CN101002817A - Medicine composition for treating kidney-yang deficiency and sexual function decrement, and its prepairng method - Google Patents
Medicine composition for treating kidney-yang deficiency and sexual function decrement, and its prepairng method Download PDFInfo
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Abstract
A composite medicine for treating kidney Yang deficiency and sexual dysfunction is prepared from ginseng, pilose antler, epimedium, dragonfly and silkmoth through pre-treating, extracting from silkmoth in alcohol, concentrating, grinding others, mixing, drying, pulverizing, and shaping.
Description
Invention field
The present invention relates to a kind of pharmaceutical composition and preparation technology thereof, particularly a kind of pharmaceutical composition and preparation technology thereof who treats insufficiency of kidney-YANG and sexual hypofunction.
Background technology
The physician investigates discovery, and insufficiency of kidney-YANG and sexual hypofunction disease patient are the trend that rises year by year in recent years, and its seriousness has more caused people's attention.The reason that insufficiency of kidney-YANG and sexual hypofunction take place is many.For a long time, western medicine and medical practitioners is aspect treatment insufficiency of kidney-YANG and sexual hypofunction, and effect is unsatisfactory, takes for a long time, easily medicine is produced dependency, and body is had side effects grievous injury patient's self hepatic and renal function.
At present, the treatment to insufficiency of kidney-YANG and sexual hypofunction is still waiting further perfect.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition, and another purpose of the present invention is to provide this preparation of drug combination method and uses thereof.
The present invention seeks to be achieved through the following technical solutions:
Pharmaceutical composition of the present invention is to make by following bulk drugs:
Radix Ginseng 100-200 weight portion, Herba Epimedii 250-400 weight portion, Cornu Cervi Pantotrichum 10-20 weight portion, Aeschna melanictera 10-20 weight portion, Bombycis mori 10-20 weight portion.
The preferred weight proportioning of above-mentioned five tastes crude drug is as follows:
Radix Ginseng 158 weight portions, Herba Epimedii 315.8 weight portions, Cornu Cervi Pantotrichum 15.8 weight portions, Aeschna melanictera 15.8 weight portions, Bombycis mori 15.8 weight portions.
The preferred weight proportioning of above-mentioned five tastes crude drug is as follows:
Radix Ginseng 110 weight portions, Herba Epimedii 380 weight portions, Cornu Cervi Pantotrichum 11 weight portions, Aeschna melanictera 18 weight portions, Bombycis mori 13 weight portions.
The preferred weight proportioning of above-mentioned five tastes crude drug is as follows:
Radix Ginseng 180 weight portions, Herba Epimedii 280 weight portions, Cornu Cervi Pantotrichum 19 weight portions, Aeschna melanictera 12 weight portions, Bombycis mori 17 weight portions.
The invention described above pharmaceutical composition can also add Fructus Cnidii, Venenum Bufonis, Semen Allii Tuberosi, the Semen Strychni of following weight portion and be made by nine flavor crude drug: Fructus Cnidii 30-70 weight portion, Venenum Bufonis 0.5-2.5 weight portion, Semen Allii Tuberosi 250-400 weight portion, Semen Strychni 3-15 weight portion.The preferred weight proportioning is respectively: Fructus Cnidii 47.4 weight portions, Venenum Bufonis 1.6 weight portions, Semen Allii Tuberosi 315.8 weight portions, Semen Strychni 7.9 weight portions; Fructus Cnidii 35 weight portions, Venenum Bufonis 0.7 weight portion, Semen Allii Tuberosi 380 weight portions, Semen Strychni 12 weight portions; Fructus Cnidii 68 weight portions, Venenum Bufonis 2 weight portions, Semen Allii Tuberosi 260 weight portions, Semen Strychni 5 weight portions.
The caffeine that can also add following weight portion in the invention described above pharmaceutical composition nine flavor crude drug is again made by 10 flavor crude drug: caffeine 3-15 weight portion.The preferred weight proportioning is respectively: caffeine 7.9 weight portions; Caffeine 4 weight portions; Caffeine 12 weight portions.
