CN100577168C - Cream for treating alopecia and preparation method thereof - Google Patents
Cream for treating alopecia and preparation method thereof Download PDFInfo
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- CN100577168C CN100577168C CN200710200305A CN200710200305A CN100577168C CN 100577168 C CN100577168 C CN 100577168C CN 200710200305 A CN200710200305 A CN 200710200305A CN 200710200305 A CN200710200305 A CN 200710200305A CN 100577168 C CN100577168 C CN 100577168C
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Abstract
The present invention discloses one kind of cream for treating alopecia. The cream is prepared with minoxidil, stearic acid, glycerol monostearate, white vaseline, propylene glycol, sodium thiosulfate, disodium edta, etc. The present invention adopts propylene glycol as both solvent and transdermal promoter, and sodium thiosulfate and disodium edta as antioxidants to prevent the oxidation of minoxidil, so as to result in even high treating effect. The cream of the present invention has obvious treating effect, no irritation, no hypersensitivity, low cost and other advantages, and is used in treating different kinds of alopecia.
Description
Technical field
The present invention relates to a kind of ointment for the treatment of alopecia and preparation method thereof, belong to the technical field of treatment alopecia external used medicine.
Background technology
Alopecia is a kind of commonly encountered diseases, frequently-occurring disease, and is on the increase trend.In the prior art, also have at the medicine of treatment alopecia, but exist the hair growth promoting weak effect, problem such as the course of treatment is long, and price is high.Minoxidil (Minoxidil) is a kind of direct relaxing smooth muscle, and open ATP sensitive potassium channel and bringing high blood pressure down is treatment hypertensive second or three-way medicine, oral surpass January after, the side effect of hirsutism can take place in nearly all patient.Prompting thus: can be used for the treatment of the alopecia disease, we are according to these characteristics, this medicine has been passed through a large amount of repeatedly tests from the preparation process to the clinical practice, and since my Drug Manufacturing Room of institute were from 1989, be mixed with minoxidil tincture always, for the clinical local topical in the court, be used for the treatment of the alopecia case and obtained significant curative effect.But, in process of clinical application, find, because this medicine is to be solvent with ethanol, short in the therapentic part holdup time, needing increases administration number of times, many patients is arranged to ethanol allergy, add and carry inconvenient and dangerous (easily catching fire), the use of this preparation is restricted.
Summary of the invention
The objective of the invention is to: provide that a kind of nothing is irritated, nonirritant, evident in efficacy, the course of treatment is short, cheap, safe to carry, treat ointment of alopecia and preparation method thereof easily.Be used for the treatment of various alopecias such as alopecia areata, male pattern baldness, seborrheic alopecia.
The ointment of treatment alopecia of the present invention, it is that feedstock production by following weight parts obtains: minoxidil 15.0～25.0 grams, stearic acid 100.0～150.0 grams, glyceryl monostearate 50.0～100.0 grams, white vaseline 50.0～100.0 grams, liquid paraffin 150.0～200.0 grams, glycerol 150.0～200.0 grams, 2.0～4.0 milliliters of triethanolamine, sodium lauryl sulphate 1.6～2.0 grams, ethyl hydroxybenzoate 1.0～2.0 grams, sodium thiosulfate 2.5～3.5 grams, disodiumedetate 2.0～3.0 grams, 20.0～25.0 milliliters of propylene glycol.
In order to reach better effect, it can be obtained by the feedstock production of following weight parts: minoxidil 20.0 grams, stearic acid 125.0 grams, glyceryl monostearate 75.0 grams, white vaseline 75.0 grams, liquid paraffin 175.0 grams, glycerol 175.0 grams, 3.0 milliliters of triethanolamine, sodium lauryl sulphate 1.8 grams, ethyl hydroxybenzoate 1.5 grams, sodium thiosulfate 3.0 grams, disodiumedetate 2.5 grams, 23.0 milliliters of propylene glycol.
In above-mentioned raw materials, add essence 0.6～1.2 gram, add 456～186 milliliters of distilled water.Perhaps in above-mentioned raw materials, add essence 0.9 gram, add 322.0 milliliters of distilled water.
