CN100528146C - 控制活性成分释放的治疗系统 - Google Patents

控制活性成分释放的治疗系统 Download PDF

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Publication number
CN100528146C
CN100528146C CNB038094851A CN03809485A CN100528146C CN 100528146 C CN100528146 C CN 100528146C CN B038094851 A CNB038094851 A CN B038094851A CN 03809485 A CN03809485 A CN 03809485A CN 100528146 C CN100528146 C CN 100528146C
Authority
CN
China
Prior art keywords
layer
tablet
coating
release
therapy system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038094851A
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English (en)
Chinese (zh)
Other versions
CN1649571A (zh
Inventor
L·马吉
U·孔特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jagotec AG
Original Assignee
Jagotec AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jagotec AG filed Critical Jagotec AG
Publication of CN1649571A publication Critical patent/CN1649571A/zh
Application granted granted Critical
Publication of CN100528146C publication Critical patent/CN100528146C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB038094851A 2002-03-12 2003-03-12 控制活性成分释放的治疗系统 Expired - Fee Related CN100528146C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000514A ITMI20020514A1 (it) 2002-03-12 2002-03-12 Sistema terapeutico per il rilascio controllato di uno o piu' principi attivi
ITMI2002A000514 2002-03-12

Publications (2)

Publication Number Publication Date
CN1649571A CN1649571A (zh) 2005-08-03
CN100528146C true CN100528146C (zh) 2009-08-19

Family

ID=11449490

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038094851A Expired - Fee Related CN100528146C (zh) 2002-03-12 2003-03-12 控制活性成分释放的治疗系统

Country Status (12)

Country Link
US (1) US20050095295A1 (enExample)
EP (1) EP1482915B1 (enExample)
JP (1) JP4664595B2 (enExample)
CN (1) CN100528146C (enExample)
AT (1) ATE454887T1 (enExample)
AU (1) AU2003239789A1 (enExample)
CA (1) CA2478406C (enExample)
DE (1) DE60330949D1 (enExample)
DK (1) DK1482915T3 (enExample)
ES (1) ES2339438T3 (enExample)
IT (1) ITMI20020514A1 (enExample)
WO (1) WO2003075897A1 (enExample)

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WO2003024430A1 (en) 2001-09-21 2003-03-27 Egalet A/S Morphine polymer release system
EP1429739A1 (en) 2001-09-21 2004-06-23 Egalet A/S Polymer release system
GB0203296D0 (en) 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
ES2570454T3 (es) 2003-03-26 2016-05-18 Egalet Ltd Sistema de liberación controlada de morfina
UA85850C2 (uk) * 2003-09-19 2009-03-10 Сан Фарма Адвансед Ресьорч Компані Лтд. Оральна система доставки лікарського препарату
US10226428B2 (en) 2003-09-19 2019-03-12 Sun Pharma Advanced Research Company Ltd. Oral drug delivery system
US10213387B2 (en) 2003-09-19 2019-02-26 Sun Pharma Advanced Research Company Ltd. Oral drug delivery system
CA2607272A1 (en) * 2005-05-09 2006-11-16 Azur Pharma Limited Formulations of mast cell stabilizing agents for delivery to the colon
AU2006254554B2 (en) * 2005-06-03 2011-11-24 Egalet Ltd A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids
JP5259413B2 (ja) * 2005-11-18 2013-08-07 エーシーシーユー−ブレイク テクノロジーズ，インク． セグメント化した薬の剤形
WO2007149860A1 (en) * 2006-06-19 2007-12-27 Accu-Break Technologies, Inc. Segmented pharmaceutical dosage forms
EP2155167A2 (en) 2007-06-04 2010-02-24 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
MX2010008861A (es) * 2008-02-15 2011-02-22 Sun Pharma Advanced Res Co Ltd Tableta oral de liberacion controlada con efecto de liberacion masiva reducido.
US20100112052A1 (en) * 2008-10-31 2010-05-06 Vincent Chen Osmotic tablet with a compressed outer coating
WO2010089132A1 (en) 2009-02-06 2010-08-12 Egalet A/S Immediate release composition resistant to abuse by intake of alcohol
CA2751627A1 (en) 2009-02-06 2010-08-12 Egalet Ltd. Pharmaceutical compositions resistant to abuse
CA2766179A1 (en) 2009-06-24 2010-12-29 Egalet Ltd. Controlled release formulations
EP2726062A1 (en) * 2011-06-29 2014-05-07 Ranbaxy Laboratories Limited Multilayered dosage form
CN104684548A (zh) 2012-07-06 2015-06-03 埃格勒特有限责任公司 防止滥用的控释药物组合物
CN104490838B (zh) * 2014-11-20 2017-03-01 河北医科大学 一种骨架型缓控释片剂及其制备方法和应用
DK3411031T3 (da) 2016-02-04 2024-10-21 Cindome Pharma Inc Deutererede domperidonpræparater og fremgangsmåder til terapi af lidelser
EP3981392A1 (en) * 2016-05-05 2022-04-13 Triastek, Inc. Controlled release dosage form
DK3592337T3 (da) 2017-03-08 2023-09-18 Cinrx Pharma Llc Farmaceutiske formuleringer af phloroglucinol og trimethylphloroglucinol
KR20240125702A (ko) 2017-06-30 2024-08-19 신돔 파마, 인크. 중수소화 돔페리돈 조성물, 방법, 및 제조
US12478612B2 (en) 2017-06-30 2025-11-25 Cindome Pharma, Inc. Deuterated domperidone compositions, methods, and preparation
EP3970701B1 (en) * 2018-06-27 2025-05-07 Amneal Complex Products Research LLC Self-regulating osmotic gastroretentive drug delivery systems
WO2020027927A1 (en) * 2018-07-30 2020-02-06 Insta Therapeutics, Inc. Sublingual diltiazem and methods of use
CN113274363B (zh) * 2021-04-29 2023-02-10 珠海润都制药股份有限公司 一种吲达帕胺制剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2213539Y (zh) * 1994-04-29 1995-11-29 天津市激光技术研究所 包衣上带有小孔的缓释药片
US5650169A (en) * 1993-05-31 1997-07-22 Jagotec Ag Pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times

