CN100515492C - 包含聚亚烷基二醇的降钙素药物-低聚物缀合物的混合物、其应用和制备方法 - Google Patents
包含聚亚烷基二醇的降钙素药物-低聚物缀合物的混合物、其应用和制备方法 Download PDFInfo
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- CN100515492C CN100515492C CNB028153022A CN02815302A CN100515492C CN 100515492 C CN100515492 C CN 100515492C CN B028153022 A CNB028153022 A CN B028153022A CN 02815302 A CN02815302 A CN 02815302A CN 100515492 C CN100515492 C CN 100515492C
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- mixture
- calcitonin
- oligomer
- conjugate
- polyalkylene glycol
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US6638906B1 (en) * | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
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US7713932B2 (en) * | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
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US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
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US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
WO2004043396A2 (en) * | 2002-11-09 | 2004-05-27 | Nobex Corporation | Modified carbamate-containing prodrugs and methods of synthesizing same |
US7648962B2 (en) * | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
CN100558398C (zh) * | 2002-11-26 | 2009-11-11 | 拜奥康有限公司 | 修饰的钠尿化合物、缀合物及其应用 |
US8133881B2 (en) | 2003-01-13 | 2012-03-13 | Shire Llc | Carbohydrate conjugates to prevent abuse of controlled substances |
EP1594513B1 (en) * | 2003-01-13 | 2011-08-10 | Shire LLC | Carbohydrate conjugates to prevent abuse of controlled substances |
CA2515889C (en) * | 2003-02-14 | 2015-07-14 | Quanta Biodesign, Ltd. | The selective and specific preparation of discrete peg compounds |
GB0305977D0 (en) * | 2003-03-15 | 2003-04-23 | Koninkl Philips Electronics Nv | Control of a conditional access mechanism |
US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
CN102895666B (zh) * | 2003-12-16 | 2015-08-19 | 尼克塔治疗公司 | 化学改性的小分子 |
US8329958B2 (en) | 2004-07-02 | 2012-12-11 | Biocon Limited | Combinatorial synthesis of PEG oligomer libraries |
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JP6329486B2 (ja) | 2011-10-21 | 2018-05-23 | シーチェイド ファーマシューティカルズ,インコーポレーテッド | 医薬組成物及びそれらの使用 |
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- 2002-06-04 EP EP02732030A patent/EP1404360B1/en not_active Expired - Lifetime
- 2002-06-04 AT AT02732030T patent/ATE454160T1/de active
- 2002-06-04 MX MXPA03011283A patent/MXPA03011283A/es active IP Right Grant
- 2002-06-04 DK DK02732030.8T patent/DK1404360T3/da active
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- 2002-06-04 KR KR1020037015912A patent/KR100930606B1/ko not_active IP Right Cessation
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Publication number | Publication date |
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CN1538851A (zh) | 2004-10-20 |
KR20040004694A (ko) | 2004-01-13 |
JP2004534782A (ja) | 2004-11-18 |
ATE454160T1 (de) | 2010-01-15 |
KR100930606B1 (ko) | 2009-12-09 |
WO2002098451A1 (en) | 2002-12-12 |
US20030060606A1 (en) | 2003-03-27 |
US20040180831A1 (en) | 2004-09-16 |
JP4272510B2 (ja) | 2009-06-03 |
CA2449686A1 (en) | 2002-12-12 |
DE60235010D1 (de) | 2010-02-25 |
DK1404360T3 (da) | 2010-05-03 |
MXPA03011283A (es) | 2004-03-26 |
CY1109932T1 (el) | 2014-09-10 |
EP1404360B1 (en) | 2010-01-06 |
EP1404360A4 (en) | 2006-04-12 |
EP1404360A1 (en) | 2004-04-07 |
ES2339224T3 (es) | 2010-05-18 |
US6713452B2 (en) | 2004-03-30 |
US7084121B2 (en) | 2006-08-01 |
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