CN109106881A - A kind of Chinese medicine composition that treating chronic prostatitis and its preparation process - Google Patents
A kind of Chinese medicine composition that treating chronic prostatitis and its preparation process Download PDFInfo
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- CN109106881A CN109106881A CN201710488374.6A CN201710488374A CN109106881A CN 109106881 A CN109106881 A CN 109106881A CN 201710488374 A CN201710488374 A CN 201710488374A CN 109106881 A CN109106881 A CN 109106881A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention provides a kind of Chinese medicine composition for treating chronic prostatitis and its preparation process, is made from the following raw materials in parts by weight: 20 ~ 35 parts of Pollen Typhae, 20 ~ 35 parts of cortex cinnamomi, 5 ~ 20 parts of pyrrosia lingua, 5 ~ 20 parts of peach kernel, 5 ~ 20 parts of Sargent gloryvine, raw 15 ~ 35 parts of the seed of jog's tears, 5 ~ 20 parts of rhizoma alismatis, 5 ~ 20 parts of gingko, 5 ~ 25 parts of herba taxilli, 10 ~ 25 parts of Semen Cuscutae, 5 ~ 20 parts and 2 ~ 10 parts of radix glycyrrhizae preparata of Fermented Soybean.Chinese medicine composition prepared by the present invention has clearing heat and promoting diuresis, promoting blood circulation, strengthens the body resistance to consolidate the constitution and other effects, suitable for damp-heat accumulation, the treatment of the chronic prostatitis of kidney qi virtual loss, have the characteristics that quick, significant in efficacy, cure rate is high, each component is refined by pure plant medicinal material, without any toxic side effect, safety is taken, and preparation process is simple.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly, to a kind of Chinese medicine composition for treating chronic prostatitis and its
Preparation process.
Background technique
Chronic prostatitis is a kind of common reproductive system syndrome of Lipid on Young-middle Male, be urinary system common disease and
One of frequently-occurring disease.Sick course of disease is long, therapeutic effect is not good enough for this, serious with a series of symptoms such as sex dysfunction, phrenoblabias,
Great harm is caused to the body and mind of male, has seriously affected normal life.Clinical symptoms performance is different, and patient has slight urine
Frequently, urgent urination, urodynia, urethra scorching hot sense or urination are not clean；It exerts oneself in stool or urination terminal phase urethra can ooze a small amount of prostate
Liquid.It with the falling inflations such as waist sacrum, lower abdomen, groin, perineum secret anguish or can involve to medial side, penis, testis etc..Because being somebody's turn to do
The course of disease is longer, and some patientss there is also impotence, premature ejaculation etc., with neurasthenia symptoms such as insomnia and dreamful sleep, dizziness, tinnitus.
Treatment for this disease, modern medicine there is no specific drug at present, mostly use alpha-receptor to block for pathogenic factor and symptomatic treatment
Agent Alfuzosin, naftopidil etc., M- receptor blocker Tolterodine, antibiotic such as quinolones, galenical sabal, Mongolian oak
The pervasive safe grade of Pi Su, non-steroid anti-inflammatory drug, antidepression and anxiolytic etc..But there are drug resistances to easily cause for these drugs
Recurrence, and medication has toxic side effect more, radical cure is ineffective, and mostly there are future troubles.
Summary of the invention
In order to solve the above technical problems, the object of the present invention is to provide a kind of Chinese medicine compositions for treating chronic prostatitis
And its preparation process.
In order to achieve the above objectives, the invention adopts the following technical scheme:
A kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: 20 ~ 35 parts of Pollen Typhae, meat
20 ~ 35 parts of osmanthus, 5 ~ 20 parts of pyrrosia lingua, 5 ~ 20 parts of peach kernel, 5 ~ 20 parts of Sargent gloryvine, raw 15 ~ 35 parts of the seed of jog's tears, 5 ~ 20 parts of rhizoma alismatis, gingko 5 ~ 20
Part, 5 ~ 25 parts of herba taxilli, 10 ~ 25 parts of Semen Cuscutae, 5 ~ 20 parts and 2 ~ 10 parts of radix glycyrrhizae preparata of Fermented Soybean.
Preferably, a kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: Pollen Typhae
25 ~ 30 parts, 25 ~ 30 parts of cortex cinnamomi, 10 ~ 15 parts of pyrrosia lingua, 10 ~ 15 parts of peach kernel, 10 ~ 15 parts of Sargent gloryvine, raw 20 ~ 30 parts of the seed of jog's tears, rhizoma alismatis 10
~ 15 parts, 10 ~ 15 parts of gingko, 15 ~ 20 parts of herba taxilli, 15 ~ 20 parts of Semen Cuscutae, 10 ~ 15 parts and 3 ~ 6 parts of radix glycyrrhizae preparata of Fermented Soybean.
