CN105412698A - Traditional Chinese medicine composition for treating chronic prostatitis and preparation process thereof - Google Patents

Traditional Chinese medicine composition for treating chronic prostatitis and preparation process thereof Download PDF

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Publication number
CN105412698A
CN105412698A CN201510910642.XA CN201510910642A CN105412698A CN 105412698 A CN105412698 A CN 105412698A CN 201510910642 A CN201510910642 A CN 201510910642A CN 105412698 A CN105412698 A CN 105412698A
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parts
chinese medicine
medicine composition
chronic prostatitis
semen
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张瓅方
郝鹏飞
丁生晨
王旭
陈丽平
周洁
高丽
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Nanyang Institute of Technology
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Nanyang Institute of Technology
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic prostatitis and a preparation process thereof. The traditional Chinese medicine composition is prepared from 12 Chinese herbal medicines including dandelion, dahurian patrinia herb, pyrrosia leaves, polygonum cuspidatum, caulis sargentodoxae, raw coix seeds, rhizoma alismatis, ginkgo, Chinese taxillus twigs, semen cuscutae, semen sojae praeparatum and raw liquorice. The Chinese herbal medicines have the functions of cleaning heat, promoting diuresis, invigorating blood circulation, removing blood stasis, supporting the healthy energy and the like, and are suitable for treating chronic prostatitis caused by damp and heat stagnation and kidney qi deficiency. The traditional Chinese medicine composition has the advantages of being quick in effect, remarkable in treatment effect, high in cure rate and the like, all the components are extracted from pure natural plant medicinal materials, and the traditional Chinese medicine composition does not have any toxic or side effect and is safe to take.

Description

A kind of Chinese medicine composition and preparation technology thereof treating chronic prostatitis
Technical field
The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine composition and the preparation technology thereof that treat chronic prostatitis.
Background technology
Chronic prostatitis is the common a kind of reproductive system syndrome of Lipid on Young-middle Male, is one of the commonly encountered diseases and frequently-occurring disease of urinary system.This course of disease is long, therapeutic effect is not good enough, serious in the series of symptoms such as sexual dysfunction, mental disorder, causes great harm, had a strong impact on orthobiosis to the body and mind of male.Clinical symptoms performance differs, and patient has slight frequent micturition, urgent micturition, dysurea, urethra scorching hot sense or row's urine retention; Stool firmly or the whole latter stage urethra of urinating can ooze a small amount of prostatic fluid.Or can involve to stock with falling inflation dull pain such as waist sacrum, hypogastric region, groin, perineal position, the place such as penis, testis.Because this course of disease is longer, some patients also there will be sexual impotence, premature ejaculation etc., with neurasthenia symptoms such as insomnia and dreamful sleep, dizziness, tinnitus.
Doctor trained in Western medicine is thought: cause the chronic prostatitis cause of disease complicated, prostate can be propagated into by pathogenic bacterium by blood and lymph urine adverse current to ducts of prostate gland causes or the infection at Posterior urethral and other positions of genito-urinary system to prostate direct extension, also can by the up infection of the direct per urethra of the pathogenic microorganism such as mycoplasma or chlamydia.For the treatment of primary disease, modern medicine there is no specific drug at present, for paathogenic factor and symptomatic treatment many employings alpha-blocking agent alfuzosin, naftopidil etc., M-receptor blocking agent tolterodine, antibiotic as quinolones, galenical sabal, the pervasive Thailand of Quercetin etc., nonsteroidal antiinflammatory drug, antidepressant and antianxiety drugs etc.But these medicines exist drug resistance easily causes recurrence, and medication has toxic and side effects more, radical cure poor effect, leaves future trouble more.
Primary disease belongs to the category such as " stranguria caused by overstrain ", " nebulousurine ", " lumbago due to renal deficiency " in the traditional Chinese medical science, adopts Chinese herb prevention chronic prostatitis with a long history, have accumulated rich experience and have the features such as evident in efficacy, untoward reaction is little.At present at the Chinese patent medicine having some treatment primary disease on the market, though great majority can alleviate clinical symptoms, general curative effect is not good, focuses on and takes stopgap measures but not effect a permanent cure.Therefore, develop a kind of simple and effective, have no adverse reaction, economic cheap Chinese medicine preparation becomes patients with chronic prostatitis in the urgent need to.Application number be 201310614446.9 Chinese invention patent disclose a kind of Chinese medicine formula for the treatment of chronic prostatitis, be made up of following component: Semen Astragali Complanati, Radix Dipsaci, Fructus Alpiniae Oxyphyllae, Fructus Rosae Laevigatae, Semen Litchi, Herba Epimedii, Rhizoma Sparganii, Rhizoma Curcumae, Squama Manis, each component coordinative role is not remarkable, do not reach treating both the principal and secondary aspects of a disease, the effect of promoting health and curing diseases.Application number be 200610046086.7 Chinese invention patent disclose a kind of medicine for the treatment of prostatosis and preparation method thereof and application, recipe ratio is more single, and therapeutic effect is undesirable.