The present invention treats the preparation method of alopecia ointment, takes by weighing stearic acid, glyceryl monostearate, liquid Paraffin, white vaseline, heating by above-mentioned weight portion and dissolves, and is incubated 80～90 ℃ and makes oil phase; With adding triethanolamine, sodium lauryl sulphate, glycerol behind hot water dissolving's ethyl hydroxybenzoate, be incubated again to 82～92 ℃ and make water; Oil phase is added aqueous phase, and same direction limit edged stirs to solidifying, and it is standby to obtain oil-in-water (O/W) type emulsifiable paste matrix; Again minoxidil is dissolved in propylene glycol, getting sodium thiosulfate, disodiumedetate dissolves in water and both is ground into pasty state, add oil-in-water (O/W) type emulsifiable paste matrix by amount (according to the equivalent method of progressively increasing) then, the limit edged stirs (same direction), add essence again, stirring and evenly mixing is sub-packed in the sealing light resistant container, preserves below 25 ℃ to get final product.
The applicant is the cream preparation of substrate by having prepared with O/W type emulsifiable paste, has overcome the shortcoming of minoxidil tincture, and through clinical practice, this preparation has and does not have allergy, non-stimulated, safe to carry, convenient, long in the therapentic part holdup time, the advantage that administration number of times is few.The applicant has done a large amount of tests ointment of the present invention has been verified, when selecting the raw material of ointment, find that minoxidil is water insoluble, after it is dissolved in propylene glycol, mix with the emulsifiable paste matrix for preparing again, reach the purpose of abundant mix homogeneously.Propylene glycol is a solvent, also is transdermal enhancer, can promote the penetrating scalp that enters of medicine.In the minoxidil structure-N is very easily oxidized, and according to test, the mode of taking to grind simultaneously adds 0.25% sodium thiosulfate and 0.2% disodiumedetate as antioxidation, better effects if.The result confirms this preparation after room temperature is placed 9 months, and its appearance color and pH value all change less, no oil-water separation and flatulence phenomenon, and the content of its principal agent is in acceptability limit after measured.
Ointment of the present invention is made skin irritation test: choose the healthy adult rabbit, the male and female number is close, in the depilation of rabbit back spinal column both sides, keeps skin complete before administration.During test the hair tonic emulsifiable paste is coated on depilation district, right side, emulsifiable paste matrix is coated on depilation district, left side makes blank, 2 times on the one, totally 7 days, observe coating part, there is no redness, erosion, show this preparation nonirritant.
Ointment of the present invention is made skin anaphylactic test: choose the healthy adult albino guinea-pig, male and female half and half, 24h is divided into 2 groups with guinea pig back both sides unhairing at random with Cavia porcellus before test, the contrast of the 1st group of coating emulsifiable paste matrix, the 2nd group of coating hair tonic emulsifiable paste, 2 times on the one, totally 7 days, observe coating part, 2 groups there is no erythema, edema, show that this preparation does not have skin hypersensitivity.
Ointment of the present invention is used for the alopecia patient, and therapeutic outcome is as follows:
Case selects 228 routine hair loss patients to be clinic case, gets rid of hypertension, diabetes and hepatorenal disease patient.228 examples are divided into two groups at random, and 193 examples are organized in treatment, male 113 examples, women 80 examples, 18～54 years old age, average 35 years old, wherein multiple alopecia areata (alopecia place＞3) 102 examples, alopecia totalis 51 examples, alopecia universalis 40 examples; The course of disease 1～4 year (average 1.6 years).Matched group 35 examples, male 21 examples, women 14 examples, 19～56 years old age, average 37 years old, the course of disease 1～4 year (average 1.7 years), its alopecia degree is similar with the treatment group.Two groups of patients have comparability.
Medication treatment group is embrocated in alopecia place with emulsifiable paste of the present invention, and every day 1～2 time, be 3～6 weeks the course of treatment.Matched group is embrocated in alopecia place with emulsifiable paste matrix, and every day 1～2 time, the course of treatment is the same, kowtows to hit with percussopunctator simultaneously for two groups and embrocates fresh ginger juice after alopecia place makes erubescence, and two groups are not used other drug during the treatment.
The efficacy assessment standard recovery from illness: the New Development growth, it is close to distribute, hair thickness, the same normal hair of color and luster; Produce effects: New Development growth＞70%, the hair thickness, color and luster is near normal; Effectively: New Development growth 10%～70%, comprise the growth of fine hair on birds or animals hair, color and luster is black or white; Invalid: as to observe New Development growth＜10% or continuation alopecia 5 months.