A kind of preparation process of Chinese medicine composition that treating chronic prostatitis, including following preparation process:
1) raw material is weighed, cleans, crush, 0.8 ~ 1.5 times of parts by weight water is added, is impregnated 0.8 ~ 1.5 hour；
2) raw material that step 1) is impregnated is added into water Microwave Extraction, extracting solution and filter residue is collected by filtration；
3) alcohol reflux is added in filter residue obtained by step 2 to extract；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
5) the dry, preparation by enriched product obtained by step 4).
Preferably, the actual conditions of the step 2 Microwave Extraction are 1200 ~ 1500 watts of raw material, 80 ~ 90 DEG C after impregnating
Add 8 ~ 10 times of water amounts, extracts 50 ~ 60 minutes.
Preferably, the condition that ethyl alcohol extracts in the step 3) is that 5 ~ 6 times of parts by weight are added in filter residue obtained by step 2
The ethyl alcohol of 90wt ~ 95wt%, 60 ~ 70 DEG C are flowed back 50 ~ 60 minutes；Filter residue is filtered to take, is added 3 ~ 4 times of parts by weight 60wt ~ 70wt%'s
Ethyl alcohol, 70 ~ 80 DEG C are flowed back 30 ~ 40 minutes.
Preferably, the dry condition of enriched product is -78 ~ -60 DEG C in the step 5), is freeze-dried 12 ~ 24 hours.
Preferably, the preparation in the step 5) is that adjuvant is added to be respectively prepared including decoction, granule, tablet, capsule
Agent, injection, pulvis, paste and pill.
Preferably, the adjuvant being added in the step 5) is mannitol, PVP K30 or the dextrin of 30wt ~ 50wt%.
Preferably, the dosage form of the preparation is rectal administration.
Preferably, the preparation process of the rectal administration includes the following steps: using fatty glyceride as matrix 65
DEG C heating and melting is cooled to 55 DEG C, and the dry products obtained therefrom of step 5) is added, is uniformly mixed, is mixed into sticky liquid, is poured in
In plastic shape-forming pipe, class warhead shape suppository is made in cooling and shaping, and wherein the additional amount of fatty glyceride is 40wt ~ 60wt%.
The beneficial effects of the present invention are:
The present invention advocates to catch this disease damp and hot for mark, kidney asthenia as the principal aspect, the stasis of blood using organic conception progress complex treatment, treating both manifestation and root cause of disease
Stagnant is the characteristics of change, and three basic pathology links are made a distinction between the important and the lesser one, and medication is weighed.The present invention is with clearing heat and promoting diuresis, promoting blood circulation, righting
It consolidates as main principle of reatment, using tcm prescription " monarch, minister, help, make " the theory side of sending medication.Monarch drug in a prescription Pollen Typhae acrid-sweet flavor,
It is cool, it is included into liver, the heart channel of Hang-Shaoyin, is stopped blooding, stagnation resolvation is treating stranguria；The big heat of cortex cinnamomi nature and flavor, it is acrid flavour, sweet, return kidney, spleen, the heart, Liver Channel, mends fire supporing yang,
Let the fire back to its origin, eliminating cold to stop pain, blood circulation are used for impotence, palace cold, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, menostasis, dysmenorrhea, Wen Jingtong
Arteries and veins, two medicines play the function of clearing heat and promoting diuresis altogether.Ministerial drug pyrrosia lingua hardship is slightly cold, sweet in flavor, inducing diuresis for treating strangurtia, cooling blood and hemostasis；Peach kernel nature and flavor are pungent,
Sweet, big heat, belongs to the heart, kidney, spleen channel, recuperating depleted yang, mends fire supporing yang, eliminating cold to stop pain, and the effect of peach kernel promoting blood circulation is very wide, can be with controlling the stasis of blood
Blood blocks various worn-out diseases；Sargent gloryvine is mild-natured, bitter, promoting blood circulation and removing obstruction in channels, beaten stasis；The raw seed of jog's tears is light, cool, sweet in flavor, clearing away heat and eliminating pus, solution
Malicious dissipating bind, invigorating spleen for diuresis；Rhizoma alismatis property is light, sweet in flavor, and clearing damp and promoting diuresis, heat symptoms caused by an exopathgenization are turbid；Four medicines share and play inducing diuresis for treating strangurtia, apocenosis dissipates the stasis of blood
The benefits of.Supplementary drug gingko property is bitter, sweet in flavor, and dehumidifying lets out turbid, inducing astrigency and descends reducing urination admittedly；Herba taxilli is bitter, flat, sweet in flavor, nourishing liver and kidney, strong
Muscles and bones, diuresis；Semen Cuscutae is warm-natured, acrid flavour, nourishing liver and kidney, astringent sperm contracting urine, miscarriage prevention, improving eyesight, antidiarrheal；Fermented Soybean hardship, acrid flavour, a surname
Send out relieving restlessness hot and suffocating；Four medicines play the benefits of kidney and spleen invigorating is soothing the liver, reinvigoration altogether.Radix glycyrrhizae preparata be make medicine, nature and flavor are sweet, return heart, lung, spleen,
Stomach meridian.It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, carbuncle swells
Sore, detachable sub- toxicity.
