CN100490886C - Medicine for treating severe sub-acute hepatitis - Google Patents
Medicine for treating severe sub-acute hepatitis Download PDFInfo
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- CN100490886C CN100490886C CNB2007100133060A CN200710013306A CN100490886C CN 100490886 C CN100490886 C CN 100490886C CN B2007100133060 A CNB2007100133060 A CN B2007100133060A CN 200710013306 A CN200710013306 A CN 200710013306A CN 100490886 C CN100490886 C CN 100490886C
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Abstract
The invention relates to a medicinal composition for treating severe hepatitis which comprises the active constituents of oriental wormwood 30g, cape jasmine 20g, yellow-corktree bark 20g, baikal skullcap root 15g, oriental water plantain rhizome 20g, radix paeoniae rubrathe 50g, root of red rooted saliva 30g, curcuma aromatica 20g, root of herbaceous peony 30g, fruit of barbary wolf berry 15g, prepared rhizome of rehmannia 30g, schisandra fruit 15g, cornus officinalis 10g, creeping euphorbia 30g, Chinese dates 15g, licorice root 5g and notoginseng powder 3g.
Description
(1) technical field
The present invention relates to a kind of medicine for the treatment of subacute severe hepatitis, belong to technical field of Chinese medicine.
(2) background technology
China's Patients with Viral Hepatitis is numerous, and especially the subacute severe hepatitis state of an illness is critical, the case fatality rate height, and the no matter doctor trained in Western medicine or the traditional Chinese medical science still do not have desirable treatment measure at present.Motherland's traditional medicine is with " icterohepatitis " ownership " damp and hot " card, and the method for heat-clearing and dampness-resolving commonly used is treated.Chen Shi thinks that the method for treatment of " stasis of blood, poison " is the main symptom of hepatitis gravis, so propose the method for treatment of " focusing on detoxifcation, being valued for silt ".But the medicine that does not also have a kind of specific treatment subacute severe hepatitis now.
(3) summary of the invention
The present invention provides a kind of medicine by the treatment subacute severe hepatitis that pure Chinese medicine is made, therapeutic effect is good, toxic and side effects is little in order to overcome the deficiency of above technology.
The present invention realizes by following measure:
The medicine of treatment subacute severe hepatitis of the present invention is characterized in that the weight proportion of making raw materials of effective components is: Herba Artemisiae Scopariae 30g Fructus Gardeniae 20g Cortex Phellodendri 20g Radix Scutellariae 15g Rhizoma Alismatis 20g Radix Paeoniae Rubra 50g Radix Salviae Miltiorrhizae 30g Radix Curcumae 20g Radix Paeoniae Alba 30g Fructus Lycii 15g Radix Rehmanniae Preparata 30g Fructus Schisandrae Chinensis 15g Fructus Corni 10g Herba Euphorbiae Humifusae 30g Fructus Jujubae 15g Radix Glycyrrhizae 5g Radix Notoginseng powder 3g.
The method for making of the medicine of the invention described above and usage are: decocting, gradation is oral, per two days potions.
Medicine of the present invention, suitable various high icterohepatitis (except the toxic hepatitis), but the chronic severe hepatitis curative effect with subacute severe hepatitis and slow extra urgaent dispatch is the most remarkable, and it is advantage by pure Chinese medicine is made, therapeutic effect is good, toxic and side effects is little fully that medicine of the present invention has.
(4) specific embodiment
Below in conjunction with the specific embodiment the present invention is made specific description.
Accurately take by weighing the raw material of following weight: Herba Artemisiae Scopariae 30g Fructus Gardeniae 20g Cortex Phellodendri 20g Radix Scutellariae 15g Rhizoma Alismatis 20g Radix Paeoniae Rubra 50g Radix Salviae Miltiorrhizae 30g Radix Curcumae 20g Radix Paeoniae Alba 30g Fructus Lycii 15g Radix Rehmanniae Preparata 30g Fructus Schisandrae Chinensis 15g Fructus Corni 10g Herba Euphorbiae Humifusae 30g Fructus Jujubae 15g Radix Glycyrrhizae 5g Radix Notoginseng powder (taking after mixing it with water) 3g.
Raw material except that Radix Notoginseng powder by cooking after its property of medicine subpackage, adopts conventional decocting method to decoct twice, dissolves in Radix Notoginseng powder again, makes the about 300ml of decocting liquid.Gradation is oral, per two days potions, 28 days courses of treatment.
The medicine of above-mentioned preparation is also referred to as three monarch's jaundice eliminating soup, and the treatment hepatitis gravis has been obtained effect preferably, and laboratory report is as follows.
