CN100482082C

CN100482082C - Chinese medicinal composite restcide and its preparation and use

Info

Publication number: CN100482082C
Application number: CNB031537936A
Authority: CN
Inventors: 姚明勤
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-08-21
Filing date: 2003-08-21
Publication date: 2009-04-29
Anticipated expiration: 2023-08-21
Also published as: CN1582670A

Abstract

A Chinese-medicinal preparation for preventing and eliminating the diseases and pests of plant and providing nutrients to plant is prepared from the liquid extract of Chinese-medicinal herbs, organic acid and trace elements.

Description

A kind of prevention and elimination of disease and pests compound Chinese medicinal preparation is used the preparation method of " Chinese medicine acoustomagnetic radiating extractor "

The present invention relates to a kind of prevention and elimination of disease and pests compound Chinese medicinal preparation and used the preparation method of " Chinese medicine acoustomagnetic radiating extractor ", it is according to traditional Chinese medical theory and practice, cheap medicinal plant compound extract is added organic acid and trace element, the disease and insect resistance nutrient of forming, extremely obviously strengthen plant disease-resistant worm ability, even the sick parasitosis that can will just sprout is removed fully at short notice.Promptly this nutrient both can strengthen the effect that the plant immune function reaches preventing disease and pest; Can reach the effect of the biopesticide of " integrated control " again.

Chinese medicine is the magnificent jewel in the Chinese traditional culture treasure-house.Practice is is for thousands of years prevented and cured diseases, and across-the-board regulation and bidirectional modulation, excites immunologic function, and the resistance against diseases of enhancing body, and advantages such as toxic and side effect is lower, noresidue are towered in the woods of world medicine.

Current, vegetables, fruit, cereal crops damage by disease and insect are used chemical pesticide mostly.According to the residue of pesticide monitoring that Hebei Prov. Health and Epidemic Prevention Station carried out Hebei the whole province scope in 3 years, find that the remains of pesticide recall rate of vegetables, fruit, grain is respectively 61.3%, 47.5% and 54.1%, detect remains of pesticide and reach 26 kinds; And increase year by year, be more than 40% as recall rate in 1997, by 1999 near 60%.Remains of pesticide is accumulated delay in the human body midium or long term can cause many chronic diseases, most importantly causes cancer, cardiovascular and cerebrovascular disease and diabetes to rise.City cardiovascular and cerebrovascular disease patient has accounted for 65% to 75% of number of patients at present, and the rural area also reaches 50%, and this and vegetable residual pesticide have direct relation.

More worried is along with the accumulation of residual medicament in the increase of pesticide dosage and the agricultural environment, and stronger damage by disease and insect produces, and forms vicious circle; Moreover contaminated soil, water, airborne toxin can exist for a long time, though in a period of time pesticide grown no longer, crops still can bring residue of pesticide, polluting has become a great problem of pendulum in face of ours.Therefore, for human health, the protection agriculture production environment, protection land resources, the control residue of pesticide have been very urgent.

Biopesticide (BT microbial pesticide, farm antibiotics and botanical pesticide) Pesticidal and sterilizing is effective, noresidue, nuisanceless, toxicity is little, safety, firmly gets people's praise.

Yet the biological pesticide containing antibiotic investment is very high, and the botanical biological pesticide investment is very low, and renewable medicine source is abundant, production is easy, is the better approach of instead of chemical agricultural chemicals.

Extract the elite of Chinese herbal medicine, be insecticide be again bactericidal agent, also play the biological foliage fertilizer effect of regulating; Wide spectrum, efficient, the effect of realization " medicine is controlled more ", " encircling and annihilating ", " integrated control ".Be that other agricultural chemicals can't be compared.What-the-hell rationally choose, scientific matching and efficient rapid extraction? and the limitation of avoiding producing and store the stability of degraded and overcoming use, aim of the present invention that Here it is.

China's Chinese medicine is produced and mostly is decocting process at present, fully effective component do not extracted, and the decoction when having the active ingredient that much is extracted out or active substance longer and destroyed.The present invention has changed decocting process, use " the efficient acoustomagnetic radiating extractor fast of Chinese medicine " (patent No. ZL01270426.1 that China Intellectual Property Office has been authorized), can be fast, effectively extract, and the bioactivator that is removed can stable existence, and further activated by electromagnetic radiation, thereby improved sterilization, the desinsection of medicine greatly, strengthened resistance against diseases.