The present invention treats the Chinese medicine composition of chronic prostatitis, and compatibility is proper to have clearing heat and promoting diuresis, promoting blood circulation, righting solid
This and other effects, suitable for the treatment of chronic prostatitis, with quick, cure rate is high, recurrence rate is low, treating both manifestation and root cause of disease, preparation
The features such as easy, low in cost.The raw material of all selections of this Chinese herbal medicine is nontoxic pure natural Chinese herbal medicine, therefore uses this
Prescription does not have any toxic side effect, takes safety.
Preparation process of the invention decocts the existing ultrasonic technique of auxiliary and alcohol reflux extracting method with traditional Chinese medicine, mentions
Effective component of chinese medicine is taken, extracting mode is simple, it is thoroughly efficient to extract.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described, it is clear that institute
The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention,
Every other embodiment obtained by those of ordinary skill in the art without making creative efforts, belongs to this hair
The range of bright protection.
Embodiment 1
A kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: 20 parts of Pollen Typhae, cortex cinnamomi 20
It is part, 5 parts of pyrrosia lingua, 5 parts of peach kernel, 5 parts of Sargent gloryvine, raw 15 parts of the seed of jog's tears, 5 parts of rhizoma alismatis, 5 parts of gingko, 5 parts of herba taxilli, 10 parts of Semen Cuscutae, light
5 parts and 2 parts of radix glycyrrhizae preparata of fermented soya bean.
Its preparation process, including following preparation process:
1) raw material is weighed, cleans, crush, 0.8 times of parts by weight water is added, is impregnated 0.8 hour；
2) 80 DEG C of raw material additions, the 8 times of amount water for impregnating step 1), 1200 watts, Microwave Extraction 50 minutes；Extracting solution is collected by filtration
And filter residue；
3) filter residue obtained by step 2 is added to the ethyl alcohol of 5 times of parts by weight 90wt%, 60 DEG C are flowed back 50 minutes；Filter residue is filtered to take, is added
The ethyl alcohol of 3 times of parts by weight 60wt%, 70 DEG C refluxing extraction 30 minutes；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
It 5) is that powder is made in adjuvant by the mannitol for -78 DEG C of enriched product obtained by step 4), being freeze-dried 12 hours, being added 30wt%
Agent.
Embodiment 2
A kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: 35 parts of Pollen Typhae, cortex cinnamomi 35
Part, 20 parts of pyrrosia lingua, 20 parts of peach kernel, 20 parts of Sargent gloryvine, raw 35 parts of the seed of jog's tears, 20 parts of rhizoma alismatis, 20 parts of gingko, 25 parts of herba taxilli, Semen Cuscutae
125 parts, 20 parts of Fermented Soybean and 10 parts of radix glycyrrhizae preparata.
Its preparation process, including following preparation process:
1) raw material is weighed, cleans, crush, 1.5 times of parts by weight water are added, is impregnated 1.5 hours；
2) 90 DEG C of raw material additions, the 10 times of amount water for impregnating step 1), 1500 watts, Microwave Extraction 60 minutes；Extraction is collected by filtration
Liquid and filter residue；
3) filter residue obtained by step 2 is added to the ethyl alcohol of 6 times of parts by weight 95wt%, 70 DEG C are flowed back 60 minutes；Filter residue is filtered to take, is added
Enter the ethyl alcohol of 4 times of parts by weight 70wt%, 80 DEG C refluxing extraction 40 minutes；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
It 5) is that injection is made in adjuvant by the dextrin for -60 DEG C of enriched product obtained by step 4), being freeze-dried 24 hours, being added 50wt%
Agent.
Embodiment 3
A kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: 22 parts of Pollen Typhae, cortex cinnamomi 22
It is part, 7 parts of pyrrosia lingua, 7 parts of peach kernel, 7 parts of Sargent gloryvine, raw 17 parts of the seed of jog's tears, 7 parts of rhizoma alismatis, 7 parts of gingko, 7 parts of herba taxilli, 12 parts of Semen Cuscutae, light
7 parts and 4 parts of radix glycyrrhizae preparata of fermented soya bean.
Its preparation process, including following preparation process:
1) raw material is weighed, cleans, crush, 0.9 times of parts by weight water is added, is impregnated 0.9 hour；
2) 81 DEG C of raw material additions, the 8.2 times of amount water for impregnating step 1), 1250 watts, Microwave Extraction 52 minutes；Extraction is collected by filtration
Liquid and filter residue；
3) filter residue obtained by step 2 is added to the ethyl alcohol of 5.2 times of parts by weight 91wt%, 62 DEG C are flowed back 52 minutes；Filter residue is filtered to take, is added
Enter the ethyl alcohol of 3.2 times of parts by weight 62wt%, 72 DEG C refluxing extraction 32 minutes；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
It 5) is adjuvant system by the PVP K30 for -76 DEG C of enriched product obtained by step 4), being freeze-dried 14 hours, being added 50wt%
At capsule.
