CN100518813C - Composite medicine for treating hepatopathy and its preparing process - Google Patents
Composite medicine for treating hepatopathy and its preparing process Download PDFInfo
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- CN100518813C CN100518813C CNB2007100519085A CN200710051908A CN100518813C CN 100518813 C CN100518813 C CN 100518813C CN B2007100519085 A CNB2007100519085 A CN B2007100519085A CN 200710051908 A CN200710051908 A CN 200710051908A CN 100518813 C CN100518813 C CN 100518813C
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Abstract
The invention relates to a medical composition for treating liver disease and its preparation, the medical composition is prepared from Radix Aconiti Laterlis, Zingiber officinale (dry), Astragalus membranaceus, Atractylodes macrocephala, Radix Paeoniae Alba, Angelica sinensis, Trionyx sinensis, Panpax notoginseng, and Salvia miltiorrhiza, may be made into orally solid reagent or orally liquid reagent, and can be used for treating viral hepatitis, chemical liver injury and liver cirrhosis.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly a kind of pharmaceutical composition for the treatment of hepatopathy and preparation method thereof.
Background technology:
Various types of all over the world at present hepatopathy sickness rate are higher, and are especially higher at developing country's sickness rate.China is the district occurred frequently of viral hepatitis, and the hepatopathy that medicine, poisonous substance cause is also very general in China, and increasing.Hepatitis not only has a strong impact on patient's health, and constitutes the threat to other many healthy persons.The mankind suffer from that can digestion power to occur after the hepatopathy poor, immunologic function degression or disorder, or concurrent disease of immune system.And the long-run development of hepatopathy process, quite a few can advance to hepatopathy in latter stage at end---liver cirrhosis, even develops into hepatocarcinoma, the serious harm human beings'health.Therefore the problem of preventing and treating of hepatopathy has become the common important topic of paying close attention to of whole world medical circle, and the various countries scholar develops the method for hepatopathys such as new treatment viral hepatitis, chemical liver injury, liver cirrhosis by different approach.Therefore the medicine of developing a kind of effective treatment hepatopathy has realistic meaning for the harm that reduces hepatopathy.
Summary of the invention
Inventor system is from the Chinese traditional treatment hepatopathy rule of treatment, through development test, by Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae nine flavor medicines, through suitable processing, the process of preparing Chinese medicine, extraction, made the pharmaceutical composition that is used for the treatment of viral hepatitis, chemical liver injury, liver cirrhosis.This medicine composite for curing effective, safe and reliable.The present invention simultaneously also provides the preparation method of clinical suitable dosage form.
Technical scheme of the present invention is based on tcm theory, at the understanding of incidence of hepatitis mechanism and formulated the Therapeutic Principle, simultaneously with reference to the modern pharmacology achievement in research, filter out have the soothing liver-QI circulation of qi promoting, by the natural Chinese medicine of functions such as wet eliminating evil, the Eradicates stasis of blood, heat clearing away YIN nourishing, and by the traditional Chinese medical science rule of treatment and the principles of formulating prescriptions, and the new pharmaceutical composition of exploitation.Therapeutic effect is obvious in clinical and pharmacological research.
The present invention realizes with following way:
The present invention treat hepatopathy Chinese medicine preparation make by following parts by weight of traditional Chinese medicines raw material:
Radix Aconiti Lateralis Preparata 5-15g, Rhizoma Zingiberis 15-25g, Radix Astragali 10-15g, Rhizoma Atractylodis Macrocephalae 15-30g, Radix Paeoniae Alba 15-30g, Radix Angelicae Sinensis 10-15g, Carapax Trionycis 10-15g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
The present invention is for the preparation method of the pharmaceutical dosage form of clinical use:
(1) production method of liquid oral medicament: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae nine flavor raw medicinal materials are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into the clear paste that relative density is 1.02-1.10, put coldly, add ethanol, stir to containing alcohol amount 50%-70%, leave standstill, filter, decompression filtrate recycling ethanol, and 60 ℃ of surveys of simmer down to relative density is the clear paste of 1.2-1.35, make corresponding liquid oral medicament behind the conventional formulation technology adding adjuvant by relevant dosage form, packing promptly;
(2) production method of oral administration solid medicament: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, after cleaning, Radix Salviae Miltiorrhizae nine flavor raw medicinal materials decoct with water 3 times, filter, remove slag the water extract, merge the water extract, be condensed into the clear paste that relative density is 1.02-1.10, add ethanol to containing alcohol amount 50%-70%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and be concentrated into 60 ℃ and survey its relative densities and be about 1.20-1.35 clear paste, to put coldly, drying gets dry extract, make corresponding oral administration solid medicament behind the conventional formulation technology adding adjuvant of the broken back of dried cream powder by relevant dosage form, packing promptly.
The specific embodiment
Embodiment 1.