Pharmaceutical composition crude drug of the present invention adds conventional adjuvant, according to common process, makes clinical acceptable any dosage form, as: capsule, pill, tablet, granule, oral liquid or injection.
The concrete preparation technology of drug composition oral preparation of the present invention is as follows:
Form different according to crude drug, get Bombycis mori crude drug or get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug simply, extract 2-4 time, add the ethanol that medical material 3-8 doubly measures at every turn with the 60-80% alcohol heat reflux, each refluxed 0.5-2 hour, collected reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is the thick paste of 1.15-1.20 when being condensed into 50-55 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Add conventional adjuvant,, make clinical acceptable oral preparation according to common process.
The preferred for preparation method of medicament composition capsule agent of the present invention is as follows:
Form different according to crude drug, get Bombycis mori crude drug or get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug simply, extract three times with 70% alcohol heat reflux, the ethanol that adds for the first time 7 times of amounts of medical material, refluxed 1.5 hours, second and third time adds 4.5 times of amounts, 3.5 times of amounts respectively, and each refluxed 1 hour, collects reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is 1.17 thick paste when being condensed into 52 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Extract powder is played mother with 55% ethanol, and general ball draws light, and drying is encapsulated, promptly.
Pharmaceutical composition of the present invention is formulated by the Chinese medicine of " strengthening the body resistance " " nourishing kidney QI invigorating ", wherein Cornu Cervi Pantotrichum sweet, become, temperature, return kidney, Liver Channel, invigorating kidney-YANG, benefiting essence-blood; Herba Epimedii suffering, temperature are returned kidney, Liver Channel, are longer than warming the kidney to invigorate YANG; Two build up one's health by taking tonic kidney and enhancing bodies, benefit are smart.The sweet temperature of Radix Ginseng, strongly invigorating primordial QI, " by vigour with tonifying five ZANG-organs, by the five internal organs with beneficial shape body "; Bombycis mori Yang nourishing-strengthening, QI invigorating are mended essence, adjusting and reinforcing liver and kidney, strongly invigorating primordial QI, Aeschna melanictera the kidney invigorating and essence nourishing.Fructus Cnidii, Semen Allii Tuberosi suffering, temperature are longer than warming the kidney to invigorate YANG; Caffeine is assembled manner, makes the energy of whole body come together in brain; The bitter temperature of Semen Strychni is returned the liver spleen channel, collateral dredging; Venenum Bufonis is hot to loose " current twelve channels and collaterals, internal organs ", and qi and blood circulation promotion is with the internal organs meridians of supplementing nutrition; Play the merit of kidney invigorating and YANG supporting, benefit essence altogether.Nephroyin and nephroyang is nourished, and then enjoys excellent health, and soreness of the waist and knees must be controlled; The kidney qi abundance, kidney energy store essential substances, the premature ejaculation of then passing out semen, sexual impotence is sterile as to control, and it is normal that growth, growth and reproductive function recover; The kidney qi abundance, gasification is normal, and astringency inducing is had the right, and bladder is opened entire degree of having, and then urine is normal.Pharmaceutical composition property of medicine gentleness of the present invention is mended and not dry, and clothes for a long time suit.Strong, the effect of refreshing oneself is arranged, and energy adjusting maincenter is regulated immunologic function, promotes substance metabolism, promotes sexual function, resisting fatigue, the anti-ageing effect of waiting for a long time.
Have according to zoopery proof pharmaceutical composition of the present invention: (1) has dual regulation excited and that suppress to nervus centralis; (2) effect of androgen sample is arranged; (3) has antifatigue effect; (4) the caused by cyclophosphamide leukopenia there is antagonism; (5) energy human body immunity improving ability; (6) the life lengthening effect is arranged; (7) the inflammation-inhibiting effect is arranged; (8) to hypophysis---adrenal cortex function has excitation.