Embodiment 4
A kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: 24 parts of Pollen Typhae, cortex cinnamomi 24
It is part, 9 parts of pyrrosia lingua, 9 parts of peach kernel, 9 parts of Sargent gloryvine, raw 19 parts of the seed of jog's tears, 9 parts of rhizoma alismatis, 9 parts of gingko, 9 parts of herba taxilli, 14 parts of Semen Cuscutae, light
9 parts and 6 parts of radix glycyrrhizae preparata of fermented soya bean.
Its preparation process, including following preparation process:
1) raw material is weighed, cleans, crush, 1.0 times of parts by weight water are added, is impregnated 1.0 hours；
2) 84 DEG C of raw material additions, the 8.4 times of amount water for impregnating step 1), 1300 watts, Microwave Extraction 54 minutes；It is collected by filtration and mentions
Take liquid and filter residue；
3) filter residue obtained by step 2 is added to the ethyl alcohol of 5.4 times of parts by weight 92wt%, 64 DEG C are flowed back 54 minutes；Filter residue is filtered to take,
Be added the ethyl alcohol of 3.4 times of parts by weight 64wt%, 74 DEG C refluxing extraction 34 minutes；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
It 5) is that piece is made in adjuvant by the mannitol for -72 DEG C of enriched product obtained by step 4), being freeze-dried 16 hours, being added 50wt%
Agent.
Embodiment 5
A kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: 26 parts of Pollen Typhae, cortex cinnamomi 26
Part, 11 parts of pyrrosia lingua, 11 parts of peach kernel, 11 parts of Sargent gloryvine, raw 21 parts of the seed of jog's tears, 11 parts of rhizoma alismatis, 11 parts of gingko, 11 parts of herba taxilli, Semen Cuscutae
16 parts, 11 parts of Fermented Soybean and 8 parts of radix glycyrrhizae preparata.
Its preparation process, including following preparation process:
1) raw material is weighed, cleans, crush, 1.1 times of parts by weight water are added, is impregnated 1.1 hours；
2) 86 DEG C of raw material additions, the 8.6 times of amount water for impregnating step 1), 1350 watts, Microwave Extraction 56 minutes；It is collected by filtration and mentions
Take liquid and filter residue；
3) filter residue obtained by step 2 is added to the ethyl alcohol of 5.6 times of parts by weight 93wt%, 66 DEG C are flowed back 56 minutes；Filter residue is filtered to take, is added
Enter the ethyl alcohol of 3.6 times of parts by weight 66wt%, 76 DEG C refluxing extraction 36 minutes；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
5) by -72 DEG C of enriched product of step 4) gained, supplemented by the PVP K30 sweet dew for being freeze-dried 18 hours, being added 35wt%
Granule is made in agent.
Embodiment 6
A kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: 28 parts of Pollen Typhae, cortex cinnamomi 28
Part, 13 parts of pyrrosia lingua, 13 parts of tiger, 13 parts of Sargent gloryvine, raw 23 parts of the seed of jog's tears, 13 parts of rhizoma alismatis, 13 parts of gingko, 13 parts of herba taxilli, Semen Cuscutae 18
Part, 13 parts of Fermented Soybean and 9 parts of radix glycyrrhizae preparata.
Its preparation process, including following preparation process:
1) raw material is weighed, cleans, crush, 1.2 times of parts by weight water are added, is impregnated 1.2 hours；
2) 88 DEG C of raw material additions, the 8.8 times of amount water for impregnating step 1), 1400 watts, Microwave Extraction 58 minutes；Extraction is collected by filtration
Liquid and filter residue；
3) filter residue obtained by step 2 is added to the ethyl alcohol of 5.8 times of parts by weight 94wt%, 68 DEG C are flowed back 58 minutes；Filter residue is filtered to take,
Be added the ethyl alcohol of 3.8 times of parts by weight 68wt%, 78 DEG C refluxing extraction 38 minutes；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
It 5) is that injection is made in adjuvant by the dextrin for -70 DEG C of enriched product obtained by step 4), being freeze-dried 20 hours, being added 35wt%
Agent.
Embodiment 7
A kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: 30 parts of Pollen Typhae, cortex cinnamomi 30
Part, 15 parts of pyrrosia lingua, 15 parts of peach kernel, 15 parts of Sargent gloryvine, raw 25 parts of the seed of jog's tears, 15 parts of rhizoma alismatis, 15 parts of gingko, 15 parts of herba taxilli, Semen Cuscutae
20 parts, 15 parts of Fermented Soybean and 9 parts of radix glycyrrhizae preparata.