Take by weighing the raw material of Chinese medicine of following portions by weight: Radix Aconiti Lateralis Preparata 5g, Rhizoma Zingiberis 15g, Radix Astragali 10g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 10g, Carapax Trionycis 10g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
Method for making: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into relative density and be 1.05 clear paste, add ethanol to containing alcohol amount 50%-70%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and the simmer down to relative density is 1.3 clear paste (60 ℃ of surveys), 80 ℃ of drying under reduced pressure, pulverize, add right amount of auxiliary materials, make tablet.
Embodiment 2.
Take by weighing the raw material of Chinese medicine of following portions by weight: Radix Aconiti Lateralis Preparata 15g, Rhizoma Zingiberis 25g, Radix Astragali 15g, Rhizoma Atractylodis Macrocephalae 30g, Radix Paeoniae Alba 30g, Radix Angelicae Sinensis 15g, Carapax Trionycis 15g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
Method for making: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into relative density and be 1.10 clear paste, add ethanol to containing alcohol amount 50%-70%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and the simmer down to relative density is 1.3 clear paste (60 ℃ of surveys), 80 ℃ of drying under reduced pressure, pulverize, add right amount of auxiliary materials, make granule.
Embodiment 3.
Take by weighing the raw material of Chinese medicine of following portions by weight: Radix Aconiti Lateralis Preparata 10g, Rhizoma Zingiberis 20g, Radix Astragali 10g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 10g, Carapax Trionycis 10g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
Method for making: with Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae is got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into the clear paste that relative density is 1.02-1.10, add ethanol to containing alcohol amount 50%-70%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and the simmer down to relative density is the clear paste (60 ℃ of surveys) of 1.2-1.35, and 80 ℃ of drying under reduced pressure are pulverized, add right amount of auxiliary materials, mixing is divided in Capsules or is sealed in the soft capsule material, and packing promptly gets hard capsule product or soft capsule product.
Embodiment 4.
Take by weighing the raw material of Chinese medicine of following portions by weight: Radix Aconiti Lateralis Preparata 5g, Rhizoma Zingiberis 25g, Radix Astragali 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 20g, Radix Angelicae Sinensis 10g, Carapax Trionycis 15g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
Method for making: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into relative density and be 1.06 clear paste, add ethanol, stir to containing alcohol amount 60%, leave standstill, filter, decompression filtrate recycling ethanol, and the simmer down to relative density is 1.25 clear paste (60 ℃ of surveys), behind glyceryl monostearate heating and melting mixing, splash in the not miscible condensed fluid, shrink condensation and make sphere or the spheric preparation of class, packing promptly gets drop pill.
Embodiment 5.
Take by weighing the raw material of Chinese medicine of following portions by weight: Radix Aconiti Lateralis Preparata 5g, Rhizoma Zingiberis 20g, Radix Astragali 15g, Rhizoma Atractylodis Macrocephalae 25g, Radix Paeoniae Alba 25g, Radix Angelicae Sinensis 10g, Carapax Trionycis 10g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
Method for making: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into the clear paste that relative density is 1.02-1.10, add ethanol to containing alcohol amount 50%-70%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and the simmer down to relative density is the clear paste (60 ℃ of surveys) of 1.2-1.35, and 80 ℃ of drying under reduced pressure are pulverized, add right amount of auxiliary materials, mixing, briquetting or adorn tea bag or fry in shallow oil in the bag then, packing promptly gets medicinal tea.
Embodiment 6.
Take by weighing the raw material of Chinese medicine of following portions by weight: Radix Aconiti Lateralis Preparata 5g, Rhizoma Zingiberis 15g, Radix Astragali 10g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 10g, Carapax Trionycis 10g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
Method for making: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into the clear paste that relative density is 1.02-1.10, add ethanol to containing alcohol amount 50%-70%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and the simmer down to relative density is the clear paste (60 ℃ of surveys) of 1.2-1.35, adds right amount of auxiliary materials, makes syrup.
Embodiment 7.
Take by weighing the raw material of Chinese medicine of following portions by weight: Radix Aconiti Lateralis Preparata 5g, Rhizoma Zingiberis 20g, Radix Astragali 10g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 25g, Radix Angelicae Sinensis 10g, Carapax Trionycis 10g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
Method for making: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into relative density and be 1.06 clear paste, add ethanol to containing alcohol amount 65%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and the simmer down to relative density is 1.23 clear paste (60 ℃), adds refined honey and receives cream, add an amount of antiseptic, packing promptly gets soft extract.
Embodiment 8.
