CN100496571C - Kidney invigorating and Yang strengthening Chinese medicine preparation - Google Patents

Abstract

The kidney invigorating and yang strengthening Chinese medicine preparation is prepared with morinda root, malaytea scurfpea fruit, cnidium fruit, pilose antler, ursine seal's penis and testes and other 16 kinds of Chinese medicinal materials. It has the function of mildly reinforcing kidney yang, strengthening sexual function, raising sperm quality, etc.

Description

The kidney invigorating and YANG supporting Chinese medicine preparation

Technical field

The invention belongs to pharmaceutical product, particularly a kind of kidney invigorating and YANG supporting Chinese medicine preparation that is used for the treatment of impotence of man premature ejaculation and man's and woman's sterility.

Background technology

Sexual impotence and premature ejaculation are two modal diseases of male sexual disorder, have 52% 40 years old to 70 years old adult male that in various degree sexual dysfunction is arranged approximately according to interrelated data report, and from the trend of seeking medical advice in recent years, this ratio has the gesture that increases gradually.Though there are a lot of male not have tangible sexual impotence, premature ejaculation symptom, body cold cold extremities, soreness of the waist and knees, hyposexuality usually appear, the phenomenon such as not smooth of urinating, belong to the insufficiency of kidney-YANG symptom.The symptom that show of insufficiency of kidney-YANG patient in sexual life is: erect not hard, sex time is too short, voluptus is strong, refractory stage is long etc.The male is in this state for a long time, not only loses many joys of life, can cause love life to be discord simultaneously, influences family harmony.

Be used for the treatment of the medicine of the medicine Western medicine of impotence of man premature ejaculation at present, can only rise for the moment soon, can not reach the purpose of effecting a permanent cure based on blood vessel dilating.Also there are some Chinese medicines to come out, but also exist some treatments not comprehensively or problem such as the course of treatment is oversize.

Summary of the invention

A kind of kidney invigorating and YANG supporting Chinese medicine preparation, it is to make with the following weight parts raw material of Chinese medicine:

Radix Morindae Officinalis 15-25, Fructus Psoraleae 15-25, Fructus Cnidii 15-25, Cornu Cervi Pantotrichum 7-12, Testis et penis callorhini 15-25, Herba Epimedii 40-60, Herba Cistanches 15-25, Cortex Eucommiae 12-18, Semen Cuscutae 15-25, Ootheca Mantidis 12-18, Rhizoma Alismatis 40-60, Poria 40-60, Cortex Moutan 25-35, Fructus Corni 40-60, Rhizoma dioscoreae (parched) 50-70, Radix Rehmanniae Preparata 100-140, Herba Pyrolae 25-35, Radix Ginseng 12-18, Fructus Lycii 25-35, Radix Asparagi 25-35, Scolopendra 15-20, Hippocampus 7-10.

The pharmaceutical formulation that the present invention recommends is (weight ratio):

Radix Morindae Officinalis 20, Fructus Psoraleae 20, Fructus Cnidii 20, Cornu Cervi Pantotrichum 10,

Testis et penis callorhini 20, Herba Epimedii 50, Herba Cistanches 20, the Cortex Eucommiae 15,

Semen Cuscutae 20, Ootheca Mantidis 15, Rhizoma Alismatis 50, Poria 50,

Cortex Moutan 30, Fructus Corni 50, Rhizoma dioscoreae (parched) 60, Radix Rehmanniae Preparata 120,

Herba Pyrolae 30, Radix Ginseng 15, Fructus Lycii 30, Radix Asparagi 30,

Scolopendra 18, Hippocampus 9.

The present invention forms efficacy of drugs:

Radix Morindae Officinalis---kidney invigorating and YANG supporting, bone and muscle strengthening is by cold-damp.

Fructus Psoraleae---kidney invigorating and YANG supporting, Gu sugared reducing urination, wet spleen antidiarrheal.

Fructus Cnidii---warming the kidney to invigorate YANG, killing parasites for relieving itching.

Cornu Cervi Pantotrichum---kidney-replenishing, beneficial glucemia, bone and muscle strengthening.