Also show according to Clinical results: medicament composition capsule agent of the present invention is taken back muscle power and is strengthened, spirit is vigorous, libido strengthens, cold-hartliness strengthens, prolong the length of one's sleep, part diseases such as colitis are alleviated, and minority bald head, rare, poliosis situation are improved, and cellular immune function strengthens.Clinical total effective rate is 92.8%, and liver function, serum cholesterol and triglyceride are all had no adverse effects; The renal excretion function there is not influence.Former medicament composition capsule agent of the present invention can be treated insufficiency of kidney-YANG, all diseases of deficiency of kidney-QI, sexual hypofunction, sexual impotence, premature ejaculation, infertility, alopecia, poliosis, weak and sickly disease such as grade; Help to improve the effect of immune status and each internal organs systemic-function; Help to improve the adaptive functions of body, be considered to safe and effective medicine infection and various environmental changes.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
The effect of experimental example 1 medicament composition capsule androgen sample of the present invention
Choose 50 of the healthy male SD kind children rats of body weight 35～40g, divide equally 5 groups at random, 10 every group.1 group of blank, per os gavages 0.5% carboxymethylcellulose sodium solution, 2 groups is the positive group of androlin, the next day intramuscular injection, dosage is 25mg/kg, 3,4 and 5 groups are medicament composition capsule agent of the present invention, dosage is respectively 200,600 and 1800mg/kg.Every day, per os gavaged 1ml/100gWT, successive administration 1 month.After the last administration 24 hours, animal was weighed and puts to death, and takes out prostate and Seminal vesicle, accurately weighs, and is scaled 100g body weight prostate and Seminal vesicle weight at last.
Table 1 medicament composition capsule agent of the present invention is to the androgen sample effect of young rat.
| Group | Dosage (mg/kg) | Number of animals (only) | Prostate+Seminal vesicle (mg/100g) | T value | The P value |
| Blank | 10 | 96.5±40.3 | |||
| Androlin | 25×15 | 10 | 1604.5±501.6 | 9.48 | ＜0.001 |
| This medicament composition capsule | 200×30 | 10 | 50.2 | 2.17 | ＜0.05 |
| This medicament composition capsule | 600×30 | 10 | 215.9±114.3 | 2.57 | ＜0.05 |
| This medicament composition capsule | 1800×30 | 10 | 215.9±114.3 | 3.12 | ＜0.01 |
Experimental result shows: male young rats gavaged medicament composition capsule 200,600 of the present invention and 1800mg/kg, the prostate and the Seminal vesicle weight of the every 100g body weight of male young rat are increased, and dose-effect relationship is arranged, check through t, compare with the blank group, significant difference (p＜0.05) is arranged.Illustrate that medicament composition capsule agent of the present invention has the effect of androgen sample.
The influence of ear swelling due to the experimental example 2 medicament composition capsule xylol of the present invention
Choose 50 of the healthy male mice in kunming of body weight 25～30g.Divide equally 5 groups at random, 10 every group.1 group of blank, per os gavages 0.5% carboxymethylcellulose sodium solution, and 2 groups is the positive group of aspirin, oral dose 100 mg/kg, 3,4 and 5 groups are medicament composition capsule agent of the present invention, dosage is respectively 200,600 and 1800 mg/kg.Every day, per os gavaged 0.5ml/20g continuous 7 days.After the last administration 30 minutes, dimethylbenzene 0.05ml is dripped in mice left side ear.After 30 minutes, cut two ears, charge and attack two ears that coincide, weigh respectively at analytical balance with the 0.7cm card punch, with two auricle weight differences as the swelling level index.
Table 2 medicament composition capsule agent of the present invention xylol causes the influence of mouse ear swelling
Experimental result shows: male mice gavaged medicament composition capsule 200,600 of the present invention and 1800 mg/kg through 2 days, and animal dimethylbenzene auricular concha swelling degree is obviously alleviated, and through the t check, the administration group is compared with blank group, and significant difference (p＜0.05) is arranged.Illustrate that medicament composition capsule of the present invention has the inflammation-inhibiting effect.
