CN100522956C - 取代的聚酮化合物,包含它们的药物组合物及其在治疗肿瘤中的用途 - Google Patents

取代的聚酮化合物,包含它们的药物组合物及其在治疗肿瘤中的用途 Download PDF

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Publication number
CN100522956C
CN100522956C CNB028154991A CN02815499A CN100522956C CN 100522956 C CN100522956 C CN 100522956C CN B028154991 A CNB028154991 A CN B028154991A CN 02815499 A CN02815499 A CN 02815499A CN 100522956 C CN100522956 C CN 100522956C
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China
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formula
och
hours
alkyl
perhaps
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Expired - Fee Related
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CNB028154991A
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English (en)
Chinese (zh)
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CN1538964A (zh
Inventor
F·R·小欣德
K·W·贝尔
T·M·拉姆齐
M·L·萨比奥
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Novartis AG
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Novartis AG
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Publication of CN100522956C publication Critical patent/CN100522956C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB028154991A 2001-08-06 2002-08-05 取代的聚酮化合物,包含它们的药物组合物及其在治疗肿瘤中的用途 Expired - Fee Related CN100522956C (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US31030701P 2001-08-06 2001-08-06
US60/310,307 2001-08-06
US34453201P 2001-10-25 2001-10-25
US60/344,532 2001-10-25
US34118901P 2001-12-13 2001-12-13
US60/341,189 2001-12-13
US34904702P 2002-01-16 2002-01-16
US60/349,047 2002-01-16
US35899702P 2002-02-22 2002-02-22
US60/358,997 2002-02-22

Publications (2)

Publication Number Publication Date
CN1538964A CN1538964A (zh) 2004-10-20
CN100522956C true CN100522956C (zh) 2009-08-05

Family

ID=27540954

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028154991A Expired - Fee Related CN100522956C (zh) 2001-08-06 2002-08-05 取代的聚酮化合物,包含它们的药物组合物及其在治疗肿瘤中的用途

Country Status (7)

Country Link
US (2) US6972292B2 (enExample)
EP (1) EP1417195A1 (enExample)
JP (1) JP4243183B2 (enExample)
CN (1) CN100522956C (enExample)
BR (1) BR0211762A (enExample)
CA (1) CA2454081A1 (enExample)
WO (1) WO2003014102A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005084349A2 (en) * 2004-03-02 2005-09-15 Kosan Biosciences, Inc. Compounds useful for the synthesis of (+)-discodermolide and methods therefor
US7214708B2 (en) * 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs
CN112424255A (zh) * 2018-07-17 2021-02-26 引能仕株式会社 反应性稀释剂、组合物、密封材、固化物、基板、电子部件、环氧化合物、及化合物的制造方法
CN113527238B (zh) * 2021-08-02 2022-12-13 昆明学院 一种海绵内生真菌来源的聚酮化合物及其在制备抗炎药物中的应用
CN119462593A (zh) * 2024-10-11 2025-02-18 暨南大学 多环聚酮类化合物和其制备方法、药物组合物及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991001982A1 (en) * 1989-08-11 1991-02-21 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and methods of preparation and use
WO2001042179A1 (en) * 1999-12-07 2001-06-14 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789605A (en) 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6870058B2 (en) 1996-12-03 2005-03-22 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide
US6096904A (en) 1996-12-03 2000-08-01 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US6127406A (en) 1998-10-09 2000-10-03 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991001982A1 (en) * 1989-08-11 1991-02-21 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and methods of preparation and use
WO2001042179A1 (en) * 1999-12-07 2001-06-14 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide

Also Published As

Publication number Publication date
WO2003014102A1 (en) 2003-02-20
US20050049249A1 (en) 2005-03-03
US6972292B2 (en) 2005-12-06
US7192980B2 (en) 2007-03-20
WO2003014102B1 (en) 2003-11-27
US20030087934A1 (en) 2003-05-08
JP2004537598A (ja) 2004-12-16
CN1538964A (zh) 2004-10-20
EP1417195A1 (en) 2004-05-12
JP4243183B2 (ja) 2009-03-25
BR0211762A (pt) 2004-10-13
CA2454081A1 (en) 2003-02-20

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Granted publication date: 20090805

Termination date: 20110805