Extensively exist alkaloid, glucoside, polysaccharose and mucopolysaccharide catabolic enzyme in the Chinese herbal medicine cell that we select for use, the active ingredient of Pesticidal and sterilizing often will prevent from during extraction the hydrolysis or the polymerization that are caused by it from all need reduce its temperature; Add these endophytic bacteriums that need low temperature to extract and also produce the various biological effect, as the promotion plant growing with to the extermination of disease and insect pest.Zymologic property shows; 36 ℃ of the most suitable temperature of enzyme effect and PH are 8.0; but promote hydrolysis to be difficult for keeping the proenzyme state owing to there is metal ion to exist; so in producing process except that stabilizing agent that is added with protectiveness and synergist; radiator is housed again; the activity and the enzymic activity of some trace element are improved, to strengthen drug effect.

The present invention is achieved by the following technical solutions:

Select for use cheap Chinese herbal medicine and consumption proportion (by weight) to be:

5-10 parts of 10-20 parts of achenes of Siberian cocklebur of 20-30 parts of thunder godvines of kuh-seng

15-25 parts on 5-10 parts of tobacco leaves of 10-20 parts of Chinese pulsatillas of reticulate millettia

After adding hydrotropy emulsification bleeding agent after extracting solvent, extracting, concentrate, add stabilizing agent, synergist in addition and be made into wide spectrum, desinsection, sterilization microemulsion efficiently.

Disease and insect resistance Chinese medicine compound prescription control agent preparation technology of the present invention is finished by the following step:

A) selected kuh-seng, thunder godvine, the achene of Siberian cocklebur, reticulate millettia, tobacco leaf, each Chinese herbal medicine of the Chinese pulsatilla;

B) with 20-30 parts of (a) kuh-sengs, 10-20 parts of thunder godvines, 5-10 parts of the achenes of Siberian cocklebur, 10-20 parts of reticulate millettias, 5-10 parts of the Chinese pulsatillas, 15-25 parts on tobacco leaf, section or pulverizing (20 order), add medicine and weigh 3-10 times extraction solvent soaking, and to add hydrotropy emulsification bleeding agent be multiple saponin and micro-organic acid salt that addition is 3-5 parts; The extraction solvent is that water, alcohol, acetone are any one or two kinds of; Extract 10-40 ℃ of temperature, normal pressure is used " acoustomagnetic radiating extractor " and is extracted 15-45min.After extracting soup out, add medicine again and weigh 3-6 times of solvents and extract for the second time;

C) mixed liquor with (b) item filters, and concentrates, and the Baume degrees that makes soup is at 10 °-13 °;

D) add stabilizing agent respectively for containing oxidation resistant flavonoids in the concentrate with (c) item, addition is 5-15 parts; Synergist is 5-15 parts of archen additions;=or contain pyrethroid or the Imidacloprid 0.5～2.0% that vegetable oil dissolves, the fully emulsified microemulsion of making.

Single medicinal material often contains multiple effective ingredient, and each effective ingredient may have many-sided pharmacological action, and Chinese medicine compound prescription, particularly big compound, its chemical analysis, pharmacological action and interaction are more complicated.By monarch, minister, assistant, make compatibility, make and contain nicotine, east scopola alkali plays the anesthesia action of contace poison, wilforonide stomach toxicity insecticidal action strengthens, thunder godvine contains endogenetic fungus can also suppress phytopathogenic fungis such as sclerotium germ and grape spore, more can effectively suppress candida albicans, make other contain the alkaloid jamaicin, matrine, Anemonins etc. are antibiotic, antiviral effect improves, so prescription and extraction process thereof are one of advantages of the present invention program, for example the Chinese pulsatilla often produces a large amount of precipitations (jamaicin) in leaching process, estimate that jamaicin and tannin or plant organic acid form salt or the molecular complex that is insoluble in water, the present invention had both improved the concentration of jamaicin, do not make its precipitation again, active substance is stable, period of storage is long.

The ill initial stage of fruit tree at first occurs in the blade of branch, and is less, look yellow; The spike top phenomenon.

Sick tree can bloom, and fruit drop is serious, even deposit fruit, most of pericarp hardening is and thick, and pulp slag succulence is few, and pericarp is coarse, and gluey scabbing is arranged, even fruit is little and hard.

From the physiological disease of solution crop generation, and found the necessary for plant growth micronutrient element.As " colored and unreal " that China rape seed producing region takes place, be that China uses the very outstanding exemplary that trace element fertilizer solves agricultural production.

Use still based on the nutrient of sterilization, except that having desinsection, sterilization, raise immunity jointly, also has the function that makes the flowers longer blooming period based on the nutrient of desinsection, is two of the present invention program's advantage.For example soup is joined 1000 times of water, be sprayed on the living azalea of 3a, camellia, the contrast blade increases by 0.5-0.7cm, and the flower amount increases by 10%, longer blooming period 3-5 days; Be sprayed on just budding kaffir lily and take, removed longer blooming period 3-5 days, the difficult drop-off of setting seeds, the leaf of jaundice turns green.