Its preparation process, including following preparation process:
1) raw material is weighed, cleans, crush, 1.3 times of parts by weight water are added, is impregnated 1.3 hours；
2) 89 DEG C of raw material additions, the 9 times of amount water for impregnating step 1), 1450 watts, Microwave Extraction 59 minutes；Extracting solution is collected by filtration
And filter residue；
3) filter residue obtained by step 2 is added to the ethyl alcohol of 5.9 times of parts by weight 95wt%, 69 DEG C are flowed back 59 minutes；Filter residue is filtered to take,
Be added the ethyl alcohol of 3.9 times of parts by weight 69wt%, 79 DEG C refluxing extraction 39 minutes；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
5) -68 DEG C of enriched product obtained by step 4), 22 hours will be freeze-dried, melt the 65 DEG C of heating of 40wt% fatty glyceride
Change, is cooled to the dry products obtained therefrom of 55 DEG C of addition step 5), is uniformly mixed, is mixed into sticky liquid, is poured in plastic shape-forming
In pipe, class warhead shape suppository is made in cooling and shaping.
Embodiment 8
A kind of Chinese medicine composition for treating chronic prostatitis, is made from the following raw materials in parts by weight: 32 parts of Pollen Typhae, cortex cinnamomi 32
Part, 17 parts of pyrrosia lingua, 17 parts of peach kernel, 17 parts of Sargent gloryvine, raw 27 parts of the seed of jog's tears, 17 parts of rhizoma alismatis, 17 parts of gingko, 17 parts of herba taxilli, Semen Cuscutae
22 parts, 17 parts of Fermented Soybean and 7 parts of radix glycyrrhizae preparata.
Its preparation process, including following preparation process:
1) raw material is weighed, cleans, crush, 1.4 times of parts by weight water are added, is impregnated 1.4 hours；
2) 87 DEG C of raw material additions, the 8.7 times of amount water for impregnating step 1), 1450 watts, Microwave Extraction 57 minutes；Extraction is collected by filtration
Liquid and filter residue；
3) filter residue obtained by step 2 is added to the ethyl alcohol of 5.7 times of parts by weight 91wt%, 67 DEG C are flowed back 57 minutes；Filter residue is filtered to take,
Be added the ethyl alcohol of 3.7 times of parts by weight 67wt%, 77 DEG C refluxing extraction 37 minutes；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
5) -66 DEG C of enriched product obtained by step 4), 23 hours will be freeze-dried, melt the 65 DEG C of heating of 60wt% fatty glyceride
Change, is cooled to the dry products obtained therefrom of 55 DEG C of addition step 5), is uniformly mixed, is mixed into sticky liquid, is poured in plastic shape-forming
In pipe, class warhead shape suppository is made in cooling and shaping.
Clinical test: protrusion effect of the invention is verified with clinical test below.
One, general information
From in July, 2013 in July, 2015, chronic prostatitis syndrome patient 156 are treated, the age is between 27-65 years old.
Two, diagnostic criteria
" Chinese prostatitis diagnosis treatment guidelines " (version in 2006) is formulated: (1) main performance: lower urinary tract infection repeatedly, different
The urination irritation of degree, urethra drip white or sex dysfunction, the pain such as perineum, pelvic cavity or waist energy portion or have the swollen sense of acid, have
When there is Spirit nerve symptoms of disease insomnia, out of strength, anxiety decrease of memory etc.；(2) 6 middle of the month symptoms of past are accumulated over 3 months；
(3) digital rectal examination (DRE) prostate is in full increase, and matter is soft, mild tenderness, course of disease elder, and prostate reduces, is hardened, no
Uniformly；(4) ultrasound diagnosis shows that prostata tissue structure boundary is unclear, and nothing significantly increases and space occupying lesion；(5) prostatic fluid is normal
It advises (EPS) reduction 30%-70%, white blood cell count(WBC) > 10/HP or has pyocyte；(6) culture of prostatic fluid bacteriology is positive.
Have any one of above (1), (3), (4), (5) and (2), (6) item person, exclusion other diseases, that is, diagnosable.
Three, efficacy assessment standard
(1) clinical healing in the recent period: symptom disappears, and prostate tenderness disappears, and quality is normal or close to normally, and EPS checks continuous 2
It is secondary above normal.
(2) effective: symptom disappears substantially, and prostate tenderness and quality have improvement, and EPS inspection continuous 2 times or more just
Often, > 2/3 is reduced before WBC value is relatively treated.
(3) effectively: symptom mitigates, and EPS inspection continuous 2 times or more normal, reduction 1/3-2/3 before WBC value is relatively treated.
(4) invalid: symptom, prostate anus, which are examined, to be checked with EPS without improving or aggravated.