Testis et penis callorhini---warming the kidney to invigorate YANG is mended sugared beneficial marrow.

Herba Epimedii---kidney invigorating and YANG supporting, expelling wind and removing dampness, blood pressure lowering, is relievingd asthma at antitussive, dispel itch.

Herba Cistanches---kidney invigorating and YANG supporting, loosening bowel to relieve constipation.

The Cortex Eucommiae---invigorating the liver and kidney, bone and muscle strengthening, solid through antiabortive, blood pressure lowering.

Semen Cuscutae---the kidney invigorating benefit sugar, nourishing the liver to improve visual acuity, strengthening the spleen antidiarrheal.

Gu Ootheca Mantidis---reinforcing the kidney and supporting YANG is sugared reducing urination.

Rhizoma Alismatis---diuretic ginseng diarrhea due to damp pathogen is ripe.

Poria---wet, the spleen invigorating invigorating middle warmer of diuretic ginseng, mind tranquilizing and the heart calming.

Cortex Moutan---clearing away heat and cooling blood, removing heat from the liver to lower the high blood pressure, activating blood circulation and dissipating blood stasis.

Fructus Corni---liver and kidney tonifying, the arresting seminal emission reducing urination, consolidating channel for hemostasis, arresting sweating takes off admittedly.

Rhizoma dioscoreae (parched)---spleen reinforcing antidiarrheal, nourishing the liver tonifying YIN, the solid sugar of kidney tonifying, YIN nourishing and the production of body fluid promoting.

Radix Rehmanniae Preparata---tonifying blood and regulating menstruation, the nourishing kidney nourishing YIN.

Radix Ginseng---QI invigorating emergency treatment of collapse is mended strengthening spleen and lung, promoting the production of body fluid to quench thirst, the mind calming and mentality promoting.

Herba Pyrolae---nourishing liver, invigorating kidney, bone and muscle strengthening, expelling wind and removing dampness, hemostasis.

Fructus Lycii---nourishing the liver and kidney, nourishing the liver to improve visual acuity.

Radix Asparagi---lung moistening nourishing kidney, removing heat-phlegm.

Scolopendra---relieving spasm by subduing liver-wind, toxin expelling is treated skin ulcer.

Hippocampus---warming the kidney to invigorate YANG, mass dissipating and swelling eliminating.

Warming and recuperating the kidney-YANG of the present invention improves significantly to insufficiency of kidney-YANG.Clinical confirmation, take medicine of the present invention after, the insufficiency of kidney-YANG symptom disappears, sexual function significantly strengthens, be embodied in: erection hardness obviously strengthens, and sex time prolongs, and voluptus is strong, be highly sexed, improved man's sperm quality, infertility is had better curative effect.

The specific embodiment

Medicine of the present invention consists of (unit of weight gram):

Embodiment 1:

Radix Morindae Officinalis 20 Fructus Psoraleaes 20 Fructus Cnidiis 20 Cornu Cervi Pantotrichums 10

Testis et penis callorhini 20 Herba Epimedii 50 Herba Cistanches 20 Cortexs Eucommiae 15

Semen Cuscutae 20 Ootheca Mantidiss 15 Rhizoma Alismatis 50 Poria 50

Cortex Moutan 30 Fructus Corni 50 Rhizoma dioscoreae (parched)s 60 Radix Rehmanniae Preparata 120

Herba Pyrolae 30 Radix Ginsengs 15 Fructus Lycii 30 Radix Asparagis 30

Scolopendra 18 Hippocampus 9.

Mix after the above medicine clean dry and pulverize, make the watered pill, take twice every day sooner or later, each 9 grams, and 15 days is a course of treatment, generally takes three courses of treatment.

Embodiment 2:

Radix Morindae Officinalis 15, Fructus Psoraleae 25, Fructus Cnidii 15, Cornu Cervi Pantotrichum 12, Testis et penis callorhini 15, Herba Epimedii 60, Herba Cistanches 15, the Cortex Eucommiae 18, Semen Cuscutae 15, Ootheca Mantidis 18, Rhizoma Alismatis 40, Poria 60, Cortex Moutan 25, Fructus Corni 60, Rhizoma dioscoreae (parched) 50, Radix Rehmanniae Preparata 140, Herba Pyrolae 25, Radix Ginseng 18, Fructus Lycii 25, Radix Asparagi 35, Scolopendra 15, Hippocampus 10.