Experimental example 3 medicament composition capsules of the present invention are to the influence of Vitamin C content among the rat adrenal gland
Choose 50 of the healthy male SD kind rats of body weight 130～150g, divide equally 5 groups at random, 10 every group.1 group of blank, per os gavages 0.5% carboxymethylcellulose sodium solution, and 2 groups of positive quiet notes are given birth to arteries and veins liquid, dosage is 5ml/kg, and 3,4 and 5 groups are medicament composition capsule of the present invention, and dosage is for being respectively 200,600 and 1800 mg/kg, every day, per os gavaged 1ml/100g WT, continuous 7 days.1 hour execution animal after the last administration, cut open rapidly and get the bilateral adrenal gland, remove adrenal gland's adhering tissue on every side careful the separation, put into the Potter-Elvehjem Tissue Grinders that has filled 1.5ml 5% trichloroacetic acid after torsion balance is weighed and make homogenate, 3000 rev/mins of homogenate are centrifugal 15 minutes, get supernatant and add acid-washed active carbon 0.3g jolting with sudden force, filter, get filtrate 0.5ml in the 10ml test tube, add 5% trichloroacetic acid 1ml then successively, 1 in 10% sulfur gland and 2,4-dinitrophenylhydrazine 0.5ml, shake up the back and after 1 hour, in ice-water bath, fully cool off, under jolting, dropwise slowly add 3.5ml 185% sulphuric acid liquid in 60 ℃ of water bath with thermostatic control insulations.Blank pipe (5% trichlorine ferment acid) is handled with method, but 2,4 dinitrophenyl hydrazine adds at last.Each pipe is found the concentration of sample contained vitamin C on standard curve after 72 type spectrophotometer 540nm measure optical density, calculate ascorbic content in the 100mg adrenal tissue again.
Table 3 medicament composition capsule of the present invention is to the influence of Vitamin C content among the rat adrenal gland
Experimental result shows: Mus great and mighty or powerful gavaged medicament composition capsule 200,600 of the present invention and 1800 mg/kg through 7 days, made that Vitamin C content obviously descends among the rat adrenal gland, and through the t check, administration group and the comparison of blank group have significant difference (p＜0.05).Illustrating that medicament composition capsule of the present invention is to hypophysis---adrenal cortex function has excitation.
The clinical observation of 4 medicament composition capsule treatment insufficiency of kidney-YANG of experimental example and sexual hypofunction
One, object of study:
Medicament composition capsule treatment group of the present invention: insufficiency of kidney-YANG group 76 examples, sexual hypofunction group 107 examples amount to 183 examples.39～64 years old insufficiency of kidney-YANG group age; 51 years old mean age.26～54 years old sexual hypofunction group age; 35.7 years old mean age.
Placebo group: 21 examples, 27～59 years old age, 40.8 years old mean age
Two, Therapeutic Method:
Medicament composition capsule agent treatment group consumption usage of the present invention is: three times on the one, each 3～5, serveing on for 1～March is a course of treatment; Placebo group clothes equivalent, color, the medicine that flavor is identical; Refuse to obey other tonics at period in a medicine, give up alcohol, suspend when exogenous diseases is arranged and take medicine.
