CN100490791C - 治疗与新血管生成相关疾病的组合物及方法 - Google Patents

治疗与新血管生成相关疾病的组合物及方法 Download PDF

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Publication number
CN100490791C
CN100490791C CNB018224156A CN01822415A CN100490791C CN 100490791 C CN100490791 C CN 100490791C CN B018224156 A CNB018224156 A CN B018224156A CN 01822415 A CN01822415 A CN 01822415A CN 100490791 C CN100490791 C CN 100490791C
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China
Prior art keywords
gossypol
pharmaceutically acceptable
acceptable salt
neovascularization
medicament
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Expired - Fee Related
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CNB018224156A
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English (en)
Chinese (zh)
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CN1529590A (zh
Inventor
汪建平
汪明中
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Wackvom Ltd
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Wackvom Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CNB018224156A 2000-12-15 2001-12-14 治疗与新血管生成相关疾病的组合物及方法 Expired - Fee Related CN100490791C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25587600P 2000-12-15 2000-12-15
US60/255,876 2000-12-15

Publications (2)

Publication Number Publication Date
CN1529590A CN1529590A (zh) 2004-09-15
CN100490791C true CN100490791C (zh) 2009-05-27

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CNB018224156A Expired - Fee Related CN100490791C (zh) 2000-12-15 2001-12-14 治疗与新血管生成相关疾病的组合物及方法

Country Status (7)

Country Link
US (1) US6608107B2 (OSRAM)
EP (1) EP1343487A2 (OSRAM)
JP (1) JP2005502579A (OSRAM)
CN (1) CN100490791C (OSRAM)
AU (1) AU2002230888A1 (OSRAM)
MY (1) MY134562A (OSRAM)
WO (1) WO2002047673A2 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385936A (en) 1990-07-12 1995-01-31 The United States Of America As Represented By The Secretary Of The Department Of The Health And Human Services Gossypol acetic acid for the treatment of cancer
CA2417500C (en) 2000-07-28 2008-11-18 Georgetown University Medical Center Erbb-2 selective small molecule kinase inhibitors
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
WO2003038060A2 (en) 2001-11-01 2003-05-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
CN100413493C (zh) * 2003-06-11 2008-08-27 中国科学院动物研究所 棉酚及其衍生物在制备治疗骨髓瘤药物中的应用
EP1653943B3 (en) * 2003-06-25 2008-07-30 The Burnham Institute Catechol derivatives for the treatment of cancer
AU2005204685B2 (en) * 2004-01-07 2007-06-21 E-L Management Corporation Cosmetic composition and method for retarding hair growth
CN1960719B (zh) 2004-03-25 2011-12-07 密执安州立大学董事会 棉酚共结晶及其应用
US20110091552A1 (en) * 2007-08-31 2011-04-21 Mccaffrey Tim Use of Bcl Inhibitors for the Treatment of Scarring Caused By Cutaneous Wounds, Burns and Abrasions
JP5406194B2 (ja) * 2007-10-01 2014-02-05 アセンタ セラピューティックス インコーポレイティッド Ｒ−ゴシポールｌ−フェニルアラニノールジエナミンを調製するための方法
CN104845532B (zh) 2009-06-22 2017-10-03 嘉柏微电子材料股份公司 化学机械抛光组合物以及用于抑制多晶硅移除速率的方法
WO2011013846A1 (ja) 2009-07-29 2011-02-03 帝人化成株式会社 ポリカーボネート−ポリジオルガノシロキサン共重合体
CN101810577B (zh) * 2010-05-06 2011-09-07 山东大学 治疗肿瘤的棉酚静脉注射脂肪乳剂
CN102690326B (zh) * 2012-05-29 2014-04-02 武汉大学 具有抗艾滋病毒活性的棉酚衍生物及其制备
US9750761B2 (en) * 2014-05-21 2017-09-05 University Of Rochester LDH inhibitors as treatment for fibrosis and fibrotic-related disorders
US20220162561A1 (en) * 2019-04-04 2022-05-26 Nissan Chemical Corporation Composition for promoting secretion of extracellular vesicles
CN110559449B (zh) * 2019-10-22 2022-09-02 长治医学院 一种聚棉酚前药胶束及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1204510A (zh) * 1997-07-09 1999-01-13 辛国芳 以棉酚或(和)其衍生物为有效成分的药栓及用途
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260327A (en) * 1985-10-02 1993-11-09 Sloan-Kettering Institute For Cancer Research Methods for inhibiting the proliferation of brain and hepatic metastases by using lonidamine
US5026726A (en) * 1989-12-11 1991-06-25 The University Of New Mexico Gossylic iminolactones and gossylic lactones and their anti-viral activities
US5936120A (en) * 1997-12-10 1999-08-10 University Of New Mexico Deoxygossylic compounds
US5780675A (en) * 1995-04-28 1998-07-14 The University Of New Mexico Deoxygossylic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer
CN1204510A (zh) * 1997-07-09 1999-01-13 辛国芳 以棉酚或(和)其衍生物为有效成分的药栓及用途

Also Published As

Publication number Publication date
JP2005502579A (ja) 2005-01-27
WO2002047673A2 (en) 2002-06-20
CN1529590A (zh) 2004-09-15
EP1343487A2 (en) 2003-09-17
US20020137801A1 (en) 2002-09-26
WO2002047673A3 (en) 2003-01-03
US6608107B2 (en) 2003-08-19
AU2002230888A1 (en) 2002-06-24
MY134562A (en) 2007-12-31

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