Preparation method is with embodiment 1.

Embodiment 3:

Radix Morindae Officinalis 25, Fructus Psoraleae 15, Fructus Cnidii 25, Cornu Cervi Pantotrichum 7, Testis et penis callorhini 25, Herba Epimedii 40, Herba Cistanches 25, the Cortex Eucommiae 12, Semen Cuscutae 25, Ootheca Mantidis 12, Rhizoma Alismatis 60, Poria 40, Cortex Moutan 35, Fructus Corni 40, Rhizoma dioscoreae (parched) 70, Radix Rehmanniae Preparata 100, Herba Pyrolae 35, Radix Ginseng 12, Fructus Lycii 35, Radix Asparagi 25, Scolopendra 20, Hippocampus 7.

Preparation method is with embodiment 1.

Below be that the present invention is used for the treatment of the impotence in male premature ejaculation.The final report of sterility or barrenness of man and women 70 examples.

One, clinical data

Age: 22-50 is between year.22-35 year 56 examples wherein, 36-50 year 14 examples.Occupation: workman, peasant, cadre for accounting for 67 examples, other 3 example more.Disease distributes: azoospermia 4 examples; Oligospermatism 10 examples; Necrospermia 10 examples; Big slightly rate obstacle 14 examples of sperm; Motility of sperm obstacle 9 examples; Sexual impotence 13 examples, female barrenness 10 examples.The patient is from various parts of the country, prescription on individual diagnosis forward part patient in the locality or the other places all done multiple diagnosis and treatment, because of invalid or unsatisfactory curative effect adopt Drug therapy of the present invention.According to outside traditional four methods of diagnosis four diagnostic methods, the strictness systems inspection with the genitals of having a medical check-up to the dysspermatism person, is carried out the seminal fluid routine inspection in diagnostic procedure, and part carries out biochemistry and the bacteriology cultivates, the mensuration of endocrine function.To the parallel conventional serum Lh of impotent patient, FSH, PRL and T mensuration and test of papaverine penis cavernosa injection and visualization etc.

Two, diagnostic criteria

Observe 70 examples and all meet traditional Chinese medical science deficiency of kidney-essence, the two diagnostic criterias of losing of negative and positive.

Main symptom: 1, body is weak, and complexion is white all of a sudden, hyposexuality, impotence and premature ejaculation; 2, lack of quantity of spermatic fluid, motility of sperm is low, movable rate variance, the sperm count deficiency, it is sterile to wed for a long time; 3, soreness of the waist and knees, insomnia and dreamful sleep.

Inferior card: 1, urine is many, and the nocturia frequency is long clearly; 2, neurolysis, limbs fatigue and weakness, the lazy speech of breathing hard; 3, fidgety irritability, testis are weighed down to expand and are not relaxed, and Necrospermia is too much.

The tongue arteries and veins: 1, pale tongue, fat tender, the tongue the lung-pulse thin and a little less than; 2, pale tongue with white fur profit, thready and weak pulse; 3, light red tongue

Thin fur, deep,thready and forceless pulse; 4, dark tongue quality, bilateral have the congestion point, deep-thready pulse and the stringy and rolling pulse sense person that holds concurrently.

All main symptom 1-2 items that meets reach tongue arteries and veins person with time card more than 2, can be diagnosed as deficiency of kidney-essence, the dysspermatism disease of the two male sterilities of losing of negative and positive and the impotence deficiency or the premature ejaculation of sexual dysfunction.

Three, Therapeutic Method

The sexual impotence of all infertility that meets azoospermia, oligospermatism, necrospermia, motility of sperm obstacle, motility rate obstacle and cause and sexual dysfunction or premature ejaculation etc. are all classified observation group as.