In China, the extermination of disease and insect pest is taked " putting prevention first integrated control ", nutrient generally can reach this purpose; But actual damage by disease and insect develops into to a certain degree, or the peak period of causing harm, and people just go to control, the botanical pesticide efficacy of a drug that seems deficiency.It is composite that Gu Te adds synergist such as pyrethroid or Imidacloprid, and the combination biopesticide compensates its defect.

It is special acoustomagnetic radiating extractor that the present invention uses the traditional Chinese medicine extraction device, and it is 20-70KH that acoustomagnetic radiating system Extraction by Ultrasound case operating frequency is arranged ₂, export out electrical power 300W-3600W, magnetic radiation control cabinet magnetic field intensity is 4500-10000GS and heating, filtration cycle system is housed that one of optional water, lower alcohol, aliphatic ketone, fatty ethers are planted or two kinds of works extract solvent.Chinese herbal medicine can be regularly, constant temperature, by ultrasonic and incentive action electromagnetism, quickens the effective component dissolving, forms the little molecule of nanoscale, and obtain drug effect height, medicament that cost is low efficiently, fast, easily.

Chinese medicine residue after the extraction is spread on the field and can kills soil insect and make green manure.

Detect through agricultural plant protection department and medicine inspection department, microemulsion water dilutes 500-1000 times of desinsections, sterilization effect generally at (48h) more than 90%, damage by disease and insect non-resistant, nuisanceless, noresidue; Be widely used in flowers, vegetables, fruit tree, vineyard, be subjected to flowers and green house of vegetables worker's welcome deeply.Especially directly fruit tree, the flowers and trees injection water to withered and damage by disease and insect dilutes 10 times nutrient, and than general sprinkling and filling root, it is faster to take effect.

Claims

1, a kind of prevention and elimination of disease and pests compound Chinese medicinal preparation is used the preparation method of " Chinese medicine acoustomagnetic radiating extractor ", it is characterized in that disease and insect resistance Chinese medicine compound prescription control agent is to be prepared by following medicinal plant, and each component consumption proportion (by weight) is:

15-25 parts on 5-10 parts of tobacco leaves of 10-20 parts of Chinese pulsatillas of 5-10 parts of reticulate millettias of 10-20 parts of achenes of Siberian cocklebur of 20-30 parts of thunder godvines of kuh-seng

Adding hydrotropy emulsification bleeding agent after extracting solvent, after application " acoustomagnetic radiating extractor " was extracted, concentrated, other added stabilizing agent, synergist is mixed with both desinsection, sterilization, strengthens the plant pesticide of plant immune function again.

2, a kind of prevention and elimination of disease and pests compound Chinese medicinal preparation according to claim 1 is used the preparation method of " Chinese medicine acoustomagnetic radiating extractor ", it is characterized in that the hydrotropy emulsification bleeding agent that adds is multiple saponin or, two kind of organic acid, and addition is 3-5 parts; The extraction solvent is that 3～10 times water, alcohol, acetone of drug weight is any one or two kinds of; Extract 10～40 ℃ of temperature, normal pressure, extraction time 15～45min.

3, a kind of prevention and elimination of disease and pests compound Chinese medicinal preparation according to claim 2 is used the preparation method of " Chinese medicine acoustomagnetic radiating extractor ", the stabilizing agent that it is characterized in that adding is for containing oxidation resistant flavonoids medicinal plant, 5-15 parts of additions, both can in Chinese medicine compound prescription is extracted, add, and also can extract flavonoids separately and then add; The synergist that adds is to contain archen and curcumin medicinal plant extraction juice for improving the sterilization bacteriostasis; For the synergist that improves insecticidal action is pyrethroid or the Imidacloprid 0.5-2.0% that contains the vegetable oil dissolving.

4, a kind of prevention and elimination of disease and pests compound Chinese medicinal preparation according to claim 3 is used the preparation method of " Chinese medicine acoustomagnetic radiating extractor ", it is characterized in that Chinese medicine acoustomagnetic radiating extractor is is 20-70KHz by operating frequency, the Extraction by Ultrasound case of electromotive power output 300W-3600W and magnetic field intensity are the interior magnetic radiation controller of 4500-10000GS and the circulating pump composition that joins, constitute the acoustomagnetic radiating extractor of the circulatory system, make Chinese herbal medicine can be regularly, the incentive action of constant temperature by ultrasonic and electromagnetism, the dissolving of acceleration effective component forms plant pesticide control agent.