CN100516041C - 新型杂芳基衍生物 - Google Patents

新型杂芳基衍生物 Download PDF

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Publication number
CN100516041C
CN100516041C CNB2004800262352A CN200480026235A CN100516041C CN 100516041 C CN100516041 C CN 100516041C CN B2004800262352 A CNB2004800262352 A CN B2004800262352A CN 200480026235 A CN200480026235 A CN 200480026235A CN 100516041 C CN100516041 C CN 100516041C
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CN
China
Prior art keywords
substituted
reference example
alkyl
group
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800262352A
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English (en)
Chinese (zh)
Other versions
CN1849303A (zh
Inventor
渡边健一
丸田克纪
后田贯太郎
永田龙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
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Filing date
Publication date
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Publication of CN1849303A publication Critical patent/CN1849303A/zh
Application granted granted Critical
Publication of CN100516041C publication Critical patent/CN100516041C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
CNB2004800262352A 2003-07-15 2004-07-13 新型杂芳基衍生物 Expired - Fee Related CN100516041C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP274684/2003 2003-07-15
JP2003274684 2003-07-15

Publications (2)

Publication Number Publication Date
CN1849303A CN1849303A (zh) 2006-10-18
CN100516041C true CN100516041C (zh) 2009-07-22

Family

ID=34113749

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800262352A Expired - Fee Related CN100516041C (zh) 2003-07-15 2004-07-13 新型杂芳基衍生物

Country Status (11)

Country Link
US (2) US7425642B2 (enExample)
EP (1) EP1647546B1 (enExample)
JP (2) JP4820169B2 (enExample)
KR (1) KR101086654B1 (enExample)
CN (1) CN100516041C (enExample)
AT (1) ATE556051T1 (enExample)
CA (1) CA2531064C (enExample)
ES (1) ES2383895T3 (enExample)
MX (1) MXPA06000539A (enExample)
TW (1) TW200523249A (enExample)
WO (1) WO2005012245A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1837329A4 (en) * 2005-01-14 2009-08-05 Dainippon Sumitomo Pharma Co NEW HETEROARYL DERIVATIVE
US20060241073A1 (en) * 2005-04-20 2006-10-26 Wanders Ronaldus J A Means and methods for counteracting fatty acid accumulation
CA2662112A1 (en) 2006-09-05 2008-03-13 Kyowa Hakko Kirin Co., Ltd. Imidazole derivatives and their use as cannabinoid type 2 (cb2) receptor modulators
US20090054450A1 (en) * 2007-06-19 2009-02-26 Ironwood Pharmaceuticals, Inc. Compositions and methods of use for treating or preventing lipid related disorders
KR20110083660A (ko) * 2008-10-31 2011-07-20 다이닛본 스미토모 세이야꾸 가부시끼가이샤 당뇨병 치료제
EP2412705B1 (en) * 2009-03-26 2014-05-07 Dainippon Sumitomo Pharma Co., Ltd. Novel therapeutic agent for cognitive impairment
WO2011002012A1 (ja) * 2009-07-01 2011-01-06 大日本住友製薬株式会社 Sglt1阻害薬とインスリン抵抗性改善薬を組み合わせてなる医薬
KR20120117905A (ko) 2010-01-28 2012-10-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 프로테아좀 활성을 향상시키는 조성물 및 방법
EP2593447B1 (de) 2010-07-15 2016-08-17 Bayer Intellectual Property GmbH 3-pyridyl-heteroarylcarboxamidverbindungen als schädlingsbekämpfungsmittel
TR201906779T4 (tr) 2011-05-12 2019-05-21 Proteostasis Therapeutics Inc Proteostaz regülatörleri.
US10266490B2 (en) * 2012-03-16 2019-04-23 Georgetown University Radioprotector compounds
WO2014116228A1 (en) 2013-01-25 2014-07-31 President And Fellows Of Harvard College Usp14 inhibitors for treating or preventing viral infections
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002121186A (ja) * 2000-05-22 2002-04-23 Takeda Chem Ind Ltd チロシンホスファターゼ阻害剤
JP2003171275A (ja) * 2001-12-11 2003-06-17 Sumitomo Pharmaceut Co Ltd ＰＰＡＲδアゴニスト

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752361A1 (de) * 1977-11-24 1979-06-07 Troponwerke Gmbh & Co Kg Neue indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US6177443B1 (en) 1997-03-07 2001-01-23 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
EP0973778A1 (en) 1997-03-07 2000-01-26 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
US6911468B2 (en) 2000-05-22 2005-06-28 Takeda Chemical Industries, Ltd. Tyrosine phosphatase inhibitors
OA12292A (en) 2000-06-26 2003-11-11 Pfizer Prod Inc PyrroloÄ2,3-dÜpyrimidine compounds as immunosuppressive agents.
DE60227655D1 (de) * 2001-04-19 2008-08-28 Dainippon Sumitomo Pharma Co Pyrrolderivat
AU2003284479A1 (en) 2002-11-28 2004-06-18 Sumitomo Pharmaceuticals Co., Ltd. Novel heteroaryl derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002121186A (ja) * 2000-05-22 2002-04-23 Takeda Chem Ind Ltd チロシンホスファターゼ阻害剤
JP2003171275A (ja) * 2001-12-11 2003-06-17 Sumitomo Pharmaceut Co Ltd ＰＰＡＲδアゴニスト

Also Published As

Publication number Publication date
US20080306275A1 (en) 2008-12-11
ES2383895T3 (es) 2012-06-27
WO2005012245A1 (ja) 2005-02-10
HK1087409A1 (en) 2006-10-13
CA2531064A1 (en) 2005-02-10
EP1647546B1 (en) 2012-05-02
MXPA06000539A (es) 2006-03-30
EP1647546A4 (en) 2008-07-23
US7425642B2 (en) 2008-09-16
ATE556051T1 (de) 2012-05-15
JP4820169B2 (ja) 2011-11-24
KR101086654B1 (ko) 2011-11-24
JPWO2005012245A1 (ja) 2006-09-14
JP2011251974A (ja) 2011-12-15
US20060194857A1 (en) 2006-08-31
KR20060040681A (ko) 2006-05-10
CA2531064C (en) 2012-05-22
EP1647546A1 (en) 2006-04-19
TW200523249A (en) 2005-07-16
CN1849303A (zh) 2006-10-18
TWI331142B (enExample) 2010-10-01

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Granted publication date: 20090722

Termination date: 20140713

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