Summary of the invention
In view of this, the object of the invention is for the deficiencies in the prior art, the object of the invention is to provide a kind of Chinese medicine composition and the preparation technology thereof that treat chronic prostatitis.
For achieving the above object, the present invention by the following technical solutions:
Treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 20 ~ 35 parts, Herba Patriniae 20 ~ 35 parts, Folium Pyrrosiae 5 ~ 20 parts, Rhizoma Polygoni Cuspidati 5 ~ 20 parts, Caulis Sargentodoxae 5 ~ 20 parts, raw Semen Coicis 15 ~ 35 parts, Rhizoma Alismatis 5 ~ 20 parts, Semen Ginkgo 5 ~ 20 parts, Herba Taxilli 5 ~ 25 parts, Semen Cuscutae 10 ~ 25 parts, Semen Sojae Preparatum 5 ~ 20 parts and Radix Glycyrrhizae 2 ~ 10 parts.
Preferably, treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, Folium Pyrrosiae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Caulis Sargentodoxae 10 ~ 15 parts, raw Semen Coicis 20 ~ 30 parts, Rhizoma Alismatis 10 ~ 15 parts, Semen Ginkgo 10 ~ 15 parts, Herba Taxilli 15 ~ 20 parts, Semen Cuscutae 15 ~ 20 parts, Semen Sojae Preparatum 10 ~ 15 parts and Radix Glycyrrhizae 3 ~ 6 parts.
Treat a preparation technology for the Chinese medicine composition of chronic prostatitis, comprise following preparation process:
1) take raw material, clean, pulverize, add 0.8 ~ 1.5 times of weight parts water, soak 0.8 ~ 1.5 hour;
2) add water the raw material that step 1) is soaked microwave extraction, collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds alcohol reflux;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) step 4) gained enriched product is dry, preparation.
Preferably, described step 2) actual conditions of microwave extraction is raw material 1200 ~ 1500 watts after soaking, 80 ~ 90 DEG C of 8 ~ 10 times amount that add water, extract 50 ~ 60 minutes.
Preferably, in described step 3), the condition of ethanol extraction is, by step 2) gained filtering residue adds the ethanol of 5 ~ 6 times of weight portion 90wt ~ 95wt%, 60 ~ 70 DEG C of backflows 50 ~ 60 minutes; Cross leaching filtering residue, add the ethanol of 3 ~ 4 times of weight portion 60wt ~ 70wt%, 70 ~ 80 DEG C are refluxed 30 ~ 40 minutes.
Preferably, the condition of enriched product drying in described step 5) is-78 ~-60 DEG C, lyophilization 12 ~ 24 hours.
Preferably, the preparation in described step 5) is made respectively comprise decoction, granule, tablet, capsule, injection, powder, unguentum and pill for being added adjuvant.
Preferably, the adjuvant added in described step 5) is the mannitol of 30wt ~ 50wt%, PVP K30 or dextrin.
Preferably, the dosage form of described preparation is rectal administration.
Preferably, the preparation process of described rectal administration comprises the steps: to take fatty glyceride as substrate 65 DEG C of heating and melting, be cooled to 55 DEG C, add the dry products obtained therefrom of step 5), mix homogeneously, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, cooling and shaping makes class warhead shape suppository, and wherein the addition of fatty glyceride is 40wt ~ 60wt%.
Wherein said PVP K30 is commercial standard PVP K30.