Three, therapeutic outcome:
Compare before and after the treatment of table 9 insufficiency of kidney-YANG cardinal symptom
| Primary symptom | Aversion to cold and cold limbs | Pale complexion | Nocturia | The loose stool | Deficiency of QI with disinclination to talk | Spiritlessness and weakness | Tinnitus | Soreness of the waist and knees | Impotence and premature ejaculation | Sexual hypofunction |
| Treatment precedent number | 103 | 56 | 33 | 30 | 73 | 122 | 78 | 112 | 86 | 99 |
| The routine number in treatment back | 9 | 13 | 4 | 4 | 16 | 25 | 15 | 18 | 20 | 24 |
| Effective percentage % | 91.3 | 76.8 | 88.0 | 86.7 | 78.0 | 80.0 | 80.8 | 84.0 | 77.0 | 75.8 |
The cardinal symptom improvement rate of insufficiency of kidney-YANG and sexual hypofunction is 75.8～91.3% after taking medicine as seen from Table 9.Illustrate take medicament composition capsule of the present invention after, insufficiency of kidney-YANG and sexual hypofunction are that main clinical manifestation all has clear improvement.
Table 10 total effects analytical table
| Grouping | Produce effects | Effectively | Invalid | Total effective rate |
| This medicament composition capsule treatment group (183 example) | 78(42.6％) | 92(50.2％) | 13(7.1％) | 170(92.8％) |
| Matched group (21 example) | 3(14.3％) | 1(19％) | 14(66.6％) | 170(33.3％) |
Take produce effects 78 examples (42.6%) behind the medicament composition capsule of the present invention, effective 92 examples (50.2%), invalid 13 examples (7.1%), total effective rate is 92.8%; The matched group total effective rate is 33.3%, and treatment group and matched group total effective rate compare, and there were significant differences (p＜0.01).
Experimental example 5 special inspection indexs detect
Detected object: 19 people are organized in treatment, matched group 8 people.Special inspection index appraisal standards: treatment group and matched group are all done the own control inspection of treatment front and back, and do statistical analysis.
Testing result:
(1) endocrine function is measured: testosterone: testosterone average 853 ± 282ng/dl before the treatment of treatment group is 975 ± 489ng/dl after the treatment, and testosterone has increase trend.
(2) to Immune Effects:
1, drench rate of rotation: the treatment group: average is 47.8 ± 10.2% before the treatment, and treatment back average is 56.1 ± 8.7%, t=2.68, and there is statistical significance p＜0.05, drenches rate of rotation at the pouring rate of rotation that has before and after the treatment before difference, the pouring rate of rotation after the treatment are higher than treatment.Show that medicament composition capsule of the present invention has the effect of increasing to drenching rate of rotation.
2, E-rosettes: treatment group: after average was 46.4 ± 8.7% treatments before the treatment, average was 59 ± 7.8%, t=3.07, there is statistical significance p＜0.01, E-rosettes value has a difference before and after treatment, after the treatment be higher than treatment before.Show that medicament composition capsule of the present invention has the effect of increasing to E-rosettes value.
Following embodiment all can realize the described effect of above-mentioned experimental example and strengthen with the increase drug action of crude drug.
Embodiment 1:The preparation of tablet
Radix Ginseng 158g, Herba Epimedii 315.8g, Cornu Cervi Pantotrichum 15.8g, Aeschna melanictera 15.8g, Bombycis mori 15.8g.
Get the above-mentioned raw materials medicine, add conventional adjuvant,, make tablet according to common process.This cured substance sexual hypofunction 20 examples.
Embodiment 2:The preparation of oral liquid
Radix Ginseng 180g, Herba Epimedii 280g, Cornu Cervi Pantotrichum 19g, Aeschna melanictera 12g, Bombycis mori 17g, Fructus Cnidii 68g, Venenum Bufonis 2g, Semen Allii Tuberosi 260g, Semen Strychni 5g.Get the above-mentioned raw materials medicine, add conventional adjuvant,, make oral liquid according to common process.
Embodiment 3:Particulate preparation
Radix Ginseng 110g, Herba Epimedii 380g, Cornu Cervi Pantotrichum 11g, Aeschna melanictera 18g, Bombycis mori 13g.
Get Bombycis mori crude drug simply, extract three times with 70% alcohol heat reflux, add the ethanol of 7 times of amounts of medical material for the first time, refluxed 1.5 hours, second and third time adds 4.5 times of amounts, 3.5 times of amounts respectively, and each refluxed 1 hour, collects reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is 1.15 thick paste when being condensed into 55 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Add conventional adjuvant,, make granule according to common process.