Medicine of the present invention is made watered pill and is obeyed 2 times each five (containing crude drug 9 grams), warm water delivery service every day.General oral 30 days is a course of treatment.It is a course of treatment that no sperm, oligospermatism serve on 75 days, because the generation of sperm needs 74 ± 2 days to ripe.Ban on opium-smoking and the opium trade wine is avoided irritable food.

Four, efficacy assessment standard

1, dysspermatism criterion of therapeutical effect

Cure: 1, treatment back wife's side pregnancy; 2, motility of sperm, activity ratio, sperm grand total etc. reach normal value standard;

Produce effects: the semen efamination sperm motility improves more than 30% than treatment is preceding, and energy increases more than "+", and sperm concentration increases more than 2,000 ten thousand for every milliliter.

Effectively: seminal fluid check motility of sperm increases "+" one-level, and activity ratio is preceding higher more than 15% than treatment, and sperm concentration increases more than 1,000 ten thousand for every milliliter.

Invalid: as to refer to the seminal fluid check treatment no obvious changer in front and back.

2, sexual impotence (sexual dysfunction) premature ejaculation efficacy assessment standard:

Cure: erection is hard and strong, sexual intercourse can success.

Effectively: erection is hard and strong, but the fashion time difference, success rate of sexual intercourse 〉=60%, mortality≤40.

Invalid: though erection makes progress, sexual intercourse can successfully or have obviously before and after the treatment and improve.

Five, therapeutic outcome

1, total effects situation: this organizes 70 examples, treat the shortest 27 days, the longest 90 days, average 49 days.Cure 52 examples and account for 74.29%, produce effects and effective 12 examples account for 17.12%, and invalid 6 examples account for 8.59%, and total effective rate is 91.41%.

2, the seminal fluid chemical examination of treatment back changes and sexual impotence curative effect situation: the seminal fluid chemical examination can be supported comparison person's 57 examples before and after the treatment.Wherein cure 42 examples, produce effects and effective 10 examples, invalid 5 examples.The sexual impotence of azoospermia, oligospermatism, necrospermia, sperm motility rate, vigor and the sexual dysfunction of the most of case in treatment back all obtains curing and improves.

Detailed observation situation is catalog as follows

The treatment of treatment disease percentage rate is observed	Azoospermia	Oligospermatism	Necrospermia	The motility rate obstacle	The vigor obstacle	Impotence and premature ejaculation	Infertilitas feminis	Add up to
									Observe routine number	4	10	10	14	9	13	10	70
Cure	1 25％	8 80％	7 70％	11 78.6％	6 66.7％	10 76.92 ％	7 70％	50 71.4％
									Produce effects	2 50％	2 20％	2 20％	2 14.％3	2 22.2％	2 15.38 ％	0 0％	12 17.1％
Invalid	1 25％	0 0％	1 10％	1 7.1％	1 11.1％	1 7.7％	3 30％	8 11.4％
									Total effective rate	75％	100％	90％	92.9％	88.9％	92.3％	70％	88.6％

(1) azoospermia: detect 4 examples.Cure 1 example; Effective 2 examples; Invalid 1 example.Total effective rate is 75%.

(2) oligospermatism: detect 10 examples.Average out to 0.8 thousand/ml ten thousand before the treatment is 2,000/ml ten thousand after the treatment, and the treatment back increases by 1.2 thousand/ml ten thousand than before treating, and cures 8 examples; Effective 2 examples; Total effective rate 100%.

(3) necrospermia: detect 10 examples.Necrospermia rate average out to 90% before the treatment; Treatment back sperm reaches normal value 7 examples; Effective 2 examples; Invalid 1 example.Total effective rate is 90%.

(4) sperm survival rate obstacle: detect 14 examples.Average 25% before the treatment, treatment back average out to 64.5%; Treatment is after increase by 29 ± 1.2% before the treatment; Treatment back survival rate 13 examples that raise, the less than that wherein raises 15%1 examples; Rising less than 30%2 examples; Or high 11 examples more than 30%.Total effective rate is 92.9%.

(5) motility of sperm obstacle: treatment motility of sperm enhancer 8 examples; Increase by 2 examples of "+" one-level; Nonresponder's 1 example.Total effective rate is 88.9%.