The invention has the beneficial effects as follows:
The present invention advocates to adopt organic conception to carry out Comprehensive Treatment, treating both the principal and secondary aspects of a disease, and catching primary disease damp and hot is mark, kidney asthenia as the principal aspect, the stagnant feature for becoming of the stasis of blood, and three basic pathology links are made a distinction between the important and the lesser one, balance medication.The present invention for primary treatment principle, adopts tcm prescription " monarch, minister, help, make " the theory side of sending medication with clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, strengthening the body resistance.Monarch drug Herba Taraxaci bitter cold, sweet in the mouth, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, dampness removing is treating stranguria; Herba Patriniae property bitter and be slightly cold, acrid in the mouth, heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing; The merit of clearing away heat-damp and promoting diuresis played altogether by two medicines.Ministerial drug Folium Pyrrosiae hardship is slightly cold, sweet in the mouth, inducing diuresis for treating stranguria syndrome, cooling blood for hemostasis; Rhizoma Polygoni Cuspidati is cold in nature, mildly bitter flavor, heat-clearing and toxic substances removing, dampness removing jaundice eliminating, dissipating blood stasis analgesic therapy; Caulis Sargentodoxae property is flat, bitter in the mouth, and promoting blood circulation to remove obstruction in the collateral, relieve internal heat dissipating blood stasis; Raw Semen Coicis is light, cool, sweet in the mouth, clearing away heat and discharging pus, detoxicating and resolving stagnation of pathogens, invigorating spleen for diuresis; Rhizoma Alismatis property is light, sweet in the mouth, and promoting diuresis to eliminate damp pathogen, pathogenic heatization are turbid; Four medicines share the effect playing inducing diuresis for treating stranguria syndrome, evacuation of pus dissipating blood stasis.Supplementary drug Semen Ginkgo property is pained, sweet in the mouth, except diarrhea due to damp pathogen is turbid, astringent therapy descends reducing urination admittedly; Herba Taxilli natural disposition is bitter, flat, sweet in the mouth, invigorating the liver and kidney, bone and muscle strengthening, diuresis; Semen Cuscutae is warm in nature, acrid in the mouth, sweet, nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal; Semen Sojae Preparatum is bitter, acrid in the mouth, and a surname sends out relieving restlessness hot and suffocating; The soothing the liver effect of kidney and spleen invigorating played altogether by four medicines, vital base and primordial QI consolidating.Radix Glycyrrhizae is for making medicine, and property is flat, sweet in the mouth, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.
The present invention treats the Chinese medicine composition of chronic prostatitis, compatibility is proper has the effects such as clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, strengthening the body resistance, be applicable to the treatment of chronic prostatitis, there is instant effect, cure rate is high, relapse rate is low, the feature such as treating both the principal and secondary aspects of a disease, preparation are easy, with low cost.The all raw materials chosen of this Chinese herbal medicine are nontoxic pure natural Chinese herbal medicine, therefore use this prescription not any toxic and side effects of tool, take safety.
Preparation technology of the present invention decocts auxiliary existing ultrasonic technique with Chinese medicine, and alcohol reflux method, extracts Effective Component of Chinese Medicine, and extracting mode is simple, extraction is thoroughly efficient.
Detailed description of the invention
Set forth content of the present invention with detailed description of the invention below, do not limit the scope of claim of the present invention protection with this.
Detailed description of the invention
embodiment 1
Treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 20 parts, Herba Patriniae 20 parts, Folium Pyrrosiae 5 parts, Rhizoma Polygoni Cuspidati 5 parts, Caulis Sargentodoxae 5 parts, raw Semen Coicis 15 parts, Rhizoma Alismatis 5 parts, Semen Ginkgo 5 parts, Herba Taxilli 5 parts, Semen Cuscutae 10 parts, Semen Sojae Preparatum 5 parts and Radix Glycyrrhizae 2 parts.
Its preparation technology, comprises following preparation process:
1) take raw material, clean, pulverize, add 0.8 times of weight parts water, soak 0.8 hour;
2) raw material 80 DEG C that step 1) is soaked is added 8 times of water gagings, 1200 watts, microwave extraction 50 minutes; Collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds the ethanol of 5 times of weight portion 90wt%, 60 DEG C of backflows 50 minutes; Cross leaching filtering residue, add the ethanol of 3 times of weight portion 60wt%, 70 DEG C of reflux, extract, 30 minutes;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) by step 4) gained enriched product-78 DEG C, lyophilization 12 hours, the mannitol adding 30wt% are that adjuvant makes powder.
embodiment 2
Treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 35 parts, Herba Patriniae 35 parts, Folium Pyrrosiae 20 parts, Rhizoma Polygoni Cuspidati 20 parts, Caulis Sargentodoxae 20 parts, raw Semen Coicis 35 parts, Rhizoma Alismatis 20 parts, Semen Ginkgo 20 parts, Herba Taxilli 25 parts, Semen Cuscutae 125 parts, Semen Sojae Preparatum 20 parts and Radix Glycyrrhizae 10 parts.