Four, therapeutic scheme
Referring to specific embodiment by taking 3 gained capsule of embodiment as an example, the 1-2 course for the treatment of is used in conjunction.
Five, statistical result
Healing 113, effective 21, effective 15, invalid 7, total effective rate 95.51%.
Typical case
Case 1: Sun, 48 years old, ShaoXing,ZheJiang people.It is white that patient frequent micturition, urine retention, urine droplet occurred without obvious inducement before half a year,
Erection hardness is poor when sex-linkage is lived.It once is being that " chronic prostatitis " gives oral antibiotic and forefront when districts and cities' hospital diagnosis
Health, effect are unobvious.After taking 1 gained medicine powder, 1 course for the treatment of of the embodiment of the present invention, clinical symptoms are completely disappeared, and EPS is checked
Continuous 3 is subnormal.Effect of follow-up visit by telephone did not recurred after 1 year.
Case 2: gold certain, 62 years old, Zhejiang Hangzhou people.There is urine waiting, dysuria, waist without inducement in two years ago in patient
It is aching and tired.Once it in multiple hospitals diagnosis and treatment, examines as " chronic prostatitis ".Oral drugs, intravenous pharmacy and local treatment, effect are equal
Difference.Appearance in nearly two months cannot urinate, and flank pain aggravates, and because of older and premature coronary heart disease, it is medical that aggravation comes here then.
After 7 gained suppository drug, 2 courses for the treatment of of the embodiment of the present invention, clinical symptoms disappear substantially, and EPS checks that continuous 3 is subnormal,
WBC value reduces > 2/3 before relatively treating.Effect of follow-up visit by telephone does not recur after half a year.
Case 3: Zhang, 43 years old, Zhejiang people from Quzhou.Into over 3 years, patient often feels the abnormal sense of urethra, occur drop it is white,
The symptoms such as perineum distending pain, waist soreness are diagnosed as chronic prostatitis by the People's Hospital, routinely take anti-inflammation analgesic, resist
Treatment, the effects such as raw element are good or bad, cannot thoroughly eradicate.It is treated afterwards in here, uses 7 gained suppository medicine of the embodiment of the present invention
After 2 courses for the treatment of of object, clinical symptoms disappear, and prostate tenderness disappears, quality is normal, and EPS checks that continuous 3 is subnormal.It is electric after half a year
Words follow-up was not recurred.
Case 4: Ma, 29 years old, Taizhou of Zhejiang people.The long-term masturbation of patient is immoderate, occurs frequent micturition, stranguria, urine over one year
Feel not to the utmost, perineum and lower abdomen pain are uncomfortable, the white secretion of terminal urine band.Nearly March is because of disease exacerbation upper after fatigue, Huan Zhejing
It is refreshing nervous, it is extremely painful, carry out here treatment then, per rectum touch: central sulcus shoals, and quality is harder, nodosity sense, it touches (+),
Prostatic fluid is conventional: leucocyte 15-20.After treating 1 course for the treatment of using 7 gained suppository drug of the embodiment of the present invention, patient is without bright
Aobvious subjective symptoms, check prostatic fluid is normal, and Effect of follow-up visit by telephone does not recur after half a year.
Case 5: making pottery certain, and 47 years old, Jinhua, Zhejiang people.Occurred frequent micturition, urodynia before 3 years, once county hospital be diagnosed as it is chronic before
Column adenositis.Through injection of antibiotic, the treatment of the methods of urethra microwave improves unobvious.Occurred lower abdomen secret anguish, anus pendant over the past two years
Swollen, urine waits, enuresis nocturna increases, the symptoms such as premature ejaculation, physical examination: Rectal tonch bilateral prostate significantly increases, tenderness, matter are partially hard, in
Centre ditch shoals, and anal sphincter is without relaxation.Laboratory check: prostatic fluid routine lecithin 30%, leucocyte expire the visual field,
Red blood cell ++, the big ring class of susceptibility is highly sensitive.Ultrasound diagnosis: forefront hylperadenosis.It is medical in here, use the embodiment of the present invention 8
Gained suppository drug 2 disappearances of course for the treatment of Posterior urethral irritations, unobstructed micturitions, laboratory, which checks, restores normal, follow-up after 1 year
It did not recurred.
Case 6: Mr. Wang 36 years old, Xianju, Zhejiang people.Readme frequent micturition, urgent urination, urine wait half a year more, not with perineum
Suitable, recent enuresis nocturna increases, enuresis nocturna 3-4 time, and the county Zeng, the inspection of hospital of city are diagnosed as chronic prostatitis, through radio frequency, prostate
Massage, hot water hip-bath etc. carry out here treatment without positive effect, physical examination: anus examines the increase of prostate II, and matter is hard, tenderness (+),
Disappearence of central groove, anal sphincter is without relaxation.Laboratory checks: prostatic fluid routine lecithin body 25%, leucocyte 18-20/
HPF.B ultrasound is shown: prostate 4.2x3.1x2.9cm, bladder residual urine 30ml.Inject 2 gained injection medicine of the embodiment of the present invention
After 1 course for the treatment of of object, controlled micturition is unobstructed, no enuresis nocturna, and items inspection is normal, and follow-up was not recurred after 1 year.