Take by weighing the raw material of Chinese medicine of following portions by weight: Radix Aconiti Lateralis Preparata 10g, Rhizoma Zingiberis 18g, Radix Astragali 13g, Rhizoma Atractylodis Macrocephalae 25g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 10g, Carapax Trionycis 10g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
Method for making: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into relative density and be 1.10 clear paste, add ethanol to containing alcohol amount 70%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and the simmer down to relative density is 1.35 clear paste (60 ℃ of surveys), and 80 ℃ of drying under reduced pressure are pulverized, add right amount of auxiliary materials, mixing, water with 5% and Mel are done binding agent and are prepared into ball, and packing promptly gets pill.
Embodiment 9.
Take by weighing the raw material of Chinese medicine of following portions by weight: Radix Aconiti Lateralis Preparata 5g, Rhizoma Zingiberis 15g, Radix Astragali 12g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 10g, Carapax Trionycis 10g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
Method for making: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into relative density and be 1.02 clear paste, add ethanol to containing alcohol amount 50%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and the simmer down to relative density is 1.2 clear paste (60 ℃ of surveys), adds right amount of auxiliary materials, makes mixture.
The described adjuvant of the foregoing description is the conventional adjuvant product that national management department regulation can be applied to pharmaceutical production.Antiseptic is the kind that meets state food additive regulation.
Substantive distinguishing features of the present invention and obvious improvement are:
1, the present invention is under the guidance of theory of Chinese medical science, according to the traditional Chinese medical science to the logos of hepatopathy, square medicine principle, used for reference the achievement of Chinese medicine modern pharmacological research simultaneously, and the tcm product of finishing with obvious therapeutic effect is the prescription with treatment hepatopathy of combination of Chinese and Western medicine characteristics.
2, the existing Eradicates heresy of function of the present invention, clear noxious dampness, the replenishing QI to invigorate the spleen of holding concurrently again, the kidney warming tonification function reaches eliminating evil and does not just hinder.The medicine compatibility of respectively distinguishing the flavor of in the pharmaceutical composition is proper, and the monarch compatibility is precise and appropriate, plays the blood stasis dispelling of removing summer-heat dampness removing altogether, and the kidney warming, replenishing QI to invigorate the spleen are set upright the merit of hepatoprotective.
The present invention treats the pharmacological research of hepatopathy:
This pharmaceutical composition has protective effect to rat chronic hepatic injury due to the carbon tetrachloride.In the protective effect of rat chronic hepatic injury due to the research carbon tetrachloride; each dosage group of the present invention can alleviate the pathology damage of model mouse liver; serum alt, AST activity are recovered to normal level; simultaneously can reduce HA, PIIIP, Hyp level; rising TP, ALB, A/G; and can alleviate hepatocellular degeneration, reduce the formation of connective tissue.As seen the present invention can alleviate hepar damnification, to the preventive and therapeutic effect that is formed with of hepatic fibrosis.
This pharmaceutical composition can improve the pathologic structure of Hepatocirrhosis Model liver tissues of rats and play therapeutical effect:
As feedstuff (the last fortnight is 80% Semen Maydis flour, 20% Adeps Sus domestica), and sneak into 0.5% cholesterol with simple Semen Maydis flour, 30% ethanol is unique beverage, press 0.5ml/100g body weight subcutaneous injection CCL4 first, 0.3ml/100g body weight injection 40%CCL4, totally 42 days were pressed in the back every 3 days.The treatment group gives this pharmaceutical composition concentrated solution 0.1ml/g gastric infusion in modeling, and 1 time/d, and give normal diet.The normal control group gives isometric normal saline.The result: the treatment group is compared the hepatic tissue structure than model group and is made moderate progress, and HA, PCIII, LN content are significantly lower, have pointed out this pharmaceutical composition to play therapeutical effect by the pathologic structure of improving hepatic tissue.The visible hepatic tissue structure disturbance of model group, the lobules of liver normal morphology disappears, and hepatic cell fattydegeneration is extensive, and part has necrosis, and more inflammatory cell infiltration is arranged in portal area and the lobules of liver, and proliferation of fibrous tissue is remarkable, and the fibrous septum forms, and cuts apart the formation pseudolobuli.The treatment group is compared the hepatic tissue structure than model group and is made moderate progress, and hepatic cell fattydegeneration significantly alleviates, and inflammatory cell infiltration and proliferation of fibrous tissue reduce.
This pharmaceutical composition is external all to have obvious inhibitory action to HBsAg, HBeAg, DHBVDNA, DHBeAg.In observing the therapeutic effect research of the present invention to duck hepatitis B virus infection, the result shows that the present invention has significant inhibitory effect in the 1.5g/kg group to duck hepatitis B virus infection.