Its preparation technology, comprises following preparation process:
1) take raw material, clean, pulverize, add 1.5 times of weight parts waters, soak 1.5 hours;
2) raw material 90 DEG C that step 1) is soaked is added 10 times of water gagings, 1500 watts, microwave extraction 60 minutes; Collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds the ethanol of 6 times of weight portion 95wt%, 70 DEG C of backflows 60 minutes; Cross leaching filtering residue, add the ethanol of 4 times of weight portion 70wt%, 80 DEG C of reflux, extract, 40 minutes;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) by step 4) gained enriched product-60 DEG C, lyophilization 24 hours, the dextrin adding 50wt% are that adjuvant makes injection.
embodiment 3
Treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 22 parts, Herba Patriniae 22 parts, Folium Pyrrosiae 7 parts, Rhizoma Polygoni Cuspidati 7 parts, Caulis Sargentodoxae 7 parts, raw Semen Coicis 17 parts, Rhizoma Alismatis 7 parts, Semen Ginkgo 7 parts, Herba Taxilli 7 parts, Semen Cuscutae 12 parts, Semen Sojae Preparatum 7 parts and Radix Glycyrrhizae 4 parts.
Its preparation technology, comprises following preparation process:
1) take raw material, clean, pulverize, add 0.9 times of weight parts water, soak 0.9 hour;
2) raw material 81 DEG C that step 1) is soaked is added 8.2 times of water gagings, 1250 watts, microwave extraction 52 minutes; Collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds the ethanol of 5.2 times of weight portion 91wt%, 62 DEG C of backflows 52 minutes; Cross leaching filtering residue, add the ethanol of 3.2 times of weight portion 62wt%, 72 DEG C of reflux, extract, 32 minutes;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) by step 4) gained enriched product-76 DEG C, lyophilization 14 hours, the PVP K30 adding 50wt% are that adjuvant makes capsule.
embodiment 4
Treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 24 parts, Herba Patriniae 24 parts, Folium Pyrrosiae 9 parts, Rhizoma Polygoni Cuspidati 9 parts, Caulis Sargentodoxae 9 parts, raw Semen Coicis 19 parts, Rhizoma Alismatis 9 parts, Semen Ginkgo 9 parts, Herba Taxilli 9 parts, Semen Cuscutae 14 parts, Semen Sojae Preparatum 9 parts and Radix Glycyrrhizae 6 parts.
Its preparation technology, comprises following preparation process:
1) take raw material, clean, pulverize, add 1.0 times of weight parts waters, soak 1.0 hours;
2) raw material 84 DEG C that step 1) is soaked is added 8.4 times of water gagings, 1300 watts, microwave extraction 54 minutes; Collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds the ethanol of 5.4 times of weight portion 92wt%, 64 DEG C of backflows 54 minutes; Cross leaching filtering residue, add the ethanol of 3.4 times of weight portion 64wt%, 74 DEG C of reflux, extract, 34 minutes;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) by step 4) gained enriched product-72 DEG C, lyophilization 16 hours, the mannitol adding 50wt% are that adjuvant makes tablet.
embodiment 5
Treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 26 parts, Herba Patriniae 26 parts, Folium Pyrrosiae 11 parts, Rhizoma Polygoni Cuspidati 11 parts, Caulis Sargentodoxae 11 parts, raw Semen Coicis 21 parts, Rhizoma Alismatis 11 parts, Semen Ginkgo 11 parts, Herba Taxilli 11 parts, Semen Cuscutae 16 parts, Semen Sojae Preparatum 11 parts and Radix Glycyrrhizae 8 parts.
Its preparation technology, comprises following preparation process:
1) take raw material, clean, pulverize, add 1.1 times of weight parts waters, soak 1.1 hours;
2) raw material 86 DEG C that step 1) is soaked is added 8.6 times of water gagings, 1350 watts, microwave extraction 56 minutes; Collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds the ethanol of 5.6 times of weight portion 93wt%, 66 DEG C of backflows 56 minutes; Cross leaching filtering residue, add the ethanol of 3.6 times of weight portion 66wt%, 76 DEG C of reflux, extract, 36 minutes;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) by step 4) gained enriched product-72 DEG C, lyophilization 18 hours, the PVP K30 manna adding 35wt% are that adjuvant makes granule.
embodiment 6
Treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 280 ~ 35 parts, Herba Patriniae 28 parts, Folium Pyrrosiae 13 parts, tiger 13 parts, Caulis Sargentodoxae 13 parts, raw Semen Coicis 23 parts, Rhizoma Alismatis 13 parts, Semen Ginkgo 13 parts, Herba Taxilli 13 parts, Semen Cuscutae 18 parts, Semen Sojae Preparatum 13 parts and Radix Glycyrrhizae 9 parts.