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GB1478759A (en) * 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US4077407A (en) * 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4503030A (en) * 1983-06-06 1985-03-05 Alza Corporation Device for delivering drug to certain pH environments
IT1201136B (it) * 1987-01-13 1989-01-27 Resa Farma Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive
US4810502A (en) * 1987-02-27 1989-03-07 Alza Corporation Pseudoephedrine brompheniramine therapy
IT1237904B (it) * 1989-12-14 1993-06-18 Ubaldo Conte Compresse a rilascio a velocita' controllata delle sostanze attive
US5256440A (en) * 1992-06-22 1993-10-26 Merck & Co., Inc. Process for producing a tablet core aperture
US5376771A (en) * 1992-07-07 1994-12-27 Merck & Co., Inc. High speed process for preparing orifices in pharmaceutical dosage forms
IT1255522B (it) * 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
IT1282576B1 (it) * 1996-02-06 1998-03-31 Jagotec Ag Compressa farmaceutica atta a cedere la sostanza attiva in tempi successivi e predeterminabili
US5783793A (en) * 1996-02-29 1998-07-21 Merck & Co., Inc. Process for producing a plurality of holes in dosage forms using a laser beam deflected by an acousto-optic deflector
CN1158071C (zh) * 1997-05-30 2004-07-21 渗透有限公司 多层渗透装置
US6004584A (en) * 1998-03-02 1999-12-21 The Procter & Gamble Company Highly absorbent body powders
CA2378829A1 (en) * 1999-07-20 2001-01-25 Merck & Co., Inc. Sustained release drug dispersion delivery device
AR026148A1 (es) * 2000-01-21 2003-01-29 Osmotica Argentina S A Dispositivo osmotico con pasaje preformado que aumenta de tamano
AR030557A1 (es) * 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650169A (en) * 1993-05-31 1997-07-22 Jagotec Ag Pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times
CN2213539Y (zh) * 1994-04-29 1995-11-29 天津市激光技术研究所 包衣上带有小孔的缓释药片

Also Published As

Publication number Publication date
CA2478406C (en) 2011-02-08
ITMI20020514A1 (it) 2003-09-12
WO2003075897A1 (en) 2003-09-18
ITMI20020514A0 (it) 2002-03-12
CN1649571A (zh) 2005-08-03
ATE454887T1 (de) 2010-01-15
JP2005526757A (ja) 2005-09-08
ES2339438T3 (es) 2010-05-20
EP1482915A1 (en) 2004-12-08
AU2003239789A1 (en) 2003-09-22
DK1482915T3 (da) 2010-04-19
JP4664595B2 (ja) 2011-04-06
DE60330949D1 (de) 2010-03-04
CA2478406A1 (en) 2003-09-18
US20050095295A1 (en) 2005-05-05
EP1482915B1 (en) 2010-01-13

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Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090819

Termination date: 20180312