The therapeutic outcome curative effect is seen attached list.
Two groups of treatments of subordinate list alopecia case curative effect relatively
Untoward reaction is used in the emulsifiable paste process of the present invention, and untoward reaction does not appear in the patient.
The specific embodiment
Embodiments of the invention: minoxidil 20 grams, stearic acid 100 grams, glyceryl monostearate 50 grams, white vaseline 50 grams, liquid paraffin 150 grams, glycerol 150 grams, triethanolamine 2ml, sodium lauryl sulphate 1.6 grams, ethyl hydroxybenzoate 1 gram, sodium thiosulfate 2.5 grams, disodiumedetate 2.1 grams, 20 milliliters of propylene glycol, essence 0.9 gram, residue adds distilled water, and total amount adds to 1000g.
Take by weighing stearic acid, glyceryl monostearate, liquid Paraffin, white vaseline, heating and melting by above-mentioned weight portion, be incubated about 82 ℃ and make oil phase.
With adding triethanolamine, sodium lauryl sulphate, glycerol behind an amount of hot water dissolving's ethyl hydroxybenzoate, be incubated again to about 80 ℃.Oil phase is slowly added aqueous phase limit edged stir to solidifying, it is standby promptly to get O/W type emulsifiable paste matrix.Again minoxidil is dissolved in propylene glycol, get that sodium thiosulfate, disodiumedetate dissolve and both are ground into pasty state in low amounts of water and add emulsifiable paste matrix limit edged by amount and stir (same direction) and add essence, stirring and evenly mixing is sub-packed in the sealing light resistant container, preserves below 25 ℃ to get final product.
During use ointment is embrocated in alopecia place, every day 1～2 time, be 3～6 weeks the course of treatment.
Claims (6)
1. ointment for the treatment of alopecia, it is characterized in that: it is that feedstock production by following weight parts obtains: minoxidil 15.0～25.0 grams, stearic acid 100.0～150.0 grams, glyceryl monostearate 50.0～100.0 grams, white vaseline 50.0～100.0 grams, liquid paraffin 150.0～200.0 grams, glycerol 150.0～200.0 grams, 2.0～4.0 milliliters of triethanolamine, sodium lauryl sulphate 1.6～2.0 grams, ethyl hydroxybenzoate 1.0～2.0 grams, sodium thiosulfate 2.5～3.5 grams, disodiumedetate 2.0～3.0 grams, 20.0～25.0 milliliters of propylene glycol.
2. the ointment of treatment alopecia according to claim 1 is characterized in that: it is that feedstock production by following weight parts obtains: minoxidil 20.0 grams, stearic acid 125.0 grams, glyceryl monostearate 75.0 grams, white vaseline 75.0 grams, liquid paraffin 175.0 grams, glycerol 175.0 grams, 3.0 milliliters of triethanolamine, sodium lauryl sulphate 1.8 grams, ethyl hydroxybenzoate 1.5 grams, sodium thiosulfate 3.0 grams, disodiumedetate 2.5 grams, 23.0 milliliters of propylene glycol.
3. the ointment of treatment alopecia according to claim 1 is characterized in that: add essence 0.6～1.2 gram in above-mentioned raw materials, add 456～186 milliliters of distilled water.
4. the ointment of treatment alopecia according to claim 3 is characterized in that: adding essence in above-mentioned raw materials is 0.9 gram, and adding distilled water is 330 milliliters.
5. as the preparation method of claim 1 or the described treatment alopecia of 2 arbitrary claim ointment, it is characterized in that: take by weighing stearic acid, glyceryl monostearate, liquid Paraffin, white vaseline, heating and melting by above-mentioned weight portion, be incubated 80～90 ℃ and make oil phase; With adding triethanolamine, sodium lauryl sulphate, glycerol behind hot water dissolving's ethyl hydroxybenzoate, be incubated again to 82～92 ℃ and make water; Oil phase is added aqueous phase, and same direction limit edged stirs to solidifying, and it is standby to obtain the oil-in-water type emulsifiable paste matrix; Again minoxidil is dissolved in propylene glycol, get sodium thiosulfate, disodiumedetate and in water, dissolve and both are ground into pasty state, add the oil-in-water type emulsifiable paste matrix by amount then, the limit edged stirs, stirring and evenly mixing is sub-packed in the sealing light resistant container, preserves below 25 ℃ to get final product.
