770A2 (https=)
JP (1) JP4954867B2 (https=)
KR (1) KR20110124317A (https=)
CN (1) CN101010087B (https=)
AU (1) AU2005240257B2 (https=)
CA (1) CA2565840A1 (https=)
WO (1) WO2005108339A2 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1622629B1 (en) * 2003-05-07 2013-07-10 Osteologix A/S Controlled-release composition containing a strontium salt
EP1745791B1 (en) 2003-05-07 2013-06-26 Osteologix A/S Treating cartilage/bone conditions with water-soluble strontium salts
ES2394782T3 (es) * 2003-05-07 2013-02-05 Osteologix A/S Composición con estroncio y vitamina D para la profilaxis y/o tratamiento de afecciones de cartílagos y/o huesos
CA2557324C (en) 2004-02-26 2012-10-16 Osteologix A/S Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
SG158073A1 (en) 2004-11-26 2010-01-29 Ucl Business Plc Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy
KR100878140B1 (ko) * 2007-01-29 2009-01-12 한미약품 주식회사 아토바스타틴의 스트론튬염 또는 이의 수화물, 및 이를포함하는 약학 조성물
CN101327203B (zh) * 2007-06-19 2011-03-30 惠州市昆泰精细化工有限公司 没食子酸螯合物组合物及其应用
CA2757373C (en) 2009-04-03 2018-05-08 Ocera Therapeutics, Inc. L-ornithine phenyl acetate and methods of making thereof
EA201691430A1 (ru) 2009-06-08 2017-02-28 ЮСиЭл БИЗНЕС ПиЭлСи Лечение портальной гипертензии и восстановление функции печени с помощью l-орнитинфенилацетата
FR2963837B1 (fr) * 2010-08-10 2012-08-31 Air Liquide Traitement a niveaux multiples pour optimiser une ou plusieurs unites de separation de fluides
MX360062B (es) 2010-10-06 2018-10-22 Ocera Therapeutics Inc Metodos de elaboracion de fenilacetato de l-ornitina.
EP2530068A1 (en) 2011-05-31 2012-12-05 Lacer, S.A. New strontium salts, synthesis and use thereof in the treatment of osteoporosis
CN103173845B (zh) * 2012-01-12 2015-06-03 江苏爱特恩高分子材料有限公司 一种对苯二甲酸金属盐晶须的生产方法与应用
RU2564858C1 (ru) * 2014-06-04 2015-10-10 Закрытое акционерное общество "ЭКОС-1" Способ получения безводного формиата стронция
US10039735B2 (en) 2014-11-24 2018-08-07 Ucl Business Plc Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
JP6464475B2 (ja) * 2015-03-02 2019-02-06 清水建設株式会社 放射性ストロンチウムの分析方法
EP3337473A4 (en) 2015-08-18 2019-04-17 Ocera Therapeutics, Inc. TREATMENT AND PREVENTION OF MUSCLE WOUND BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE
WO2018084959A2 (en) * 2016-09-30 2018-05-11 Nelson Deanna J Pharmaceutical quality strontium l-lactate
CN106699781B (zh) * 2016-12-16 2018-11-16 商丘师范学院 基于衣康酸-吡嗪混合配体的锌(ii)荧光材料及制备方法
WO2018208677A1 (en) 2017-05-11 2018-11-15 Ocera Therapeutics, Inc. Processes of making l-ornithine phenylacetate
CA3068058C (en) 2017-06-27 2023-08-22 Ecolab Usa Inc. Non-phosphorous transition metal control in laundry applications
CN108047155A (zh) * 2017-11-29 2018-05-18 浙江震元制药有限公司 一种双芳基取代的异恶唑化合物的定向制备方法及用途
US11499952B2 (en) 2018-05-11 2022-11-15 Premex, Inc. Process for quantification of metal amino acid chelates in solutions and solids
JP7499259B2 (ja) * 2018-09-25 2024-06-13 ポンス デ レオン ヘルス デジグネイテッド アクティビティ カンパニー αケトグルタル酸カルシウムを製造するためのプロセス
CN109444277B (zh) * 2018-10-29 2021-05-11 郑州大学第一附属医院 代谢标志物在制备胶质瘤诊断试剂盒方面的应用
CN109622238B (zh) * 2018-12-18 2020-07-17 商洛学院 一种用于从金红石重选中矿中浮选回收金红石的药剂组合
CN110668934A (zh) * 2019-10-14 2020-01-10 惠州市志海新威科技有限公司 一种酒石酸锌的制备方法及其在稳定剂中的应用
CN114479098B (zh) * 2021-12-17 2023-05-23 广东石油化工学院 一种可控微介孔金属有机框架hkust-1材料及其制备方法和应用
CN117205363A (zh) * 2023-08-24 2023-12-12 中鼎凯瑞科技成都有限公司 基于没食子酸复合盐的自凝固复合骨植入物及其制备方法