Embodiment 5:Capsular preparation
Radix Ginseng 180g, Herba Epimedii 280g, Cornu Cervi Pantotrichum 19g, Aeschna melanictera 12g, Bombycis mori 17g.
Get Bombycis mori crude drug simply, extract 2 times with 65% alcohol heat reflux, add the ethanol of 8 times of amounts of medical material for the first time, refluxed 1.5 hours, second and third time adds 4 times of amounts, 3.2 times of amounts respectively, and each refluxed 1 hour, collects reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is 1.25 thick paste when being condensed into 51 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Extract powder is played mother with 51% ethanol, general ball, coating draws light, and drying is encapsulated, every dress 0.58g.Usage and consumption are: oral, and every day 3 times, each 3-5 grain.This cured substance sexual hypofunction 20 examples.
Embodiment 6:The preparation of pill
Radix Ginseng 110g, Herba Epimedii 380g, Cornu Cervi Pantotrichum 11g, Aeschna melanictera 18g, Bombycis mori 13g, Fructus Cnidii 35g, Venenum Bufonis 0.7g, Semen Allii Tuberosi 380g, Semen Strychni 12g.
Get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug, extract 4 times with 75% alcohol heat reflux, the ethanol that adds for the first time 7.5 times of amounts of medical material, refluxed 1.8 hours, add for the second time the ethanol of 6.5 times of amounts of medical material, refluxed 1.5 hours, third and fourth time adds 5 times of amounts, 4 times of amounts respectively, each refluxed 1.2 hours, collected reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is 1.19 thick paste when being condensed into 54 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Add conventional adjuvant,, make pill according to common process.
Embodiment 7:Capsular preparation
Radix Ginseng 158g, Herba Epimedii 315.8g, Cornu Cervi Pantotrichum 15.8g, Aeschna melanictera 15.8g, Bombycis mori 15.8g, Fructus Cnidii 47.4g, Venenum Bufonis 1.6g, Semen Allii Tuberosi 315.8g, Semen Strychni 7.9g.
Get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug, extract three times, add the ethanol of 7 times of amounts of medical material for the first time with 70% alcohol heat reflux, refluxed 1.5 hours, second and third time adds 4.5 times of amounts, 3.5 times of amounts respectively, and each refluxed 1 hour, collects reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is 1.20 thick paste when being condensed into 50 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Extract powder is played mother with 50% ethanol, general ball, coating draws light, and drying is encapsulated, every dress 0.58g.Usage and consumption are: oral, and every day 3 times, each 3-5 grain.
Embodiment 8:Capsular preparation
Radix Ginseng 158g, Herba Epimedii 315.8g, Cornu Cervi Pantotrichum 15.8g, Aeschna melanictera 15.8g, Bombycis mori 15.8g, Fructus Cnidii 47.4g, Venenum Bufonis 1.6g, Semen Allii Tuberosi 315.8g, Semen Strychni 7.9g, caffeine 7.9g.
Get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug, extract three times, add the ethanol of 7 times of amounts of medical material for the first time with 70% alcohol heat reflux, refluxed 1.5 hours, second and third time adds 4.5 times of amounts, 3.5 times of amounts respectively, and each refluxed 1 hour, collects reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is 1.17 thick paste when being condensed into 52 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Extract powder is played mother with 55% ethanol, and general ball draws light, and drying is encapsulated, every dress 0.32g.Usage and consumption are: oral, and every day 3 times, each 3-5 grain.This cured substance sexual hypofunction 100 example and take nontoxic pair of effect for a long time.
Embodiment 9:Capsular preparation
Radix Ginseng 180g, Herba Epimedii 280g, Cornu Cervi Pantotrichum 19g, Aeschna melanictera 12g, Bombycis mori 17g, Fructus Cnidii 68g, Venenum Bufonis 2g, Semen Allii Tuberosi 260g, Semen Strychni 5g, caffeine 12g.