(6) sexual impotence: full group is observed 13 examples.Cure 0 example; Effective 2 examples; Invalid 1 example.Total effective rate is 92.3%.

(7) infertilitas feminis: observe 10 examples, 7 examples are through conceived son, the effective percentage 70% of giving birth in treatment back.

Many because the deficiency of kidney-essence of the smart unusual and impotence and premature ejaculation disease of sterility, negative and positive two thanks to due to.Kidney storing essence, main reproductive development is the dominator of storing essence, and is only suitable astringent or styptic treatment for spontaneous sweating, unsuitable catharsis.Dysspermatism and sexual impotence are many to be crossed and tired the damage in kidney by catharsis.So clinical have only by invigorating blood circulation sensible, enriching kidney essence, Yin-nourishing and Yang-supporting just can be removed the obstinate disease severe and lingering illness, with reach the rehabilitation kidney hide function this.Efficacy of drugs of the present invention with cure mainly the disease performance normal in clinical seminal fluid and sexual impotence of just being in step with, say that as forefathers clinical have its disease, and its side is just arranged, have its disease that its medicine must be arranged and be that is solved problem.

By and clinical practice 70 examples are cured 50 examples, account for 71.4%, effective 12 examples account for 17.1%, invalid 8 examples account for 11.4%, total effective rate is 88.6% remarkable result.

Medicine particularly of the present invention not only is fit to treatment impotence of man premature ejaculation and sterile, also female barrenness is produced effect.

Model case

1, shut out so-and-so, the man, 25 years old, the material people of Fuping County, Shaanxi little Xixiang Fan family, 2 years after marriage are sterile.Soreness of the waist and knees usually, dizziness and tinnitus, smart tired power, deficiency of QI with disinclination to talk, pale tongue white and thin fur, thready pulse without strength, card belongs to deficiency of the kidney, and negative and positive are two empty, the seminal fluid chemical examination: measure 3 milliliters, liquefaction in 20 minutes, survival rate 70%, energy 60% is good, and 30% is general, counts 10,000 ten thousand/every milliliter.

2, Zhao so-and-so, 24 years old, Gao Wanzhen village, Yao County, the Shaanxi woods material people wedded 1 year, penis anorthosis 3 years, the wife struggles for a divorce, come the court to seek medical advice, original frequent masturbation history, soreness of the waist and knees usually, the weak lazy speech of gas, dizziness and tinnitus, weak breath is unable, and complexion is white all of a sudden, light red tongue, white and thin fur, thready pulse without strength.Card belongs to deficiency of the kidney, the two empty impotence diseases of negative and positive, and the cavernous body of penis test is positive, and the gonadal hormone endocrine is measured all in normal range.Give the thing February of taking medicine, erection is strong firmly, and is energetic, the sexual intercourse success.

3, Lee so-and-so, 28 years old, Rhizoma Polygonati Odorati township, Hu County, Shaanxi Korea Spro east villager, 3 years after marriage are sterile.Soreness of the waist and knees usually, the lazy speech of breathing hard, the white all of a sudden weak breath of complexion is unable, pale tongue, white and thin fur, thready pulse without strength, card belongs to deficiency of the kidney, deficiency of both YIN and YANG, the seminal fluid chemical examination measure 3 milliliters, mirror under can/HP, diagnose: serious oligospermatism.The thing of taking medicine is surplus March, the check seminal fluid: measure 2 milliliters, liquefied in 20 minutes, and survival rate 80%, energy 60% is counted 5.5 thousand/ten thousand every milliliter.

4, ancient so-and-so, 27 years old, Xianyang city Qindu District peasant, wed 3 years sterile, be " the spermatozoon number is few " once at the man examination in hospital of number, the wife kicks up a great deal of fuss about, and comes institute's prescription on individual diagnosis.Soreness of the waist and knees when Mental fatigue is unable, has dizziness and tinnitus usually, and frequent micturition is indifferent to sexual life, light red tongue, white and thin fur, deep-thready pulse.Card belongs to deficiency of the kidney, deficiency of both YIN and YANG.Check: testis and external genitalia are grown normal, the seminal fluid chemical examination: measure 3 milliliters, 3-6 HP, diagnosis: serious oligospermatism.Clothes kind of smart capsule more than 50 day is braced up, and the check seminal fluid is measured 2 milliliters, survival rate 40%, and motility rate 40% is good, and 30% is general, counts 2,000/ten thousand every milliliter.Imitate more not square, continue clothes control it.