Its preparation technology, comprises following preparation process:
1) take raw material, clean, pulverize, add 1.2 times of weight parts waters, soak 1.2 hours;
2) raw material 88 DEG C that step 1) is soaked is added 8.8 times of water gagings, 1400 watts, microwave extraction 58 minutes; Collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds the ethanol of 5.8 times of weight portion 94wt%, 68 DEG C of backflows 58 minutes; Cross leaching filtering residue, add the ethanol of 3.8 times of weight portion 68wt%, 70 ~ 80 DEG C of reflux, extract, 38 minutes;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) by step 4) gained enriched product-70 DEG C, lyophilization 20 hours, the dextrin adding 35wt% are that adjuvant makes injection.
embodiment 7
Treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 30 parts, Herba Patriniae 30 parts, Folium Pyrrosiae 15 parts, Rhizoma Polygoni Cuspidati 15 parts, Caulis Sargentodoxae 15 parts, raw Semen Coicis 25 parts, Rhizoma Alismatis 15 parts, Semen Ginkgo 15 parts, Herba Taxilli 15 parts, Semen Cuscutae 20 parts, Semen Sojae Preparatum 15 parts and Radix Glycyrrhizae 9 parts.
Its preparation technology, comprises following preparation process:
1) take raw material, clean, pulverize, add 1.3 times of weight parts waters, soak 1.3 hours;
2) raw material 89 DEG C that step 1) is soaked is added 9 times of water gagings, 1450 watts, microwave extraction 59 minutes; Collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds the ethanol of 5.9 times of weight portion 95wt%, 69 DEG C of backflows 59 minutes; Cross leaching filtering residue, add the ethanol of 3.9 times of weight portion 69wt%, 79 DEG C of reflux, extract, 39 minutes;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) by step 4) gained enriched product-68 DEG C, lyophilization 22 hours, by 40wt% fatty glyceride 65 DEG C of heating and melting, be cooled to 55 DEG C and add the dry products obtained therefrom of step 5), mix homogeneously, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, cooling and shaping makes class warhead shape suppository.
embodiment 8
Treat a Chinese medicine composition for chronic prostatitis, be made up of the raw material of following weight portion: Herba Taraxaci 32 parts, Herba Patriniae 32 parts, Folium Pyrrosiae 17 parts, Rhizoma Polygoni Cuspidati 17 parts, Caulis Sargentodoxae 17 parts, raw Semen Coicis 27 parts, Rhizoma Alismatis 17 parts, Semen Ginkgo 17 parts, Herba Taxilli 17 parts, Semen Cuscutae 22 parts, Semen Sojae Preparatum 17 parts and Radix Glycyrrhizae 7 parts.
Its preparation technology, comprises following preparation process:
1) take raw material, clean, pulverize, add 1.4 times of weight parts waters, soak 1.4 hours;
2) raw material 87 DEG C that step 1) is soaked is added 8.7 times of water gagings, 1450 watts, microwave extraction 57 minutes; Collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds the ethanol of 5.7 times of weight portion 91wt%, 67 DEG C of backflows 57 minutes; Cross leaching filtering residue, add the ethanol of 3.7 times of weight portion 67wt%, 77 DEG C of reflux, extract, 37 minutes;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) by step 4) gained enriched product-66 DEG C, lyophilization 23 hours, by 60wt% fatty glyceride 65 DEG C of heating and melting, be cooled to 55 DEG C and add the dry products obtained therefrom of step 5), mix homogeneously, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, cooling and shaping makes class warhead shape suppository.
Clinical trial: verify outstanding effect of the present invention with clinical trial below.
One, physical data
From year July in July, 2013 to 2015, treatment chronic prostatitis syndrome patient 156 example, the age 27-65 year between.
Two, diagnostic criteria
" Chinese prostatitis diagnosis treatment guidelines " (version in 2006) is formulated: (1) main manifestations: lower urinary tract infection repeatedly, irritation of urinating in various degree, urethra drip white or sexual dysfunction,, sometimes there are Spirit nerve symptoms of disease insomnia, weak, anxiety hypomnesis etc. in pain such as perineum, pelvic cavity or waist energy portion or have sour swollen sense; (2) past 6 symptom accumulations in the middle of the month were more than 3 months; (3) digital rectal examination (DRE) prostate is full increase, and matter is soft, mild tenderness, course of disease elder, and prostate reduces, hardening, uneven; (4) ultrasound diagnosis display prostata tissue structure boundary is unclear, without obviously increasing and space occupying lesion; (5) prostatic fluid routine (EPS) reduces 30%-70%, numeration of leukocyte >10/HP or have pus cell; (6) prostatic fluid bacteriology cultivates the positive.Possess above (1), (3), (4), any one of (5) and (2), (6) item person, get rid of other diseases and diagnosable.
Three, efficacy assessment standard
(1) clinical recent healing: transference cure, prostate tenderness disappears, and quality is normal or close to normal, EPS check continuous 2 times more than normally.
(2) effective: symptom disappears substantially, prostate tenderness and quality are all improved, EPS check continuous 2 times more than normal, WBC value comparatively treats front minimizing >2/3.