Case 7: Mr. Wang, 33 years old, Zhejiang Huzhou people.There is lower abdomen secret anguish, delayed urination without risk factor before 1 year, arranges
Posterior urethral burn feeling to be urinated, antibiotic treatment is once voluntarily taken, specific drug is unknown, and it is ineffective, carry out here treatment out of admiration for a famous person.Through examining
It looks into anus and examines that prostate quality is harder, tenderness, central sulcus exists, and no tubercle, surface is smooth；Prostate color ultrasound is shown: prostate is big
It is small be 4.5cm × 3.2cm × 3.0cm, prostatic fluid leucocyte ++++, ovum ++, routine urinalysis is normal.Take the embodiment of the present invention 5
After 1 course for the treatment of of gained granules medicine, clinical symptoms disappear, and check that normally effect is obvious.Effect of follow-up visit by telephone is without recurrence after half a year.
Case 8: Liu 57 years old, Wenzhou District of Zhejiang Province people.Because being engaged in taxi driver's more than ten years, there is frequent micturition, urgent urination in two years ago,
The symptoms such as the uncomfortable, soreness of waist pain of perineum.Once it was diagnosed as chronic prostatitis in local hospital, through injection of antibiotic, urethra microwave
The methods for the treatment of make moderate progress.Occurs perineum secret anguish again because occupation is special, over nearly 1 year, urine waits, enuresis nocturna such as increases at the symptoms
Here is medical, through physical examination: Rectal tonch prostate bilateral increased, tenderness, matter are partially hard, and central sulcus shoals.Laboratory checks
: prostatic fluid routine lecithin 30%, leucocyte expire the visual field.B ultrasound is shown: forefront hylperadenosis.Inject the embodiment of the present invention 6
After 1 course for the treatment of of gained injection medicine, indices check that normally clinical effectiveness is obvious.Phone follow-up study is without multiple after 1 year
Hair.
Case 9: gold certain, 63 years old, people from Haining.Started frequent micturition, urgent urination, urodynia symptom occur before 1 year, goes out within nearly 4 months
Existing underbelly yin pain, rectal tenesmus, the symptoms such as insomnia.Local county hospital inspection shows that bilateral prostate has significantly increased scleroma, touching
(+) bitterly, prostate central sulcus shoal, and Sphincter ani chalasia quality is harder.Prostatic fluid routine test: leucocyte: +++, ovum
Phosphatide corpusculum is few, is diagnosed as chronic prostatitis.Carry out here diagnosis and treatment because local therapeutic effect is bad, through taking the embodiment of the present invention
After 3 courses for the treatment of of gained capsule medicine 1, urination sense of discomfort is substantially reduced, and for one course for the treatment of of solid curative effect following the service, items refer on inspection
Mark is normal, and effect is obvious.Effect of follow-up visit by telephone is without recurrence after half a year.
Case 10: closing certain, and 33 years old, ShaoXing,ZheJiang people.There is night pollakiuria because pressures of Business is big in two years ago, urgent urination, urodynia,
Life quality is not high, insomnia is serious.It is diagnosed as chronic prostatitis in certain Civilian Hospital inspection of locality afterwards, treats aftereffect
Fruit is bad, carrys out here treatment then.Through physical examination: prostate significantly increases, matter is hard, tenderness is obvious, is gently pressed with fester discharge.Urinate microscopy
Look into a large amount of leucocytes, prostate lecithin ++.After taking 4 gained tablet drug, 2 courses for the treatment of of the embodiment of the present invention, clinical condition
Shape disappears, every inspection is normal, and phone follow-up study is without recurrence after half a year.
The above description of the embodiment is only used to help understand the method for the present invention and its core ideas.To these embodiments
A variety of modifications will be readily apparent to those skilled in the art, the general principles defined herein can be with
Without departing from the spirit or scope of the present invention, it realizes in other embodiments.Therefore, the present invention will not be limited
In the embodiments shown herein, and it is to fit to widest model consistent with the principles and novel features disclosed in this article
It encloses.
Claims (10)
1. a kind of Chinese medicine composition for treating chronic prostatitis, which is characterized in that be made from the following raw materials in parts by weight: raw Pu
20 ~ 35 parts yellow, 20 ~ 35 parts of cortex cinnamomi, 5 ~ 20 parts of pyrrosia lingua, 5 ~ 20 parts of peach kernel, 5 ~ 20 parts of Sargent gloryvine, raw 15 ~ 35 parts of the seed of jog's tears, rhizoma alismatis 5 ~ 20
Part, 5 ~ 20 parts of gingko, 5 ~ 25 parts of herba taxilli, 10 ~ 25 parts of Semen Cuscutae, 5 ~ 20 parts and 2 ~ 10 parts of radix glycyrrhizae preparata of Fermented Soybean.