5, Feng so-and-so, 26 years old, Fengxiang County, Shaanxi chief angle town Yang Dancai, wed 3 years sterile, sexual function is general, and to discharge seminal fluid thin at every turn, usually soreness of the waist and knees, limbs fear of cold, complexion are white all of a sudden, and asthenia is unable, the thin in vain thready and rapid pulse of pale tongue, tongue, card belongs to deficiency of the kidney, deficient and weak YANG QI, repeatedly seminal fluid chemical examination " no sperm " is had a medical check-up: testis * 3 * 2cm size, in the matter, epididymis does not have tuberosity, and deferent duct is grown normal.Semen efamination: measure 5 milliliters, thin, microscopy " no sperm ", the thing March of taking medicine, 2 milliliters of check semen volumes, greyish white, liquefaction in 30 minutes, survival rate 40%, vigor II-III level is counted 8.9 thousand ten thousand/every milliliter.

6, the king so-and-so, 28 years old, the Xianyang colored picture tube workman of factory, 2 years after marriage are sterile, soreness of the waist and knees usually, spiritlessness and weakness, dizziness and tinnitus, frequent micturition, light red tongue, white and thin fur, deep-thready pulse.The seminal fluid chemical examination: measure 4 milliliters, greyish white, liquefaction in 30 minutes, survival rate 20%, vigor is poor, counts 5,000 ten thousand/every milliliter, and card belongs to the kidney yang deficiency necrospermia.Take medicine thing March, the mental status is good, the check seminal fluid: measure 2 milliliters, and greyish white, motility rate 60%, vigor II-III level is counted 9.3 thousand ten thousand/every milliliter.

7, Zhang, 31 years old, the workman of enterprise; Marry back 7 years infertile, its husband is through checking that every index all meets the fertility requirement.Conceived after March through taking medicine of the present invention.

Claims (2)

1, a kind of kidney invigorating and YANG supporting Chinese medicine preparation is characterized in that making with the following weight parts raw material of Chinese medicine:

Radix Morindae Officinalis 15-25, Fructus Psoraleae 15-25, Fructus Cnidii 15-25, Cornu Cervi Pantotrichum 7-12, Testis et penis callorhini 15-25, Herba Epimedii 40-60, Herba Cistanches 15-25, Cortex Eucommiae 12-18, Semen Cuscutae 15-25, Ootheca Mantidis 12-18, Rhizoma Alismatis 40-60, Poria 40-60, Cortex Moutan 25-35, Fructus Corni 40-60, Rhizoma dioscoreae (parched) 50-70, Radix Rehmanniae Preparata 100-140, Herba Pyrolae 25-35, Radix Ginseng 12-18, Fructus Lycii 25-35, Radix Asparagi 25-35, Scolopendra 15-20 and Hippocampus 7-10.

2, kidney invigorating and YANG supporting Chinese medicine preparation according to claim 1 is characterized in that making with the following weight parts raw material of Chinese medicine:

Radix Morindae Officinalis 20, Fructus Psoraleae 20, Fructus Cnidii 20, Cornu Cervi Pantotrichum 10,

Testis et penis callorhini 20, Herba Epimedii 50, Herba Cistanches 20, the Cortex Eucommiae 15,

Semen Cuscutae 20, Ootheca Mantidis 15, Rhizoma Alismatis 50, Poria 50,

Cortex Moutan 30, Fructus Corni 50, Rhizoma dioscoreae (parched) 60, Radix Rehmanniae Preparata 120,

Herba Pyrolae 30, Radix Ginseng 15, Fructus Lycii 30, Radix Asparagi 30,

Scolopendra 18 and Hippocampus 9.