1 data and method
1.1 physical data is selected subacute severe hepatitis (inferior heavy) patient's 86 examples of in January, 1996 to 2000 year December clinical definite, diagnosis meets the viral hepatitis diagnostic criteria that October nineteen ninety-five (Beijing), the 5th national infectious disease parasitic disease academic conference formulated.Be divided into treatment at random according to the 2:1 ratio and organize wherein male 41 examples of 56 examples, women 15 examples, age 12-69 year, average (40.5 ± 12.3) year; Matched group 30 examples, wherein male 22 examples, women 8 examples, age 18-65 year, average (38.7 ± 13.1) year.Two groups of patients have comparability by analysis.
1.2 two groups of patients of Therapeutic Method all adopt the composite basis therapy, the treatment group adds on this therapy basis with three monarch's jaundice eliminating soup of the present invention.Gradation is oral, per two days potions, 28 days courses of treatment.
1.3 observation index is mainly observed treatment front and back patient's clinical manifestation, the variation of PTA, Tbil and serum albumin (Alb), and followed up a case by regular visits to for 12 weeks
1.4 curative effect determinate standard is clinical cure 1.: symptom and sign disappears substantially, quantizes score value≤10 minute, PTA 〉=65%, TBil≤35umol/L, ALT≤65U/L, Alb 〉=35g/L.
2. produce effects: symptom and sign disappears substantially or obviously improves, and PTA 〉=40%, TBil descend more than 50%, ALT decline 65%, Alb 〉=30g/L.
3. invalid: as except that ALT, to compare not have obviously before all the other every indexs and the treatment and improve.
1.5 quantizing standards of grading, clinical manifestation sees Table 1.
The inferior heavy liver main clinical manifestation of table 1 quantizes standards of grading
| Project | Normally | Slightly | Moderate | Severe |
| Weak (waiting General Symptoms) | 0 | 2 | 5 | 10 |
| Poor appetite (etc. symptom of digestive tract) | 0 | 2 | 5 | 10 |
| Hemorrhage (blood, ecchymosis etc.) | 0 | 5 | 15 | 25 |
| Complexion (complexion, liver palm, spider angioma) | 0 | 3 | 5 | 10 |
| Jaundice | 0 | 5 | 10 | 20 |
| The liver stink | 0 | 5 | 10 | 15 |
| Hepatic region pain, liver are touched a tender spot and are kowtowed pain | 0 | 2 | 5 | 10 |
| Liver volume (mainly judge that liver recto dwindle degree) | 0 | 5 | 15 | 25 |
| Ascites and edema | 0 | 5 | 10 | 15 |
| Hepatorenal syndrome | 0 | 5 | 15 | 25 |
| Disturbance of consciousness | 0 | 5 | 15 | 25 |
1.6 the statistical procedures quantitative data adopts the t check, qualitative data adopts x
2Check.
2 results
2.1 two groups of patient's comprehensive therapeutic effects relatively saw Table 2. when finished the course of treatment
Two groups of patient's comprehensive therapeutic effects relatively when table 2 finished the course of treatment
| n | Cure | Produce effects | Invalid | Survival | |
| The treatment group | 56 | 12(21.4) Δ | 33(58.9) | 11(19.6) Δ | 51(91.1) |
| Matched group | 30 | 2(6.7) | 15(50.0) | 13(43.3) | 25(83.3) |
Compare △ P＜0.01 with matched group
2.2 two groups of patient's comprehensive therapeutic effects relatively saw Table 3 when 12 weeks followed up a case by regular visits to
Two groups of patient's comprehensive therapeutic effects compared (n (%)) when 12 weeks of table 3 followed up a case by regular visits to
| n | Cure | Produce effects | Invalid | Survival | |
| The treatment group | 56 | 31(55.4) Δ | 12(21.4) | 13(23.2) Δ | 43(76.8) Δ |
| Matched group | 30 | 6(20.0) | 7(23.4) | 17(56.7) | 14(46.7) |
Compare △ P＜0.01 with matched group
2.3 the variation of two groups of clinical leading indicators in patient treatment front and back relatively sees Table 4.
The variation comparison of clinical leading indicator before and after 12 liang of groups of table 4 patient treatment (x ± s)
With on the same group the treatment before ratio, * △ P＜0.01; Compare △ P＜0.01 with matched group; Treatment group and matched group respectively have 5 routine patients dead in 28 days in hospital, do not include this table statistics in.
2.4 untoward reaction is taken, and feeling sick appears in small number of patients after three monarch's jaundice eliminating soup, just rare and laxativeness or show as original these sxs is taken the back obviously with volume; After taking medicine, decrement can alleviate or disappear.
