CN100586948C - 结晶性抗胆碱能药,其制备方法及其在药物制备中的用途 - Google Patents

结晶性抗胆碱能药,其制备方法及其在药物制备中的用途 Download PDF

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Publication number
CN100586948C
CN100586948C CN02812303A CN02812303A CN100586948C CN 100586948 C CN100586948 C CN 100586948C CN 02812303 A CN02812303 A CN 02812303A CN 02812303 A CN02812303 A CN 02812303A CN 100586948 C CN100586948 C CN 100586948C
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CN
China
Prior art keywords
tiotropium bromide
crystal
anhydrous
preparation
tiotropium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN02812303A
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English (en)
Chinese (zh)
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CN1520294A (zh
Inventor
彼得·西格
乌尔里克·沃思曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
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Boehringer Ingelheim Pharma GmbH and Co KG
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Publication of CN1520294A publication Critical patent/CN1520294A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CN02812303A 2001-06-22 2002-06-08 结晶性抗胆碱能药,其制备方法及其在药物制备中的用途 Expired - Lifetime CN100586948C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10129710.6 2001-06-22
DE10215436.8 2002-04-08
DE10215436 2002-04-08

Publications (2)

Publication Number Publication Date
CN1520294A CN1520294A (zh) 2004-08-11
CN100586948C true CN100586948C (zh) 2010-02-03

Family

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CN02812303A Expired - Lifetime CN100586948C (zh) 2001-06-22 2002-06-08 结晶性抗胆碱能药,其制备方法及其在药物制备中的用途

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EP (1) EP1401445B1 (enExample)
JP (1) JP2005504015A (enExample)
KR (2) KR100971616B1 (enExample)
CN (1) CN100586948C (enExample)
AR (1) AR037491A1 (enExample)
AT (1) ATE337006T1 (enExample)
AU (1) AU2002345016B2 (enExample)
BG (1) BG66303B1 (enExample)
BR (1) BR0210537A (enExample)
CA (1) CA2450961C (enExample)
CO (1) CO5550423A2 (enExample)
CY (1) CY1105223T1 (enExample)
CZ (1) CZ302786B6 (enExample)
DE (1) DE50207943D1 (enExample)
DK (1) DK1401445T3 (enExample)
EA (1) EA005813B1 (enExample)
EE (1) EE05316B1 (enExample)
EG (1) EG24851A (enExample)
ES (1) ES2271280T3 (enExample)
HR (1) HRP20031066B1 (enExample)
HU (1) HUP0400333A3 (enExample)
IL (2) IL159238A0 (enExample)
ME (1) ME00412B (enExample)
MX (1) MXPA03011718A (enExample)
MY (1) MY122779A (enExample)
NO (1) NO334301B1 (enExample)
NZ (1) NZ530690A (enExample)
PE (2) PE20081305A1 (enExample)
PL (1) PL208137B1 (enExample)
PT (1) PT1401445E (enExample)
RS (1) RS50441B (enExample)
SA (1) SA02230255B1 (enExample)
SI (1) SI1401445T1 (enExample)
SK (1) SK287262B6 (enExample)
TW (2) TW200617007A (enExample)
UY (1) UY27342A1 (enExample)
WO (1) WO2003000265A1 (enExample)

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CN101163706A (zh) 2005-04-21 2008-04-16 贝林格尔·英格海姆国际有限公司 用于治疗炎性疾病的二氢噻吩并嘧啶
MX2007012907A (es) 2005-04-28 2008-03-14 Boehringer Ingelheim Int Nuevos compuestos para el tratamiento de enfermedades inflamatorias.
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CN102256963B (zh) 2008-12-19 2014-06-11 贝林格尔.英格海姆国际有限公司 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
WO2010101538A2 (en) 2009-03-06 2010-09-10 Bilgic Mahmut New crystal forms
MX346393B (es) 2009-12-17 2017-03-17 Centrexion Therapeutics Corp Nuevos antagonistas del receptor ccr2 y usos de los mismo.
US20130143905A1 (en) 2009-12-17 2013-06-06 Boehringer Ingelheim International Gmbh Novel antagonists for ccr2 and uses thereof
EP2528915B1 (en) 2010-01-29 2015-10-28 Boehringer Ingelheim International GmbH Substituted naphthyridines and their use as syk kinase inhibitors
JP2013526507A (ja) 2010-05-12 2013-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用
WO2011141477A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
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Also Published As

Publication number Publication date
AR037491A1 (es) 2004-11-17
NO20035696D0 (no) 2003-12-19
CZ2004120A3 (cs) 2004-05-12
KR100971616B1 (ko) 2010-07-22
IL159238A0 (en) 2004-06-01
CA2450961A1 (en) 2003-01-03
HRP20031066B1 (en) 2011-10-31
PL364489A1 (en) 2004-12-13
EE200400029A (et) 2004-04-15
MY122779A (en) 2006-05-31
EP1401445B1 (de) 2006-08-23
EP1401445A1 (de) 2004-03-31
DE50207943D1 (de) 2006-10-05
CN1520294A (zh) 2004-08-11
CO5550423A2 (es) 2005-08-31
ME00412B (me) 2011-10-10
MXPA03011718A (es) 2004-12-06
PL208137B1 (pl) 2011-03-31
JP2005504015A (ja) 2005-02-10
YU99703A (sh) 2006-05-25
EA005813B1 (ru) 2005-06-30
ATE337006T1 (de) 2006-09-15
CY1105223T1 (el) 2010-03-03
AU2002345016B2 (en) 2008-04-17
KR20090031638A (ko) 2009-03-26
SK522004A3 (en) 2004-06-08
KR20040018285A (ko) 2004-03-02
UY27342A1 (es) 2003-02-28
SA02230255B1 (ar) 2006-10-31
HK1068540A1 (zh) 2005-04-29
HRP20031066A2 (en) 2004-04-30
SI1401445T1 (sl) 2007-02-28
BG66303B1 (bg) 2013-03-29
WO2003000265A1 (de) 2003-01-03
KR101011353B1 (ko) 2011-01-28
SK287262B6 (sk) 2010-04-07
EA200301293A1 (ru) 2004-08-26
RS50441B (sr) 2010-03-02
PE20081305A1 (es) 2008-10-01
PT1401445E (pt) 2006-10-31
CZ302786B6 (cs) 2011-11-09
CA2450961C (en) 2010-03-30
BG108440A (bg) 2004-08-31
MEP62008A (en) 2011-05-10
DK1401445T3 (da) 2006-11-27
HUP0400333A2 (hu) 2004-12-28
PE20030130A1 (es) 2003-04-02
IL159238A (en) 2010-04-15
NZ530690A (en) 2005-05-27
TWI261589B (en) 2006-09-11
HUP0400333A3 (en) 2012-10-29
NO334301B1 (no) 2014-02-03
ES2271280T3 (es) 2007-04-16
EE05316B1 (et) 2010-08-16
BR0210537A (pt) 2004-06-22
EG24851A (en) 2010-10-27
TW200617007A (en) 2006-06-01

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