The present invention treats the clinical prerun of the Chinese medicine preparation of hepatopathy:
Observe the clinical efficacy of treatment chronic hepatitis B with granule of the present invention.Method: 48 routine chronic hepatitis B patients are divided into treatment group and matched group at random, and 25 examples are organized in treatment, use granule treatment of the present invention, and matched group 23 examples are treated with oxymatrine.Be 3 months the course of treatment, observes the variation of treatment front and back liver function, HBV-M, hepatitis B virus serologic marker HBVDNA, T lymph subgroup.The result: after the treatment, treatment group and matched group patient ALT and AST level all obviously reduce (P＜0.05) before the treatment, and the treatment group is better than matched group (P＜0.05) aspect horizontal reducing ALT, AST; The numerical value of treatment back two groups of CD3+, CD4+, CD8+ and CD4+/CD8+ all has rising (P＜0.05), and the rising of treatment group CD3+, CD4+ and CD4+/CD8+ level is better than matched group (P＜0.05 or P＜0.01).Two groups of serum HBV DNA titres all descend, but two groups of zero difference (P〉0.05) conclusions relatively: the present invention has the liver protecting and ALT lowering, improves liver function, improves immunologic function, function of resisting hepatitis B virus.
Drug induced hepatic injury patient 10 people are carried out clinical prerun, give qualified patient each 1 bag of granule of the present invention, 3 times on the one, 5 examples of wherein fully recovering, produce effects 3 examples, effective 1 example, total obvious effective rate 80%, total effective rate 90%.
This medicine does not have untoward reaction to occur in clinical prerun.
In sum as can be known, the present invention has toxin expelling liver protection effect preferably to chemical liver injury, and viral hepatitis, liver cirrhosis are had obvious curative effects.
Claims (2)
1, a kind of pharmaceutical composition for the treatment of liver cirrhosis, chronic hepatitis B, drug induced hepatic injury is characterized in that it being the medicament of being made by the following weight proportion raw material: Radix Aconiti Lateralis Preparata 5-15g, Rhizoma Zingiberis 15-25g, Radix Astragali 10-15g, Rhizoma Atractylodis Macrocephalae 15-30g, Radix Paeoniae Alba 15-30g, Radix Angelicae Sinensis 10-15g, Carapax Trionycis 10-15g, Radix Notoginseng 10g, Radix Salviae Miltiorrhizae 15g.
2, the production method of the pharmaceutical composition of treatment liver cirrhosis according to claim 1, chronic hepatitis B, drug induced hepatic injury is characterized in that:
(1) production method of liquid oral medicament: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, Radix Salviae Miltiorrhizae nine flavor raw medicinal materials are got the raw materials ready, decoct with water after cleaning 3 times, filter, remove slag the water extract, merge the water extract, be condensed into the clear paste that relative density is 1.02-1.10, put coldly, add ethanol, stir to containing alcohol amount 50%-70%, leave standstill, filter, decompression filtrate recycling ethanol, and 60 ℃ of surveys of simmer down to relative density is the clear paste of 1.2-1.35, make corresponding liquid oral medicament behind the conventional formulation technology adding adjuvant by relevant dosage form, packing promptly;
(2) production method of oral administration solid medicament: Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Radix Notoginseng, after cleaning, Radix Salviae Miltiorrhizae nine flavor raw medicinal materials decoct with water 3 times, filter, remove slag the water extract, merge the water extract, be condensed into the clear paste that relative density is 1.02-1.10, add ethanol to containing alcohol amount 50%-70%, stir, leave standstill, filter, decompression filtrate recycling ethanol, and be concentrated into 60 ℃ and survey its relative densities and be about 1.20-1.35 clear paste, to put coldly, drying gets dry extract, make corresponding oral administration solid medicament behind the conventional formulation technology adding adjuvant of the broken back of dried cream powder by relevant dosage form, packing promptly.
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| CNB2007100519085A CN100518813C (en) | 2007-04-15 | 2007-04-15 | Composite medicine for treating hepatopathy and its preparing process |
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| CNB2007100519085A CN100518813C (en) | 2007-04-15 | 2007-04-15 | Composite medicine for treating hepatopathy and its preparing process |
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| CN100518813C true CN100518813C (en) | 2009-07-29 |
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| CN102526230B (en) * | 2012-01-21 | 2013-11-20 | 北京亚东生物制药有限公司 | Traditional Chinese composition for curing liver disease and preparation method, quality detection method and application thereof |
| CN102940773A (en) * | 2012-12-04 | 2013-02-27 | 邓鑫 | Chinese medicinal preparation for inhibiting liver cancer metastasis and preparation method thereof |
| CN104523869B (en) * | 2014-12-02 | 2017-11-10 | 陈永华 | It is a kind of to treat chronic hepatitis, the Chinese medicine composition and preparation method thereof of hepatic sclerosis |
| CN110693937A (en) * | 2019-10-23 | 2020-01-17 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Application of astragalus and pseudo-ginseng composition as medicine for relieving acute liver injury caused by triptolide |
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| "乙型肝炎"对症治疗法. 潘文昭.农村新技术，第5期. 2002 |
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