3 discuss
China's Patients with Viral Hepatitis is numerous, and especially the hepatitis gravis state of an illness is critical, the case fatality rate height, and no matter doctor trained in Western medicine still is the traditional Chinese medical science is not at present still had desirable treatment measure.Motherland's traditional medicine is with " icterohepatitis " ownership " damp and hot " card, and the method for heat-clearing and dampness-resolving commonly used is treated.Chen Shi thinks that the method for treatment of " stasis of blood, poison " is the main symptom of hepatitis gravis, so propose the method for treatment of " focusing on detoxifcation, being valued for silt ".We think that subacute severe hepatitis many " damp and hotly lay equal stress on, hepatobiliary hyperactivity, excessive noxious heat " accompanies by " qi depression to blood stasis, the hepatic and renal YIN deficiency " on the basis of clinical experience for the treatment of for many years.So on the basis of Traditional Chinese medical theory determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, widely collect crowd side, adopt " eliminating fire and detoxication, heat clearing and damp drying, dampness removing jaundice eliminating " three therapeutic methods of traditional Chinese medicine and usefulness, and assistant is with the method for " blood-cooling and spirit-quieting, dispersing the stagnated live-QI to relieve the stagnation of QI, circulation of qi promoting silt, nourishing the liver and kidney ", make it to attack and do not hinder, mend your reinforcement and elimination in combination method of treatment only, selected 17 herbal medicines are mixed with three monarch's jaundice eliminating soup treatment subacute severe hepatitis, have obtained significant curative effect; Result of study shows that three monarch's jaundice eliminating soup can significantly improve subacute severe hepatitis patient's clinical symptoms and liver function, reduces serum T Bil, obviously improves PAT and serum Alb.Medication treatment 28 days, effective percentage 80.4%; Follow-up results shows that three monarch's jaundice eliminating soup treatment survival rate is 76.8% after 12 weeks, and each clinical indices is all good and matched group, significant difference (P＜0.01).
The hepatitis gravis state of an illness is critical, and symptom of digestive tract is obvious.Feeling sick appears in small number of patients after taking three monarch's jaundice eliminating soup on this basis, takes the back obviously with volume.Consider avirulence Chinese herbal medicine in the prescription formation, may be relevant with tension force physical stimulation or combined reaction after volume is taken.The obvious timely decrement drug administration symptom of person of reaction can be alleviated or disappear.
Claims (1)
1. medicine for the treatment of subacute severe hepatitis is characterized in that the weight proportion of making raw materials of effective components is:
Herba Artemisiae Scopariae 30g Fructus Gardeniae 20g Cortex Phellodendri 20g Radix Scutellariae 15g Rhizoma Alismatis 20g Radix Paeoniae Rubra 50g Radix Salviae Miltiorrhizae 30g Radix Curcumae 20g Radix Paeoniae Alba 30g Fructus Lycii 15g Radix Rehmanniae Preparata 30g Fructus Schisandrae Chinensis 15g Fructus Corni 10g Herba Euphorbiae Humifusae 30g Fructus Jujubae 15g Radix Glycyrrhizae 5g Radix Notoginseng powder 3g.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100133060A CN100490886C (en) | 2007-02-13 | 2007-02-13 | Medicine for treating severe sub-acute hepatitis |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2007100133060A CN100490886C (en) | 2007-02-13 | 2007-02-13 | Medicine for treating severe sub-acute hepatitis |
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| Publication Number | Publication Date |
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| CN101015669A CN101015669A (en) | 2007-08-15 |
| CN100490886C true CN100490886C (en) | 2009-05-27 |
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| CNB2007100133060A Expired - Fee Related CN100490886C (en) | 2007-02-13 | 2007-02-13 | Medicine for treating severe sub-acute hepatitis |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612363B (en) * | 2009-08-07 | 2014-08-06 | 张喜田 | Natural medicinal preparation for raising albumin |
| CN104922207A (en) * | 2015-07-22 | 2015-09-23 | 于淑玲 | Medicine for treating jaundice type hepatitis A |
| CN105998362A (en) * | 2016-06-27 | 2016-10-12 | 中国人民解放军第三〇七医院 | Compound cotinus coggygria oral solution and preparation method thereof |
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2007
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Non-Patent Citations (2)
| Title |
|---|
| 三君退黄汤治疗亚急性重型肝炎的初步研究. 张学海等.中西医结合肝病杂志，第13卷第6期. 2003 |
| 三君退黄汤治疗亚急性重型肝炎的初步研究. 张学海等.中西医结合肝病杂志，第13卷第6期. 2003 * |
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| CN101015669A (en) | 2007-08-15 |
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