Get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug, extract 2 times, add the ethanol of 7.5 times of amounts of medical material for the first time, refluxed 1.5 hours, add 4.5 times of amounts for the second time, refluxed 1 hour, collect reflux extracting liquid with 78% alcohol heat reflux; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is 1.18 thick paste when being condensed into 53 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Extract powder is played mother with 53% ethanol, and general ball draws light, and drying is encapsulated, every dress 0.32g.Usage and consumption are: oral, and every day 3 times, each 3-5 grain.This cured substance sexual hypofunction 100 example and take nontoxic pair of effect for a long time.
Claims (18)
1, the hypokinetic pharmaceutical composition of a kind of therapeutic is characterized in that this pharmaceutical composition is to be made by following raw material medicaments in part by weight:
Radix Ginseng 100-200 weight portion Herba Epimedii 250-400 weight portion
Cornu Cervi Pantotrichum 10-20 weight portion Aeschna melanictera 10-20 weight portion
Bombycis mori 10-20 weight portion.
2, pharmaceutical composition as claimed in claim 1, it is characterized in that this pharmaceutical composition is to be made by following raw material medicaments in part by weight: Radix Ginseng 158 weight portions, Herba Epimedii 315.8 weight portions, Cornu Cervi Pantotrichum 15.8 weight portions, Aeschna melanictera 15.8 weight portions, Bombycis mori 15.8 weight portions.
3, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition is to be made by following raw material medicaments in part by weight: Radix Ginseng 110 weight portions, Herba Epimedii 380 weight portions, Cornu Cervi Pantotrichum 11 weight portions, Aeschna melanictera 18 weight portions, Bombycis mori 13 weight portions.
4, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition is to be made by following raw material medicaments in part by weight: Radix Ginseng 180 weight portions, Herba Epimedii 280 weight portions, Cornu Cervi Pantotrichum 19 weight portions, Aeschna melanictera 12 weight portions, Bombycis mori 17 weight portions.
5, as claim 1,2 or 3 described pharmaceutical compositions, it is characterized in that this pharmaceutical composition also adds following bulk drugs: Fructus Cnidii 30-70 weight portion, Venenum Bufonis 0.5-2.5 weight portion, Semen Allii Tuberosi 250-400 weight portion, Semen Strychni 3-15 weight portion.
6, pharmaceutical composition as claimed in claim 5 is characterized in that the crude drug that this pharmaceutical composition adds is: Fructus Cnidii 47.4 weight portions, Venenum Bufonis 1.6 weight portions, Semen Allii Tuberosi 315.8 weight portions, Semen Strychni 7.9 weight portions.
7, pharmaceutical composition as claimed in claim 5 is characterized in that the crude drug that this pharmaceutical composition adds is: Fructus Cnidii 35 weight portions, Venenum Bufonis 0.7 weight portion, Semen Allii Tuberosi 380 weight portions, Semen Strychni 12 weight portions.
8, pharmaceutical composition as claimed in claim 5 is characterized in that the crude drug that this pharmaceutical composition adds is: Fructus Cnidii 68 weight portions, Venenum Bufonis 2 weight portions, Semen Allii Tuberosi 260 weight portions, Semen Strychni 5 weight portions.
9, pharmaceutical composition as claimed in claim 5 is characterized in that this pharmaceutical composition also adds following bulk drugs: caffeine 3-15 weight portion.
10, pharmaceutical composition as claimed in claim 9 is characterized in that the crude drug that this pharmaceutical composition adds is: caffeine 7.9 weight portions.
11, pharmaceutical composition as claimed in claim 9 is characterized in that the crude drug that this pharmaceutical composition adds is: caffeine 4 weight portions.
12, pharmaceutical composition as claimed in claim 9 is characterized in that the crude drug that this pharmaceutical composition adds is: caffeine 12 weight portions.
