CN100558727C - 喹唑啉生物碱类产品的制备方法 - Google Patents

喹唑啉生物碱类产品的制备方法 Download PDF

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Publication number
CN100558727C
CN100558727C CNB2004800034182A CN200480003418A CN100558727C CN 100558727 C CN100558727 C CN 100558727C CN B2004800034182 A CNB2004800034182 A CN B2004800034182A CN 200480003418 A CN200480003418 A CN 200480003418A CN 100558727 C CN100558727 C CN 100558727C
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CN
China
Prior art keywords
compound
accordance
iii
reaction mixture
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800034182A
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English (en)
Chinese (zh)
Other versions
CN1745084A (zh
Inventor
约奇姆·莫尔曼
汉斯来纳·霍夫曼
鲁道夫·玛土奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HF Arzneimittelforschung GmbH and Co KG
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HF Arzneimittelforschung GmbH and Co KG
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Application filed by HF Arzneimittelforschung GmbH and Co KG filed Critical HF Arzneimittelforschung GmbH and Co KG
Publication of CN1745084A publication Critical patent/CN1745084A/zh
Application granted granted Critical
Publication of CN100558727C publication Critical patent/CN100558727C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
CNB2004800034182A 2003-02-03 2004-01-22 喹唑啉生物碱类产品的制备方法 Expired - Fee Related CN100558727C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10304141A DE10304141B4 (de) 2003-02-03 2003-02-03 Verfahren zur Herstellung von Chinazolin-Alkaloiden
DE10304141.9 2003-02-03

Publications (2)

Publication Number Publication Date
CN1745084A CN1745084A (zh) 2006-03-08
CN100558727C true CN100558727C (zh) 2009-11-11

Family

ID=32747532

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800034182A Expired - Fee Related CN100558727C (zh) 2003-02-03 2004-01-22 喹唑啉生物碱类产品的制备方法

Country Status (25)

Country Link
US (1) US7495096B2 (https=)
EP (1) EP1590351B1 (https=)
JP (1) JP2006516578A (https=)
KR (1) KR20050096165A (https=)
CN (1) CN100558727C (https=)
AR (1) AR042946A1 (https=)
AT (1) ATE407135T1 (https=)
AU (1) AU2004208873B2 (https=)
BR (1) BRPI0407012A (https=)
CA (1) CA2514945A1 (https=)
DE (2) DE10304141B4 (https=)
DK (1) DK1590351T3 (https=)
EA (1) EA009047B1 (https=)
ES (1) ES2314366T3 (https=)
MX (1) MXPA05008179A (https=)
MY (1) MY141734A (https=)
NO (1) NO20053689L (https=)
NZ (1) NZ541101A (https=)
PL (1) PL378406A1 (https=)
PT (1) PT1590351E (https=)
SI (1) SI1590351T1 (https=)
TW (1) TW200418811A (https=)
UA (1) UA81287C2 (https=)
WO (1) WO2004069836A1 (https=)
ZA (1) ZA200505160B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004048927A1 (de) * 2004-10-06 2006-04-20 Lts Lohmann Therapie-Systeme Ag Pharmazeutische Kombination enthaltend Desoxypeganin und Cyp2D6 Inhibitoren
EP3661502A4 (en) 2017-08-03 2020-12-02 Galectin Sciences, LLC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF MEDICAL CONDITIONS AND THEIR USES
KR102728780B1 (ko) * 2021-11-30 2024-11-08 이화여자대학교 산학협력단 데옥시바시시논을 유효성분으로 포함하는 미백용 조성물 및 상기 데옥시바시시논 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU605614A1 (ru) * 1971-10-20 1978-05-05 Ордена Трудового Красного Знамени Институт Химии Растительных Веществ Ан Узбекской Сср Антихолинэстеразное средство
JP3180464B2 (ja) * 1991-08-30 2001-06-25 新日本理化株式会社 ジアセタール化合物の製造方法
DE19530606A1 (de) * 1995-08-21 1997-02-27 Basf Ag 1-(Pyridyl)-pyrazole
JP3958452B2 (ja) * 1997-10-31 2007-08-15 大日精化工業株式会社 新規化学発光試薬及びその製造方法
DE19906975B4 (de) 1999-02-19 2004-04-15 Lts Lohmann Therapie-Systeme Ag Arzneiform zur Behandlung von Alzheimer'scher Demenz
DE19906979B4 (de) 1999-02-19 2004-07-08 Lts Lohmann Therapie-Systeme Ag Verwendung von Desoxypeganin zur Behandlung der Nikotinabhängigkeit
DE19906978B4 (de) 1999-02-19 2004-07-08 Lts Lohmann Therapie-Systeme Ag Pharmazeutische Zusammensetzung enthaltend Desoxypeganin zur Behandlung der Drogenabhängigkeit

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"Amidines. 5. Synthesis of... JEN T. ET AL.JOURNAL OF MEDICINAL CHEMISTRY,Vol.Vol 16 No.No.6. 1973
"Amidines. 5. Synthesis of... JEN T. ET AL.JOURNAL OF MEDICINAL CHEMISTRY,Vol.Vol 16 No.No.6. 1973 *
"Microwave-assisted rapid ... YADAV, J.S. et al.TETRAHEDRON LETTERS,Vol.Vol 43 . 2002
"Microwave-assisted rapid ... YADAV, J.S. et al.TETRAHEDRON LETTERS,Vol.Vol 43 . 2002 *
"Uber Derivate des Peganins und ihre Ring-Homologen. SPATH, E., PLATZER, N.CHEMISCHE BERICHTE. 1935
"Uber Derivate des Peganins und ihre Ring-Homologen. SPATH, E., PLATZER, N.CHEMISCHE BERICHTE. 1935 *
AL"Amidines.5.Synthesis of...". JENT.ET.JOURNAL OF MEDICINAL CHEMISTRY,Vol.16 No.6. 1973
AL"Amidines.5.Synthesis of...". JENT.ET.JOURNAL OF MEDICINAL CHEMISTRY,Vol.16 No.6. 1973 *

Also Published As

Publication number Publication date
PL378406A1 (pl) 2006-04-03
EA009047B1 (ru) 2007-10-26
MXPA05008179A (es) 2006-02-17
MY141734A (en) 2010-06-15
AU2004208873B2 (en) 2009-12-17
HK1075898A1 (zh) 2005-12-30
DE502004007980D1 (de) 2008-10-16
ZA200505160B (en) 2007-01-31
CA2514945A1 (en) 2004-08-19
US7495096B2 (en) 2009-02-24
KR20050096165A (ko) 2005-10-05
UA81287C2 (en) 2007-12-25
EP1590351B1 (de) 2008-09-03
EA200501135A1 (ru) 2006-02-24
ES2314366T3 (es) 2009-03-16
AU2004208873A1 (en) 2004-08-19
WO2004069836A1 (de) 2004-08-19
US20060084669A1 (en) 2006-04-20
BRPI0407012A (pt) 2006-01-10
DK1590351T3 (da) 2008-12-15
PT1590351E (pt) 2008-11-21
DE10304141B4 (de) 2006-03-09
JP2006516578A (ja) 2006-07-06
AR042946A1 (es) 2005-07-06
TW200418811A (en) 2004-10-01
DE10304141A1 (de) 2004-08-26
EP1590351A1 (de) 2005-11-02
NZ541101A (en) 2009-03-31
SI1590351T1 (sl) 2009-02-28
ATE407135T1 (de) 2008-09-15
NO20053689L (no) 2005-07-29
CN1745084A (zh) 2006-03-08

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Termination date: 20120122