(3) effective: symptom alleviates, EPS check continuous 2 times more than normal, WBC value comparatively treats front minimizing 1/3-2/3.
(4) invalid: symptom, prostate anus are examined and checked all without improving or increasing the weight of to some extent with EPS.
Four, therapeutic scheme
With reference to detailed description of the invention for embodiment 3 gained capsule, be used in conjunction 1-2 the course for the treatment of.
Five, statistical result
Cure 113 examples, effective 21 examples, effective 15 examples, invalid 7 examples, total effective rate 95.51%.
Model case
Case 1: grandson, 48 years old, Nanyang, henan people.Without obvious inducement, patient occurred that frequent micturition, urine retention, urine dripped before half a year white, and during sex-linkage life, erection hardness is poor.Once oral antibiotic and QIANLIEKANG was being given, DeGrain when districts and cities' hospital diagnosis for " chronic prostatitis ".After taking 1 course for the treatment of of the embodiment of the present invention 1 gained medicine powder, clinical symptoms disappears completely, and EPS checks continuous 3 subnormal.After 1 year, Effect of follow-up visit by telephone did not recur.
Case 2: gold certain, 62 years old, Henan Tanghe people.Without inducement, patient occurred that urine wait, dysuria, waist were aching and tired before 2 years.Once at many hospital therapies, examined as " chronic prostatitis ".Oral drugs, intravenous pharmacy and topical therapeutic, effect inequality.Appearance in nearly two months can not be urinated, and flank pain increases the weight of, and because of older and premature coronary heart disease, aggravation then here is gone to a doctor.After using 2 courses for the treatment of of the embodiment of the present invention 7 gained suppository drug, clinical symptoms disappears substantially, and EPS checks continuous 3 subnormal, and WBC value comparatively treat front minimizing > 2/3.After half a year, Effect of follow-up visit by telephone did not recur.
Case 3: Zhao, 43 years old, Nanyang, henan people.Enter over 3 years, patient often feels the sense of urethra difference, and the symptoms such as appearance is dripped in vain, perineal position distending pain, waist soreness, be diagnosed as chronic prostatitis by the People's Hospital, routine takes the treatment such as anti-inflammation analgesic, antibiotic, bad during effect fashion, can not thoroughly effect a radical cure.After in here treatment, after using 2 courses for the treatment of of the embodiment of the present invention 7 gained suppository drug, clinical symptom disappearance, prostate tenderness disappears, quality is normal, and EPS checks continuous 3 subnormal.After half a year, Effect of follow-up visit by telephone did not recur.
Case 4: Lee, 29 years old, Henan people from Sheqi County.The long-term masturbation of patient is immoderate, occurs frequent micturition, stranguria, urine retention sense over one year, perineum and lower abdomen pain discomfort, eventually the white secretions of end urine band.Nearly March goes up disease increasing the weight of afterwards because of fatigue, and patient mental is nervous, very painful, here treatment then, per rectum touch: Rolandic fissure shoals, and quality is comparatively hard, and nodosity sense is touched a tender spot (+), and prostatic fluid is conventional: leukocyte 15-20.After using the embodiment of the present invention 7 gained suppository drug to treat 1 course for the treatment of, patient is without obvious subjective symptoms, and check prostatic fluid is normal, and after half a year, Effect of follow-up visit by telephone did not recur.
Case 5: poplar, 47 years old, Henan Xixia Mine people.There is frequent micturition, dysurea before 3 years, be once diagnosed as chronic prostatitis at county hospital.Through injection of antibiotic, the method treatments such as urethra microwave improve not obvious.Occurred the symptoms such as lower abdomen dull pain, rectal tenesmus, urine are waited for, nocturia increases, premature ejaculation over the past two years, have a medical check-up: Rectal tonch bilateral prostate obviously increases, tenderness, matter are partially hard, Rolandic fissure shoals, and anal sphincter is without lax.Lab testing: the conventional lecithin 30% of prostatic fluid, the full visual field of leukocyte, erythrocyte ++, the large lopps of susceptibility is extremely sensitive.Ultrasound diagnosis: prostate increases.Medical in here, use 2 the Posterior urethral irritation disappearances course for the treatment of of the embodiment of the present invention 8 gained suppository drug, unobstructed micturition, lab testing recovers normal, follows up a case by regular visits to and do not recur after 1 year.