13, as claim 1,2,3,4,6,7,8,9,10,11 or 12 described preparation of drug combination methods, it is characterized in that this method is: form different according to crude drug, get Bombycis mori crude drug or get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug simply, extract 2-4 time with the 60-80% alcohol heat reflux, add the ethanol that medical material 3-8 doubly measures at every turn, each refluxed 0.5-2 hour, collected reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is the thick paste of 1.15-1.20 when being condensed into 50-55 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Add conventional adjuvant,, make clinical acceptable oral solid formulation according to common process.
14, preparation of drug combination method as claimed in claim 5, it is characterized in that this method is: form different according to crude drug, get Bombycis mori crude drug or get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug simply, extract 2-4 time with the 60-80% alcohol heat reflux, add the ethanol that medical material 3-8 doubly measures at every turn, each refluxed 0.5-2 hour, collected reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is the thick paste of 1.15-1.20 when being condensed into 50-55 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Add conventional adjuvant,, make clinical acceptable oral solid formulation according to common process.
15, preparation of drug combination method as claimed in claim 13, the preparation method that it is characterized in that capsule is: form different according to crude drug, get Bombycis mori crude drug or get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug simply, extract three times with 70% alcohol heat reflux, add for the first time the ethanol of 7 times of amounts of medical material, refluxed 1.5 hours, second and third time adds 4.5 times of amounts, 3.5 times of amounts respectively, each refluxed 1 hour, collected reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is 1.17 thick paste when being condensed into 52 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Extract powder is played mother with 55% ethanol, and general ball draws light, and drying is encapsulated, promptly.
16, preparation of drug combination method as claimed in claim 14, the preparation method that it is characterized in that capsule is: form different according to crude drug, get Bombycis mori crude drug or get Bombycis mori, Fructus Cnidii, scald Semen Strychni and Semen Allii Tuberosi four flavor crude drug simply, extract three times with 70% alcohol heat reflux, add for the first time the ethanol of 7 times of amounts of medical material, refluxed 1.5 hours, second and third time adds 4.5 times of amounts, 3.5 times of amounts respectively, each refluxed 1 hour, collected reflux extracting liquid; Filter, merging filtrate, with the medicinal liquid decompression recycling ethanol, proportion is 1.17 thick paste when being condensed into 52 ℃; All the other crude drug are ground into fine powder; With fine powder and the abundant mixing of above-mentioned thick paste, vacuum drying; Be ground into extract powder; Extract powder is played mother with 55% ethanol, and general ball draws light, and drying is encapsulated, promptly.
17, as claim 1,2,3,4,6,7,8,9,10, the application of 11 or 12 described pharmaceutical compositions in preparation therapeutic hypofunction medicine.
18, the application of pharmaceutical composition as claimed in claim 5 in preparation therapeutic hypofunction medicine.
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| CNB2006100021535A CN100528181C (en) | 2006-01-19 | 2006-01-19 | Medicine composition for treating kidney-yang deficiency and sexual function decrement, and its prepairng method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103549415A (en) * | 2013-10-24 | 2014-02-05 | 北京一品堂医药科技有限公司 | Composition with biological traditional Chinese medicinal prescription for relieving fatigue, invigorating the kidney and strengthening yang, traditional Chinese medicinal preparation, preparation method and application thereof |
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2006
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103549415A (en) * | 2013-10-24 | 2014-02-05 | 北京一品堂医药科技有限公司 | Composition with biological traditional Chinese medicinal prescription for relieving fatigue, invigorating the kidney and strengthening yang, traditional Chinese medicinal preparation, preparation method and application thereof |
| CN103549415B (en) * | 2013-10-24 | 2015-04-29 | 北京一品堂医药科技有限公司 | Composition with biological traditional Chinese medicinal prescription for relieving fatigue, invigorating the kidney and strengthening yang, traditional Chinese medicinal preparation, preparation method and application thereof |
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