2. a kind of Chinese medicine composition for treating chronic prostatitis as described in claim 1, which is characterized in that by following weight
Part raw material be made: 25 ~ 30 parts of Pollen Typhae, 25 ~ 30 parts of cortex cinnamomi, 10 ~ 15 parts of pyrrosia lingua, 10 ~ 15 parts of peach kernel, 10 ~ 15 parts of Sargent gloryvine,
Raw 20 ~ 30 parts of the seed of jog's tears, 10 ~ 15 parts of rhizoma alismatis, 10 ~ 15 parts of gingko, 15 ~ 20 parts of herba taxilli, 15 ~ 20 parts of Semen Cuscutae, Fermented Soybean 10 ~ 15
Part and 3 ~ 6 parts of radix glycyrrhizae preparata.
3. a kind of preparation process of the Chinese medicine composition for the treatment of chronic prostatitis as described in claim 1, which is characterized in that
Including following preparation process:
1) raw material is weighed, cleans, crush, 0.8 ~ 1.5 times of parts by weight water is added, is impregnated 0.8 ~ 1.5 hour；
2) raw material that step 1) is impregnated is added into water Microwave Extraction, extracting solution and filter residue is collected by filtration；
3) alcohol reflux is added in filter residue obtained by step 2 to extract；
4) extracting solution obtained by step 2 and step 3) is merged, concentration；
5) the dry, preparation by enriched product obtained by step 4).
4. a kind of preparation process for the Chinese medicine composition for treating chronic prostatitis as claimed in claim 3, which is characterized in that
The actual conditions of the step 2 Microwave Extraction are 1200 ~ 1500 watts of raw material after impregnating, and 80 ~ 90 DEG C plus 8 ~ 10 times of water amounts mention
It takes 50 ~ 60 minutes.
5. a kind of preparation process for the Chinese medicine composition for treating chronic prostatitis as claimed in claim 3, which is characterized in that
The condition that ethyl alcohol extracts in the step 3) is that filter residue obtained by step 2 is added to the second of 5 ~ 6 times of parts by weight 90wt ~ 95wt%
Alcohol, 60 ~ 70 DEG C are flowed back 50 ~ 60 minutes；Filter residue is filtered to take, the ethyl alcohol of 3 ~ 4 times of parts by weight 60wt ~ 70wt% is added, 70 ~ 80 DEG C are returned
Stream 30 ~ 40 minutes.
6. a kind of preparation process for the Chinese medicine composition for treating chronic prostatitis as claimed in claim 3, which is characterized in that
The dry condition of enriched product is -78 ~ -60 DEG C in the step 5), is freeze-dried 12 ~ 24 hours.
7. a kind of preparation process of Chinese medicine composition for treating chronic prostatitis as described in claim 3 ~ 6, feature exist
In the preparation in the step 5) is that adjuvant is added to be respectively prepared including decoction, granule, tablet, capsule, injection, powder
Agent, paste and pill.
8. a kind of preparation process for the Chinese medicine composition for treating chronic prostatitis as claimed in claim 7, which is characterized in that
The adjuvant being added in the step 5) is mannitol, PVP K30 or the dextrin of 30wt ~ 50wt%.
9. the preparation process of the Chinese medicine composition such as treatment chronic prostatitis any in claim 3 ~ 6, which is characterized in that
The dosage form of the preparation is rectal administration.
10. a kind of preparation process for the Chinese medicine composition for treating chronic prostatitis as claimed in claim 9, feature exist
In the preparation process of the rectal administration includes the following steps: using fatty glyceride as 65 DEG C of heating and meltings of matrix, drop
Temperature is added the dry products obtained therefrom of step 5), is uniformly mixed, is mixed into sticky liquid, is poured in plastic shape-forming pipe to 55 DEG C,
Class warhead shape suppository is made in cooling and shaping, and wherein the additional amount of fatty glyceride is 40wt ~ 60wt%.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058715A (en) * | 2010-12-20 | 2011-05-18 | 郭瑶 | Chinese medicine preparation for treating chronic prostatitis and preparation method thereof |
| CN105412698A (en) * | 2015-12-10 | 2016-03-23 | 南阳理工学院 | Traditional Chinese medicine composition for treating chronic prostatitis and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058715A (en) * | 2010-12-20 | 2011-05-18 | 郭瑶 | Chinese medicine preparation for treating chronic prostatitis and preparation method thereof |
| CN105412698A (en) * | 2015-12-10 | 2016-03-23 | 南阳理工学院 | Traditional Chinese medicine composition for treating chronic prostatitis and preparation process thereof |
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