Case 6: Mr. Wang 36 years old, Tongbai in Henan Province people.Readme frequent micturition, urgent micturition, urine wait for that half a year is many, uncomfortable with perineal position, recent nocturia increases, nocturia 3--4 time, Zeng county, city's examination in hospital are diagnosed as chronic prostatitis, through radio frequency, massage of prostate, hot water hip-bath etc. all without positive effect, and carry out here treatment, have a medical check-up: anus examines prostate II increase, matter is hard, tenderness (+), disappearence of central groove, and anal sphincter is without lax.Lab testing: the conventional lecithin body of prostatic fluid 25%, leukocyte 18-20/HPF.B ultrasonic shows: prostate 4.2x3.1x2.9cm, bladder residual urine 30ml.After injection 1 course for the treatment of of the embodiment of the present invention 2 gained injection medicine, controlled micturition is unobstructed, and without nocturia, every inspection is normal, follows up a case by regular visits to and do not recur after 1 year.
Case 7: Wang, 33 years old, people from Henan Fangcheng.Occurred hypogastric region dull pain, delayed urination without risk factor before 1 year, Posterior urethral burn feeling of urinating, once took antibiotic therapy voluntarily, and concrete medicine is not quite clear, poor effect, carried out here treatment out of admiration for a famous person.On inspection anus examine prostate quality comparatively hard, touch a tender spot, Rolandic fissure exists, without tuberosity, smooth surface; Prostate color ultrasound shows: prostate size is 4.5cm × 3.2cm × 3.0cm, prostatic fluid leukocyte ++++, ovum ++, routine urinalysis is normal.After taking 1 course for the treatment of of the embodiment of the present invention 5 gained granules medicine, clinical symptom disappearance, checks normal, successful.After half a year, Effect of follow-up visit by telephone is without recurrence.
Case 8: Liu 57 years old, Tongbai in Henan Province people.Because being engaged in taxi driver's more than ten years, there is frequent micturition, urgent micturition before 2 years, the symptoms such as perineal position discomfort, soreness of waist pain.Once be diagnosed as chronic prostatitis at local hospital, through injection of antibiotic, the method treatments such as urethra microwave make moderate progress.Because occupation is special, occur again over nearly 1 year that the symptoms such as perineal position dull pain, urine wait, nocturia increase are come here and gone to a doctor, through having a medical check-up: Rectal tonch prostate bilateral increases to some extent, tenderness, matter are partially hard, and Rolandic fissure shoals.Lab testing: the conventional lecithin 30% of prostatic fluid, the full visual field of leukocyte.B ultrasonic shows: prostate increases.After injection 1 course for the treatment of of the embodiment of the present invention 6 gained injection medicine, indices inspection is normal, and clinical effectiveness is obvious.After 1 year, phone follow-up study is without recurrence.
Case 9: gold certain, 63 years old, the new savage in Henan.Started before 1 year to occur frequent micturition, urgent micturition, dysurea symptom, within nearly 4 months, occur lower abdomen pain over the perineum, rectal tenesmus, the symptoms such as insomnia.Local county hospital inspection display bilateral prostate obviously increases scleroma, tenderness (+), and prostate Rolandic fissure shoals, and Sphincter ani chalasia quality is harder.Prostatic fluid routine test: leukocyte: +++, lecithin is few, is diagnosed as chronic prostatitis.Carry out here diagnosis and treatment because local therapeutic effect is not good, after taking 1 course for the treatment of of the embodiment of the present invention 3 gained capsule medicine, sense of discomfort of urinating obviously alleviates, and be a course for the treatment of of solid curative effect following the service, indices is normal on inspection, successful.After half a year, Effect of follow-up visit by telephone is without recurrence.
Case 10: Lee, 33 years old, people from Dengzhou, Henan.Because pressures of Business is large before 2 years, occur nocturia, urgent micturition, dysurea, life quality are not high, insomnia is serious.After be diagnosed as chronic prostatitis in certain Civilian Hospital inspection local, poor effect after treatment, here treatment then.Through having a medical check-up: prostate obviously increases, matter is hard, tenderness is obvious, being gently pressed with pus and discharging.The a large amount of leukocyte of urine spectroscopy, prostate lecithin ++.After taking 2 courses for the treatment of of the embodiment of the present invention 4 obtained sheet agent medicine, clinical symptom disappearance, every inspection are normal, and after half a year, phone follow-up study is without recurrence.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, other amendments that those of ordinary skill in the art make technical scheme of the present invention or equivalently to replace, only otherwise depart from the spirit and scope of technical solution of the present invention, all should be encompassed in the middle of right of the present invention.

Claims (10)

1. treat the Chinese medicine composition of chronic prostatitis for one kind, it is characterized in that, be made up of the raw material of following weight portion: Herba Taraxaci 20 ~ 35 parts, Herba Patriniae 20 ~ 35 parts, Folium Pyrrosiae 5 ~ 20 parts, Rhizoma Polygoni Cuspidati 5 ~ 20 parts, Caulis Sargentodoxae 5 ~ 20 parts, raw Semen Coicis 15 ~ 35 parts, Rhizoma Alismatis 5 ~ 20 parts, Semen Ginkgo 5 ~ 20 parts, Herba Taxilli 5 ~ 25 parts, Semen Cuscutae 10 ~ 25 parts, Semen Sojae Preparatum 5 ~ 20 parts and Radix Glycyrrhizae 2 ~ 10 parts.