CN119874570A (zh) * 2024-12-16 2025-04-25 天津理工大学 碱土金属甲基磺酸盐化合物及其晶体、制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL77097C (https=) 1952-04-29
US3478083A (en) * 1966-02-01 1969-11-11 Abbott Lab Nor-androstene steroid derivatives
SE340807B (https=) * 1966-05-06 1971-12-06 Astra Ab
US4056567A (en) * 1976-03-08 1977-11-01 Lever Brothers Company Chemical processes for preparing citric acid
DE2913592C2 (de) * 1979-04-04 1988-11-10 Chemische Werke München Otto Bärlocher GmbH, 8000 München Verfahen zur Herstellung von Metallseifen
DE3735264C1 (de) * 1987-10-17 1988-08-25 Degussa Verfahren zur Herstellung von Erdalkalimetallsalzen der L-2-Pyrrolidon-5-carbonsaeure
FR2651497B1 (fr) * 1989-09-01 1991-10-25 Adir Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2658816A1 (fr) * 1990-02-27 1991-08-30 Adir Nouveaux sels de metaux alcalinoterreux d'oxa-polyacides leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2665896A1 (fr) * 1990-08-16 1992-02-21 Rhone Poulenc Chimie Carboxylates metalliques, leur preparation et compositions supraconductrices obtenues a partir de ceux-ci.
JP3566984B2 (ja) * 1994-06-02 2004-09-15 帝人株式会社 骨形成促進剤
FR2749759B1 (fr) * 1996-06-17 1999-11-26 Adir Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
GB9814316D0 (en) 1998-07-02 1998-09-02 Smithkline Beecham Plc Novel compounds
DE19837522A1 (de) * 1998-08-19 2000-02-24 Clariant Gmbh Verwendung von Metall-Carboxylaten und -Sulfonaten als Ladungssteuermittel
US6232497B1 (en) * 1998-12-23 2001-05-15 Skw Trostberg Aktiengesellschaft Method for producing alkali metal and alkaline earth metal pyruvates
NO20014746D0 (no) * 2001-09-28 2001-09-28 Clas M Kjoelberg Smertelindrende middel
FR2844795B1 (fr) * 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
EP1622629B1 (en) * 2003-05-07 2013-07-10 Osteologix A/S Controlled-release composition containing a strontium salt
EP1745791B1 (en) 2003-05-07 2013-06-26 Osteologix A/S Treating cartilage/bone conditions with water-soluble strontium salts
ES2394782T3 (es) 2003-05-07 2013-02-05 Osteologix A/S Composición con estroncio y vitamina D para la profilaxis y/o tratamiento de afecciones de cartílagos y/o huesos
CA2557324C (en) 2004-02-26 2012-10-16 Osteologix A/S Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
US20090035315A1 (en) 2004-06-17 2009-02-05 Stephan Christgau Method of Improving Treatments in Rheumatic and Arthritic Diseases
AU2005254154A1 (en) 2004-06-17 2005-12-29 Osteologix A/S Improving pain treatment with strontium combinations
EP1855654A1 (en) 2005-02-28 2007-11-21 Osteologix A/S Tablets comprising a high load of strontium
AU2006265491A1 (en) 2005-07-06 2007-01-11 Osteologix A/S High yield synthesis methods for producing organic salts of strontium

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
B. Briggman, Å. Oskarsson.The crystal structures of calcium malonate dihydrate and strontium malonate.《Acta Crystallographica Section B》.1977,第33卷(第6期),1900–1906. *

Also Published As

Publication number Publication date
WO2005108339A2 (en) 2005-11-17
US7589235B2 (en) 2009-09-15
US20090291926A1 (en) 2009-11-26
CN101010087A (zh) 2007-08-01
AU2005240257A1 (en) 2005-11-17
JP4954867B2 (ja) 2012-06-20
AU2005240257B2 (en) 2011-11-24
EP1744770A2 (en) 2007-01-24
US8183409B2 (en) 2012-05-22
US20070282127A1 (en) 2007-12-06
KR20110124317A (ko) 2011-11-16
WO2005108339A3 (en) 2005-12-29
CA2565840A1 (en) 2005-11-17
JP2007536288A (ja) 2007-12-13

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