6. as the preparation method of claim 3 or the described treatment alopecia of 4 arbitrary claim ointment, it is characterized in that: take by weighing stearic acid, glyceryl monostearate, liquid Paraffin, white vaseline, heating and melting by above-mentioned weight portion, be incubated 80～90 ℃ and make oil phase; With adding triethanolamine, sodium lauryl sulphate, glycerol behind hot water dissolving's ethyl hydroxybenzoate, be incubated again to 82～92 ℃ and make water; Oil phase is added aqueous phase, and same direction limit edged stirs to solidifying, and it is standby to obtain the oil-in-water type emulsifiable paste matrix; Again minoxidil is dissolved in propylene glycol, getting sodium thiosulfate, disodiumedetate dissolves in water and both is ground into pasty state, add the oil-in-water type emulsifiable paste matrix by amount then, the limit edged stirs, add essence again, stirring and evenly mixing is sub-packed in the sealing light resistant container, preserves below 25 ℃ to get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710200305A CN100577168C (en) | 2007-03-21 | 2007-03-21 | Cream for treating alopecia and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710200305A CN100577168C (en) | 2007-03-21 | 2007-03-21 | Cream for treating alopecia and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101019868A CN101019868A (en) | 2007-08-22 |
| CN100577168C true CN100577168C (en) | 2010-01-06 |
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| CN200710200305A Expired - Fee Related CN100577168C (en) | 2007-03-21 | 2007-03-21 | Cream for treating alopecia and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105848640A (en) * | 2013-12-23 | 2016-08-10 | 强生消费者公司 | Topical gel compositions including polycaprolactone polymer and methods for enhancing the topical application of a benefit agent |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800150A (en) * | 2015-05-13 | 2015-07-29 | 常州市第四制药厂有限公司 | Minoxidil cream and preparation method thereof |
| WO2017061610A1 (en) * | 2015-10-07 | 2017-04-13 | 国立研究開発法人理化学研究所 | Hair growth composition |
| CN107802512B (en) * | 2017-12-07 | 2020-06-09 | 武汉大学 | Vitamin E nanoemulsion, nano cream and preparation method thereof |
| CN110755286A (en) * | 2019-11-18 | 2020-02-07 | 童婧 | Hairline filling composition helpful for hair growth |
| CN112891299A (en) * | 2021-02-01 | 2021-06-04 | 遵义医科大学附属医院 | Brazilian hematoxylin emulsifiable paste and preparation method thereof |
| CN117815169A (en) * | 2024-03-04 | 2024-04-05 | 山东第二医科大学 | Repair paste rich in concentrated growth factors, preparation method and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139619A (en) * | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| US4596812A (en) * | 1976-05-24 | 1986-06-24 | The Upjohn Company | Methods and solutions for treating male pattern alopecia |
| CN1244113A (en) * | 1997-01-23 | 2000-02-09 | 大正制药株式会社 | Persistent hair tonic |
| CN1857268A (en) * | 2005-04-30 | 2006-11-08 | 深圳市天和医药科技开发有限公司 | Minoxidil solution and preparing method of minoxidil liniment tablet |
-
2007
- 2007-03-21 CN CN200710200305A patent/CN100577168C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139619A (en) * | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| US4596812A (en) * | 1976-05-24 | 1986-06-24 | The Upjohn Company | Methods and solutions for treating male pattern alopecia |
| CN1244113A (en) * | 1997-01-23 | 2000-02-09 | 大正制药株式会社 | Persistent hair tonic |
| CN1857268A (en) * | 2005-04-30 | 2006-11-08 | 深圳市天和医药科技开发有限公司 | Minoxidil solution and preparing method of minoxidil liniment tablet |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105848640A (en) * | 2013-12-23 | 2016-08-10 | 强生消费者公司 | Topical gel compositions including polycaprolactone polymer and methods for enhancing the topical application of a benefit agent |
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| CN101019868A (en) | 2007-08-22 |
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