2. treat the Chinese medicine composition of chronic prostatitis for one kind, it is characterized in that, be made up of the raw material of following weight portion: Herba Taraxaci 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, Folium Pyrrosiae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Caulis Sargentodoxae 10 ~ 15 parts, raw Semen Coicis 20 ~ 30 parts, Rhizoma Alismatis 10 ~ 15 parts, Semen Ginkgo 10 ~ 15 parts, Herba Taxilli 15 ~ 20 parts, Semen Cuscutae 15 ~ 20 parts, Semen Sojae Preparatum 10 ~ 15 parts and Radix Glycyrrhizae 3 ~ 6 parts.
3. a kind of preparation technology treating the Chinese medicine composition of chronic prostatitis as claimed in claim 1, is characterized in that, comprise following preparation process:
1) take raw material, clean, pulverize, add 0.8 ~ 1.5 times of weight parts water, soak 0.8 ~ 1.5 hour;
2) add water the raw material that step 1) is soaked microwave extraction, collecting by filtration extracting solution and filtering residue;
3) by step 2) gained filtering residue adds alcohol reflux;
4) by step 2) and step 3) gained extracting solution merge, concentrated;
5) step 4) gained enriched product is dry, preparation.
4. a kind of preparation technology treating the Chinese medicine composition of chronic prostatitis as claimed in claim 3, it is characterized in that, described step 2) actual conditions of microwave extraction is raw material 1200 ~ 1500 watts after soaking, 80 ~ 90 DEG C of 8 ~ 10 times amount that add water, extract 50 ~ 60 minutes.
5. a kind of preparation technology treating the Chinese medicine composition of chronic prostatitis as claimed in claim 3, it is characterized in that, in described step 3), the condition of ethanol extraction is, by step 2) gained filtering residue adds the ethanol of 5 ~ 6 times of weight portion 90wt ~ 95wt%, 60 ~ 70 DEG C of backflows 50 ~ 60 minutes; Cross leaching filtering residue, add the ethanol of 3 ~ 4 times of weight portion 60wt ~ 70wt%, 70 ~ 80 DEG C are refluxed 30 ~ 40 minutes.
6. a kind of preparation technology treating the Chinese medicine composition of chronic prostatitis as claimed in claim 3, it is characterized in that, the condition of enriched product drying in described step 5) is-78 ~-60 DEG C, lyophilization 12 ~ 24 hours.
7. a kind of preparation technology treating the Chinese medicine composition of chronic prostatitis as described in claim 3 ~ 6, it is characterized in that, the preparation in described step 5) is made respectively comprise decoction, granule, tablet, capsule, injection, powder, unguentum and pill for being added adjuvant.
8. a kind of preparation technology treating the Chinese medicine composition of chronic prostatitis as claimed in claim 7, is characterized in that, the adjuvant added in described step 5) is the mannitol of 30wt ~ 50wt%, PVP K30 or dextrin.
9., as the preparation technology of the Chinese medicine composition of any one treatment chronic prostatitis in claim 3 ~ 6, it is characterized in that, the dosage form of described preparation is rectal administration.
10. a kind of preparation technology treating the Chinese medicine composition of chronic prostatitis as claimed in claim 9, it is characterized in that, the preparation process of described rectal administration comprises the steps: to take fatty glyceride as substrate 65 DEG C of heating and melting, be cooled to 55 DEG C, add the dry products obtained therefrom of step 5), mix homogeneously, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, cooling and shaping makes class warhead shape suppository, and wherein the addition of fatty glyceride is 40wt ~ 60wt%.
CN201510910642.XA 2015-12-10 2015-12-10 Traditional Chinese medicine composition for treating chronic prostatitis and preparation process thereof Pending CN105412698A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109106881A (en) * 2017-06-23 2019-01-01 梁根娣 A kind of Chinese medicine composition that treating chronic prostatitis and its preparation process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
文档铺子: ""慢性前列腺炎（张春和20100612案例教学）", 《HTTP://WWW.DOCIN.COM/P-997128675.HTML&DPAGE=1&KEY=%E5%89%8D%E5%88%97%E8%85%BA%E7%82%8E%E6%80%8E%E4%B9%88%E6%B2%BB》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109106881A (en) * 2017-06-23 2019-01-01 梁根娣 A kind of Chinese medicine composition that treating chronic prostatitis and its preparation process

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