CN100513417C - 用于雾化的环索奈德水悬液 - Google Patents

用于雾化的环索奈德水悬液 Download PDF

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Publication number
CN100513417C
CN100513417C CNB2004800368287A CN200480036828A CN100513417C CN 100513417 C CN100513417 C CN 100513417C CN B2004800368287 A CNB2004800368287 A CN B2004800368287A CN 200480036828 A CN200480036828 A CN 200480036828A CN 100513417 C CN100513417 C CN 100513417C
Authority
CN
China
Prior art keywords
ciclesonide
suspension
sterilized water
water suspension
osmolality
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB2004800368287A
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English (en)
Chinese (zh)
Other versions
CN1890256A (zh
Inventor
A·布吕克-谢夫勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kevis Pharmaceutical Co ltd
Original Assignee
Altana Pharma AG
Nycomed GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Altana Pharma AG, Nycomed GmbH filed Critical Altana Pharma AG
Publication of CN1890256A publication Critical patent/CN1890256A/zh
Application granted granted Critical
Publication of CN100513417C publication Critical patent/CN100513417C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CNB2004800368287A 2003-12-16 2004-12-15 用于雾化的环索奈德水悬液 Expired - Lifetime CN100513417C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03028848 2003-12-16
EP03028848.4 2003-12-16

Publications (2)

Publication Number Publication Date
CN1890256A CN1890256A (zh) 2007-01-03
CN100513417C true CN100513417C (zh) 2009-07-15

Family

ID=34684543

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800368287A Expired - Lifetime CN100513417C (zh) 2003-12-16 2004-12-15 用于雾化的环索奈德水悬液

Country Status (21)

Country Link
US (2) US20070117783A1 (enExample)
EP (2) EP1697398B1 (enExample)
JP (1) JP5001657B2 (enExample)
KR (1) KR101086095B1 (enExample)
CN (1) CN100513417C (enExample)
AR (1) AR046892A1 (enExample)
AU (1) AU2004298447B2 (enExample)
BR (1) BRPI0416854B8 (enExample)
CA (1) CA2549038C (enExample)
CO (1) CO5700832A2 (enExample)
EA (1) EA012388B1 (enExample)
EC (1) ECSP066608A (enExample)
IL (1) IL175461A (enExample)
MY (1) MY159377A (enExample)
NO (1) NO337225B1 (enExample)
NZ (1) NZ547217A (enExample)
PE (1) PE20050941A1 (enExample)
TW (1) TWI350757B (enExample)
UA (1) UA87123C2 (enExample)
WO (1) WO2005058935A2 (enExample)
ZA (1) ZA200603768B (enExample)

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EP3311823B1 (en) 2009-09-02 2020-11-25 Synedgen, Inc. Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds
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US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
KR20140057604A (ko) 2011-08-12 2014-05-13 베링거잉겔하임베트메디카게엠베하 고양잇과 동물의 심부전을 치료 및 예방하는 방법에 사용하기 위한 퍼니 전류 억제제
WO2013024070A1 (en) 2011-08-18 2013-02-21 Nycomed Gmbh Pharmaceutical aerosol product for administration by oral or nasal inhalation
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AU2015204558B2 (en) 2014-01-10 2020-04-30 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
HUE051527T2 (hu) 2014-06-18 2021-03-01 Boehringer Ingelheim Vetmedica Gmbh Muszkarin-antagonisták és kombinációik légúti betegség lovakban történõ kezelésére
WO2016040899A1 (en) * 2014-09-11 2016-03-17 Synedgen, Inc. Compositions and methods of use thereof
WO2017022814A1 (ja) * 2015-08-05 2017-02-09 第一三共株式会社 ネブライザー用組成物
CN106692163A (zh) * 2015-11-13 2017-05-24 天津金耀集团有限公司 一种吸入用环索奈德混悬液组合物
WO2019090405A1 (pt) * 2017-11-11 2019-05-16 Carvalho Junior Mario Virgilio De Medicamento de ciclesonida para cura e prevenção da gripe causada pelo vírus influenza
US20220023282A1 (en) * 2018-12-13 2022-01-27 Mannkind Corporation Compositions of Bedaquiline, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them
US20210346613A1 (en) * 2020-05-05 2021-11-11 Mahesh Kumar KHAITAN Controlled delivery device for treating coronavirus infections and methods thereof
CN115835885B (zh) * 2020-06-23 2025-02-07 广州谷森制药有限公司 包含奥达特罗和布地奈德的药物组合物的制备
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CA2549038A1 (en) 2005-06-30
JP5001657B2 (ja) 2012-08-15
IL175461A (en) 2013-12-31
AU2004298447B2 (en) 2011-04-21
IL175461A0 (en) 2006-09-05
MY159377A (en) 2016-12-30
US20160015634A1 (en) 2016-01-21
EP1697398B1 (en) 2012-07-04
PE20050941A1 (es) 2005-11-08
EA012388B1 (ru) 2009-10-30
WO2005058935A3 (en) 2006-05-18
ECSP066608A (es) 2006-10-25
BRPI0416854B1 (pt) 2018-05-02
AR046892A1 (es) 2005-12-28
CA2549038C (en) 2014-08-05
JP2007513993A (ja) 2007-05-31
BRPI0416854B8 (pt) 2021-05-25
EP2319858A1 (en) 2011-05-11
EA200601091A1 (ru) 2006-12-29
US20070117783A1 (en) 2007-05-24
CO5700832A2 (es) 2006-11-30
KR20060122890A (ko) 2006-11-30
NZ547217A (en) 2009-05-31
ZA200603768B (en) 2007-10-31
HK1098486A1 (zh) 2007-07-20
TWI350757B (en) 2011-10-21
KR101086095B1 (ko) 2011-11-25
AU2004298447A1 (en) 2005-06-30
NO20063047L (no) 2006-09-05
WO2005058935A2 (en) 2005-06-30
BRPI0416854A (pt) 2007-02-13
EP1697398A2 (en) 2006-09-06
TW200524615A (en) 2005-08-01
CN1890256A (zh) 2007-01-03
UA87123C2 (uk) 2009-06-25
EP2319858B1 (en) 2017-08-09
US11052042B2 (en) 2021-07-06
NO337225B1 (no) 2016-02-15

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